Nordic Journal of Psychiatry最新文献

Exploring temperament and sleep patterns in disruptive mood dysregulation disorder among children and adolescents: implications for clinical practice.

IF 1.5 4区医学

Nordic Journal of Psychiatry Pub Date : 2025-01-19 DOI: 10.1080/08039488.2025.2455079

Helin Abursu, Mehmet Fatih Ceylan, Selma Tural Hesapcıoglu

{"title":"Exploring temperament and sleep patterns in disruptive mood dysregulation disorder among children and adolescents: implications for clinical practice.","authors":"Helin Abursu, Mehmet Fatih Ceylan, Selma Tural Hesapcıoglu","doi":"10.1080/08039488.2025.2455079","DOIUrl":"https://doi.org/10.1080/08039488.2025.2455079","url":null,"abstract":"Background: Disruptive Mood Dysregulation Disorder (DMDD), characterized by severe irritability and temper outbursts, is a relatively new diagnosis included in the DSM-5. The study aimed to investigate the clinical characteristics, temperament, comorbidities, medication use, and sleep quality of children and adolescents diagnosed with DMDD and compare them with Major Depressive Disorder (MDD).Methods: A total of 233 participants (DMDD: n = 106; MDD: n = 127) were assessed using the K-SADS-PL. Evaluation tools included the Children's Temperament and Character Inventory, Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale, Strengths and Difficulties Child and Parent Form, Children's Depression Inventory for children, and sociodemographic form.Results: The DMDD group scored significantly lower in harm avoidance, reward dependence, and cooperation than the MDD group (p ≤ 0.001, p ≤ 0.02, p ≤ 0.002, respectively). DMDD exhibits significantly lower levels of social skill-related temperament traits, such as empathy, compassion, and helpfulness. Furthermore, a higher proportion of patients in the DMDD group received antipsychotic, mood stabilizer, and stimulant medications during treatment.Conclusion: Children and adolescents diagnosed with DMDD demonstrated significantly lower scores in anticipatory worry, fear of uncertainty, shyness, fatigability, sentimentality, dependence, empathy, and helpfulness compared to those with MDD. Conversely, they exhibited higher levels of impulsiveness, disorderliness, and self-acceptance. These findings underscore the necessity of evaluating and enhancing social skills and reward sensitivity in the clinical management of DMDD, as these distinct psychological and behavioral profiles suggest the need for more tailored therapeutic approaches.","PeriodicalId":19201,"journal":{"name":"Nordic Journal of Psychiatry","volume":" ","pages":"1-8"},"PeriodicalIF":1.5,"publicationDate":"2025-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143008997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interconnectedness of borderline personality pathology and affective temperaments in patients with mood disorders: a network analysis.

IF 1.5 4区医学

Nordic Journal of Psychiatry Pub Date : 2025-01-19 DOI: 10.1080/08039488.2025.2451370

Hyukjun Lee, Yewon Eom, Jakyung Lee, Daseul Lee, Hyeona Yu, Hyo Shin Kang, Jungkyu Park, Woojae Myung

{"title":"Interconnectedness of borderline personality pathology and affective temperaments in patients with mood disorders: a network analysis.","authors":"Hyukjun Lee, Yewon Eom, Jakyung Lee, Daseul Lee, Hyeona Yu, Hyo Shin Kang, Jungkyu Park, Woojae Myung","doi":"10.1080/08039488.2025.2451370","DOIUrl":"https://doi.org/10.1080/08039488.2025.2451370","url":null,"abstract":"Purpose: Mood disorders frequently coexist with borderline personality pathology (BPP), presenting considerable clinical challenges. Affective temperaments (AT) play a role in modulating mood disorders and influence the manifestation of illness. BPP and AT share common characteristics, such as emotional instability, impulsivity, and difficulties in interpersonal relationships. However, research on the relationship between BPP and AT remains limited. This study employed network analysis to explore the network structure between BPP and AT in a cohort of patients with mood disorders.Materials and methods: A total of 720 patients with mood disorders (major depressive disorder, n = 267; bipolar affective disorder, n = 453) were included in the analysis. The Personality Assessment Inventory-Borderline Features Scale (PAI-BOR) and the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego-Auto questionnaire short version (TEMPS-A) were utilized. Network analysis was conducted to identify central symptoms and network structures across the five AT dimensions and 24 BPP items.Results: The BPP and TEMPS-A items were intricately interwoven, with no distinct groupings. The most significant symptoms identified were \"Mood shifts\" and \"Cyclothymic temperament.\" Additionally, irritable temperament was strongly linked to \"Little control over anger,\" while anxious temperament was closely associated with \"Worry about people leaving.\"Conclusion: The overlap of BPP and AT in the network, without a clear separation, suggests a significant interconnection between these clinical concepts. The centrality of \"Mood shifts\" and \"Cyclothymic temperament\" in this network underscores the importance of targeting these symptoms in the treatment of patients with prominent BPP and AT.","PeriodicalId":19201,"journal":{"name":"Nordic Journal of Psychiatry","volume":" ","pages":"1-10"},"PeriodicalIF":1.5,"publicationDate":"2025-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of depression and association to socioeconomic position. Results from the Lolland-Falster Health Study.

IF 1.5 4区医学

Nordic Journal of Psychiatry Pub Date : 2025-01-17 DOI: 10.1080/08039488.2024.2448816

Aake Packness, Andreas Heltberg, Anne Møller, Erik Simonsen

{"title":"Prevalence of depression and association to socioeconomic position. Results from the Lolland-Falster Health Study.","authors":"Aake Packness, Andreas Heltberg, Anne Møller, Erik Simonsen","doi":"10.1080/08039488.2024.2448816","DOIUrl":"https://doi.org/10.1080/08039488.2024.2448816","url":null,"abstract":"Purpose: To describe the prevalence of self-reported depression in a socioeconomically deprived area in Denmark and the association to socioeconomic position (SEP) defined by education, occupation, and being in financial strain.Method: 13,955 adults completing the Major Depression Inventory (MDI) in the Lolland-Falster Health Study questionnaire were included.Multivariate logistic regression on symptoms of depression based on MDI sum score and ICD-10 scores, associated to education, occupation, and financial strain - unadjusted and adjusted for sex and age group.Results: We found a prevalence of depression at 2.7% using the ICD-10 category, at 7.6% using the MDI sum score, and a very strong association between symptoms of depression and SEP.The adjusted odd ratios (aORs) for depression for each socioeconomic group compared to the opposite showed that having no postsecondary education was associated with an aOR of 2.9; being temporarily out of job with an aOR of 7, and being in financial strain with an aOR of 8. Using more strict criteria for depression (ICD-10), showed an aOR of 4 when having no education, an aOR of 8 when temporarily out of job, and an aOR of 10 for positive depression when in financial strain.Conclusion: Symptoms of depression are strongly associated to SEP. Estimations of the prevalence of depressive disorders in population studies should take this into account. We estimate a more accurate prevalence of depressive disorders to be at 7.6% in this socioeconomically deprived area of Denmark.","PeriodicalId":19201,"journal":{"name":"Nordic Journal of Psychiatry","volume":" ","pages":"1-7"},"PeriodicalIF":1.5,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Time trends in mortality for people with severe mental illness in Denmark 2000-2018.

IF 1.5 4区医学

Nordic Journal of Psychiatry Pub Date : 2025-01-01 Epub Date: 2024-12-26 DOI: 10.1080/08039488.2024.2444262

Christine Lindstrӧm, Volkert Siersma, Margit Kriegbaum, Tora Grauers Willadsen, Catrine Bakkedal, John Brandt Brodersen, Susanne Reventlow, Anne Møller, Maarten Pieter Rozing

{"title":"Time trends in mortality for people with severe mental illness in Denmark 2000-2018.","authors":"Christine Lindstrӧm, Volkert Siersma, Margit Kriegbaum, Tora Grauers Willadsen, Catrine Bakkedal, John Brandt Brodersen, Susanne Reventlow, Anne Møller, Maarten Pieter Rozing","doi":"10.1080/08039488.2024.2444262","DOIUrl":"10.1080/08039488.2024.2444262","url":null,"abstract":"Purpose: People with a severe mental illness (SMI) have a marked reduction in life expectancy which is largely attributable to somatic morbidity. Life expectancy has increased in Global North populations, yet it remains unclear whether people with SMI have benefitted equally from this increase. Our objective was to explore time trends of all-cause and selected cause-specific mortality among all people in Denmark with registered diagnosis codes of SMI: depression, bipolar disorder, or schizophrenia at psychiatric out- and in-patient settings.Materials and methods: In consecutive yearly cohorts from 2000 to 2018, we examined all-cause and cause-specific mortality in all adults (aged ≥18) with and without diagnosis codes of SMI.Results: We found that all-cause mortality, and mortality from cardiovascular, cancer, respiratory, infections, trauma, and suicide were consistently elevated in those registered with SMI. While the crude all-cause mortality decreased substantially for all, also in people registered with SMI, after adjustment for sex and age, the mortality relative to people without SMI, remained unchanged or slightly increased for people registered with SMI, particularly among people registered with schizophrenia.Conclusion: Despite a decrease in crude all-cause mortality, the consistently elevated mortality for people registered with SMI relative to the general population suggests that concerted efforts to reduce health inequity remain important.","PeriodicalId":19201,"journal":{"name":"Nordic Journal of Psychiatry","volume":" ","pages":"79-85"},"PeriodicalIF":1.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142896475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in sick leave one year before and after starting treatment: a naturalistic study of employed outpatients with common mental health disorders.

IF 1.5 4区医学

Nordic Journal of Psychiatry Pub Date : 2025-01-01 Epub Date: 2024-12-02 DOI: 10.1080/08039488.2024.2434602

Jakob Lundqvist, Martin Schevik Lindberg, Martin Brattmyr, Audun Havnen, Odin Hjemdal, Stian Solem

{"title":"Changes in sick leave one year before and after starting treatment: a naturalistic study of employed outpatients with common mental health disorders.","authors":"Jakob Lundqvist, Martin Schevik Lindberg, Martin Brattmyr, Audun Havnen, Odin Hjemdal, Stian Solem","doi":"10.1080/08039488.2024.2434602","DOIUrl":"10.1080/08039488.2024.2434602","url":null,"abstract":"Background: This study explores sick leave changes 1-year pre- and post-treatment start for common mental health issues and their associations with self-reported symptoms, functioning, and health changes.Methods: Ninety-five employed patients, without previous disability benefits, underwent treatment at a public mental health outpatient clinic. Sick leave data was obtained from the Norwegian Labour and Welfare Administration. Symptoms, work/social functioning, and health quality were self-reported at treatment onset and completion.Results: Twelve months before starting treatment, only 6.3% were on sick leave, contrasting with 69.5% at treatment start. At post-treatment, 25% received work assessment allowance (WAA), 63% were off sick leave, and 12% were on sick leave. Sick leave days exhibited an inverted U-shape for non-WAA recipients. Those on sick leave post-treatment reported less improvement in symptoms and health, while the WAA group showed diminished work functioning enhancement.Discussion: Evaluating the effect mental health treatment has on sick leave is clearly affected by the timing of assessments. Treatment seems associated with improved sick leave outcomes compared with status at treatment start, but less so when compared with status one year before starting treatment. Also, a large group of patients went on to receive WAA, constituting a group in need of further longitudinal evaluations and interventions.","PeriodicalId":19201,"journal":{"name":"Nordic Journal of Psychiatry","volume":" ","pages":"62-69"},"PeriodicalIF":1.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrated mental health care and vocational rehabilitation intervention to improve return to work rates for people on sick leave due to common mental and functional disorders (IBBIS-II) - results from a randomized clinical trial.

IF 1.5 4区医学

Nordic Journal of Psychiatry Pub Date : 2025-01-01 Epub Date: 2025-01-06 DOI: 10.1080/08039488.2024.2446362

Thomas Nordahl Christensen, Carsten Hjorthøj, Chalotte Heinsvig Poulsen, Bea Ebersbach, Lene Falgaard Eplov

{"title":"Integrated mental health care and vocational rehabilitation intervention to improve return to work rates for people on sick leave due to common mental and functional disorders (IBBIS-II) - results from a randomized clinical trial.","authors":"Thomas Nordahl Christensen, Carsten Hjorthøj, Chalotte Heinsvig Poulsen, Bea Ebersbach, Lene Falgaard Eplov","doi":"10.1080/08039488.2024.2446362","DOIUrl":"10.1080/08039488.2024.2446362","url":null,"abstract":"Background: More than 50% of people receiving long-term sickness benefits in Denmark have a common mental illness. At the same time, a significant treatment gap exists where less than 30% receive sufficient care for their mental illness.Methods: The trial was designed as an investigator-initiated, randomized, two-group parallel superiority trial. Nine hundred participants with a common mental illness were randomly assigned into two groups: (1) IBBIS II, consisting of integrated mental health care and vocational rehabilitation, or (2) service as usual (SAU), at two sites in Denmark. The primary outcome was the difference between the two groups in time to return to work (RTW) at 12 months.Results: There was no difference between the integrated IBBIS II intervention and SAU in time from baseline to RTW at the 12-month follow-up (Hazard ratio (HR) = 1.16 (95% CI 0.99-1.37), p = 0.07), but there was a tendency that the IBBIS II group had worse outcomes on several exploratory employment measures, including time to return to work at 6-month follow-up (HR = 1.36 (95% CI 1.03-1.55), p = 0.02), and number of weeks in work at 12-month follow-up (incidence rate ratio = 1.14 (95% CI 1.04-1.27), p = 0.008).Discussion: The integrated employment and health intervention (IBBIS II) was not more effective than SAU in any of the included vocational outcomes and may even have been inferior to SAU on certain outcome measures. Based on these results, it is not recommended that the IBBIS II intervention is widely implemented in countries with service as usual comparable with Denmark.Trial registration: ClinicalTrials.gov. Registered June 16, 2020, NCT04432129. https://clinicaltrials.gov/ct2/show/NCT04432129?term = IBBIS+II.","PeriodicalId":19201,"journal":{"name":"Nordic Journal of Psychiatry","volume":" ","pages":"86-95"},"PeriodicalIF":1.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142932595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The significance of DNA methylation of the NR3C1 gene encoding the glucocorticoid receptor for developing resilience in individuals exposed to early life stress.

IF 1.5 4区医学

Nordic Journal of Psychiatry Pub Date : 2025-01-01 Epub Date: 2025-01-07 DOI: 10.1080/08039488.2024.2436987

Ditte Mathilde Klith Forum, Camilla Bjerregaard, Per Hove Thomsen

{"title":"The significance of DNA methylation of the NR3C1 gene encoding the glucocorticoid receptor for developing resilience in individuals exposed to early life stress.","authors":"Ditte Mathilde Klith Forum, Camilla Bjerregaard, Per Hove Thomsen","doi":"10.1080/08039488.2024.2436987","DOIUrl":"10.1080/08039488.2024.2436987","url":null,"abstract":"Purpose: To analyze and interpret why some individuals are resilient to ELS while others are susceptible, resulting in psychiatric outcome later in life, with a focus on the role of DNAm of the NR3C1 gene as a mediating mechanism between ELS and the risk of psychiatric outcomes. We hypothesized that a high level of mental resilience to ELS, expressed as lower incidence of psychiatric outcomes, was associated with attenuated NR3C1 DNAm levels.Materials and methods: The first authors conducted a systematic search on PubMed to identify primary research studies. Abstract were screened and full-text were reviewed to assess the eligibility for inclusion. Consensus on assessment was reached after discussion of eligibility criteria. Studies were sorted based on whether they investigated the association between ELS and NR3C1 DNAm in 1) individuals exposed compared to unexposed to ELS both without a psychiatric outcome or in 2) individuals exposed to ELS with a psychiatric outcome compared to exposed individuals without a psychiatric outcome.Results and conclusion: Seven studies met the eligibility criteria. The results were inconsistent; two studies supported our hypothesis, two studies indicated that increased NR3C1 DNAm mediated resilience to ELS, and three studies found no association.","PeriodicalId":19201,"journal":{"name":"Nordic Journal of Psychiatry","volume":" ","pages":"1-14"},"PeriodicalIF":1.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142952358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term psychopathology rates of children and adolescents and associated factors in the worst-sticken area of 2023 Kahramanmaras earthquake. 2023 年卡赫拉曼马拉什地震重灾区儿童和青少年的长期心理病态率及相关因素。

IF 1.5 4区医学

Nordic Journal of Psychiatry Pub Date : 2025-01-01 Epub Date: 2024-11-18 DOI: 10.1080/08039488.2024.2430245

Mehtap Eroglu, Nese Yaksı

{"title":"Long-term psychopathology rates of children and adolescents and associated factors in the worst-sticken area of 2023 Kahramanmaras earthquake.","authors":"Mehtap Eroglu, Nese Yaksı","doi":"10.1080/08039488.2024.2430245","DOIUrl":"10.1080/08039488.2024.2430245","url":null,"abstract":"Introduction: Earthquakes are natural disasters that can have significant psychological impacts on individuals, particularly children. While physical injuries are often the immediate focus following an earthquake, the psychological effects can be long-lasting and profound. Understanding the psychiatric effects of traumatic experiences in children following earthquakes is crucial for developing effective interventions and support systems.Method: One hundred fifty three children and adolescents who experienced the earthquake were evaluated in the first year of the earthquake. Depression, anxiety, and post-traumatic stress disorder (PTSD) symptoms were measured using standardized assessment tools. Factors that may be related to psychopathology, such as sleep disturbance, the extent of trauma, and where one lived after the earthquake, were also evaluated. The anxiety, depression and stress levels of the mother and father separately and their relationship with the child's psychopathology were evaluated.Results: The frequency of depression risk among participants was found to be 24.8%, while the frequency of anxiety risk was 62.8%. The frequency of PTSD risk was 97.4%. Children who migrated to another province after the earthquake had higher scale scores. Parental depression anxiety stress level was positively correlated with children's scale scores. Disruption in sleep patterns increased the risk of depression by 2.38 times. Experiencing the loss of friends in the earthquake increased PTSD score by 6.27.Discussion: The findings of this study highlight the importance of addressing the psychiatric needs of children following earthquakes. Psychosocial support and access to appropriate treatment should be prioritized to mitigate the long-term psychological effects of traumatic experiences in children.","PeriodicalId":19201,"journal":{"name":"Nordic Journal of Psychiatry","volume":" ","pages":"26-33"},"PeriodicalIF":1.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Persistent pro-inflammatory trait in elderly patients following treatment-resistant major depressive disorder: a longitudinal exploratory study.

IF 1.5 4区医学

Nordic Journal of Psychiatry Pub Date : 2025-01-01 Epub Date: 2024-12-03 DOI: 10.1080/08039488.2024.2432981

Torfinn Lødøen Gaarden, Knut Engedal, Jūratė Šaltytė Benth, Marianne Larsen, Bernhard Lorentzen, Tom Eirik Mollnes, Tor Magne Bjølseth, Albert Gyllencreutz Castellheim

{"title":"Persistent pro-inflammatory trait in elderly patients following treatment-resistant major depressive disorder: a longitudinal exploratory study.","authors":"Torfinn Lødøen Gaarden, Knut Engedal, Jūratė Šaltytė Benth, Marianne Larsen, Bernhard Lorentzen, Tom Eirik Mollnes, Tor Magne Bjølseth, Albert Gyllencreutz Castellheim","doi":"10.1080/08039488.2024.2432981","DOIUrl":"10.1080/08039488.2024.2432981","url":null,"abstract":"Objectives: Considering that the remission rate for major depressive disorder (MDD) in elderly patients is below 50%, there is a compelling requirement for an enhanced comprehension of the underlying mechanisms. Chronic low-grade inflammation has been posited as one potential contributor to treatment-resistant MDD in the elderly. Accordingly, the objective of our study was to explore the longitudinal trends of systemic immune markers in elderly inpatients referred to electroconvulsive therapy due to an episode of treatment resistant unipolar MDD.Methods: The study encompassed 64 elderly inpatients with unipolar MDD that had failed to respond to therapy in primary health care, and 18 non-depressed controls. Blood samples were collected at pre-treatment, mid-treatment, post-treatment and 12 weeks follow-up. We assessed 27 immune markers via multiplex assays. Depressive symptoms were evaluated using the Hamilton Rating Scale of Depression at these timepoints. For controls, the immune markers and depressive symptoms, were measured at baseline and eight weeks follow-up using identical methods.Results: At follow-up, patients showed higher concentrations of 23 immune markers compared to controls, although the concentration of 19 immune markers decreased significantly from pre-treatment to follow-up. No differences in immune marker concentrations between treatment responders and non-responders were observed pre- and post-treatment in the patient group.Conclusion: Our findings suggest that a pro-inflammatory trait persists in elderly after an episode of treatment resistant unipolar MDD. Thus, our study supports that chronic low-grade inflammation may characterise elderly with treatment-resistant unipolar MDD.","PeriodicalId":19201,"journal":{"name":"Nordic Journal of Psychiatry","volume":" ","pages":"42-51"},"PeriodicalIF":1.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gender-stratified national mental health norms of BSI-53, BSI-18, SCL-10, ADHD-9, and ADHD-6 for Denmark.

IF 1.5 4区医学

Nordic Journal of Psychiatry Pub Date : 2025-01-01 Epub Date: 2024-12-27 DOI: 10.1080/08039488.2024.2435515

Kristian H Reveles Jensen

{"title":"Gender-stratified national mental health norms of BSI-53, BSI-18, SCL-10, ADHD-9, and ADHD-6 for Denmark.","authors":"Kristian H Reveles Jensen","doi":"10.1080/08039488.2024.2435515","DOIUrl":"10.1080/08039488.2024.2435515","url":null,"abstract":"Background: Reliable gender-sensitive normative data is needed to facilitate mental health research and clinical utility of commonly used symptoms scales. This study establishes Danish gender-stratified norms for the 53-item and 18-item Brief Symptom Inventory (BSI-53, BSI-18), proposed attention deficit hyperactivity disorder (ADHD) symptomatology scales from the BSI-53, and the 10-item Symptom Checklist (SCL-10). This study also examines gender-differences in symptom reporting of the ADHD and SCL-10 scales, and assesses potential bias in recent SCL-10 norms.Methods: Norms for the BSI-53, BSI-18, two ADHD scales and SCL-10 were established using archived Hopkins Symptom Checklist 90-R (SCL-90R) normative data collected in spring 2000 (n = 1079, age 18-80, 53% female). SCL-10 norms from 2000 were compared with proposed norms collected in spring 2020 (n = 2819, age 18-80, 55% female) during the first COVID-19 lockdown in Denmark, and with first-episode depression patients from 2020 to 2023 (n = 221, age 18-65, 73% female).Results: The scales showed high internal consistencies (McDonald's ω > 0.81), except for 4-5 item scales (ω > 0.73). Women scored higher on both ADHD scales (Cohen's d = 0.15 and 0.19, p ≤ 0.019). Women scored higher on the SCL-10 in the 2000 population sample (d = 0.22, p < 0.0001) and in patients (d = 0.44, p = 0.004). The average population SCL-10 score in 2000 was lower than 2020 (d = 0.52, p < 0.001).Conclusion: This study provides gender-stratified Danish mental health norms for multiple symptom scales. The considerable gender differences in the SCL-10 underscore the importance of gender-specific norms. The 2020 SCL-10 norms are biased by COVID-19 distress. Until new normative data is available, the gender-specific norms provided here are recommended.","PeriodicalId":19201,"journal":{"name":"Nordic Journal of Psychiatry","volume":" ","pages":"96-102"},"PeriodicalIF":1.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142896474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0