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Incidence and survival characteristics of pediatric ganglioglioma from 2004 to 2018, with focus on infratentorial sites 2004年至2018年小儿神经节胶质瘤的发病率和存活特征，重点关注幕下部位
IF 2.7
Neuro-oncology practice Pub Date : 2024-02-09 DOI: 10.1093/nop/npae012
Yongzhen Chen, Paula Buchanan, N. Brossier, P. Navalkele
{"title":"Incidence and survival characteristics of pediatric ganglioglioma from 2004 to 2018, with focus on infratentorial sites","authors":"Yongzhen Chen, Paula Buchanan, N. Brossier, P. Navalkele","doi":"10.1093/nop/npae012","DOIUrl":"https://doi.org/10.1093/nop/npae012","url":null,"abstract":"\u0000 \u0000 \u0000 Ganglioglioma (GG) is a slow-growing glioneuronal neoplasm, most frequently seen in the supratentorial location in older children and associated with epilepsy syndromes. GG is rare in the infratentorial location, hence we embarked upon analyzing the National Cancer Institute’s (NCI) Survival, Epidemiology, and End Results (SEER) database to better evaluate GG outcomes by location in comparison to the broader pediatric low-grade glioma (pLGG) population.\u0000 \u0000 \u0000 \u0000 Pediatric patients diagnosed with GG and pLGG from 2004 to 2018 were included in the study. Their demographic, clinical and survival characteristics were analyzed using SEER*Stat.\u0000 \u0000 \u0000 \u0000 This study describes the largest cohort of pediatric GG, including 852 cases from year 2004 to 2018, with focus on infratentorial sites. Patients with brainstem GG or those with subtotally resected disease were identified as having higher risk of death.\u0000 \u0000 \u0000 \u0000 Our analysis highlights brainstem GG as a high-risk, poor-prognostic subgroup and elaborates on the incidence and survival characteristic of this lesser-known subgroup.\u0000","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139787792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incidence and survival characteristics of pediatric ganglioglioma from 2004 to 2018, with focus on infratentorial sites 2004年至2018年小儿神经节胶质瘤的发病率和存活特征，重点关注幕下部位
IF 2.7
Neuro-oncology practice Pub Date : 2024-02-09 DOI: 10.1093/nop/npae012
Yongzhen Chen, Paula Buchanan, N. Brossier, P. Navalkele
{"title":"Incidence and survival characteristics of pediatric ganglioglioma from 2004 to 2018, with focus on infratentorial sites","authors":"Yongzhen Chen, Paula Buchanan, N. Brossier, P. Navalkele","doi":"10.1093/nop/npae012","DOIUrl":"https://doi.org/10.1093/nop/npae012","url":null,"abstract":"\u0000 \u0000 \u0000 Ganglioglioma (GG) is a slow-growing glioneuronal neoplasm, most frequently seen in the supratentorial location in older children and associated with epilepsy syndromes. GG is rare in the infratentorial location, hence we embarked upon analyzing the National Cancer Institute’s (NCI) Survival, Epidemiology, and End Results (SEER) database to better evaluate GG outcomes by location in comparison to the broader pediatric low-grade glioma (pLGG) population.\u0000 \u0000 \u0000 \u0000 Pediatric patients diagnosed with GG and pLGG from 2004 to 2018 were included in the study. Their demographic, clinical and survival characteristics were analyzed using SEER*Stat.\u0000 \u0000 \u0000 \u0000 This study describes the largest cohort of pediatric GG, including 852 cases from year 2004 to 2018, with focus on infratentorial sites. Patients with brainstem GG or those with subtotally resected disease were identified as having higher risk of death.\u0000 \u0000 \u0000 \u0000 Our analysis highlights brainstem GG as a high-risk, poor-prognostic subgroup and elaborates on the incidence and survival characteristic of this lesser-known subgroup.\u0000","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139847787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Understanding the association between fatigue and neurocognitive functioning in patients with glioma: a cross-sectional multinational study 了解胶质瘤患者疲劳与神经认知功能之间的关系：一项横断面多国研究
IF 2.7
Neuro-oncology practice Pub Date : 2024-02-09 DOI: 10.1093/nop/npae011
J. G. Röttgering, J. W. Taylor, M. Brie, T. Luks, S. Hervey-Jumper, S. Phan, P. Bracci, E. Smith, P. C. de Witt Hamer, L. Douw, C. Weyer-Jamora, M. Klein
{"title":"Understanding the association between fatigue and neurocognitive functioning in patients with glioma: a cross-sectional multinational study","authors":"J. G. Röttgering, J. W. Taylor, M. Brie, T. Luks, S. Hervey-Jumper, S. Phan, P. Bracci, E. Smith, P. C. de Witt Hamer, L. Douw, C. Weyer-Jamora, M. Klein","doi":"10.1093/nop/npae011","DOIUrl":"https://doi.org/10.1093/nop/npae011","url":null,"abstract":"\u0000 \u0000 \u0000 Fatigue and neurocognitive impairment are highly prevalent in patients with glioma, significantly impacting health-related quality of life. Despite the presumed association between these two factors, evidence remains sparse. Therefore, we aimed to investigate this relationship using multinational data.\u0000 \u0000 \u0000 \u0000 We analyzed data on self-reported fatigue and neurocognitive outcomes from postoperative patients with glioma from the University of California San Francisco (n = 100, UCSF) and Amsterdam University Medical Center (n = 127, Amsterdam UMC). We used multiple linear regression models to assess associations between fatigue and seven (sub)domains of neurocognitive functioning and latent profile analysis to identify distinct patterns of fatigue and neurocognitive functioning.\u0000 \u0000 \u0000 \u0000 UCSF patients were older (median age 49 vs. 43 years, p = 0.002), had a higher proportion of grade 4 tumors (32% vs. 18%, p = 0.03), and had more neurocognitive deficits (p = 0.01). While the number of clinically fatigued patients was similar between sites (64% vs. 58%, p = 0.12), fatigue and the number of impaired neurocognitive domains were not correlated (p = 0.16-0.72). At UCSF, neurocognitive domains were not related to fatigue, and at Amsterdam UMC attention and semantic fluency explained only 4 to 7% of variance in fatigue. Across institutions, we identified four distinct patterns of neurocognitive functioning, which were not consistently associated with fatigue.\u0000 \u0000 \u0000 \u0000 Although individual patients might experience both fatigue and neurocognitive impairment, the relationship between the two is weak. Consequently, both fatigue and neurocognitive functioning should be independently assessed and treated with targeted therapies.\u0000","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139790546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Target delineation for glioblastoma- Is it time to sever historical ties? 胶质母细胞瘤的靶点划分--现在是切断历史联系的时候了吗？
IF 2.7
Neuro-oncology practice Pub Date : 2024-02-09 DOI: 10.1093/nop/npae013
Simon S Lo, C. Tseng, A. Sahgal
{"title":"Target delineation for glioblastoma- Is it time to sever historical ties?","authors":"Simon S Lo, C. Tseng, A. Sahgal","doi":"10.1093/nop/npae013","DOIUrl":"https://doi.org/10.1093/nop/npae013","url":null,"abstract":"","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139789161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Target delineation for glioblastoma- Is it time to sever historical ties? 胶质母细胞瘤的靶点划分--现在是切断历史联系的时候了吗？
IF 2.7
Neuro-oncology practice Pub Date : 2024-02-09 DOI: 10.1093/nop/npae013
Simon S Lo, C. Tseng, A. Sahgal
{"title":"Target delineation for glioblastoma- Is it time to sever historical ties?","authors":"Simon S Lo, C. Tseng, A. Sahgal","doi":"10.1093/nop/npae013","DOIUrl":"https://doi.org/10.1093/nop/npae013","url":null,"abstract":"","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139849168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antidepressants and survival in glioma: unravelling a complex puzzle 抗抑郁药与胶质瘤患者的生存：解开复杂的谜题
IF 2.7
Neuro-oncology practice Pub Date : 2024-02-02 DOI: 10.1093/nop/npae010
A. Rooney
{"title":"Antidepressants and survival in glioma: unravelling a complex puzzle","authors":"A. Rooney","doi":"10.1093/nop/npae010","DOIUrl":"https://doi.org/10.1093/nop/npae010","url":null,"abstract":"","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139810758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antidepressants and survival in glioma: unravelling a complex puzzle 抗抑郁药与胶质瘤患者的生存：解开复杂的谜题
IF 2.7
Neuro-oncology practice Pub Date : 2024-02-02 DOI: 10.1093/nop/npae010
A. Rooney
{"title":"Antidepressants and survival in glioma: unravelling a complex puzzle","authors":"A. Rooney","doi":"10.1093/nop/npae010","DOIUrl":"https://doi.org/10.1093/nop/npae010","url":null,"abstract":"","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139870389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel EGFR Mutations in Diffuse Midline Gliomas Using Cost-Effective Strategies: A Report of Two Cases 使用经济有效的策略治疗弥漫中线胶质瘤中的新型表皮生长因子受体突变：两个病例的报告
IF 2.7
Neuro-oncology practice Pub Date : 2024-01-31 DOI: 10.1093/nop/npae008
Iman Dandapath, Saumya Sahu, Supriya Bhardwaj, T. Mohan, Rituparna Chakraborty, Jyotsna Singh, Swati Singh, Ajay Garg, Deepak Gupta, M. Sharma, V. Suri
{"title":"Novel EGFR Mutations in Diffuse Midline Gliomas Using Cost-Effective Strategies: A Report of Two Cases","authors":"Iman Dandapath, Saumya Sahu, Supriya Bhardwaj, T. Mohan, Rituparna Chakraborty, Jyotsna Singh, Swati Singh, Ajay Garg, Deepak Gupta, M. Sharma, V. Suri","doi":"10.1093/nop/npae008","DOIUrl":"https://doi.org/10.1093/nop/npae008","url":null,"abstract":"\u0000 Diffuse midline gliomas are malignant tumors primarily affecting children and are associated with poor outcomes. The 2021 WHO classification introduces three subtypes that all exhibit the universal phenomenon of H3K27 trimethylation loss. In this report, we present two cases of DMG, EGFR mutant, each featuring novel EGFR mutations within exon 20. These findings contribute to a deeper understanding of the molecular characteristics of these complex pediatric brain tumors. Notably, both cases were detected using cost-effective diagnostic approaches.","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140474174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of Different Target Volume Delineation Strategies Based on Recurrence Patterns in Adjuvant Radiotherapy for Glioblastoma 基于胶质母细胞瘤辅助放疗中复发模式的不同靶区划分策略比较
IF 2.7
Neuro-oncology practice Pub Date : 2024-01-31 DOI: 10.1093/nop/npae009
M. T. Yılmaz, A. Kahvecioglu, F. Yedekci, E. Yigit, Gokcen Coban Ciftci, N. Kertmen, F. Zorlu, G. Yazici
{"title":"Comparison of Different Target Volume Delineation Strategies Based on Recurrence Patterns in Adjuvant Radiotherapy for Glioblastoma","authors":"M. T. Yılmaz, A. Kahvecioglu, F. Yedekci, E. Yigit, Gokcen Coban Ciftci, N. Kertmen, F. Zorlu, G. Yazici","doi":"10.1093/nop/npae009","DOIUrl":"https://doi.org/10.1093/nop/npae009","url":null,"abstract":"\u0000 \u0000 \u0000 Radiation Therapy Oncology Group (RTOG) and European Organization for Research and Treatment of Cancer (EORTC) recommendations are commonly used guidelines for adjuvant radiotherapy in glioblastoma. In our institutional protocol, we delineate T2-FLAIR alterations as gross target volume (GTV) with reduced clinical target volume (CTV) margins. We aimed to present our oncologic outcomes and compare the recurrence patterns and planning parameters with EORTC and RTOG delineation strategies.\u0000 \u0000 \u0000 \u0000 Eighty-one patients who received CRT between 2014 and 2021 were evaluated retrospectively. EORTC and RTOG delineations performed on the simulation computed tomography and recurrence patterns and planning parameters were compared between delineation strategies. Statistical Package for the Social Sciences (SPSS) version 23.0 (IBM, Armonk, NY, USA) was utilized for statistical analyses.\u0000 \u0000 \u0000 \u0000 Median overall survival and progression-free survival were 21 months and 11 months, respectively. At a median 18 month follow-up, of the 48 patients for whom recurrence pattern analysis is performed, recurrence was encompassed by only our institutional protocol’s CTV in 13 (27%) of them. For the remaining 35 (73%) patients, recurrence was encompassed by all separate CTVs. In addition to the 100% rate of in-field recurrence, the smallest CTV and lower OAR doses were obtained by our protocol.\u0000 \u0000 \u0000 \u0000 The current study provides promising results for including the T2-FLAIR alterations to the GTV with smaller CTV margins with impressive survival outcomes without any marginal recurrence. The fact that our protocol didn’t result in larger irradiated brain volume is further encouraging in terms of toxicity.\u0000","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140474853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
“It changes everything” Understanding how people experience the impact of living with a lower-grade glioma "它改变了一切"，了解人们如何体验低级别胶质瘤对生活的影响
IF 2.7
Neuro-oncology practice Pub Date : 2024-01-29 DOI: 10.1093/nop/npae006
B. Rimmer, Michelle Balla, Lizzie Dutton, Sophie Williams, J. Lewis, Pamela Gallagher, Tracy Finch, Richéal Burns, Vera Araújo-Soares, Fiona Menger, Linda Sharp
{"title":"“It changes everything” Understanding how people experience the impact of living with a lower-grade glioma","authors":"B. Rimmer, Michelle Balla, Lizzie Dutton, Sophie Williams, J. Lewis, Pamela Gallagher, Tracy Finch, Richéal Burns, Vera Araújo-Soares, Fiona Menger, Linda Sharp","doi":"10.1093/nop/npae006","DOIUrl":"https://doi.org/10.1093/nop/npae006","url":null,"abstract":"\u0000 \u0000 \u0000 Quantitative studies show people living with a lower-grade glioma (LGG) often report low health-related quality-of-life. However, it is unclear how this impact is experienced; resulting supportive care needs are also poorly understood. We explored how people experience the impact of living long-term with an LGG, to help identify potential supportive care needs.\u0000 \u0000 \u0000 \u0000 We conducted semi-structured interviews with a diverse group of people with LGG (n=28) across the United Kingdom, who had completed primary treatment (male n=16, female n=12, mean age 54.6 years, mean time since diagnosis 8.7 years). Interviews were transcribed and inductive thematic analysis was conducted.\u0000 \u0000 \u0000 \u0000 Four themes relating to the impact experiences of people with LGG were generated: ‘Emotional response to the diagnosis’, ‘Living with the ‘What ifs’’, ‘Changing relationships’, and ‘Faltering independence’. These reflect participants’ experiences with symptoms (e.g. fatigue, seizures) and impairments (e.g. motor dysfunction, cognitive deficits), and how these, in turn, drive impacts on daily living (including on work, relationships, social activities and transport). Participants spoke about their experiences with profound emotion throughout.\u0000 \u0000 \u0000 \u0000 People with LGG can experience wide-ranging everyday impacts and may have extensive supportive care needs. This study highlights how this impact is experienced and what it means to people with LGG. Best practice suggestions for conducting comprehensive needs assessments tailored to those with LGG, and development of personalised plans to meet those needs, would be a critical step to ensure that people with LGG are best supported in living with their condition.\u0000","PeriodicalId":19234,"journal":{"name":"Neuro-oncology practice","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140487936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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