Neuroscience Research Communications最新文献_第9页

Neural correlates of visual perceptual learning in humans indexed by event‐related potentials 由事件相关电位索引的人类视觉知觉学习的神经关联

Neuroscience Research Communications Pub Date : 2003-01-01 DOI: 10.1002/NRC.10053

Yulong Ding, Yan Song, S. Fan, Lin Chen

引用次数: 3

Homeobox gene repertoire in adult rat dorsal root ganglia 成年大鼠背根神经节同源盒基因库

Neuroscience Research Communications Pub Date : 2003-01-01 DOI: 10.1002/NRC.10058

C. Vogelaar, S. Smits, J. Brakkee, W. Gispen, M. Smidt, L. Schrama, M. Hoekman, J. Burbach

引用次数: 2

Efffects of vigabatrin on spontaneous locomotor activity of rats 维加巴特林对大鼠自发性运动活动的影响

Neuroscience Research Communications Pub Date : 2003-01-01 DOI: 10.1002/NRC.10060

B. M. Bouwman, C. Rijn, E. W. Bree, A. Coenen

引用次数: 2

Intact spatial discrimination performance but impaired reaction time performance after frontal cortex lesions in the rat 额叶皮质损伤后大鼠空间辨别能力完好，但反应时间表现受损

Neuroscience Research Communications Pub Date : 2003-01-01 DOI: 10.1002/NRC.10076

A. Blokland, L. Broersen, H. Uylings, J. Jolles

引用次数: 9

Levation of serum macrophage colony stimulating factor level in patients with Alzheimer's disease 阿尔茨海默病患者血清巨噬细胞集落刺激因子水平的升高

Neuroscience Research Communications Pub Date : 2003-01-01 DOI: 10.1002/NRC.10059

Jianmin Zhang, Qingli Kong, Zhenxin Zhang, Pingjiang Ge, D. Ba, Wei He

引用次数: 0

Dose-dependence of the effect of nicotine on c-Fos expression in the hippocampus of young rats 尼古丁对幼龄大鼠海马c-Fos表达影响的剂量依赖性

Neuroscience Research Communications Pub Date : 2003-01-01 DOI: 10.1002/NRC.10054

M. Jang, M. Shin, Hong Kim, Hong Kim, Ee-Hwa Kim, Chang-Ju Kim

{"title":"Dose-dependence of the effect of nicotine on c-Fos expression in the hippocampus of young rats","authors":"M. Jang, M. Shin, Hong Kim, Hong Kim, Ee-Hwa Kim, Chang-Ju Kim","doi":"10.1002/NRC.10054","DOIUrl":"https://doi.org/10.1002/NRC.10054","url":null,"abstract":"It is generally accepted that nicotine affect learning ability and memory functions, especially during adolescence. c-Fos is an immediate early gene whose expression is sometimes used as a marker for stimulation-induced changes in the metabolic activity of neurons. The expression of c-Fos is induced by a variety of stimuli and expression of c-fos mRNA in hippocampal regions is used as a marker for neuronal activity. In the present study, the effect of dose-dependence of the nicotine on the c-Fos expression in the hippocampus of young rats was investigated via immunohistochemistry. From the present results, the number of Fos-positive cells in each region of the hippocampus was decreased following treatment with nicotine as dose-dependently. In addition, it appears that nicotine at low doses does not affect the level of apoptosis in the dentate gyrus of the hippocampus; in contrast, nicotine at high doses seems to enhance apoptosis in the dentate gyrus. Based on the results, it can be suggested that nicotine-induced suppression on Fos expression in the hippocampus of young rats may be an underlying mechanism of nicotine-induced disruption of information processing during the adolescence.","PeriodicalId":19198,"journal":{"name":"Neuroscience Research Communications","volume":"1 1","pages":"11-19"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83266698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Numerical density of pyramidal neurons in the hippocampus of 4 and 20 week old male and female rats 4、20周龄雌雄大鼠海马锥体神经元的数值密度

Neuroscience Research Communications Pub Date : 2003-01-01 DOI: 10.1002/NRC.10057

S. Kaplan, M. Rağbetli, S. Canan, B. Sahin, C. Marangoz

{"title":"Numerical density of pyramidal neurons in the hippocampus of 4 and 20 week old male and female rats","authors":"S. Kaplan, M. Rağbetli, S. Canan, B. Sahin, C. Marangoz","doi":"10.1002/NRC.10057","DOIUrl":"https://doi.org/10.1002/NRC.10057","url":null,"abstract":"A study designed to investigate how the cellular laterality in rosto-caudal direction changes due to age and sex was presented. It is a well-known fact that asymmetry is an important issue in understanding brain functions. Frontal sections of 5 µm thickness with 200 µm intervals were taken from both dorsal hippocampi of 4- and 20-week-old male and female rats. Sections were stained with hematoxylin-eosin and the levels of sections were determined according to a stereotaxic atlas. In each level, numerical density of pyramidal cells of the right and left area CA1, CA3 and CA4 of dorsal hippocampi were estimated by means of counting pyramidal cells under 10 × 40 magnification. Numerical cell density obtained from the right and left dorsal hippocampi of male and female rats were compared. Results are as follows: 1) Numerical cell density in the left and right dorsal hippocampi of 20-week female rats was not high than 4-week female dorsal hippocampi (p>0.05). 2) Difference between 4-week old female and male dorsal hippocampi of right and left CA1, CA3 and CA4 areas were not raised a significant level (p>0.05). Differences between 20-week-old group of male and female rats with the exception of female CA4 area were not also significant. 3) Right and left dorsal hippocampi CA4 areas of the 20-week-old group showed a higher numerical density than the same area of the 4-week-old group (p<0.007). This difference may show a postnatal neurogenesis in area CA4. The results, which are summarized above, may be helpful in understanding the mechanisms of human brains.","PeriodicalId":19198,"journal":{"name":"Neuroscience Research Communications","volume":"275 1","pages":"37-48"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73289495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Florid prion protein (PrP) plaques in patients with variant Creutzfeldt-Jakob disease (vCJD) are spatially related to blood vessels 变异克雅氏病(vCJD)患者的荧光朊蛋白(PrP)斑块与血管有空间关系

Neuroscience Research Communications Pub Date : 2003-01-01 DOI: 10.1002/NRC.10056

R. Armstrong, N. Cairns, J. Ironside, P. Lantos

引用次数: 4

Comparison between 2‐day and 10‐day MPTP treatment modalities in the mouse model of Parkinson's disease 帕金森病小鼠模型2天和10天MPTP治疗方式的比较

Neuroscience Research Communications Pub Date : 2003-01-01 DOI: 10.1002/NRC.10055

Ki-Sok Kim, C. Kim, Youngbuhm Huh, B. Ahn, B. Han, K. Choi

{"title":"Comparison between 2‐day and 10‐day MPTP treatment modalities in the mouse model of Parkinson's disease","authors":"Ki-Sok Kim, C. Kim, Youngbuhm Huh, B. Ahn, B. Han, K. Choi","doi":"10.1002/NRC.10055","DOIUrl":"https://doi.org/10.1002/NRC.10055","url":null,"abstract":"We employed a novel regimen of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment to produce a Parkinson's disease (PD) animal model demonstrating typical Parkinsonian symptoms. In order to compare the effects of the different durations of MPTP treatment (daily intraperitoneal injections of 30 mg/kg MPTP for 2 or 10 days), the numbers and distribution patterns of tyrosine hydroxylase-immunoreactive (TH-ir) neurons and fibers were examined in the substantia nigral and stiatal brain regions of C57/B16 mice. The mean numbers of TH-ir neurons in the substantia nigra were significantly lower (57.3% and 48.1%) than the numbers in the saline-treated controls after 2 and 10 days of MPTP treatment, respectively. Furthermore, the optical density of the TH-ir fibers in the striatum was reduced by 9.8% and 14.1% after 2- and 10-day treatments, respectively. However, the reduction in numbers of TH-ir neurons in the substantia nigra and striatum was not significantly different between the 2-day and 10-day treatment groups. Yet, it seems that only the 10-day treatment regimen exceeded the threshold of motor deficits. Thus, chronic MPTP treatment appears to be required to mirror the pathophysiological characteristics of Parkinsonism.","PeriodicalId":19198,"journal":{"name":"Neuroscience Research Communications","volume":"25 1","pages":"21-28"},"PeriodicalIF":0.0,"publicationDate":"2003-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87150113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Effects of acute amitriptyline administration on memory, anxiety and activity in male and female mice 急性阿米替林给药对雌雄小鼠记忆、焦虑和活动的影响

Neuroscience Research Communications Pub Date : 2002-11-01 DOI: 10.1002/NRC.10046

A. Parra, E. Everss, S. Monleón, C. Vinader-Caerols, M. Arenas

引用次数: 20