Neurosurgical Review最新文献

{"title":"Helsinki computed tomography score in predicting short- and long-term outcomes after primary decompressive craniectomy for traumatic brain injury.","authors":"Yu-Hua Huang, Tsung-Han Lee","doi":"10.1007/s10143-025-03410-7","DOIUrl":"https://doi.org/10.1007/s10143-025-03410-7","url":null,"abstract":"<p><p>Primary decompressive craniectomy (DC) is performed alongside the removal of mass lesions from traumatic brain injury (TBI). The Helsinki computed tomography (CT) score predicts post-TBI outcomes and is partly based on the size of the mass lesion. It remains unclear if this scoring system can be applied to this subgroup and exhibit discriminative ability. This study sought to validate the prognostic value of the Helsinki CT score in TBI patients undergoing primary DC. In this retrospective analysis, we evaluated 187 patients who underwent primary DC for TBI. Short-term outcomes, identified at discharge, included all participants (N = 187), while long-term outcomes were ascertained either through a minimum 12-month follow-up or up to the patient's death (N = 162). The Glasgow Outcome Scale (GOS) score of 1-3 denoted unfavorable outcomes. Higher Helsinki CT scores corresponded with an increase in unfavorable outcomes. The Helsinki CT score's predictive capability for these outcomes was evident in both the short term (OR: 1.36, 95% CI: 1.08-1.71, p = 0.009) and long term (OR: 1.30, 95% CI: 1.01-1.67, p = 0.041). The area under the Receiver Operating Characteristic curves was 0.743 (p < 0.001) for the short term and 0.686 (p < 0.001) for the long term. In conclusions, the Helsinki CT score holds considerable prognostic value following primary DC for TBI. Our findings suggest that the size of the mass lesion is not the predominant factor in prognostic judgments after primary DC, nor does it reduce the Helsinki score's utility.</p>","PeriodicalId":19184,"journal":{"name":"Neurosurgical Review","volume":"48 1","pages":"258"},"PeriodicalIF":2.5,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Outcomes for standalone anterolateral corpectomy for thoracolumbar burst fractures.","authors":"Michael J Ortiz Torres, Kaushik Ravipati, Caitlyn J Smith, Kiersten Norby, Jamir Pleitez, Walter Galicich, Thomas Bergman, Christopher Roark, Farhan Siddiq","doi":"10.1007/s10143-025-03417-0","DOIUrl":"https://doi.org/10.1007/s10143-025-03417-0","url":null,"abstract":"","PeriodicalId":19184,"journal":{"name":"Neurosurgical Review","volume":"48 1","pages":"259"},"PeriodicalIF":2.5,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence in neurovascular decision-making: a comparative analysis of ChatGPT-4 and multidisciplinary expert recommendations for unruptured intracranial aneurysms.","authors":"Alexis Hadjiathanasiou, Leonie Goelz, Florian Muhn, Rebecca Heinz, Lutz Kreißl, Paul Sparenberg, Johannes Lemcke, Ingo Schmehl, Sven Mutze, Patrick Schuss","doi":"10.1007/s10143-025-03341-3","DOIUrl":"https://doi.org/10.1007/s10143-025-03341-3","url":null,"abstract":"<p><p>In the multidisciplinary treatment of cerebrovascular diseases, specialists from different disciplines strive to develop patient-specific treatment recommendations. ChatGPT is a natural language processing chatbot with increasing applicability in medical practice. This study evaluates ChatGPT's ability to provide treatment recommendations for patients with unruptured intracranial aneurysms (UIA). Anonymized patient data and radiological reports of 20 patients with UIAs were provided to GPT-4 in a standardized format and used to generate a treatment recommendation for different clinical scenarios. GPT-4 responses were evaluated by a multidisciplinary panel of specialists by means of the Likert scale and subsequently benchmarked against the Unruptured Intracranial Aneurysm Treatment Score (UIATS) as well as the actual treatment decision made by the multidisciplinary institutional neurovascular board (INVB). Agreement between expert raters was measured using linear weighted Fleiss-Kappa coefficient. GPT-4 analyzed individual pathological features of the radiological reports and formulated a corresponding assessment for each aspect. None of the recommendations generated reflected evidence of factual hallucination, although in 25% of the case studies no specific recommendation could be derived from the GPT-4 responses. The expert panel rated the overall quality of the GPT-4 recommendations with a median of 3.4 out of 5 points. The GPT-4 recommendations were congruent with those of the INBI in 65% of cases. Interrater reliability among experts showed moderate to low agreement in the assessment of AI-assisted decision making. GPT-4 appears to be able to process clinical information about UIAs and generate treatment recommendations. However, the level of ambiguity and the utilization of scientific evidence in the recommendations are not yet patient/case specific enough to substitute the decision-making of a multidisciplinary neurovascular board. A prospective evaluation of GPT-4 competence as a companion in decision-making panels is deemed necessary.</p>","PeriodicalId":19184,"journal":{"name":"Neurosurgical Review","volume":"48 1","pages":"261"},"PeriodicalIF":2.5,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping neuroendoscopy practices: an assessment of endoscopic practices and training needs across Latin American and African countries.","authors":"Guilherme Mansur, Leopoldo Mandic Ferreira Furtado, Jose Aloysio da Costa Val Filho, Rodrigo Moreira Faleiro, Jose Mauricio Siqueira, Jair Raso, Roberto Alexandre Dezena, Samuel Tau Zymberg, Artur Cunha, Luis Alencar Borba, Mikail Sallé, Daniel M Prevedello, Diego Armando Servian Duarte, Ellianne J Dos Santos Rubio, Adilson de Oliveira, Álvaro Córdoba, Adrian Caceres Chacon, Lucas Ramos Lima","doi":"10.1007/s10143-025-03421-4","DOIUrl":"https://doi.org/10.1007/s10143-025-03421-4","url":null,"abstract":"<p><p>Neurosurgical capabilities vary significantly across Latin American and African countries, with advanced centers having state-of-the-art technology while others struggle with basic procedures. This study aims to assess the current state of endoscopic neurosurgery in Latin American and Portuguese or Spanish-speaking African countries (LAPSSAC), focusing on infrastructure and training needs. A 50-question survey was distributed to neurosurgeons across 19 Latin American countries and six Portuguese- or Spanish-speaking African countries between May 19th and June 20th, 2023. The survey covered institutional types, residency programs, availability of endoscopic equipment, types of procedures performed, and interest in additional training. Data from 202 responses representing 216 hospitals were analyzed using descriptive statistics. Most respondents worked in public institutions (69.42%), with 58.42% having residency programs. Essential equipment for endoscopic procedures was available in 83.17% of hospitals, while 71.29% had the necessary tools for ventricular and 61.39% for skull base endoscopy. Ventricular endoscopy was performed in 89.11% of hospitals, compared to 71.78% for skull base procedures. Significant gaps in equipment and training were identified, especially in African countries. Interest in additional training was high, with 83.33% and 92.41% of respondents expressing a need for training in ventricular and skull base endoscopy, respectively. The findings highlight disparities in neurosurgical capabilities, with many centers lacking essential resources for endoscopic procedures. While most hospitals have some basic tools, there remains a need for investment in education and equipment. The study suggests that enhancing international collaborations and targeted investments could address these gaps and improve neurosurgical care in low-resource settings. Significant disparities in neuroendoscopic training and equipment exist across LAPSSAC. Addressing these disparities through strategic investments and international partnerships is essential to improving neurosurgical outcomes in these regions.</p>","PeriodicalId":19184,"journal":{"name":"Neurosurgical Review","volume":"48 1","pages":"260"},"PeriodicalIF":2.5,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of accuracy of pedicle screw placement for adolescent idiopathic scoliosis using freehand fluoroscopic, navigation, and robotic-assisted techniques - a systematic review and bayesian network meta-analysis.","authors":"Paweł Łajczak, Ayesha Ayesha, Rabbia Jabbar, Yasmin Picanço Silva, Eshita Sharma, Oguz Kagan Sahin, Kaike Eduardo da Silva Lobo, Iago Nathan Simon Petry, Aisha Rizwan Ahmed, Fabio Victor Vieira Rocha, Walter Fagundes, Yan G M D Silva","doi":"10.1007/s10143-025-03333-3","DOIUrl":"https://doi.org/10.1007/s10143-025-03333-3","url":null,"abstract":"<p><p>Adolescent idiopathic scoliosis (AIS) is a prevalent spinal deformity, often requiring surgical intervention. Posterior pedicle spine instrumentation, a common procedure for correcting AIS, can be performed using freehand fluoroscopic (FHF), navigation-assisted (NVA), or robotic-assisted (RBA) techniques for pedicle screw insertion. This study aimed to evaluate the accuracy and clinical outcomes of these techniques through a Bayesian network meta-analysis (BNMA) of 764 patients and 8,144 screws from twelve studies. Our findings suggest that RBA offers superior accuracy in pedicle screw placement compared to both FHF and NVA. However, RBA is associated with longer operative times. NVA, in contrast, provides a balanced approach by offering good accuracy with relatively shorter surgery times. No significant differences were observed in blood loss, Cobb angle correction, or hospital stay between the techniques. Additionally, no statistically significant differences were found between RBA and NVA in terms of operative duration or blood loss. These results have important clinical implications, indicating that RBA may be the preferred option for achieving high precision, particularly in complex cases, while NVA remains a viable alternative for quicker procedures. Further research is needed to assess the long-term outcomes, radiation exposure, and cost-effectiveness of these techniques in clinical practice.</p>","PeriodicalId":19184,"journal":{"name":"Neurosurgical Review","volume":"48 1","pages":"257"},"PeriodicalIF":2.5,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sarcopenia as a predictor of poor functional outcome of cervical spine surgery: a systematic review and meta-analysis.","authors":"Anish Tayal, Satyam Wahi, Aiman Perween Afsar, Bhavya Pahwa, Kanwaljeet Garg","doi":"10.1007/s10143-025-03398-0","DOIUrl":"https://doi.org/10.1007/s10143-025-03398-0","url":null,"abstract":"<p><p>Sarcopenia is a progressive loss of muscle mass. This study aims to determine the association of pre-operative sarcopenia with the outcome of cervical spine surgery. Pubmed, Ovid, Embase, and Web of Sciences databases were searched until September 2023 to include articles regarding the prognostic role of preoperative sarcopenia in cervical spine surgery patients. The Quality In Prognosis Studies (QUIPS) tool was used to assess the risk of bias. Meta-analyses Of Observational Studies in Epidemiology (MOOSE) and Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines were followed. The vote-counting model was used for the qualitative appraisal of the studies. Statistical analysis was performed with a significant p < 0.05 using SPSS software (version 23). Of the 1,134 articles revealed from the search, 15 studies with 1463 patients were included. A significant difference between patients with and without sarcopenia was not found for the occurrence of loss of lordosis (OR = 1.28, 95%CI = 0.21 to 7.62, p = 0.6137), and deterioration of the Neck disability index postoperatively (OR = 1.53, 95%CI = 0.0 to 632.04, p = 0.7914). In the vote-counting model, there was strong evidence that sarcopenia worsens postoperative patient-reported outcomes and spine stability, while evidence was conflicting on whether sarcopenia can affect the occurrence of surgical complications. Sarcopenia may predispose cervical spine surgery patients to a worse surgical outcome as compared to non-sarcopenic patients, and it can be used to prognosticate the patients.</p>","PeriodicalId":19184,"journal":{"name":"Neurosurgical Review","volume":"48 1","pages":"256"},"PeriodicalIF":2.5,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determining the optimal hematoma volume-based thresholds for surgical and medical strategies in basal ganglia hemorrhage.","authors":"Chonnawee Chaisawasthomrong, Atthaporn Boongird","doi":"10.1007/s10143-025-03403-6","DOIUrl":"10.1007/s10143-025-03403-6","url":null,"abstract":"<p><p>Hematoma volume is a significant concern in basal ganglia hemorrhage, with no clear cutoff to guide the choice between conservative and surgical management, particularly for larger hematomas where the optimal approach remains controversial. This study aimed to determine the maximum hematoma volume suitable for conservative treatment and the volume that necessitates surgical intervention in patients with basal ganglia hemorrhage. A total of 387 cases of basal ganglia hemorrhage from 2019 to 2021 were analyzed, evaluating patient demographics, medical history, and initial CT brain scans to assess hematoma volume. Outcomes of medical and surgical treatments were compared using multivariate logistic and Cox regression analysis. For patients treated with medical management alone, mortality rates did not differ significantly between hematoma volumes of 10-39.9 mL and those under 10 mL. Receiver operating characteristic (ROC) curve analysis identified a cutoff volume of 45.3 mL, with a sensitivity of 80.82% and specificity of 91.67% for predicting survival. Kaplan-Meier survival analysis revealed a reduced mortality hazard ratio (0.17) with surgical intervention for hematomas exceeding 45.3 mL. However, surgical treatment for volumes under 30 mL was associated with higher mortality compared to medical management. Surgical intervention showed a clear survival benefit for hematoma volumes of at least 60 mL, while conservative treatment remained appropriate for volumes up to 45.3 mL. For volumes between 45.3 mL and 59.9 mL, the decision to operate should be guided by the surgeon's judgment and patient-specific factors such as comorbidities, brain atrophy. In conclusion, conservative management is effective for hematomas up to 45.3 mL, while surgical intervention is absolutely indicated for volumes of 60 mL or more. These findings provide valuable guidance for optimizing treatment strategies in basal ganglia hemorrhage.</p>","PeriodicalId":19184,"journal":{"name":"Neurosurgical Review","volume":"48 1","pages":"255"},"PeriodicalIF":2.5,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11839887/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MR‑guided laser interstitial thermal therapy followed by early application of temozolomide for recurrent IDH-wildtype glioblastomas: preliminary results from a prospective study.","authors":"Xuzhe Zhao, Chao Li, Kai Wang, Yutao Zhang, Haibin Wan, Pei Yang, Dabiao Zhou","doi":"10.1007/s10143-025-03402-7","DOIUrl":"https://doi.org/10.1007/s10143-025-03402-7","url":null,"abstract":"<p><p>This study aims to evaluate the safety, tolerability, and preliminary efficacy of combining laser interstitial thermal therapy (LITT) with early administration of temozolomide (TMZ) in patients with recurrent glioblastoma (rGBM). Ten patients with rGBM were enrolled. Following the LITT procedure, TMZ was administered at a dose of 75 mg/m²/day during the early-TMZ phase for three weeks. After a 7-day interval, TMZ was given according to the standard dosage scheme for 6 cycles. Adverse events and complications encountered were documented. Regular follow-up assessments were conducted to evaluate both patient performance status and tumor progression. All patients demonstrated good tolerance to LITT, with six out of ten achieving an ablation rate above 90%, and only one patient had an ablation rate below 70%. Oral administration of TMZ was well-tolerated by all patients during the early-TMZ phase. Mild headache was the most common adverse event (3/10), and only one severe adverse event occurred. At a 6-month follow-up post-LITT, tumor progression was observed in five patients; noneof the patients reached survival endpoints. This preliminary report substantiates the favorable tolerability of early application of TMZ in combination with LITT. The safety profile was found to be acceptable, and the initial efficacy results were promising. Future studies should explore the potential of LITT combination therapy in greater detail and with larger patient samples.</p>","PeriodicalId":19184,"journal":{"name":"Neurosurgical Review","volume":"48 1","pages":"254"},"PeriodicalIF":2.5,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of surgical approaches to the hippocampal formation with artificial intelligence.","authors":"Tolga Turan Dundar, Meltem Kurt Pehlivanoğlu, Ayşe Gül Eker, Nur Banu Albayrak, Ahmet Serdar Mutluer, İsmail Yurtsever, İhsan Doğan, Nevcihan Duru, Uğur Türe","doi":"10.1007/s10143-025-03345-z","DOIUrl":"10.1007/s10143-025-03345-z","url":null,"abstract":"<p><p>The relatively complex functional anatomy of the mediobasal temporal region makes surgical approaches to this area challenging. Several studies describe various surgical approaches, along with their combinations and modifications, to reach lesions of this region. Some of these surgical approaches have been compared using artificial intelligence-based approaches that can be predicted, classified, and analyzed for complex data. Several surgical approaches, such as anterior transsylvian, trans-superior temporal sulcus, trans-middle temporal gyrus, subtemporal-transparahippocampal, presigmoid-retrolabyrinthine, supratentorial-infraoccipital, and paramedian supracerebellar-transtentorial, were selected for comparison. Magnetic resonance images (MRIs) were taken according to the criteria specified by the Radiology Department. With an open-source software tool, volumetric data from cranial MRIs were segmented and anatomical structures in the main regions were reconstructed. The Q-learning algorithm was used to find pathways similar to these standard surgical pathways. The Q-learning scores among the selected pathways are as follows: anterior transsylvian (Q_A) = 31.01, trans-superior temporal sulcus (Q_B) = 25.00, trans-middle temporal gyrus (Q_C) = 28.92, subtemporal-transparahippocampal (Q_D) = 23.51, presigmoid- retrolabyrinthine (Q_E) = 27.54, supratentorial-infraoccipital (Q_F) = 27.2, and paramedian supracerebellar-transtentorial (Q _G) = 21.04. The Q-value score for the supracerebellar transtentorial approach was the highest among the examined approaches and therefore optimal. A difference was also found between the total risk score of all points with pathways drawn by clinicians and the total risk scores of the pathways formed and followed by Q-learning. Artificial intelligence-based approaches may significantly contribute to the success of the surgical approaches examined. Furthermore, artificial intelligence can contribute to clinical outcomes in both preoperative surgical planning and intraoperative technical equipment-assisted neurosurgery. However, further studies with more detailed data are needed for more sensitive results.</p>","PeriodicalId":19184,"journal":{"name":"Neurosurgical Review","volume":"48 1","pages":"251"},"PeriodicalIF":2.5,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11839795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oedema as a prognostic factor for seizures in meningioma - a systematic review and meta-analysis.","authors":"Matthew J Tanti, Sarah Nevitt, Molly Yeo, William Bolton, Paul Chumas, Ryan Mathew, Melissa J Maguire","doi":"10.1007/s10143-025-03416-1","DOIUrl":"10.1007/s10143-025-03416-1","url":null,"abstract":"<p><p>Meningiomas are benign intracranial tumours that commonly lead to seizures and oedema. An understanding of seizure risk factors is essential for the meningioma community. Many studies have differing conclusions on whether oedema is associated with seizure. Existing meta-analyses are limited by lack of focus on oedema. Our objective was to summarise all literature on oedema as a prognostic factor for seizures in meningioma patients. We searched OVID, Scopus, Pubmed, Web of Science, ClinicalTrials.gov and Google scholar up to April 2024 for reports with more than 10 human meningioma participants. Statistics were performed on R-Studio. Cochrane and Campbell guides for systematic reviews and meta-analysis were followed. Risk of bias was assessed with ROBINS-E. Our protocol was uploaded to INPLASY. We included 51 studies for meta-analysis and 21 for narrative review. Most studies were of surgically treated adults. Heterogeneity was low once outliers were removed. Preoperative oedema was associated with preoperative seizure (k = 28, n = 7,725, OR 3.5, 95% CI = 3.1-4.0, I2 = 0%, p < .001), early postoperative seizure (k = 9, n = 2,929, OR 1.5, CI = 1.1-1.9, I2 = 0%, p = .011) and late postoperative seizure (k = 9, n = 2,150, OR 1.9, CI = 1.5-2.2, I2 = 0%, p < .001). We performed an additional adjusted analysis for preoperative seizures which was also significant (k = 3, n = 2,241, OR 3.9, CI = 2.4-6.3, I2 = 0%, p = .007). There were few studies of post-radiosurgery oedema and seizure, and of postoperative oedema and seizure, with insignificant but positive associations. Preoperative oedema is a key factor for preoperative seizures. Oedema also increases risk of postoperative seizures. Further study in conservative, radiosurgery and paediatric populations, as well as study of oedema and seizure severity or subtype is warranted.</p>","PeriodicalId":19184,"journal":{"name":"Neurosurgical Review","volume":"48 1","pages":"249"},"PeriodicalIF":2.5,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11839703/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}