Neuroreport最新文献_第9页

Aberrant dynamic functional and effective connectivity changes of the primary visual cortex in patients with retinal detachment via machine learning. 通过机器学习研究视网膜脱离患者初级视觉皮层的动态功能和有效连接性异常变化。

IF 1.6 4区医学

Neuroreport Pub Date : 2024-12-04 Epub Date: 2024-10-03 DOI: 10.1097/WNR.0000000000002100

Yu Ji, Yuan-Yuan Wang, Qi Cheng, Wen-Wen Fu, Ben-Liang Shu, Bin Wei, Qin-Yi Huang, Xiao-Rong Wu

{"title":"Aberrant dynamic functional and effective connectivity changes of the primary visual cortex in patients with retinal detachment via machine learning.","authors":"Yu Ji, Yuan-Yuan Wang, Qi Cheng, Wen-Wen Fu, Ben-Liang Shu, Bin Wei, Qin-Yi Huang, Xiao-Rong Wu","doi":"10.1097/WNR.0000000000002100","DOIUrl":"10.1097/WNR.0000000000002100","url":null,"abstract":"Objective: Previous neuroimaging studies have identified significant alterations in brain functional activity in retinal detachment (RD) patients, these investigations predominantly concentrated on local functional activity changes. The potential directional alterations in functional connectivity within the primary visual cortex (V1) in RD patients remain to be elucidated.Methods: In this study, we employed seed-based functional connectivity analysis along with Granger causality analysis to examine the directional alterations in dynamic functional connectivity (dFC) within the V1 region of patients diagnosed with RD. Finally, a support vector machine algorithm was utilized to classify patients with RD and healthy controls (HCs).Results: RD patients exhibited heightened dynamic functional connectivity (dFC) and dynamic effective connectivity (dEC) between the Visual Network (VN) and default mode network (DMN), as well as within the VN, compared to HCs. Conversely, dFC between VN and auditory network (AN) decreased, and dEC between VN and sensorimotor network (SMN) significantly reduced. In state 4, RD patients had higher frequency. Notably, variations in dFC originating from the left V1 region proved diagnostically effective, achieving an AUC of 0.786.Conclusion: This study reveals significant alterations in the connectivity between the VN and the default mode network in patients with RD. These changes may disrupt visual information processing and higher cognitive integration in RD patients. Additionally, alterations in the left V1 region and whole-brain dFC show promising potential in aiding the diagnosis of RD. These findings offer valuable insights into the neural mechanisms underlying visual and cognitive impairments associated with RD.","PeriodicalId":19213,"journal":{"name":"Neuroreport","volume":" ","pages":"1071-1081"},"PeriodicalIF":1.6,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142471000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

pRb phosphorylation regulates the proliferation of supporting cells in gentamicin-damaged neonatal avian utricle: Erratum. pRb磷酸化调控庆大霉素损伤的新生禽类胞器支持细胞的增殖勘误。

IF 1.6 4区医学

Neuroreport Pub Date : 2024-11-06 Epub Date: 2024-09-25 DOI: 10.1097/WNR.0000000000002102

引用次数: 0

Altered static brain activity and functional connectivity after heat stroke. 中暑后大脑静态活动和功能连接的改变。

IF 1.6 4区医学

Neuroreport Pub Date : 2024-11-06 Epub Date: 2024-09-19 DOI: 10.1097/WNR.0000000000002096

Ting Yang, Xinyu Hou, Xu Li, Xiaoxin Chen, Zhengwei Qu, Wenzheng Zhang, Maoyang Wang, Jun Li

{"title":"Altered static brain activity and functional connectivity after heat stroke.","authors":"Ting Yang, Xinyu Hou, Xu Li, Xiaoxin Chen, Zhengwei Qu, Wenzheng Zhang, Maoyang Wang, Jun Li","doi":"10.1097/WNR.0000000000002096","DOIUrl":"10.1097/WNR.0000000000002096","url":null,"abstract":"This study aimed to investigate the alteration of brain function based on resting-state functional MRI in patients after heat stroke. This study included 10 cases of patients after heat stroke and 10 cases of healthy controls. Abnormal brain function was calculated using amplitude of low-frequency fluctuations (ALFF) and degree centrality analysis, as well as functional connectivity analysis based on regions of interest (ROI). Correlation analyses were performed to evaluate the association between brain function changes and clinical scales. Combining ALFF and degree centrality results, the decreased brain regions included the left cuneus and the right angular gyrus, while the increased brain regions included the right cerebellar_Crus1. Using the left cuneus with significant differences in ALFF and degree centrality as ROI, the functional connectivity results revealed decreased brain regions including bilateral lingual gyrus, bilateral postcentral cingulate gyrus, and left precentral gyrus. The degree centrality value of the right cerebellar_Crus1 was positively correlated with glasgow coma scale (GCS) scores ( r = 0.726, P = 0.027), and the functional connectivity value of the right posterior cingulate gyrus was positively correlated with GCS scores ( r = 0.717, P = 0.030). Heat stroke patients exhibit abnormal activity in multiple brain regions, which has important clinical significance for evaluating the severity of the disease.","PeriodicalId":19213,"journal":{"name":"Neuroreport","volume":" ","pages":"1035-1040"},"PeriodicalIF":1.6,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adipose-derived stem cell transplantation enhances spinal cord regeneration by upregulating PGRN expression. 脂肪源性干细胞移植通过上调PGRN的表达增强脊髓再生。

IF 1.6 4区医学

Neuroreport Pub Date : 2024-11-06 Epub Date: 2024-09-12 DOI: 10.1097/WNR.0000000000002091

Qiongchi Zhang, Jingtao Wu, Dong Guo, Ning Ji, Weidong Liu, Xinyu Li, Hao Liu, Chengyi Zhang, Minchao Zhao, Haopeng Li, Hongxu Jin, Su'e Chang, Dong Wang

{"title":"Adipose-derived stem cell transplantation enhances spinal cord regeneration by upregulating PGRN expression.","authors":"Qiongchi Zhang, Jingtao Wu, Dong Guo, Ning Ji, Weidong Liu, Xinyu Li, Hao Liu, Chengyi Zhang, Minchao Zhao, Haopeng Li, Hongxu Jin, Su'e Chang, Dong Wang","doi":"10.1097/WNR.0000000000002091","DOIUrl":"10.1097/WNR.0000000000002091","url":null,"abstract":"This study aims to investigate the effect of adipose-derived stem cells (ADSCs) transplantation on progranulin (PGRN) expression and functional recovery in rats with spinal cord injury (SCI). ADSCs were isolated from the inguinal adipose tissue of rats. A SCI model was created, and ADSCs were injected into the injured area. Various techniques were used to assess the effects of ADSCs transplantation, including hematoxylin-eosin staining, Masson staining, immunofluorescence staining, electron microscopy, MRI, and motor function assessment. The potential mechanisms of ADSC transplantation were investigated using gene expression analysis and protein analysis. Finally, the safety of this therapy was evaluated through hematoxylin-eosin staining and indicators of liver and kidney damage in serum. PGRN expression increased in the injured spinal cord, and ADSCs transplantation further enhanced PGRN levels. The group that received ADSCs transplantation showed reduced inflammation, decreased scar formation, increased nerve regeneration, and faster recovery of bladder function. Importantly, motor function significantly improved in the ADSC transplantation group. ADSCs transplantation enhances functional regeneration in SCI by upregulating PGRN expression, reducing inflammation and scar formation, and promoting nerve regeneration and myelin repair. These findings suggest that ADSC transplantation is a potential therapy for SCI.","PeriodicalId":19213,"journal":{"name":"Neuroreport","volume":" ","pages":"1019-1029"},"PeriodicalIF":1.6,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A revisit to interactions of stimulus quality and semantic context on N400 in visual word recognition. 重新审视刺激质量和语义语境对视觉单词识别 N400 的交互作用。

IF 1.6 4区医学

Neuroreport Pub Date : 2024-11-06 Epub Date: 2024-09-25 DOI: 10.1097/WNR.0000000000002095

Rongmin Xiong, Yong Zhang, Wenyi Hu, Shixue Zhu, Zhongxuan Huang, Quanhong Wang

{"title":"A revisit to interactions of stimulus quality and semantic context on N400 in visual word recognition.","authors":"Rongmin Xiong, Yong Zhang, Wenyi Hu, Shixue Zhu, Zhongxuan Huang, Quanhong Wang","doi":"10.1097/WNR.0000000000002095","DOIUrl":"10.1097/WNR.0000000000002095","url":null,"abstract":"Much behavioral research has revealed interactive effects between stimulus quality and semantic priming in visual word recognition, practically in favor of the interactive activation model. However, the limited number of event-related brain potential (ERP) studies have yielded inconsistent results considering this interaction's impact on N400 amplitude. The current ERP study aimed to examine whether the joint effects of stimulus quality and semantic priming were specific to the lexical decision task. We used both behavioral measures and ERP recordings to evaluate the joint effects of stimulus degradation (i.e. highly vs. slightly degraded) and semantic priming (i.e. semantically related vs. unrelated) in a lexical decision task involving visual recognition of Chinese characters. The results showed significant degradation-by-priming interactions on response times and N400 amplitude ( P < 0.05), with larger semantic priming effects on slightly degraded targets. These converging behavioral and electrophysiological findings provide evidence in accordance with the interactive activation models of visual word recognition, in which the early-stage visual processing (i.e. degradation) cascades into the later-stage semantic processing (i.e. priming), thus yielding interactions observed in N400 amplitude.","PeriodicalId":19213,"journal":{"name":"Neuroreport","volume":" ","pages":"1030-1034"},"PeriodicalIF":1.6,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142154692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Specific mode electroacupuncture stimulation opens the blood-brain barrier of the infarcted border zone in rats during MCAO/R recovery via modulation of tight junction protein expression by VEGFA and NF-κB. 特定模式电针刺激通过调节 VEGFA 和 NF-κB 的紧密连接蛋白表达，在 MCAO/R 恢复期打开大鼠梗死边界区的血脑屏障。

IF 1.6 4区医学

Neuroreport Pub Date : 2024-11-06 Epub Date: 2024-09-19 DOI: 10.1097/WNR.0000000000002098

Kecheng Qian, Mengyuan Dai, Lin Gan, Qinyu Ye, Xingying Wu, Tianyu Qian, Congcong Ma, Xianming Lin

{"title":"Specific mode electroacupuncture stimulation opens the blood-brain barrier of the infarcted border zone in rats during MCAO/R recovery via modulation of tight junction protein expression by VEGFA and NF-κB.","authors":"Kecheng Qian, Mengyuan Dai, Lin Gan, Qinyu Ye, Xingying Wu, Tianyu Qian, Congcong Ma, Xianming Lin","doi":"10.1097/WNR.0000000000002098","DOIUrl":"10.1097/WNR.0000000000002098","url":null,"abstract":"The blood-brain barrier (BBB) strictly limits the entry of most exogenous therapeutic drugs into the brain, which brings great challenges to the drug treatment of refractory central diseases, including the treatment of ischemic stroke. Our previous studies have shown that specific mode electroacupuncture stimulation (SMES) can temporarily open the BBB, but with the mechanisms largely unknown. This study explored whether SMES opens the BBB in the infarcted border zone of rats during middle cerebral artery occlusion/reperfusion recovery, and whether this is related to p65 or vascular endothelial growth factor A (VEGFA) modulation of tight junction protein expression through in vivo and in vitro studies. Evans blue, FITC-dextran, mouse-derived nerve growth factor (NGF), and transendothelial electrical resistance values were used to evaluate the permeability of the BBB. Additionally, microvascular endothelial cells and astrocytes were utilized for in vitro study. Immunofluorescence, immunohistochemistry, western blot, and ELISA were employed to assess related protein expression. SMES significantly increased vascular permeability for Evans blue and NGF in the infarcted border zone, and increased the expression of VEGFA by activating p-p65, thereby reducing the expression of tight junction proteins Occludin and ZO-1. Correspondingly, oxygen glucose deprivation/reoxygenation activated p-p65 in and induced VEGFA secretion from astrocytes in vitro. Their conditioned medium reduced the expression of Occludin in bEnd.3 cells and increased the permeability of FITC-dextran. The mechanism of SMES opening infarcted border zone BBB is partly related to its actions on p65, VEGFA, and tight junction proteins.","PeriodicalId":19213,"journal":{"name":"Neuroreport","volume":" ","pages":"1052-1060"},"PeriodicalIF":1.6,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergism of salvianolic acid B and ginsenoside Rg1 magnifies the therapeutic potency against ischemic stroke. 丹酚酸 B 和人参皂苷 Rg1 的协同作用增强了对缺血性中风的疗效。

IF 1.6 4区医学

Neuroreport Pub Date : 2024-11-06 Epub Date: 2024-09-19 DOI: 10.1097/WNR.0000000000002099

Haishang Shen, Yuhan Zhang, Yanan Shao, Siqi Chen, Ping Yin, Xin Liu, Linlin Wang, Lingxiao Zhang, Yi Jin, Yiyu Wang, Rongrong Xing, Kenka Cho, Baohong Jiang

{"title":"Synergism of salvianolic acid B and ginsenoside Rg1 magnifies the therapeutic potency against ischemic stroke.","authors":"Haishang Shen, Yuhan Zhang, Yanan Shao, Siqi Chen, Ping Yin, Xin Liu, Linlin Wang, Lingxiao Zhang, Yi Jin, Yiyu Wang, Rongrong Xing, Kenka Cho, Baohong Jiang","doi":"10.1097/WNR.0000000000002099","DOIUrl":"10.1097/WNR.0000000000002099","url":null,"abstract":"Even though considerable progress has been made to reduce insult, ischemic stroke is still a significant cause of mortality and morbidity in the world, and new therapeutic strategies are urgently needed. In the present study, the magnesium salt of salvianolic acid B (SalB) and ginsenoside Rg1 (Rg1) combination as a multicomponent strategy against stroke was evaluated. The synergistic effect of Sa1B and Rg1 was evaluated by Bliss independence analysis on the middle cerebral artery occlusion model. The infarct volume, neuroethology, cerebral structure, and neurocyte number were evaluated by 3,5-triphenyltetrazolium chloride staining, Longa score, Garcia score, hematoxylin-eosin staining, and Nissl staining, respectively. Metabolomics was used to search for potential biomarkers and explore the mechanism of Sa1B/Rg1. First, the superior effects of SalB/Rg1 than SalB or Rg1 at the same dose were evaluated. Compared with SalB ( P < 0.001) or Rg1 ( P < 0.01), SalB/Rg1 significantly decreased infarct volume through 3,5-triphenyltetrazolium chloride staining and protected the structural integrity of cortex and striatum. The superior effect of SalB/Rg1 on neurological behavior was also detected compared with SalB or Rg1 significantly. Accompanying behavioral improvement, a considerable increase of SalB/Rg1 on neurons detected by Nissl staining was found on the cortex compared with SalB ( P < 0.05) or Rg1 ( P < 0.01). Second, the synergistic effect between SalB and Rg1 was strictly verified by Bliss independence analysis ( P < 0.01) based on infarct volume. Finally, alleviation of cerebral metabolic disorders may be the possible mechanism of SalB/Rg1. Our study provided a multicomponent strategy against ischemic stroke, with not only dose reduction but also improved efficacy relative to single agents.","PeriodicalId":19213,"journal":{"name":"Neuroreport","volume":" ","pages":"1041-1051"},"PeriodicalIF":1.6,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11424057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in gene expression due to aging in the hypothalamus of mice. 小鼠下丘脑衰老导致的基因表达变化。

IF 1.6 4区医学

Neuroreport Pub Date : 2024-10-16 Epub Date: 2024-08-13 DOI: 10.1097/WNR.0000000000002092

Masataka Narukawa, Yoshikazu Saito, Yoichi Kasahara, Tomiko Asakura, Takumi Misaka

{"title":"Changes in gene expression due to aging in the hypothalamus of mice.","authors":"Masataka Narukawa, Yoshikazu Saito, Yoichi Kasahara, Tomiko Asakura, Takumi Misaka","doi":"10.1097/WNR.0000000000002092","DOIUrl":"10.1097/WNR.0000000000002092","url":null,"abstract":"Aging generally affects food consumption and energy metabolism. Since the feeding center is located in the hypothalamus, it is a major target for understanding the mechanism of age-related changes in eating behavior and metabolism. To obtain insight into the age-related changes in gene expression in the hypothalamus, we investigated genes whose expression changes with age in the hypothalamus. A DNA microanalysis was performed using hypothalamus samples obtained from young (aged 24 weeks) and old male mice (aged 138 weeks). Gene Ontology (GO) analysis was performed using the identified differentially expressed genes. We observed that the expression of 377 probe sets was significantly altered with aging (177 were upregulated and 200 were downregulated in old mice). As a result of the GO analysis of these probe sets, 16 GO terms, including the neuropeptide signaling pathway, were obtained. Intriguingly, although the food intake in old mice was lower than that in young mice, we found that several neuropeptide genes, such as agouti-related neuropeptide ( Agrp ), neuropeptide Y ( Npy ), and pro-melanin-concentrating hormone ( Pmch ), all of which promote food intake, were upregulated in old mice. In conclusion, this suggests that the gene expression pattern in the hypothalamus is regulated to promote food intake.","PeriodicalId":19213,"journal":{"name":"Neuroreport","volume":" ","pages":"987-991"},"PeriodicalIF":1.6,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11389885/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142009141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Palatable solution overconsumption in the Cntnap2-/- murine model of autism: a link with oxytocin. Cntnap2-/-自闭症小鼠模型中美味溶液的过度摄入：与催产素有关。

IF 1.6 4区医学

Neuroreport Pub Date : 2024-10-16 Epub Date: 2024-08-07 DOI: 10.1097/WNR.0000000000002089

Savannah Harvey, Donisha S N K Liyanagamage, Tapasya Pal, Anica Klockars, Allen S Levine, Pawel K Olszewski

{"title":"Palatable solution overconsumption in the Cntnap2-/- murine model of autism: a link with oxytocin.","authors":"Savannah Harvey, Donisha S N K Liyanagamage, Tapasya Pal, Anica Klockars, Allen S Levine, Pawel K Olszewski","doi":"10.1097/WNR.0000000000002089","DOIUrl":"10.1097/WNR.0000000000002089","url":null,"abstract":"Dysregulated appetite is common in autism spectrum disorder (ASD) and it includes excessive interest in tasty foods. Overconsumption of palatable fluids has been found in the valproic acid-induced ASD rat. Though ASD has a strong genetic component, the link between ASD-related genes and appetite for palatable foods remains elusive. We focused on the CNTNAP2 gene whose deletion in mice recapitulates human ASD symptoms. We investigated whether Cntnap2-/- male mice consume greater amounts of palatable 10% sucrose, 0.1% saccharin, and 4.1% intralipid solutions offered in episodic meals either in a no-choice paradigm or a two-bottle choice test. We examined how sucrose intake affects c-Fos immunoreactivity in feeding-related brain areas. Finally, we determined doses at which intraperitoneal oxytocin decreases sucrose intake in mutants. In the single-bottle tests, Cntnap2-/- mice drank more sucrose, saccharin, and intralipid compared to WTs. Given a choice between two tastants, Cntnap2-/- mice had a higher preference for sucrose than intralipid. While the standard 1 mg/kg oxytocin dose reduced sucrose intake in WTs, a low oxytocin dose (0.1 mg/kg) decreased sucrose intake in Cntnap2-/- mice. Sucrose intake induced a more robust c-Fos response in wild-type (WT) than Cntnap2-/- mice in the reward and hypothalamic sites and it increased the percentage of Fos-immunoreactivity oxytocin neurons in WTs, but not in mutants. We conclude that Cntnap2-/- mice overconsume palatable solutions, especially sucrose, beyond levels seen in WTs. This excessive consumption is associated with blunted c-Fos immunoreactivity in feeding-related brain sites, and it can be reversed by low-dose oxytocin.","PeriodicalId":19213,"journal":{"name":"Neuroreport","volume":" ","pages":"980-986"},"PeriodicalIF":1.6,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142009159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temporal dynamic alterations of regional homogeneity in major depressive disorder: a study integrating machine learning. 重度抑郁障碍中区域同质性的时间动态变化：一项结合机器学习的研究。

IF 1.6 4区医学

Neuroreport Pub Date : 2024-10-16 Epub Date: 2024-09-11 DOI: 10.1097/WNR.0000000000002086

Xiaofeng Wu, Xiaojun Shen, Qinghe Li, Peiyuan Wang

{"title":"Temporal dynamic alterations of regional homogeneity in major depressive disorder: a study integrating machine learning.","authors":"Xiaofeng Wu, Xiaojun Shen, Qinghe Li, Peiyuan Wang","doi":"10.1097/WNR.0000000000002086","DOIUrl":"https://doi.org/10.1097/WNR.0000000000002086","url":null,"abstract":"Previous studies have found alterations in the local regional homogeneity of brain activity in individuals diagnosed with major depressive disorder. However, many studies have failed to consider that even during resting states, brain activity is dynamic and time-varying. The lack of investigation into the dynamic regional homogeneity has hindered the discovery of biomarkers for depression. This study aimed to assess the utility of the dynamic regional homogeneity by a machine learning model (support vector machine). Sixty-five individuals with dynamic regional homogeneity and 57 healthy controls participated in resting-state functional magnetic resonance rescanning and scale estimating. The dynamic regional homogeneity and receiver operating characteristic curve methods were used for analysis of the imaging data. Relative to healthy controls, major depressive disorder patients displayed increased dynamic regional homogeneity values in the left precuneus and right postcentral gyrus. Additionally, receiver operating characteristic curve results of the dynamic regional homogeneity values in the left precuneus and right postcentral gyrus could distinguish major depressive disorder patients from healthy controls; furthermore, changes in the dynamic regional homogeneity were correlated with depression severity.","PeriodicalId":19213,"journal":{"name":"Neuroreport","volume":"35 15","pages":"972-979"},"PeriodicalIF":1.6,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0