Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology最新文献_第3页

JSNP Excellent Presentation Award for CINP2014: reduced supraspinal nociceptive responses and distinct gene expression profile in CXBH recombinant inbred mice. 2014年CINP2014年度JSNP优秀展示奖:CXBH重组近交系小鼠的椎上伤害性反应减少和基因表达谱不同。

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology Pub Date : 2015-04-01

Shinya Kasai, Kazutaka Ikeda

引用次数: 0

[JSNP Excellent Presentation Award for CINP2014: PACAP]. [2014年CINP2014 JSNP优秀演讲奖:PACAP]。

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology Pub Date : 2015-04-01

A Hayata, K Hazama, K Moriguchi, Y Ago, N Encho, T Nakazawa, K Nagayasu, A Kasai, Y Onaka, N Shintani, A Baba, H Hashimoto

引用次数: 0

[JSNP Excellent Presentation Award for CINP2014]. [2014年CINP2014 JSNP优秀演讲奖]。

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology Pub Date : 2015-04-01

A Yoshimi, S Kunimoto, S Yamada, B Aleksic, A Hirakawa, T Nagai, N Ozaki

引用次数: 0

[JSNP Excellent Presentation Award for CINP20 14]. [2014年CINP20 JSNP优秀演讲奖]。

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology Pub Date : 2015-04-01

H Hagihara, T Horikawa, H K Nakamura, H Shoji, Y Kamitani, T Miyakawa

引用次数: 0

[JSNP Excellent Presentation Award for CINP2014: Tsc2 haploinsufficiency is associated with more severe autism-related behavioral deficits in mouse models of tuberous sclerosis complex]. [2014年cinpjsnp优秀演讲奖:Tsc2单倍不全与结节性硬化症小鼠模型中更严重的自闭症相关行为缺陷相关]。

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology Pub Date : 2015-04-01

A Sato, Y Takamatsu, Y Kasai, S Kobayashi, T Hino, K Ikeda, M Mizuguchi

引用次数: 0

[JSNP Excellent Presentation Award for CINP2014]. [2014年CINP2014 JSNP优秀演讲奖]。

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology Pub Date : 2015-04-01

K Uno, D Nishizawa, S Seo, N Sakai, K Ohi, T Nabeshima, R Hashimoto, N Ozaki, K Ikeda, Y Miyamoto, A Nitta

引用次数: 0

[JSNP Excellent Presentation Award for CINP2014: pathway-specific modulation of nucleus accumbens in reward and aversive learning behaviors and drug addiction via selective transmitter receptors]. [2014年CINP2014年度JSNP优秀演讲奖:选择性递质受体介导伏隔核在奖励、厌恶学习行为和药物成瘾中的通路特异性调节]。

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology Pub Date : 2015-04-01

Hikida T

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[Utility of organotypic raphe slice cultures to investigate the effects of psychotropic drugs on the function of serotoninergic neurons]. [利用器官型缝片培养研究精神药物对血清素能神经元功能的影响]。

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology Pub Date : 2015-04-01

Takayuki Nakagawa, Kazuki Nagayasu, Shuji Kaneko

{"title":"[Utility of organotypic raphe slice cultures to investigate the effects of psychotropic drugs on the function of serotoninergic neurons].","authors":"Takayuki Nakagawa, Kazuki Nagayasu, Shuji Kaneko","doi":"","DOIUrl":"","url":null,"abstract":"A number of behavioral, neurochemical and electrophysiological studies have emphasized the importance of the serotonergic neurons in the pathophysiology of psychiatric disorders and the therapeutic actions of psychotropics. However, no in vitro serotonergic culture systems have successfully analyzed the long-term effects of psychotropics or the neural interaction between serotonergic and excitatory/inhibitory neurons. Recently, we have established rat organotypic raphe slice cultures, which have functional serotonergic neurons with the ability to release 5-HT in response to stimulation and to reuptake 5-HT through serotonin transporter and retain neural and synaptic functions. Here, we show the following results in the raphe slice cultures: 1) acute and sustained treatments with 3,4-methylenedioxymethamphetamine induce the 5-HT efflux via serotonin transporter and AMPA receptor-mediated exocytotic 5-HT release, respectively; 2) sustained treatment with antidepressants enhances the exocytotic 5-HT release, which is dependent on AMPA receptor stimulation, but not on desensitization of 5-HT(1A/1B) autoreceptors; 3) the augmentation therapy of an atypical antipsychotic, olanzapine, with antidepressants is caused by the decrease in the raphe inhibitory GABAergic tone through 5-HT6 receptor antagonism. Our findings suggest that the raphe slice cultures are suitable for analyzing the neural and molecular mechanisms underlying the efficacy of psychotropics in vitro.","PeriodicalId":19250,"journal":{"name":"Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology","volume":"35 2","pages":"39-44"},"PeriodicalIF":0.0,"publicationDate":"2015-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33345647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[JSNP Excellent Presentation Award for CINP2014]. [2014年CINP2014 JSNP优秀演讲奖]。

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology Pub Date : 2015-04-01

S Ishiwata, D T Balu, A Umino, J T Coyle, T Nishikawa

引用次数: 0

[Mechanisms underlying the pathogenesis of neuropathic pain revealing by the role of glial cells]. [神经胶质细胞作用揭示神经性疼痛发病机制]。

Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology Pub Date : 2015-02-01

Makoto Tsuda

{"title":"[Mechanisms underlying the pathogenesis of neuropathic pain revealing by the role of glial cells].","authors":"Makoto Tsuda","doi":"","DOIUrl":"","url":null,"abstract":"Injury to the nervous system results in debilitating chronic pain states (called neuropathic pain) whose mechanisms remain unclear. Emerging lines of evidence indicate the pivotal role of spinal glial cells in neuropathic pain. Spinal microglia rapidly respond to peripheral nerve injury (PNI) and become activated with changing expression of a variety of genes. The best known example is purinergic P2X4 receptors, an ATP-gated cation channel. The expression of P2X4 receptors is upregulated in spinal microglia after PNI, and inhibition of P2X4 activity suppresses neuropathic pain. Furthermore, interferon regulatory factor-8 (IRF8) and IRF5 are identified as microglial transcription factors whose expression is upregulated in spinal microglia after PNI, and the IRF8-IRF5 transcriptional cascade is the core process for shifting spinal microglia toward a state with high expression of P2X4 receptors. Astrocytes in the spinal cord show a delayed onset of activation and play an important role in the maintenance of neuropathic pain via the transcription factor STAT3 and the intracellular kinase JNK. These results obtained from glial cell research will advance our understanding of the development and maintenance of neuropathic pain and provide a new target for treating this pain.","PeriodicalId":19250,"journal":{"name":"Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology","volume":"35 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2015-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33167198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0