News of Pharmacy最新文献

{"title":"The study of peculiarities of creating the brand of a higher education institution","authors":"A. Kotvitska, O. Yakovlieva","doi":"10.24959/nphj.21.60","DOIUrl":"https://doi.org/10.24959/nphj.21.60","url":null,"abstract":"Aim. To study peculiarities of the brand of a higher education institution, to determine the factors affecting the success of the brand development for a higher education institution, to substantiate theoretical and methodological measures for creating a brand of a higher education institution.\u0000Materials and methods. The object of our research was the literature data on the brand system of a higher education institution. Statistical, analytical, comparative and logical research methods were used in the work.\u0000Results and discussion. The scientific works of researchers who studied the concept of a “higher education institution brand” have been studied. The definition of “branding of educational services” has been proposed. The distinctive features of educational services – tangible, intangible and imaginary – have been formed. The structure of quality of educational services in the form of the three-level factor model has been proposed: the quality of the interaction of a higher education institution as a producer of educational service with the target audience, the quality of the external environment, and the quality of the educational service result. The elements and components of the higher education institution brand have been formed. It has been proposed to consider the brand of a higher education institution from three points of view, in particular, the internal potential; the interaction with the environment; the development of an educational institution. Peculiarities of the brand of a higher education institution have been determined. The impact of the brand of the educational institution on different audiences has been noted, namely: applicants and (or) their parents; students; competitors; the state; society. The functional, psychological and cultural influence of the brand of a higher education institution has been studied. The main conditions of a successful brand of a higher education institution have been formulated. The system of functions of the educational brand has been highlighted. The brand effectiveness of a higher education institution has been generalized. Factors affecting the brand of a higher education institution have been studied. The internal and external appearance of the brand of a higher education institution has been investigated. The models of the brand of a higher education institution in the education market have been studied.\u0000Conclusions. The algorithm for the dynamic brand management of a higher education institution has been proposed. The advantages of creating an educational brand have been determined.","PeriodicalId":19221,"journal":{"name":"News of Pharmacy","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72565021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of the particle size of the catiazine substance by laser difraction","authors":"O. I. Cherniaieva, L. Y. Nikishyna, S. V. Kravchenko, I. S. Gritsenko","doi":"10.24959/nphj.21.67","DOIUrl":"https://doi.org/10.24959/nphj.21.67","url":null,"abstract":"Aim. To determine the particle size distribution of the new original substance cathiazine by laser diffraction.\u0000Materials and methods. The substance cathiazine was synthesized on the basis of d,l-camphoric acid and 2-aminothiazoline at the Institute of Endocrine Pathology Problems. The sperm-modulating effect of the new compound was proven in experimental animals. Its low toxicity at rather high efficiency was also confirmed. Determination of the particlesize of the powder of the substance cathiazine was performed by laser diffraction. The study was conducted on three laboratory batches. Optical microscopy was used to compare and confirm the results.\u0000Results and discussion. It was found that the average median particle size of the powder of the substance cathiazine was: for batch 1 – 38 μm, for batch 2 – 33 μm, for batch 3 – 53 μm. The maximum size for 80 % of particles of batch 1 was 115 μm, batch 2 – 90 μm, batch 3 – 125 μm. Microphotographs of three batches of the substance cathiazine obtained by optical microscopy were presented. This method also confirmed that the size of the registered particles did not exceed 200 μm. This was in good agreement with the previous studies, in which the recommended average particle size should not exceed 100 μm, and the mass fraction of larger fractions was proposed to be controlled.\u0000Conclusions. The particle size values of the powder substance cathiazine for three laboratory batches have been obtained. It has been found that the particle size and their size distribution in all laboratory batches of the substance cathiazine do not differ significantly. The data obtained can be used to normalize particle sizes in technology whendeveloping drugs","PeriodicalId":19221,"journal":{"name":"News of Pharmacy","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90667263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The biotechnological studies when developing lozenges with probiotics","authors":"U. Starushenko, L. Yarova, O. Kaliuzhnaia, N. Khokhlenkova, O. Kaliuzhnyi","doi":"10.24959/nphj.21.49","DOIUrl":"https://doi.org/10.24959/nphj.21.49","url":null,"abstract":"Aim. To develop lozenges with probiotic components for the treatment and prevention of ENT diseases and analyze their effectiveness.Materials and methods. The study objects were lozenges based on xylitol and sorbitol of two compositions – based on live probiotic cultures and their metabolites. The following methods of control of the sample efficiency werechosen: determination of the number of viable lactobacilli in the study of their combined use with the drug components and the number of viable bacteria in finished oral probiotics by the Koch method (direct seeding on cups), as well as the method of diffusion into agar with the growth inhibition zone determination.Results and discussion. The studies of the properties of probiotic strains of L. fermentum 90-TC and L plantarum 8P-A3 have shown the prospects for their use in oral probiotics. It has been also proposed to use metabolitesof these strains as active components, which have a rather high antimicrobial potential to opportunistic pathogens that cause infectious ENT diseases. The oral probiotics in the form of lozenges of two compositions – based on live lactobacilli and their metabolites – have shown high efficiency, bacterial survival and antimicrobial properties, respectively.Conclusions. During the complex of the theoretical, technological and biotechnological studies, lozenges with a probiotic of two compositions (based on viable probiotic cultures and their metabolites) have been developed. After further research they can be recommended as a biologically active additive to support the oral microflora, stimulate the own immunity and as a therapeutic and prophylactic agent in infectious diseases of the oral cavity for use in both adults and children.","PeriodicalId":19221,"journal":{"name":"News of Pharmacy","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74773083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementation of the Quality by Design approach for developing the composition and the manufacturing technology of an injectable drug for intra-articular introduction","authors":"O. Saliy, O. Los, T. Palchevska, K. Nebylytsia","doi":"10.24959/nphj.21.44","DOIUrl":"https://doi.org/10.24959/nphj.21.44","url":null,"abstract":"Aim. To implement the Quality by Design (QbD) approach in order to develop the composition and the manufacturing technology of injectable hyaluronate sodium (HS) in combination with chondroitin sulfate (CS) for intra-articularintroduction.\u0000Materials and methods. The composition of the solution for injection was developed using samples of the active pharmaceutical ingredient (API) of HS and CS. The approaches of the ICH international guidelines were used to create the QbD protocol. The quality target product profile (QTPP) was developed based on the literature review, analysis of similar drugs and the previous in-house experimental studies. Determination of critical quality assessment (CQA) product indicators was performed by risk analysis for all quality indicators listed in QTPP. The risk assessment of quality indicators was performed by assessing them according to the Risk Priority Number system (hereinafter – RPN) by a 9-point scale. When studying the composition and the manufacturing technology of the injectable solution the quality risk management (QRM) was developed according to the Ishikawa diagram.\u0000Results and discussion. It has been found that the QbD concept is a systematic approach to the drug development. At the first stage QTPP was developed. Based on the QTPP data the CQA indicators were determined, and quality risks were assessed. The critical process parameters (CPP) of the solution for injection based on HS and CS, their control methods, as well as the critical material attributes (CMA) were determined. Based on the data obtained the drug control strategy was proposed taking into account the need to minimize the repetition of control experiments. Using the Isikawa diagram the variability of the material and the process with the environmental factors affecting the qualityof the solution for injection with HS and CS was shown.Conclusions. Using the basic QbD approaches when developing the composition and the manufacturing technology of an injectable drug for intra-articular introduction it has been found that the route of administration, dose, potency, and consumer properties of the product are important aspects of QTPP. It has been proven that the quality indicators, such as transparency, viscosity, sterility and the quantitative content of API are determined as CQA to achieve the objectives defined in QTPP. The study shows that almost all stages of production are critical, therefore, they need to be constantly monitored and checked to obtain a quality product. In further experimental studies to confirm the composition developed and the manufacturing technology according to QRM it is necessary to focus on such indicators as the solution temperature, stabilization time, degassing mode and filtration conditions.","PeriodicalId":19221,"journal":{"name":"News of Pharmacy","volume":"604 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77436287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The current state and prospects of the development of soft dosage forms with Boraginaceae species","authors":"S. Svirska","doi":"10.24959/nphj.21.38","DOIUrl":"https://doi.org/10.24959/nphj.21.38","url":null,"abstract":"Soft dosage forms make up a significant segment in the structure of medicines both pharmaceutical and industrial production. Herbal ointments are an integral part of this group. Species of the Boraginaceae family are the source of biologically active substances used to treat inflammatory processes of all layers of the skin, muscle tissue, tendons and joints.Aim. To determine data on the current state of the development of soft dosage forms based on species of the Boraginaceae family and identify further prospects for studies in this area.Materials and methods. The scientific databases, in particular Abdata Pharma-Daten-Service, BioMed Central, Scopus, scientific periodicals of Ukraine – Vernadsky National Library of Ukraine, etc., were analyzed.Results and discussion. As a result of the data analysis of the Information Fund “State Register of Medicines of Ukraine” it has been found that only medicines with comfrey (Symphytum officinale L.) are registered in Ukraine. In the EU countries, only soft dosage forms with comfrey are registered, with the exception of Greece where there are ointments with Alkanna tinctoria (L.) Taush, and France where there are substances for the production of ointments withPulmonaria obscura Dumort. and Anchusa officinalis L. There are many soft homeopathic dosage forms with comfrey at the US pharmaceutical market; however, there are ointments and suppositories with Borago officinalis L. and a gel with Myosotis arvensis (L.) Hill. At the Brazilian pharmaceutical market there is the cream “Acheflan” based on Cordia verbenacea DC. The European and Asian scientists study ointments with Cordia myxa L., Cordia obliqua Willd., Heliotropium indicum L., Arnebia euchroma Rolye. (Johnst.), Onosma dichroanthum Boiss, Arnebia densiflora (Nordm.) Ledeb, Ehretia microphylla Lam., Anchusa officinalis L.Conclusions. Homeopathic products predominate among the soft dosage forms based on Boraginaceae species. At the pharmaceutical market, along with comfrey drugs, there are medicines and active substances with Borago officinalis, Myosotis arvensis (L.) Hill, Alkanna tinctoria (L.) Taush, Pulmonaria obscura Dumort., Anchusa officinalis L. and Cordia verbenacea DC. There is an active research of the existing products with comfrey, as well as the development and study of new soft dosage forms with species of Arnebia, Heliotropium, Cordia, Onosma, Ehretia and Anchusa genus. Taking the above into account the further research for creating effective and safe drugs based on the Boraginaceae species is promising. ","PeriodicalId":19221,"journal":{"name":"News of Pharmacy","volume":"73 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86378884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The thermogravimetric study of the ointment with the water-soluble proteinpolysaccharide complex of Pleurotus ostreatus","authors":"O. Kolpakova, N. Kucherenko, M. Tiukin","doi":"10.24959/nphj.21.41","DOIUrl":"https://doi.org/10.24959/nphj.21.41","url":null,"abstract":"The manufacturing process for soft dosage forms is always accompanied by the action of a certain temperature, which violation can lead not only to the deterioration of technological indicators, but also significantly affect the pharmacological activity of the finished drug.Aim. To study the water-soluble protein-polysaccharide complex (WSPPC) of Pleurotus ostreatus (oyster mushroom) and the ointment composition developed on its basis using thermogravimetry.Materials and methods. The thermogravimetric analysis, which allowed determining the change of the mass of the test sample under the conditions of the controlled temperature rise, was chosen as the research method. Determination of thermogravimetric characteristics was performed using a Q-1500 D derivatograph of the “F. Paulik, J. Paulik, L. Erdey” system with a platinum-platinum-rhodium thermocouple when heating samples 30 to 250 °C.Results and discussion. In the course of the thermogravimetric study it has been determined that WSPPC and the ointment composition developed on its basis have physical transformations at certain temperatures. The presence of thermal effects on the thermogram of the ointment developed coincides with the thermal effects of WSPPC; and it subjectively indicates the absence of the chemical interaction between the active pharmaceutical ingredient and the excipients of the carrier base.Conclusions. Based on the results obtained the optimal conditions of the temperature regime for the manufacturing process have been determined. They will provide the stability of the physicochemical properties and the pharmacological effect of the finished ointment.","PeriodicalId":19221,"journal":{"name":"News of Pharmacy","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80330800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The methodological support of adaptive management of manufacturing pharmaceutical enterprises","authors":"K. Holybtsova, I.-M. Gurina-Rapinchuk","doi":"10.24959/nphj.21.50","DOIUrl":"https://doi.org/10.24959/nphj.21.50","url":null,"abstract":"Aim. To develop the methodological support for management of the manufacturing pharmaceutical enterprises (MPE) of Ukraine.Materials and methods. The methods used in the study include methods of theoretical generalization, analysis and synthesis, synergetic approach.Results and discussion. The organizational and economic mechanism of adaptive management of MPE has been constructed. It carries out its activities on the basis of elements that determine the main directions of the organization of management of pharmaceutical entities and substantively represents a set of sequential processes determining the complex managerial impact on all management facilities involved in financial and economic activities andproviding optimization and the efficient use of all types of production and economic resources. It has been determined that the formation of organizational and economic mechanism of adaptive management of manufacturing pharmaceutical companies requires pharmaceutical companies to effectively implement management functions that exist within the stages of the management process based on the use of all elements of the mechanism.Conclusions. It has been concluded that the methodological support of adaptive management of manufacturing pharmaceutical enterprises will allow businesses to adapt to change, develop in the direction of combining the interests of all stakeholders on the competitiveness of the pharmaceutical industry of Ukraine.","PeriodicalId":19221,"journal":{"name":"News of Pharmacy","volume":"110 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88604506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The analysis of the drug assortment of immunostimulants presented at the Ukrainian market","authors":"V. Rybachuk, Yu. Lyakhovchenko, A. Yanko","doi":"10.24959/nphj.21.46","DOIUrl":"https://doi.org/10.24959/nphj.21.46","url":null,"abstract":"Aim. To analyze the registered medicines of the group of immunostimulants in order to determine the feasibility of creating and organizing the production of new drugs based on natural clays, in particular green and yellow clays.Materials and methods. The list of medicinal products compiled from official sources of information was used in the work; it was processed by the methods of generalization, systematization, graphical method, as well as the methods of comparative and structural analysis.Results and its discussion. The analysis of the Ukrainian pharmaceutical market concerning the range of the registered immunostimulants has been performed. Structuring of the selected list of medicines by the ATC-classification, origin, composition, production characteristic and dosage form type has been carried out. By production basis the majority of medicines are of domestic production (63.58 %). It has been determined that drugs of the segment studied are produced in solid and liquid dosage forms. Solutions for injection are prevalent at the domestic pharmaceutical market, and the range of solid dosage forms is under developed. At the pharmaceutical market, there are no drugs of this group with natural clays, in particular yellow and green clays.Conclusions. The absence of immunostimulants based on natural clays at the Ukrainian market has been proven; it indicates the feasibility of introducing new domestic drugs with the immunostimulating action on the basis of natural clays, in particular yellow and green clays, to the market.","PeriodicalId":19221,"journal":{"name":"News of Pharmacy","volume":"127 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76717275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potentiometric determination of organic acids in the medicinal plant raw material","authors":"T. Oproshanska, O. Khvorost","doi":"10.24959/nphj.21.42","DOIUrl":"https://doi.org/10.24959/nphj.21.42","url":null,"abstract":"Aim. To analyze the results of the quantitative content of the amount of organic acids in rhizomes with roots of Rumex confertus, rhizomes with roots of Sanguisorba officinalis, roots of Rosa majalis and roots of Rosa canina, roots of Arctium minus and roots of Arctium tomentosum, herb of Bidens tripartite by the potentiometric method, which is available in the monograph “Hibiscus” in the SPhU 2.0.\u0000Materials and methods. The study subjects were batches of rhizomes with roots of Rumex confertus, rhizomes with roots of Sanguisorba officinalis, roots of Rosa majalis and roots of Rosa canina, roots of Arctium minus and roots of Arctium tomentosum, herb of Bidens tripartite. The quantitative content of the amount of organic acids was determined by the potentiometric method from the monograph “Hibiscus” SPhU 2.0 using a HI 2550 potentiometer of the “HANNA instruments” company (Germany).\u0000Results and discussion. The highest content of the amount of organic acids, among the study subjects was in roots of Arctium minus (from 1.02 ± 0.04 % to 1.05 ± 0.04 %). At the same time, in roots of Arctium tomentosum this amount was almost 3 times lower (from 0.36 ± 0.01 % to 0.37 ± 0.01 %). In the batches of roots of Rosa majalis the content of this group of compounds was almost 2 times higher than in roots of Rosa canina. In rhizomes with roots of Rumex confertus and rhizomes with roots of Sanguisorba officinalis the content of the amount of organic acids differed insignificantly. In herb of Bidens tripartite the content of this group of compounds was 0.78 ± 0.03  – 0.79 ± 0.03 %. In different batches of one type of the raw material the quantitative content of the amount of organic acids varied slightly.\u0000Conclusions. For the first time, the quantitative content of the amount of organic acids has been determined in the batches of rhizomes with roots of Rumex confertus, rhizomes with roots of Sanguisorba officinalis, roots of Rosa majalis and roots of Rosa canina, roots of Arctium minus and roots of Arctium tomentosum, herb of Bidens tripartite using the potentiometric method which is available in the monograph “Hibiscus” in the SPhU 2.0. It has been found that the highest content of the amount of organic acids is observed in roots of Arctium minus (not less than 1.02 %) and herb of Bidens tripartite (not less than 0.78 %). The results obtained will be used in further research when creating new herbal medicines with the anti-inflammatory and antimicrobial activity.","PeriodicalId":19221,"journal":{"name":"News of Pharmacy","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82183430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The preclinical studies of the stress-protective activity of “Tonus-aktiv” homeopathic granules","authors":"O. Gaidukova, Y. Nikolenko, G. Kvitchata, S. Oliinyk, L. Belyaeva","doi":"10.24959/NPHJ.20.36","DOIUrl":"https://doi.org/10.24959/NPHJ.20.36","url":null,"abstract":"Aim . To perform the preclinical studies of the stress-protective activity of a new “Tonus-Aktiv” homeopathic medicinal product. Materials and methods . The stress-protective effect of the “Tonus-Aktiv” homeopathic medicinal product (MP) and the reference drug – “Stress-gran” homeopathic granules were studied on the model of neuromuscular tension by Selye. The stress-protective effect of the drugs was assessed by the conventional methods described in the sci entific literature and the corresponding current instructional guidelines. All factual material was processed by variational statistics methods using parametric (Newman-Keuls test) and non-parametric methods of analysis (Kruskal-Wallis, Mann-Whitney). Results and discussion . It was found that “Tonus-Aktiv” had a pronounced gastro-protective effect, reducing the area of ulcers by almost 3 times, having a statistically significant antioxidant effect, reducing the level of TBA (thiobarbituric acid) active products in the liver homogenate. It did not have a normalizing effect on the protein metabolism, but it did contribute to enhancing energy-supplying metabolic processes: aerobic glycolysis indicated by a reliable increase of the pyruvic acid level in the blood serum, and lipolysis, as evidenced by a significantly higher level of the total blood lipids. “Tonus-Aktiv” showed a pronounced antioxidant activity: it reduced the TBA level of active products in the liver homogenate. At the same time, the level of endogenous antioxidant of reduced glutathione was observed to be lower than in the stressed animals against the background of the “Tonus-Aktiv” application. It indicates the physiological nature of the stress protective activity of the drug. Conclusions. A moderate stress-protective activity of “Tonus-Aktiv” homeopathic granules can be observed; it is caused by antioxidant properties, as well as a probable activating effect on the hypothalamic-pituitary-adrenal system, which may be manifested by the protective action.","PeriodicalId":19221,"journal":{"name":"News of Pharmacy","volume":"88 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76417622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}