Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology最新文献_第4页

[Gliaotransmission and brain functions]. [神经胶质传递与脑功能]。

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology Pub Date : 2015-02-01

Schuichi Koizumi

引用次数: 0

[Interoception and decision-making]. [拦截和决策]。

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology Pub Date : 2015-02-01

Hideki Ohira

引用次数: 0

[Proceeding of 44th annual meeting of the Japanese Society of Neuropsychopharmacology. Nagoya, Japan. November 20-22, 2014. Abstracts]. 日本神经精神药理学学会第44届年会论文集。日本名古屋。2014年11月20日至22日。摘要]。

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology Pub Date : 2014-11-01

引用次数: 0

[Mechanisms for regulation of fear conditioning and memory]. [恐惧条件反射和记忆的调节机制]。

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology Pub Date : 2014-11-01

Satoshi Kida

{"title":"[Mechanisms for regulation of fear conditioning and memory].","authors":"Satoshi Kida","doi":"","DOIUrl":"","url":null,"abstract":"Pavlovian fear conditioning is a model of fear learning and memory. The mechanisms regulating fear conditioning and memory have been investigated in humans and rodents. In this paradigm, animals learn and memorize an association between a conditioned stimulus (CS), such as context, and an unconditioned stimulus (US), such as an electrical footshock that induces fear. Fear memory generated though fear conditioning is stabilized via a memory consolidation process. Moreover, recent studies have shown the existence of memory processes that control fear memory following the retrieval of consolidated memory. Indeed, when fear memory is retrieved by re-exposure to the CS, the retrieved memory is re-stabilized via the reconsolidation process. On the other hand, the retrieval of fear memory by prolonged re-exposure to the CS also leads to fear memory extinction, new inhibitory learning against the fear memory, in which animals learn that they do not need to respond to the CS. Importantly, the reinforcement of fear memory after retrieval (i.e., re-experience such as flashbacks or nightmares) has been thought to be associated with the development of emotional disorders such as post-traumatic stress disorder (PTSD). In this review, I summarize recent progress in studies on the mechanism of fear conditioning and memory consolidation, reconsolidation and extinction, and furthermore, introduce our recent establishment of a mouse PTSD model that shows enhancement of fear memory after retrieval.","PeriodicalId":19250,"journal":{"name":"Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology","volume":"34 5-6","pages":"117-25"},"PeriodicalIF":0.0,"publicationDate":"2014-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32930493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[The therapeutic plasma concentrations of antiparkinson dopamine agonists and their in vitro pharmacology at dopamine receptors]. [抗帕金森多巴胺激动剂的治疗血浆浓度及其在多巴胺受体上的体外药理学]。

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology Pub Date : 2014-11-01

Yoshihiro Tadori, Hiroyuki Kobayashi

{"title":"[The therapeutic plasma concentrations of antiparkinson dopamine agonists and their in vitro pharmacology at dopamine receptors].","authors":"Yoshihiro Tadori, Hiroyuki Kobayashi","doi":"","DOIUrl":"","url":null,"abstract":"This review discusses the relationship between therapeutic plasma concentrations of antiparkinson dopamine agonists (rotigotine, pergolide, cabergoline, apomorphine, bromocriptine, ropinirole, pramipexole, and talipexole) and their in vitro pharmacology at dopamine D1, D2 and D3 receptors. A significant correlation was found between therapeutic plasma concentrations of these dopamine agonists and their agonist potencies (EC50) at D2 receptors, although no such correlation existed at D1 or D3 receptors, suggesting that D2 receptors could be the primary and common target for the antiparkinson action of all dopamine agonists. However, D1 receptor stimulation is also important for maintaining swallowing reflex, bladder function and cognition. In particular, continuous D1 and D2 receptor stimulation may be reduced to low levels among Parkinson's disease patients. Our findings revealed therapeutic plasma concentrations of rotigotine were similar to its agonist potencies at both D1 and D2 receptors. Thus, rotigotine may be beneficial for the treatment of Parkinson's disease patients in that this dopamine agonist has the potential of continuous stimulation of both D1 and D2 receptors in the clinical setting.","PeriodicalId":19250,"journal":{"name":"Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology","volume":"34 5-6","pages":"127-32"},"PeriodicalIF":0.0,"publicationDate":"2014-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32930385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Roles of inflammation-related molecules in emotional changes induced by repeated stress]. [炎症相关分子在反复应激引起的情绪变化中的作用]。

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology Pub Date : 2014-08-01

Shiho Kitaoka, Tomoyuki Furuyashiki

{"title":"[Roles of inflammation-related molecules in emotional changes induced by repeated stress].","authors":"Shiho Kitaoka, Tomoyuki Furuyashiki","doi":"","DOIUrl":"","url":null,"abstract":"Stress is a risk factor for psychiatric disorders. Studies using rodent stress models have shown critical roles for inflammation-related molecules in stress-induced behavioral changes. Under chronic mild stress, IL-1beta through IL-1 receptor type 1 (IL-1RI) in the brain activates the hypothalamic-pituitary-adrenal axis, thereby stimulating glucocorticoid release, which in turn decreases motivation to obtain reward. IL-1beta can also suppress proliferation of neural progenitor cells directly through IL-1RI and/or indirectly through glucocorticoid. In repeated social defeat stress, endothelial IL-1RI is involved in stress-induced upregulation of inflammation-related molecules and elevated anxiety. Prostaglandin (PG) E2 and its receptor EP1 mediate elevated anxiety and social avoidance induced by repeated social defeat through attenuating a stress-coping action of the meso-prefrontal dopaminergic pathway. IL-1beta and PGE2 are thought to be released from microglia activated by repeated stress. Whereas the mechanism for stress-induced microglial activation remains elusive, it has been reported that repeated stress induces migration of peripheral macrophages into the brain in a manner dependent on IL-1RI and multiple chemokines, which are also critical for stress-induced elevated anxiety. These findings reveal multiple actions of inflammation-related molecules in the brain and the crosstalk between neurons and microglia as well as that between the brain and the periphery in rodent stress models.","PeriodicalId":19250,"journal":{"name":"Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology","volume":"34 4","pages":"109-15"},"PeriodicalIF":0.0,"publicationDate":"2014-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32696429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Neurochemical basis for social encounter-induced hyperactivity in post-weaning isolation-reared mice]. [断奶后隔离饲养小鼠社交接触诱发多动症的神经化学基础]。

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology Pub Date : 2014-08-01

Yukio Ago

{"title":"[Neurochemical basis for social encounter-induced hyperactivity in post-weaning isolation-reared mice].","authors":"Yukio Ago","doi":"","DOIUrl":"","url":null,"abstract":"Rearing rodents in social isolation from post-weaning causes abnormal behaviors in adulthood, such as hyper-locomotion, aggression, cognitive impairments, and depression- and anxiety-like behaviors. This social isolation is widely used as a model to study the effects of adverse early-life experiences on behavior and the neural mechanisms associated with neuropsychological development. Previous studies have shown abnormalities of dendritic spine density, synaptic protein levels and amine metabolism in the prefrontal cortex and hippocampus of isolation-reared animals, but the neurochemical basis for induction of abnormal behaviors is not known. We have established a novel methodology for assessing social interaction, focusing on the psychological stressor responsible for induction of abnormal behaviors as a transient environmental factor. This review summarizes the effect of a social encounter with an unfamiliar conspecific on behavior and neurochemistry in isolation-reared mice. The current analysis using the encounter response will provide new strategies to clarify the pathophysiology of psychiatric disorders including schizophrenia, depression and drug dependence.","PeriodicalId":19250,"journal":{"name":"Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology","volume":"34 4","pages":"101-7"},"PeriodicalIF":0.0,"publicationDate":"2014-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32696428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[An introduction of the Translational Medical Science Committee (TMSC) of the Japanese Society of Neuropsychopharmacology]. [日本神经精神药理学学会转化医学委员会(TMSC)的介绍]。

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology Pub Date : 2014-06-01

Jun Ishigooka

引用次数: 0

[The involvement of hippocampal cholinergic neurostimulating peptide and its precursor in Alzheimer pathogenesis]. [海马胆碱能神经刺激肽及其前体在阿尔茨海默病发病中的作用]。

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology Pub Date : 2014-06-01

Noriyuki Matsukawa

引用次数: 0

[Immaturity of brain as an endophenotype of neuropsychiatric disorders]. [脑不成熟作为神经精神疾病的一种内表型]。

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology Pub Date : 2014-06-01

Hideo Hagihara, Hirotaka Shoji, Keizo Takao, Noah M Walton, Mitsuyuki Matsumoto, Tsuyoshi Miyakawa

{"title":"[Immaturity of brain as an endophenotype of neuropsychiatric disorders].","authors":"Hideo Hagihara, Hirotaka Shoji, Keizo Takao, Noah M Walton, Mitsuyuki Matsumoto, Tsuyoshi Miyakawa","doi":"","DOIUrl":"","url":null,"abstract":"Schizophrenia and bipolar disorder are severe neuropsychiatric disorders, affecting about 1% of the population. Identifying endophenotypes in the brains of neuropsychiatric patients is now considered the way to understand the underlying mechanisms and to improve therapeutic outcomes. However, the endophenotypes and brain mechanisms of the disorders remain unknown. We have previously reported that alpha-CaMKII heterozygous knockout mice show abnormal behaviors related to neuropsychiatric disorders. In these mutant mice, almost all neurons in the hippocampal dentate gyrus stay at a pseudo-immature state, which we refer to as \"immature dentate gyrus (iDG).\" So far, the iDG phenotype and similar behavioral abnormalities have been found in Schnurri-2 knockout, SNAP-25 mutant, and forebrain-specific calcineurin knockout mice. In addition, we found that both chronic fluoxetine treatment and pilocarpine-induced seizures can reverse the maturation state of the mature neurons, resulting in the iDG phenotype in wild-type mice. Such an iDG-like phenomenon was observed in the post-mortem brains from patients with schizophrenia/bipolar disorder. Recent studies suggest that cortex and amygdala of schizophrenia patients are also at a pseudo-immature state. Based on the findings, we proposed that immaturity of certain types of cells in the brain is a potential endophenotype of neuropsychiatric disorders.","PeriodicalId":19250,"journal":{"name":"Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology","volume":"34 3","pages":"67-79"},"PeriodicalIF":0.0,"publicationDate":"2014-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32547089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0