Neuromodulation最新文献

{"title":"Effects of Ultrasound-Guided Percutaneous Neuromodulation on Shoulder Muscle Strength in CrossFit Athletes: A Pilot Randomized Controlled Trial","authors":"Romina Sangiacomo MSc ,&nbsp;Fermín Valera-Garrido PhD ,&nbsp;Francisco Minaya-Muñoz PhD ,&nbsp;Alberto Carcasona-Otal PT, MSc ,&nbsp;Pablo Herrero PhD ,&nbsp;Diego Lapuente-Hernández PT, MSc","doi":"10.1016/j.neurom.2025.03.072","DOIUrl":"10.1016/j.neurom.2025.03.072","url":null,"abstract":"<div><h3>Background</h3><div>CrossFit integrates diverse functional movements to optimize overall fitness, with muscle strength training being a core component. Ultrasound-guided percutaneous neuromodulation (US-guided PNM) has emerged as a potential adjunct to enhance muscle strength gains; however, its efficacy in the upper limb in healthy individuals remains unexplored.</div></div><div><h3>Objective</h3><div>This study evaluated the efficacy of two US-guided PNM protocols (three sessions and one session) targeting the axillary and suprascapular nerves in improving shoulder muscle strength in healthy CrossFit athletes.</div></div><div><h3>Materials and Methods</h3><div>A pilot, randomized, controlled, single-blind clinical trial was conducted with 39 healthy CrossFit athletes randomly allocated to one of three groups: control (G1, no intervention), one session of US-guided PNM (G2), or three sessions of US-guided PNM (G3). Shoulder muscle strength was assessed using a hand-held dynamometer to measure external and internal rotation muscle strength at various shoulder positions before each treatment session (days 1, 7, and 14) and one week after the last session (day 21). Moreover, the one-repetition maximum (1RM) shoulder press exercise was evaluated on day 1 and day 21.</div></div><div><h3>Results</h3><div>No statistically significant differences were observed among groups for any outcome. However, the within-group analysis indicated statistically significant improvements over time in the treated limbs of intervention groups (G2 and G3), whereas no statistically significant changes were observed in the control (G1) or the untreated limbs of G2 and G3. The improvements were more consistent for shoulder strength measured in the neutral position than at 90° abduction.</div></div><div><h3>Conclusions</h3><div>Although US-guided PNM did not yield significantly greater improvements than did the control group, both one and three sessions targeting the axillary and suprascapular nerves enhanced rotational shoulder muscle strength in treated limbs and 1RM shoulder press performance. These findings should be interpreted with caution, and further investigation is warranted, particularly in populations with lower baseline strength and in exploring varied application parameters to optimize efficacy.</div></div><div><h3>Clinical Trial Registration</h3><div>The <span><span>Clinicaltrials.gov</span><svg><path></path></svg></span> registration number for the study is NCT06529770.</div></div>","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"28 4","pages":"Pages 600-610"},"PeriodicalIF":3.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"33. Multidimensional outcomes of spinal cord simulation in patients with chronic pain: results from a European prospective multicenter observational study","authors":"S. Thomson ,&nbsp;N. Varela ,&nbsp;V. Mehta ,&nbsp;J. Calle ,&nbsp;J. Vesper ,&nbsp;S. Love-Jones ,&nbsp;J. De Andres ,&nbsp;S. Bayerl ,&nbsp;B. Bujedo ,&nbsp;G. Baranidharan ,&nbsp;A. Mendiola ,&nbsp;C. Perez ,&nbsp;L. Demartini ,&nbsp;J.W. Kallewaard ,&nbsp;K. Gatzinsky ,&nbsp;G. Matis ,&nbsp;E. Goldberg","doi":"10.1016/j.neurom.2025.03.035","DOIUrl":"10.1016/j.neurom.2025.03.035","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"28 4","pages":"Page S17"},"PeriodicalIF":3.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"22. Economic evaluations comparing deep brain stimulation to best medical therapy for movement disorders: a meta-analysis","authors":"M. Lannon ,&nbsp;T. Duda ,&nbsp;A. Mastrolonardo ,&nbsp;E. Huang ,&nbsp;A. Martyniuk ,&nbsp;F. Farrokhyar ,&nbsp;F. Xie ,&nbsp;M. Bhandari ,&nbsp;S.K. Kalia ,&nbsp;S. Sharma","doi":"10.1016/j.neurom.2025.03.024","DOIUrl":"10.1016/j.neurom.2025.03.024","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"28 4","pages":"Page S12"},"PeriodicalIF":3.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"35. Non-invasive modulation of spinal nerve root activity","authors":"C. Keogh,&nbsp;J.J. FitzGerald","doi":"10.1016/j.neurom.2025.03.037","DOIUrl":"10.1016/j.neurom.2025.03.037","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"28 4","pages":"Page S18"},"PeriodicalIF":3.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"29. Initial experience with deep brain stimulation in a patient in minimally conscious state","authors":"K. Waterhouse,&nbsp;A.M. Vitali,&nbsp;L. Gould,&nbsp;J. Norton,&nbsp;S. McLeod","doi":"10.1016/j.neurom.2025.03.031","DOIUrl":"10.1016/j.neurom.2025.03.031","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"28 4","pages":"Page S15"},"PeriodicalIF":3.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"51. Restorative multifidus neurostimulation: a retrospective analysis of outcomes at 1 year at York hospital","authors":"H. Soar,&nbsp;P. Armstrong,&nbsp;P. Hall,&nbsp;A. Britten,&nbsp;H. Lambert,&nbsp;S. Atkin","doi":"10.1016/j.neurom.2025.03.053","DOIUrl":"10.1016/j.neurom.2025.03.053","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"28 4","pages":"Page S26"},"PeriodicalIF":3.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"54. The successful use of narrow paddle electrodes for occipital nerve stimulation – a single centre study","authors":"D. Anwar,&nbsp;S.C. Balasubramanian,&nbsp;G. Vajramani","doi":"10.1016/j.neurom.2025.03.056","DOIUrl":"10.1016/j.neurom.2025.03.056","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"28 4","pages":"Page S28"},"PeriodicalIF":3.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"25. First long term objective quantification of multifidus activity during restorative stimulation - 18F-FDG PET/CT assessment of multifidus activity and radiomics-based heterogeneity analysis","authors":"K. Poply ,&nbsp;A. Haroon ,&nbsp;T. Wodehouse ,&nbsp;B. Ganeshan ,&nbsp;R. Endozo ,&nbsp;B. Goss ,&nbsp;V. Mehta","doi":"10.1016/j.neurom.2025.03.027","DOIUrl":"10.1016/j.neurom.2025.03.027","url":null,"abstract":"","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"28 4","pages":"Page S13"},"PeriodicalIF":3.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144189927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of an Educational Curriculum for Implanting and Managing Vagus Nerve Stimulators for Epilepsy","authors":"David Bieber MD ,&nbsp;Kunal Gupta MD, PhD ,&nbsp;Rany Abdallah MD ,&nbsp;Alaa Abd-Elsayed MD ,&nbsp;Alyson Engle MD ,&nbsp;Irina Duff MD, PhD ,&nbsp;Duvan Hoffman MBA ,&nbsp;Hemant Kalia MD, MPH ,&nbsp;Joshua Rosenow MD ,&nbsp;Micheal Macken MD ,&nbsp;Ahmed M. Raslan MD ,&nbsp;Konstantin Slavin MD ,&nbsp;Amy Tennant NP ,&nbsp;Jeffrey S. Raskin MS, MD","doi":"10.1016/j.neurom.2024.12.008","DOIUrl":"10.1016/j.neurom.2024.12.008","url":null,"abstract":"<div><h3>Background</h3><div>Vagus nerve stimulation (VNS) devices are commonly used for extracranial neuromodulation of drug-resistant epilepsy. These devices are implanted by multiple surgical subspecialties and managed by practitioners with varying levels of epilepsy-specific expertise. The North American Neuromodulation Society (NANS) education committee presents a curriculum defining level-dependent recommendations within the six-core competency rubric for the implantation and management of VNS devices.</div></div><div><h3>Material and Methods</h3><div>A multidisciplinary (anesthesiology, neurology, neurosurgery, and physiatrists) and diverse (advanced practice providers, physicians, and surgeons) subcommittee of the NANS education committee met virtually over a year to develop a curriculum following the Accreditation Council for Graduate Medical Education (ACGME) core competencies. The subcommittee used a consensus approach, evidence-based development strategy; once completed, the VNS curriculum was approved by the NANS board.</div></div><div><h3>Results</h3><div>The subcommittee developed a VNS curriculum as a standard to be used for implanting surgeons, managing physicians, and advanced practice providers. The vertical orientation of the curriculum uses the ACGME educational core competencies framework; within this paradigm is a horizontal progression of skills with distinct competency groups for implanting surgeons and/or managing physicians. The horizontal progression defines the expected competence for early learner, advanced learner, and independent practitioner.</div></div><div><h3>Conclusion</h3><div>A NANS education subcommittee iteratively developed a VNS curriculum for defining progressive competence of myriad care providers, including clinicians and advanced practice providers, within the ACGME six core competencies.</div></div>","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"28 4","pages":"Pages 551-557"},"PeriodicalIF":3.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phase-Amplitude Coupling in Response to Transcutaneous Vagus Nerve Stimulation: Focus on Regions Implicated in Mood and Memory","authors":"Charlotte Keatch PhD ,&nbsp;Elisabeth Lambert PhD ,&nbsp;Will Woods PhD ,&nbsp;Tatiana Kameneva PhD","doi":"10.1016/j.neurom.2025.01.011","DOIUrl":"10.1016/j.neurom.2025.01.011","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to investigate whether transcutaneous vagus nerve stimulation (tVNS) at different frequencies affects phase-amplitude coupling among regions of the brain linked to mood and memory disorders using simultaneous magnetoencephalography (MEG) in healthy participants.</div></div><div><h3>Materials and Methods</h3><div>Phase-amplitude coupling was measured among brain areas in response to different stimulation frequencies of tVNS using concurrent MEG and tVNS in 17 healthy participants. The 4 protocols were: 24 Hz cymba concha, 1 Hz cymba concha, PFM cymba concha, and 24 Hz ear lobe. A driven autoregressive method was used to estimate the coupling among brain areas in different physiological frequency bands in response to these protocols.</div></div><div><h3>Results</h3><div>Different tVNS stimulation protocols led to alterations in phase-amplitude coupling among multiple brain regions linked to mood and memory, notably the prefrontal cortex, hippocampus, and temporal pole. Stimulation delivered at 24 Hz was observed to decrease delta-gamma coupling within the temporal pole and cingulate cortex when contrasted with 24-Hz sham stimulation.</div><div>Increased alpha-gamma coupling was observed between the hippocampus and prefrontal cortex when contrasting 24 Hz with pulse-frequency–modulated stimulation. Finally, a comparison of 24-Hz with low-frequency 1-Hz stimulation showed an increase in theta-gamma coupling within the prefrontal cortex.</div></div><div><h3>Significance</h3><div>To our knowledge, this study represents the first attempt to quantify phase-amplitude coupling in response to tVNS and suggests that different stimulation frequencies can modulate coupling between different areas of the brain. Abnormal phase-amplitude coupling has been linked to multiple mood and memory disorders. Further investigations using different stimulation frequencies of tVNS to alter phase-amplitude coupling may lead to the development of tVNS as a therapeutic option for different medical conditions.</div></div>","PeriodicalId":19152,"journal":{"name":"Neuromodulation","volume":"28 4","pages":"Pages 663-671"},"PeriodicalIF":3.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143493059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}