Neuromodulation最新文献

{"title":"ID# 2179405 DYNAMIC STIMULATION WAVEFORMS IN SPINAL CORD STIMULATION ENHANCE BENEFITS OF VARIABLE ACTIVATION OF DORSAL COLUMNS","authors":"Tianhe Zhang PhD, Rosana Esteller PhD","doi":"10.1016/j.neurom.2026.06.036","DOIUrl":"10.1016/j.neurom.2026.06.036","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"29 7","pages":"Page e22"},"PeriodicalIF":3.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149095546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ID# 2195489 HEALTH CARE RESOURCE UTILIZATION IN SPINAL CORD STIMULATION TRIAL VS PATIENTS WITH IMPLANTS: A FIVE-YEAR ANALYSIS","authors":"David Provenzano MD, Scott Pritzlaff MD, Julie Pilitsis MD, PhD, MBA, Nicolas Gasquet MPH, Christine Ricker MA, MBA, Charlotte Wu MS Biostatistics, MBBS/Bachelor of Medicine","doi":"10.1016/j.neurom.2026.06.066","DOIUrl":"10.1016/j.neurom.2026.06.066","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"29 7","pages":"Page e40"},"PeriodicalIF":3.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149095713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Functional Magnetic Stimulation Parameters and Effectiveness for Neurogenic Detrusor Overactivity: A Systematic Review and Network Meta-Analysis","authors":"Hongxia Pan MD,&nbsp;Xin Sun MD,&nbsp;Liang Zhu MD,&nbsp;Mingfu Ding MD,&nbsp;Quan Wei MD, PhD","doi":"10.1016/j.neurom.2025.10.060","DOIUrl":"10.1016/j.neurom.2025.10.060","url":null,"abstract":"<div><h3>Objectives</h3><div>This network meta-analysis (NMA) aimed to evaluate the comparative efficacy of different functional magnetic stimulation (FMS) protocols—including stimulation site, frequency, and duration—on urodynamic and symptom outcomes in patients with neurogenic detrusor overactivity (NDO), and to provide evidence-based guidance on treatment parameters.</div></div><div><h3>Materials and Methods</h3><div>A systematic search was conducted across PubMed, Embase, Medline, Web of Science, Scopus, Ovid, CNKI, Chinese Biomedical Database, Wanfang, Weipu, and <span><span>ClinicalTrials.gov</span><svg><path></path></svg></span> up to October 20, 2023. Randomized controlled trials (RCTs) involving patients with NDO secondary to neurologic disorders and reporting urodynamic or symptom outcomes (including maximum cystometric capacity [MCC], daily urinary incontinence [UI] episodes, P_vesmax, volume at first desire to void [FDV], postvoid residual urine volume [PVR], average voided volume [AVV], etc) were included. Interventions included any FMS protocol, including repetitive transcranial magnetic stimulation (TMS), repetitive transpinal magnetic stimulation (rTSMS), and repetitive sacral magnetic stimulation (SMS). Safety outcomes, including adverse events, also were considered.</div></div><div><h3>Results</h3><div>The study included 20 RCTs involving 1316 participants, and all trials were used for the meta-analysis. SMS significantly improved MCC (MD: 31.94 mL; 95% CI, 8.18–55.71), and reduced PVR (MD: 24.33 mL; 95% CI, −42.89 to −5.77) vs control. TMS decreased FDV (MD: −59.70 mL; 95% CI, −96.45 to −22.95). Among the frequencies evaluated, 15 Hz produced the largest improvement in MCC (+39.41 mL; 95% CI, 15.09–63.74), ranking highest among tested frequencies. An eight-week regimen achieved the greatest MCC improvement (+46.16 mL; 95% CI, 11.79–80.51) and ranked highest by <em>p-</em>score among the treatment durations evaluated. SMS was superior for reducing daily UI episodes (Surface Under the Cumulative Ranking curve: 0.86).</div></div><div><h3>Conclusions</h3><div>FMS, particularly SMS, significantly improves bladder storage capacity and reduces incontinence in patients with NDO. Among evaluated parameters, 15-Hz stimulation and an eight-week regimen were associated with the greatest improvements in MCC; however, these parameters were analyzed independently, and evidence regarding their combined effects or interactions across stimulation sites is limited. TMS showed mixed effects, increasing AVV but decreasing FDV, suggesting enhanced bladder sensitivity rather than improved storage. These findings indicate that SMS has the most favorable profile among single-parameter comparisons, but further studies are needed to evaluate combinations of stimulation site, frequency, and duration, in addition to individualized treatment strategies for NDO.</div></div>","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"29 7","pages":"Pages 1103-1119"},"PeriodicalIF":3.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145989371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping the Evidence on Peripheral Magnetic Stimulation for Urinary Incontinence: A Systematic Umbrella Review","authors":"Mohsen Mohammad-Rahimi MD,&nbsp;Masoud Sahebari MD,&nbsp;Hanieh Salehi-Pourmehr PhD,&nbsp;Fateme Tahmasbi MD","doi":"10.1016/j.neurom.2026.07.641","DOIUrl":"10.1016/j.neurom.2026.07.641","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Peripheral magnetic stimulation therapy (PMST) has emerged as a promising, noninvasive alternative to the traditional treatment approaches for urinary incontinence (UI). This systematic umbrella review aimed to synthesize the available secondary literature to provide a definitive, high-level overview of PMST’s efficacy, safety parameters, and clinical utility.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Materials and Methods&lt;/h3&gt;&lt;div&gt;A systematic overview was conducted following the Cochrane Handbook and Preferred Reporting Items for Systematic Reviews and Meta-Analyses reporting guidelines. An a priori protocol was registered via the International Prospective Register of Systematic Reviews (PROSPERO), and systematic literature screening was performed using Rayyan. The Joanna Briggs Institute critical appraisal checklist was utilized to evaluate the methodological quality of the included systematic reviews and meta-analyses. Primary study overlap across the portfolio was structurally mapped and mathematically quantified using the Corrected Covered Area (CCA) formula. The certainty of the synthesized evidence across key clinical end points was evaluated using the narrative GRADE framework. Data extraction was restricted strictly to the systematic review components.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Fifteen systematic reviews and meta-analyses were included. Citation matrix analysis revealed a Corrected Covered Area (CCA) of 3.64%, demonstrating a slight overlap and confirming that the synthesized secondary evidence base is non-redundant. Synthesized data revealed a consistent frequency-specific pattern across the included reviews, whereby higher-frequency protocols (35-50 Hz) were most commonly applied to pelvic floor muscle recruitment in stress urinary incontinence, whereas lower-frequency protocols (10-15 Hz) were more frequently used for urgency urinary incontinence and overactive bladder. However, these observations represent prevailing treatment approaches rather than a validated therapeutic paradigm. Relative to sham/placebo configurations, PMST yielded statistically and clinically significant improvements in objective leakage metrics (pad tests) and subjective symptom indices (ICIQ-SF, Health-Related Quality of Life). Safety data demonstrated a remarkable tolerability profile, with adverse events limited to mild, transient, and self-limiting symptoms (eg, local tingling, mild soreness, or increased stool frequency), with no severe complications reported. Methodological quality across the evidence base was highly polarized, with 25% of reviews scoring high and the remainder classified as moderate or low due to deficits in comprehensive database search strings or formal primary study risk-of-bias monitoring.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;PMST appears to be a safe and potentially effective therapeutic option for the management of urinary incontinence and may be considered either as a standalone treatment or as an adjunct to ","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"29 7","pages":"Pages 1120-1138"},"PeriodicalIF":3.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148796029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ID# 2190476 INTEGRATED PROCEDURAL CARE WITH INTRATHECAL PUMP IN ADVANCED CANCER: A CASE STUDY ENHANCING PATIENT-CENTERED CARE","authors":"Alexander Nguyen MD,&nbsp;Alex Russel MD,&nbsp;Ann Shah MD,&nbsp;Dominique N. Sherry BA, MPH","doi":"10.1016/j.neurom.2026.06.055","DOIUrl":"10.1016/j.neurom.2026.06.055","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"29 7","pages":"Page e35"},"PeriodicalIF":3.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149094618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ID# 2189953 CORTICAL AND SPINAL NEUROMODULATION MODULATE HOFFMANN'S REFLEX AND ALLEVIATE UPPER-EXTREMITY SPASTICITY AFTER CERVICAL SPINAL CORD INJURY","authors":"Ali Sadeghi,&nbsp;Ali Sadeghi n/a,&nbsp;Isabella Marossa n/a,&nbsp;Logan Murphy n/a,&nbsp;Keon Deng n/a,&nbsp;Robert Robinson n/a,&nbsp;Chet Moritz n/a,&nbsp;Steve Perlmutter n/a,&nbsp;Christoph Hofstetter n/a","doi":"10.1016/j.neurom.2026.06.054","DOIUrl":"10.1016/j.neurom.2026.06.054","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"29 7","pages":"Page e34"},"PeriodicalIF":3.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149094694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ID# 2184037 DEEP BRAIN STIMULATION OF COMMON MOVEMENT DISORDER TARGETS FOR COMORBID TINNITUS","authors":"Alexander C. Greven MD, MBA,&nbsp;Devin Nikjou BS,&nbsp;Alexander Cheung MD,&nbsp;Markey Olson PhD,&nbsp;Terry Fife MD,&nbsp;Francisco Ponce MD,&nbsp;Alexander C. Greven MD, MBA","doi":"10.1016/j.neurom.2026.06.043","DOIUrl":"10.1016/j.neurom.2026.06.043","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"29 7","pages":"Page e27"},"PeriodicalIF":3.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149093727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ID# 2171223 ADDRESSING LOSS OF EFFICACY IN PATIENTS WITH LONG-TERM, PERMANENTLY IMPLANTED SPINAL CORD STIMULATION: THERAPY SALVAGE USING STANDARDIZED CONNECTIONS OR ADAPTERS","authors":"Namath Hussain MD, MBA,&nbsp;Ewan Gillespie MBA,&nbsp;Rajat Shivacharan PhD","doi":"10.1016/j.neurom.2026.06.015","DOIUrl":"10.1016/j.neurom.2026.06.015","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"29 7","pages":"Page e10"},"PeriodicalIF":3.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149094025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ID# 2185410 CENTRAL SENSITIZATION RESPONSE AFTER OCCIPITAL NERVE STIMULATION: A TEN-YEAR PROSPECTIVE FOLLOW-UP","authors":"Theresa Wodehouse BSc, PhD,&nbsp;Anish Bahra MB ChB, FRCP, MD,&nbsp;Deepika Arora FRCP,&nbsp;Kavita Poply FRCA, FFPM RCA, PhD,&nbsp;Alaa A. Abd-Elsayed MD, MPH, FASA,&nbsp;Vivek Mehta FRCA, MD, FFPMRCA","doi":"10.1016/j.neurom.2026.06.046","DOIUrl":"10.1016/j.neurom.2026.06.046","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"29 7","pages":"Page e29"},"PeriodicalIF":3.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149095392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ID# 2191097 Supracondylar Peripheral Nerve Stimulator Implant: A Unique Success for Thumb Pain","authors":"Sai Kaushik Yeturu MD,&nbsp;Saagar Sheth DO,&nbsp;Stephen Miranda MD,&nbsp;Daniel Kanzer MD","doi":"10.1016/j.neurom.2026.06.059","DOIUrl":"10.1016/j.neurom.2026.06.059","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"29 7","pages":"Page e37"},"PeriodicalIF":3.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149095716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}