Neuro-oncology practice最新文献

{"title":"Forthcoming Meetings","authors":"Jennie W Taylor","doi":"10.1093/nop/npad052","DOIUrl":"https://doi.org/10.1093/nop/npad052","url":null,"abstract":"Journal Article Forthcoming Meetings Get access Jennie W Taylor Jennie W Taylor Search for other works by this author on: Oxford Academic Google Scholar Neuro-Oncology Practice, Volume 10, Issue 5, October 2023, Page 495, https://doi.org/10.1093/nop/npad052 Published: 15 September 2023 Article history Corrected and typeset: 15 September 2023 Published: 15 September 2023","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135395584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing an exercise training program in pediatric brain tumour survivors: Does timing postradiotherapy matter?","authors":"Éloïse Baudou, Jennifer L Ryan, Elizabeth Cox, Lisa Nham, Krista Johnston, Éric Bouffet, Ute Bartels, Brian Timmons, Cynthia de Medeiros, Donald J Mabbott","doi":"10.1093/nop/npad055","DOIUrl":"10.1093/nop/npad055","url":null,"abstract":"<p><strong>Background: </strong>While exercise training (ET) programs show positive outcomes in cognition, motor function, and physical fitness in pediatric brain tumor (PBT) survivors, little is known about the optimal timing of intervention. The aim of this work was to explore the feasibility and benefits of ET based on its timing after radiotherapy.</p><p><strong>Methods: </strong>This retrospective analysis (ClinicalTrials.gov, NCT01944761) analyzed data based on the timing of PBT survivors' participation in an ET program relative to their completion of radiotherapy: <2 years (<i>n</i> = 9), 2-5 years (<i>n</i> = 10), and > 5 years (<i>n</i> = 13). We used repeated measures analysis of variance to compare feasibility and efficacy indicators among groups, as well as correlation analysis between ET program timing postradiotherapy and preliminary treatment effects on cognition, motor function and physical fitness outcomes.</p><p><strong>Results: </strong>Two to five years postradiotherapy was the optimal time period in terms of adherence (88.5%), retention (100%), and satisfaction (more fun, more enjoyable and recommend it more to other children). However, the benefits of ET program on memory recognition (<i>r</i> = -0.379, <i>P</i> = .047) and accuracy (<i>r</i> = -0.430, <i>P</i> = .032) decreased with increased time postradiotherapy. Motor function improved in all groups, with greater improvements in bilateral coordination (<i>P</i> = .043) earlier postradiotherapy, and in running (<i>P</i> = .043) later postradiotherapy. The greatest improvement in pro-rated work rate occurred in the < 2-year group (<i>P</i> = .008).</p><p><strong>Conclusion: </strong>Participation in an ET program should be offered as part of routine postradiotherapy care in the first 1-2 years and strongly encouraged in the first 5 years.</p>","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10785595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44978280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ventriculoperitoneal shunting with an on-off valve for patients with leptomeningeal metastases and intracranial hypertension.","authors":"Kristin M Huntoon, Jaime Gasco, Isabella C Glitza Oliva, Sherise D Ferguson, Nazarin K Majd, Ian E McCutcheon","doi":"10.1093/nop/npad056","DOIUrl":"10.1093/nop/npad056","url":null,"abstract":"<p><strong>Background: </strong>We report our experience with using a ventriculoperitoneal shunt (VPS) with an on-off valve and in-line Ommaya reservoir for the treatment of hydrocephalus or intracranial hypertension in patients with leptomeningeal disease (LMD). Our goal was to determine whether control of intracranial pressure elevation combined with intrathecal (IT) chemotherapy would extend patient survival.</p><p><strong>Methods: </strong>In this IRB-approved retrospective study, we reviewed 58 cases of adult patients with LMD from solid cancers who received a VPS with a reservoir and an on-off valve at M D Anderson Cancer Center from November 1996 through December 2021. Primary tumors were most often melanoma (<i>n</i> = 19) or breast carcinoma (<i>n</i> = 20). Hydrocephalus was diagnosed by clinical symptoms and findings on magnetic resonance imaging (MRI), and LMD by MRI or cerebrospinal fluid analysis. Differences in overall survival (OS) were assessed with standard statistical techniques.</p><p><strong>Results: </strong>Patients who received a VPS and more than 3 IT chemotherapy sessions survived longer (<i>n</i> = 26; OS time from implantation 11.7 ± 3.6 months) than those who received an occludable shunt but no IT chemotherapy (<i>n</i> = 24; OS time from implantation 2.8 ± 0.7 months, <i>P</i> < .018). Peritoneal seeding appeared after shunt insertion in only two patients (3%).</p><p><strong>Conclusions: </strong>This is the largest series reported to date of patients with LMD who had had shunts with on-off valves placed to relieve symptoms of intracranial hypertension. Use of IT chemotherapy and control of hydrocephalus via such shunts was associated with improved survival.</p>","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2023-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10785578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47932935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health-related Quality of Life of Pediatric Brain Tumor Survivors after Treatment in Jordan","authors":"Han Choi, Amr S Soliman, Randa Al Mousa, Jennifer Yeh, Jamal Khader, Iyad Sultan, Ahmad K H Ibrahimi","doi":"10.1093/nop/npad054","DOIUrl":"https://doi.org/10.1093/nop/npad054","url":null,"abstract":"Abstract Background The number of cancer survivors and survivorship are increasing. Health-related quality of life (HRQOL) has not been widely studied in low-and-middle-income countries (LMICs). The aim of this study is to explore HRQOL of childhood brain tumor survivors and its determinants in Jordan. Methods Health-related quality of life information was collected from 80 patients treated at the King Hussein Cancer Center and their parents using the Pediatric Quality of Life Inventory (PedsQL) Generic Core Scales questionnaire in Arabic. Multivariable linear OLS regression models were used to analyze correlates of HRQOL and compare differences between child- and parent-reported responses. Results Health-related quality of life scores reported by survivors and by parents were positively correlated on all subscales and total PedsQL scores (r = 0.59, P = .001). Survivors reported better HRQOL in cognitive subscale (β = 0.56, P = .03) and worse HRQOL in work subscale (β = 0.43, P = .04), but no significant differences in the physical, emotional, and social subscales and total PedsQL scores. Significant predictors of HRQOL reported by parents and by children were different. Supratentorial tumor location was associated with a 10.97-unit lower physical HRQOL score, and recurrence of tumors predicted a 17.5-unit lower total HRQOL score, indicating worse quality of life. Male gender (β = 14.9, P = .002) and diagnosis of hypopituitarism (β = 16.1, P = .03) were associated with better HRQOL. Furthermore, patients that only had radiotherapy treatment had better emotional HRQOL (β = 32.9, P = .006) compared to patients that had combined radiotherapy and chemotherapy. Conclusion This study provides evidence on determinants of HRQOL of pediatric brain tumor patients in Jordan. Future studies need to capitalize on the findings of this study to institute a system for regular assessment of quality of life of pediatric cancer patients in Jordan and other countries with similar health care systems and sociocultural backgrounds.","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135830584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter regarding \"Acceptability and feasibility of neurocognitive assessments with adults with primary brain cancer and brain metastasis: A systematic review\".","authors":"M Gorter, J G Röttgering, V Belgers, P C De Witt Hamer, L Douw, M Klein","doi":"10.1093/nop/npad043","DOIUrl":"10.1093/nop/npad043","url":null,"abstract":"","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10502772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10360907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma exchange as a tool for removal of bevacizumab: Highlighting application for urgent surgery.","authors":"Bryan J Neth, Jeffrey L Winters, Revathi Thirumushi Sairaj, Ali Gharibi Loron, Masum Rahman, Renee Hirte, Cecile Riviere-Cazaux, Michael W Ruff, Terry C Burns","doi":"10.1093/nop/npad053","DOIUrl":"10.1093/nop/npad053","url":null,"abstract":"<p><strong>Background: </strong>Bevacizumab is commonly used to manage cerebral edema associated with brain tumors. However, its long half-life poses challenges for patients requiring urgent surgery due to wound complications. We present a case of utilizing therapeutic plasma exchange (TPE) to remove bevacizumab in a patient with recurrent glioblastoma requiring urgent surgery.</p><p><strong>Methods: </strong>A 58-year-old male with recurrent glioblastoma, IDH-wildtype, presented with clinical and radiographic concern for ventriculitis requiring urgent wound washout only 4 days after his last bevacizumab infusion. TPE was performed for 3 sessions after surgery using a centrifugation-based cell separator. Replacement fluids included normal serum albumin, normal saline, and fresh frozen plasma. Bevacizumab levels were quantified using an enzyme-linked immunoabsorbent assay before and after each TPE session.</p><p><strong>Results: </strong>TPE effectively removed bevacizumab, enabling safe surgery without new complications. Plasma bevacizumab levels decreased from 1087.63 to 145.35 ng/mL (13.4% of original) by the end of the last TPE session. This decline is consistent with nearly 3 half-lives, which compares favorably to the expected timeline of natural decline given the 21-day half-life.</p><p><strong>Conclusions: </strong>We report a complex clinical scenario of a patient requiring urgent wound washout 4 days after last bevacizumab infusion for CNS infection. Surgery was successfully performed without new complications with use of TPE to remove bevacizumab immediately following surgery. This case highlights the feasibility of this approach, which may be utilized effectively in patients requiring surgery after having recently received bevacizumab.</p>","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10666800/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47728978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploratory analysis of the spatial distribution of adult glioma age-adjusted county incidence rates, Nebraska Medicine, 2009-2019.","authors":"Kendra L Ratnapradipa, Amulya Yellala, Nicole Shonka","doi":"10.1093/nop/npad050","DOIUrl":"10.1093/nop/npad050","url":null,"abstract":"<p><strong>Background: </strong>Central nervous system (CNS) cancers including gliomas have low incidence but high mortality. The age-adjusted incidence rate for CNS cancers is higher in Nebraska than nationally. This exploratory study was motivated by glioma patient inquiries about possible clustering of cases within the state to see if more in-depth investigation was warranted.</p><p><strong>Methods: </strong>Using electronic health records from Nebraska Medicine, we identified Nebraska adult (age ≥19) glioma patients diagnosed between January 1, 2009 and November 1, 2019. Patient residential addresses were geocoded, mapped, and combined with annual US Census data to compute age-adjusted incidence rates (AAIR) at the county level. Counties with fewer than five cases were excluded to protect patient identity. ArcGIS software was used for geocoding and mapping.</p><p><strong>Results: </strong>Of the 285 cases included in the analysis, 53.2% were geocoded with exact match and the remainder were processed manually. Cases occurred in 47 of the 93 counties. After data suppression, 11 counties (228 cases) visually clustered in eastern and central Nebraska with AAIR ranging from 0.85 to 5.66 per 100 000.</p><p><strong>Conclusions: </strong>Many counties in the state were excluded from analysis of this rare cancer due to the small number of cases leading to unstable rates and the need to suppress data to protect patient privacy. However, this preliminary study suggests that glioma incidence is highest in central and eastern Nebraska. Next steps include analysis of state cancer registry data to ensure more complete case ascertainment.</p>","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2023-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10785590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48835344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to letter regarding “Assessing the association between preoperative neurocognitive status and IDH1 mutation status in high-grade gliomas: A deeper look into potential confounding variables.”","authors":"Evangelia Liouta, Aristotelis V Kalyvas, Spyridon Komaitis, Evangelos Drosos, Christos Koutsarnakis, Juan M García-Gómez, Javier Juan-Albarracín, Vasileios Katsaros, Theodosis Kalamatianos, Theodoros Argyrakos, George Stranjalis","doi":"10.1093/nop/npad045","DOIUrl":"https://doi.org/10.1093/nop/npad045","url":null,"abstract":"Journal Article Response to letter regarding “Assessing the association between preoperative neurocognitive status and IDH1 mutation status in high-grade gliomas: A deeper look into potential confounding variables.” Get access Evangelia Liouta, Evangelia Liouta Department of Neurosurgery, National and Kapodistrian University of Athens, Evangelismos Hospital, Athens, GreeceAthens Microneurosurgery LaboratoryHellenic Center for Neurosurgical Research “Prof. Petros Kokkalis”, Athens, Greece Corresponding Author: Evangelia Liouta, PhD, Department of Neurosurgery, National and Kapodistrian University of Athens, Evangelismos Hospital, Athens, Greece, Hellenic Center for Neurosurgical Research “Prof. Petros Kokkalis,” Athens, Greece (evangelialiouta286@hotmail.com). https://orcid.org/0000-0003-2948-9631 Search for other works by this author on: Oxford Academic Google Scholar Aristotelis V Kalyvas, Aristotelis V Kalyvas Department of Neurosurgery, National and Kapodistrian University of Athens, Evangelismos Hospital, Athens, GreeceDivision of Neurosurgery, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON, Canada https://orcid.org/0000-0002-0222-488X Search for other works by this author on: Oxford Academic Google Scholar Spyridon Komaitis, Spyridon Komaitis Department of Neurosurgery, National and Kapodistrian University of Athens, Evangelismos Hospital, Athens, GreeceAthens Microneurosurgery Laboratory https://orcid.org/0000-0002-7250-414X Search for other works by this author on: Oxford Academic Google Scholar Evangelos Drosos, Evangelos Drosos Department of Neurosurgery, National and Kapodistrian University of Athens, Evangelismos Hospital, Athens, GreeceAthens Microneurosurgery Laboratory https://orcid.org/0000-0002-0456-7317 Search for other works by this author on: Oxford Academic Google Scholar Christos Koutsarnakis, Christos Koutsarnakis Department of Neurosurgery, National and Kapodistrian University of Athens, Evangelismos Hospital, Athens, GreeceAthens Microneurosurgery Laboratory https://orcid.org/0000-0002-1363-5385 Search for other works by this author on: Oxford Academic Google Scholar Juan M García-Gómez, Juan M García-Gómez Grupo de Informática Biomédica (IBIME), Instituto de Aplicaciones de las Tecnologías de la Información y de las Comunicaciones Avanzadas (ITACA), Universitat Politècnica de València, Valencia, Spain Search for other works by this author on: Oxford Academic Google Scholar Javier Juan-Albarracín, Javier Juan-Albarracín Grupo de Informática Biomédica (IBIME), Instituto de Aplicaciones de las Tecnologías de la Información y de las Comunicaciones Avanzadas (ITACA), Universitat Politècnica de València, Valencia, Spain Search for other works by this author on: Oxford Academic Google Scholar Vasileios Katsaros, Vasileios Katsaros Department of Radiology, General Anti-Cancer and Oncological Hospital of Athens “St. Savvas,” Athens, Greece https://orcid.org/0000-0003-3087-1475 Search for ot","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135285641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the association between preoperative neurocognitive status and IDH1 mutation status in high-grade gliomas: A deeper look into potential confounding variables.","authors":"Aimen Waqar Khan, Syed Muhammad Mehdi Rizvi, Abdul Basit Khan, Maraj Ud Din, Zain Ul Abidin","doi":"10.1093/nop/npad046","DOIUrl":"10.1093/nop/npad046","url":null,"abstract":"","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10666805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44915262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiscale network neuroscience in neuro-oncology: How tumors, brain networks, and behavior connect across scales.","authors":"Dorien A Maas, Linda Douw","doi":"10.1093/nop/npad044","DOIUrl":"10.1093/nop/npad044","url":null,"abstract":"<p><p>Network neuroscience refers to the investigation of brain networks across different spatial and temporal scales, and has become a leading framework to understand the biology and functioning of the brain. In neuro-oncology, the study of brain networks has revealed many insights into the structure and function of cells, circuits, and the entire brain, and their association with both functional status (e.g., cognition) and survival. This review connects network findings from different scales of investigation, with the combined aim of informing neuro-oncological healthcare professionals on this exciting new field and also delineating the promising avenues for future translational and clinical research that may allow for application of network methods in neuro-oncological care.</p>","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10666814/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41250474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}