Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology最新文献_第9页

Involvement of sigma 1 receptor in the SSRI-induced suppression of the methamphetamine-induced behavioral sensitization and rewarding effects in mice. 西格玛 1 受体参与抑制 SSRI 诱导的小鼠甲基苯丙胺行为敏化和奖赏效应。

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology Pub Date : 2013-04-01

Mahardian Rahmadi, Tomohisa Mori, Megumi Kanazawa, Hitomi Kubota, Masahiro Shibasaki, Tsutomu Suzuki

{"title":"Involvement of sigma 1 receptor in the SSRI-induced suppression of the methamphetamine-induced behavioral sensitization and rewarding effects in mice.","authors":"Mahardian Rahmadi, Tomohisa Mori, Megumi Kanazawa, Hitomi Kubota, Masahiro Shibasaki, Tsutomu Suzuki","doi":"","DOIUrl":"","url":null,"abstract":"The abuse of methamphetamine causes abnormal behaviors which are indistinguishable from schizophrenia in humans. Recent reports have shown that selective serotonin reuptake inhibitors (SSRIs) have beneficial effects on methamphetamine-related behaviors, including behavioral sensitization and rewarding effects in animals. However, the exact mechanisms by which SSRIs affect methamphetamine-related behaviors are not yet clear. The present study was designed to investigate the effects of SSRIs on the development of methamphetamine-induced behavioral sensitization and rewarding effects in mice. Behavioral sensitization was measured by examining the locomotor activity of mice in a tilting cage after repeated injections of methamphetamine. Repeated administration of methamphetamine significantly induced a behavioral sensitization. Some SSRIs (fluoxetine and fluvoxamine), which have sigma-1 receptor agonistic activity, inhibited the development of methamphetamine-induced behavioral sensitization. Fluoxetine also dose-dependently attenuated the rewarding effects of methamphetamine as measured by the conditioned place preference paradigm. Furthermore, the sigma-1 receptor antagonist NE-100 significantly reversed the inhibitory effects of fluoxetine on methamphetamine-induced behavioral sensitization and rewarding effects. These results suggest that sigma-1 receptor agonistic activity might be involved in the attenuating effects of fluoxetine and fluvoxamine on methamphetamine-induced behavioral sensitization and rewarding effects.","PeriodicalId":19250,"journal":{"name":"Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology","volume":"33 2","pages":"49-56"},"PeriodicalIF":0.0,"publicationDate":"2013-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32540213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Influence of GIRK channel inhibition on relapse in Japanese alcohol-dependent inpatients]. [GIRK通道抑制对日本酒精依赖住院患者复发的影响]。

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology Pub Date : 2013-04-01

Nagisa Sugaya, Yasukazu Ogai, Yoichi Kakibuchi, Eiichi Senoo, Kazutaka Ikeda

引用次数: 0

[Cell therapy using stem cells: trophic factor, differentiation, and cell transplantation]. 干细胞的细胞治疗:营养因子、分化和细胞移植。

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology Pub Date : 2013-02-01

Hideki Hida

{"title":"[Cell therapy using stem cells: trophic factor, differentiation, and cell transplantation].","authors":"Hideki Hida","doi":"","DOIUrl":"","url":null,"abstract":"Our research of stem cell transplantation using mouse embryonic stem (ES) cells and induced pluripotent (iPS) cells was carried out from the aspect of trophic factor, cell differentiation, and better survival of grafted cells. Pleiotrophin, an enhanced trophic factor in the dopamine (DA)-depleted striatum, increased the number of DAergic neurons from ES-derived neural stem cells (ES-NSCs), increased cell survival of cultured DAergic neurons, and affected cell survival of grafted DAergic cells in Parkinson model rats. It was shown that DAergic differentiation from ES-NSCs was mediated by hypoxia inducible factor 1-alpha. Our challenges of the transplantation of ES-NSCs and iPS-derived oligodendrocyte progenitor cells (iPS-OPCs) into periventricular leukomalasia (PVL) model rats are also presented. It was found that grafted ES-NSCs survived better in the corpus callosum without immunosuppressant and most of them differentiated into neurons near the grafted site. It was also revealed that only a few of the grafted iPS-OPCs induced by a stepwise culture method with no use of serum could survive in PVL model rats, indicating that trophic factor (s) and improvement of graft techniques will be needed for better survival of grafted iPS-OPCs.","PeriodicalId":19250,"journal":{"name":"Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology","volume":"33 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2013-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32537714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[The molecular basis for the protection and axon regeneration of motor neurons after nerve injury]. [神经损伤后运动神经元保护和轴突再生的分子基础]。

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology Pub Date : 2013-02-01

Hiroshi Kiyama

引用次数: 0

[Man meets snake]. [人遇见蛇]。

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology Pub Date : 2013-02-01

Nobuo Masataka

引用次数: 0

[Development of social cognition: a functional neuroimaging approach]. [社会认知的发展:功能性神经成像方法]。

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology Pub Date : 2012-11-01

Norihiro Sadato

{"title":"[Development of social cognition: a functional neuroimaging approach].","authors":"Norihiro Sadato","doi":"","DOIUrl":"","url":null,"abstract":"Social cognition is defined as the capacity to engage in information processing with the aim of accurate cognition of other persons' character or intentions. Development of social cognition can be observed in behavioral patterns. However, their neural basis remains largely unknown. A functional neuroimaging technique has enabled us to observe neural activities in the human brain noninvasively. First the principle and history of functional magnetic resonance imaging (fMRI), and its future perspective are introduced. As an example, presented is our attempt to apply simultaneous fMRI measurements of two individuals to elucidate the neural basis of joint attention, one of the most important behavioral milestones in the development of social cognition. Second, neural substrates of pro-social behavior are discussed. Specifically, it was found that social acceptance or praise is important for human altruistic behavior, and has a neural basis similar to that of basic reward or monetary reward. Lastly, I stress the importance of combining current and ongoing progress in neuroscience, from the 'micro' through 'macro' levels, with scholarship within the humanities. As a connecting node for the different research fields, functional neuroimaging techniques will play a critical for the ultimate goal of comprehensive understanding of human social cognition.","PeriodicalId":19250,"journal":{"name":"Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology","volume":"32 5-6","pages":"299-303"},"PeriodicalIF":0.0,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31207260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Neurodegeneration and epigenetics]. [神经变性和表观遗传学]。

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology Pub Date : 2012-11-01

Atsushi Iwata

引用次数: 0

[Neurogenesis in the postnatal and adult brain]. [出生后和成人大脑中的神经发生]。

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology Pub Date : 2012-11-01

Itaru Imayoshi

引用次数: 0

[An approach toward CNS dysfunction associated with metabolic syndrome; implication of leptin, which is a key molecule of obesity, in depression associated with obesity]. 代谢综合征相关中枢神经系统功能障碍的研究;瘦素是肥胖的关键分子，在与肥胖相关的抑郁中的意义。

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology Pub Date : 2012-11-01

Nobuko Yamada-Goto, Goro Katsuura, Yukari Ochi, Kazuwa Nakao

{"title":"[An approach toward CNS dysfunction associated with metabolic syndrome; implication of leptin, which is a key molecule of obesity, in depression associated with obesity].","authors":"Nobuko Yamada-Goto, Goro Katsuura, Yukari Ochi, Kazuwa Nakao","doi":"","DOIUrl":"","url":null,"abstract":"Obesity is the most critical factor in the pathology of metabolic syndrome (MetS), and is associated with an increased risk of depression. The imbalance of hormones and neural peptides which are involved in energy regulation are observed in obesity. It becomes evident that these hormones and neural peptides also affect mood. Leptin plays a pivotal role in energy regulation mainly acting in the hypothalamus of the brain. Although obese humans and rodents usually have high circulating levels of leptin, leptin neither reduces food intake nor increases energy expenditure. This paradoxical situation in obesity has been termed \"leptin resistance\", which is considered to be a central dogma for obesity. Based on these observations, we examined the functional significance of leptin in the regulation of the depressive state in diet-induced obese (DIO) mice. Our recent study demonstrated that DIO mice showed severe depressive behavior without response to the antidepressant effect of leptin, which is, in part, due to the impairment of leptin action in the hippocampus (Yamada, et al., Endocrinology, 2011). MetS and CNS dysfunction might have common pathological bases vulnerable to these disorders. Our future direction is to investigate a new treatment strategy of MetS by analyzing CNS dysfunction associated with obesity.","PeriodicalId":19250,"journal":{"name":"Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology","volume":"32 5-6","pages":"245-50"},"PeriodicalIF":0.0,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31207345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Restorative therapy in amyotrophic lateral sclerosis]. 肌萎缩侧索硬化症的恢复性治疗。

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology Pub Date : 2012-11-01

Masashi Aoki

{"title":"[Restorative therapy in amyotrophic lateral sclerosis].","authors":"Masashi Aoki","doi":"","DOIUrl":"","url":null,"abstract":"Amyotrophic lateral sclerosis (ALS) is an adult onset neurodegenerative disorder characterized by the death of upper and lower motor neurons. About 10% of all ALS cases are familial; approximately 20% of familial ALS cases are caused by mutations in the superoxide dismutase 1 (SOD1) gene. We developed rats that express a human SOD1 transgene with ALS-associated mutations, developing striking motor neuron degeneration and paralysis. The larger size of this rat model as compared with the ALS mice, will facilitate studies involving manipulations of spinal fluid and the spinal cord. Hepatocyte growth factor (HGF) is one of the most potent survival-promoting factors for motor neurons. We administered human recombinant HGF (hrHGF) by continuous intrathecal delivery to the transgenic rats at the onset of paralysis for 4 weeks. Intrathecal administration of hrHGF attenuated motor neuron degeneration and prolonged the duration of the disease by 63%. To translate this strategy to human treatment, we induced a contusive cervical spinal cord injury in the common marmoset, a primate, and then administered hrHGF intrathecally. The intrathecal administration of hrHGF promoted functional recovery. These results prompted further clinical trials in ALS using continuous intrathecal administration of hrHGF.","PeriodicalId":19250,"journal":{"name":"Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology","volume":"32 5-6","pages":"287-92"},"PeriodicalIF":0.0,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31207258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0