Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology最新文献

[Basal Ganglia Circuit Mechanisms in Cognitive Learning]. 认知学习中的基底神经节回路机制。

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology Pub Date : 2017-04-01

Takatoshi Hikida, Tom MacPherson, Makiko Morita

引用次数: 0

Experience-dependent development of visual cortical functions. 视觉皮质功能的经验依赖性发展。

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology Pub Date : 2017-04-01

Yumiko Yoshimura

{"title":"Experience-dependent development of visual cortical functions.","authors":"Yumiko Yoshimura","doi":"","DOIUrl":"","url":null,"abstract":"Visual cortical neurons selectively respond to particular features of visual stimuli. Selective visual responsiveness is modified by visual expe- rience during development. We report that fine-scale networks of precisely interconnected excitatory neurons were embedded in the rat visual cortex and suggest that this network could be a functional unit for visual information processing. We also investigated the effects of visual dep- rivation on the development of visual cortical circuits. We used two kinds of deprivation, binocular deprivation and dark rearipg, which allowed visual inputs with only diffuse light and no visual input, respectively. The probability and strength of excitatory connections t layer 2/3 pyrami- dal cells increased during the 2 weeks after eye opening, and these changes were prevented by dark rearing, but not binocular eprivation. Fine- scale networks were absent just after eye opening and established during the following 2 weeks in rats reared with normal visual experience, but not with either type of deprivation. These results indicate that patterned vision is required for the emergence of the fine-scale network, whereas diffuse light stimulation is sufficient for the mituration of individual synapses. The critical role of early sensory experience may be to organize cell assemblies underlying visual information processing in the visual cortex.","PeriodicalId":19250,"journal":{"name":"Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology","volume":"37 2","pages":"29-33"},"PeriodicalIF":0.0,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36695651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Experimental disease models for mechanistic understanding and drug discovery for psychiatric disorders. 精神疾病的机制理解和药物发现的实验疾病模型。

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology Pub Date : 2017-04-01

Hitoshi Hashimoto

引用次数: 0

The contribution of neuroplasticity induced in cholinergic neurons of the laterodorsal tegmental nucleus to cocaine addiction. 背外侧被盖核胆碱能神经元的神经可塑性对可卡因成瘾的影响。

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology Pub Date : 2017-02-01

Katsuyuki Kaneda

{"title":"The contribution of neuroplasticity induced in cholinergic neurons of the laterodorsal tegmental nucleus to cocaine addiction.","authors":"Katsuyuki Kaneda","doi":"","DOIUrl":"","url":null,"abstract":"Cocaine-induced neuroplasticity in brain reward circuitry consisting of the ventral tegmental area (VTA), nucleus accumbens and medial pre- frontal cortex is critical for developing cocaine addiction. Recent studies have investigated the involvement of brain areas in addition to the mesocorticolimbic circuitry in cocaine addiction. One such area is the laterodorsal tegmental nucleus (LDT). Cholinergic neurons in the LDT project to the VTA and regulate the activity of dopaminergic neurons. Using the cocaine-induced conditioned place preference (CPP) paradigm in rats, we found that the activity of LDT cholinergic neurons and cholinergic transmission-from the LDT to VTA are critical for the acquisition and expression of cocaine CPP. Moreover, ex vivo electrophysiological analyses revealed that chronic cocaine administration induces plasticity in excitatory synaptic transmission and membrane excitability of LDT cholinergic neurons. Furthermore, noradrenaline, which is released from locus coeruleus axon terminals, attenuated inhibitory synaptic transmission in LDT cholinergic neurons which were obtained from rats that had received chronic cocaine but not saline administrations. This cocaine-induced plasticity in LDT cholinergic neurons may enhance the excitability of these neurons, resulting in changes in the reward circuit activity that might be associated with the development of addicted behaviors induced by cocaine.","PeriodicalId":19250,"journal":{"name":"Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology","volume":"37 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2017-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36696187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Neuroimaging studies of depression: Current status and future direction.] [抑郁症的神经影像学研究:现状和未来方向]

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology Pub Date : 2016-11-01

Asako Mori, Yasumasa Okamoto, Go Okada, Shigeto Yamawaki

{"title":"[Neuroimaging studies of depression: Current status and future direction.]","authors":"Asako Mori, Yasumasa Okamoto, Go Okada, Shigeto Yamawaki","doi":"","DOIUrl":"","url":null,"abstract":"Recent advances in neuroimaging studies enable us to measure brain function non-invasively. Over the past several decades, neuroimaging measurement has been substantially applied to elucidate the neurobiological mechanisms underlying major depressive disorder (MDD). Since MDD is a wide spectrum which consists of various symptoms such as low mood or loss of interest and is considered to affect a biologically het- erogeneous population, we have not yet elucidated the biological underpinnings of MDD. It seems to be more promising to consider MDD as an integral network abnormality instead of deficits in specific brain regions or neurotransmitters. We firstly provide a comprehensive review of the extant neuroimaging literature including structural and functional magnetic resonance imaging, magnetic resonance spectroscopy, single pho- ton emission computed tomography, and positron emission tomography studies. Then we show our neuroimaging studies for MDD toward po- tential application as a biomarker for diagnosis and treatment. We believe it will facilitate the development, of a more integrative model of neural dysfunction in MDD.","PeriodicalId":19250,"journal":{"name":"Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology","volume":"36 5-6","pages":"101-108"},"PeriodicalIF":0.0,"publicationDate":"2016-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35956168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Pharmacokinetics and safety of aripiprazole long-acting injection, following multiple deltoid administrations in schizophrenia patients in Japan]. [日本精神分裂症患者多次三角肌注射后长效阿立哌唑的药代动力学和安全性]。

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology Pub Date : 2016-06-01

Jun Ishigooka, Takamasa Noda, Kosuke Nishiyama, Noriko Tamaru, Tomoko Shima, Yumiko Yamasaki, Yoshihiro Tadori

{"title":"[Pharmacokinetics and safety of aripiprazole long-acting injection, following multiple deltoid administrations in schizophrenia patients in Japan].","authors":"Jun Ishigooka, Takamasa Noda, Kosuke Nishiyama, Noriko Tamaru, Tomoko Shima, Yumiko Yamasaki, Yoshihiro Tadori","doi":"","DOIUrl":"","url":null,"abstract":"Aripiprazole once-monthly (AOM) was previously approved for treatment of schizophrenia as monthly injections in the gluteal muscle. The deltoid muscle provides a more accessible injection site. The present study was conducted in Japanese schizophrenia patients as a 24-week, open-label trial that assessed the pharmacokinetics and safety of 5 sequential doses of AOM 400 mg (AOM 400) once every 4 weeks administered in the deltoid muscle. Patients treated with an oral atypical antipsychotic (other than aripiprazole) continued to receive their pre-study medication up to 14 days after the first AOM 400 injection. The completion rate was 76.5% (n = 13/17). Mean aripiprazole plasma C(min) almost reached steady-state by the fourth AOM 400 injection. After the fifth AOM 400 injection, mean aripiprazole AUC(28d), C(max) and C(min) were 165 μg x h/ml, 331 ng/ml and 201 ng/ml, respectively, which were similar to previously published pharmacokinetic parameters after the fifth gluteal injection of AOM 400. The most common treatment-emergent adverse event (TEAE) was injection site pain (35.3%). Most TEAEs were classified as mild in intensity. In conclusion, the deltoid injection of AOM can be considered an alternative route of administration, as deltoid and gluteal injections are interchangeable in terms of aripiprazole plasma concentrations, with no additional safety issues.","PeriodicalId":19250,"journal":{"name":"Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology","volume":"36 3","pages":"63-8"},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34743436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Biological review of completed suicide]. [自杀未遂的生物学回顾]。

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology Pub Date : 2016-06-01

Ikuo Otsuka, Ichiro Sora, Akitoyo Hishimoto

{"title":"[Biological review of completed suicide].","authors":"Ikuo Otsuka, Ichiro Sora, Akitoyo Hishimoto","doi":"","DOIUrl":"","url":null,"abstract":"Family, twin and adoption studies have revealed genetic factors involved in suicide, while the accumulation of stress and mental illnesses are major contributing factors of suicide. Since higher lethality of suicidal behavior is considered to increase familial liability to suicidal behavior, we believe biological research of completed suicide is most important for a better understanding of the pathophysiology in suicide. Dysregulated hypothalamic-pituitary-adrenal axis has gained a special interest in the neurobiology of suicide, mostly because of the findings using a dexamethasone suppression test (DST), in which DST non-suppressors show a nearly 10-fold higher risk of completed suicide than DST suppressors in a depressed cohort. Other data mainly from postmortem brain studies indicate abnormalities of the noradrenergic-locus coeruleus system, serotonergic system, endogenous opioid system, brain-derived neurotrophic factor, inflammatory cytokines and omega-3 fatty acid in completed suicide. However, genetic research of complete suicide is behind other mental problems because it is extremely difficult to obtain tissue samples of completed suicide. Under the difficult situation, we now retain over 800 blood samples of suicide completers thanks to bereaved families' cooperation. We are actively working on the research of suicide, for instance, by performing a GWAS using 500 samples of suicide completers.","PeriodicalId":19250,"journal":{"name":"Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology","volume":"36 3","pages":"55-61"},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34743435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Newly developed nomenclature (Neuroscience-based Nomenclature)]. [新发展的命名法(基于神经科学的命名法)]。

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology Pub Date : 2016-06-01

Hiroyuki Uchida, Shigeto Yamawaki

{"title":"[Newly developed nomenclature (Neuroscience-based Nomenclature)].","authors":"Hiroyuki Uchida, Shigeto Yamawaki","doi":"","DOIUrl":"","url":null,"abstract":"The current nomenclature is based on clinical indications; for example, drugs used for mania and psychosis are classified as \"mood stabilizers\" and \"antipsychotic drugs\", respectively. This discrepancy between their names and indications often confuses patients and their caregivers and sometimes leads to a misunderstanding of the effects of prescribed medications. In addition, up-to-date scientific knowledge on these drugs has not been reflected in the current nomenclature. To overcome these limitations of the current nomenclature, following an initiative of the European Congress of Neuropsychopharmacology (ECNP), a taskforce for psychotropic nomenclature was established with representatives from 5 international organizations, including the Asian College of Neuropsychopharmacology (AsCNP). The mission of this taskforce is to provide a pharmacologically-driven (rather than indication-based) nomenclature, which is now referred to as Neuroscience-based Nomenclature (NbN). The NbN project has just started. Since it always takes time to change the culture, we understand the transition will likely involve some expected and unexpected responses from the field. However, we believe that such responses and feedback will surely improve the quality of the NbN, which in turn will be beneficial for clinicians, researchers, and patients as well as their caregivers.","PeriodicalId":19250,"journal":{"name":"Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology","volume":"36 3","pages":"69-71"},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34355042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Thermosensitive TRP channels and brain function]. [热敏TRP通道与脑功能]。

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology Pub Date : 2016-04-01

Makoto Tominaga

引用次数: 0

Hibernation, Hypothermia and a Possible Therapeutic "Shifted Homeostasis" Induced by Central Activation of A1 Adenosine Receptor (A1AR). 冬眠、低温和A1腺苷受体(A1AR)中枢激活诱导的可能的治疗性“内稳态转移”。

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology Pub Date : 2016-04-01

Domenico Tupone, Justin S Cetas, Shaun F Morrison

引用次数: 0