Neuropathology and Applied Neurobiology最新文献_第3页

Revisiting the relevance of Hirano bodies in neurodegenerative diseases 重新审视平野体在神经退行性疾病中的相关性

IF 5 2区医学

Neuropathology and Applied Neurobiology Pub Date : 2024-04-18 DOI: 10.1111/nan.12978

Koji Yoshida, Shelley L. Forrest, Shojiro Ichimata, Hidetomo Tanaka, Tomoya Kon, Maria Carmela Tartaglia, Charles H. Tator, Anthony E. Lang, Naoki Nishida, Gabor G. Kovacs

{"title":"Revisiting the relevance of Hirano bodies in neurodegenerative diseases","authors":"Koji Yoshida, Shelley L. Forrest, Shojiro Ichimata, Hidetomo Tanaka, Tomoya Kon, Maria Carmela Tartaglia, Charles H. Tator, Anthony E. Lang, Naoki Nishida, Gabor G. Kovacs","doi":"10.1111/nan.12978","DOIUrl":"https://doi.org/10.1111/nan.12978","url":null,"abstract":"AimsHirano bodies (HBs) are eosinophilic pathological structures with two morphological phenotypes commonly found in the hippocampal CA1 region in Alzheimer's disease (AD). This study evaluated the prevalence and distribution of HBs in AD and other neurodegenerative diseases.MethodsThis cross‐sectional study systematically evaluated HBs in a cohort of 193 cases with major neurodegenerative diseases, including AD (n = 91), Lewy body disease (LBD, n = 87), progressive supranuclear palsy (PSP, n = 36), multiple system atrophy (MSA, n = 14) and controls (n = 26). The prevalence, number and morphology of HBs in the stratum lacunosum (HBL) and CA1 pyramidal cell layer were examined. In addition, we investigated the presence of HBs in five additional hippocampal subregions.ResultsThe morphological types of HBs in CA1 were divided into three, including a newly discovered type, and were evaluated separately, with their morphology confirmed in three dimensions: (1) classic rod‐shaped HB (CHB), (2) balloon‐shaped HB (BHB) and the newly described (3) string‐shaped HB (SHB). The prevalence of each HB type differed between disease groups: Compared with controls, for CHB in AD, AD + LBD, PSP and corticobasal degeneration, for BHB in AD + LBD and PSP, and SHB in AD + LBD and PSP were significantly increased. Regression analysis showed that CHBs were independently associated with higher Braak NFT stage, BHBs with LBD and TDP‐43 pathology, SHBs with higher Braak NFT stage, PSP and argyrophilic grain disease and HBLs with MSA.ConclusionsThis study demonstrates that HBs are associated with diverse neurodegenerative diseases and shows that morphological types appear distinctively in various conditions.","PeriodicalId":19151,"journal":{"name":"Neuropathology and Applied Neurobiology","volume":"19 1","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140630059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adult brain tumour research in 2024: Status, challenges and recommendations 2024 年的成人脑肿瘤研究：现状、挑战和建议

IF 5 2区医学

Neuropathology and Applied Neurobiology Pub Date : 2024-04-12 DOI: 10.1111/nan.12979

Karin Purshouse, Helen J. Bulbeck, Alasdair G. Rooney, Karen E. Noble, Ross D. Carruthers, Gerard Thompson, Petra Hamerlik, Christina Yap, Kathreena M. Kurian, Sarah J. Jefferies, Juanita S. Lopez, Michael D. Jenkinson, C. Oliver Hanemann, Lucy F. Stead

引用次数: 0

Immune system involvement in neuronal intranuclear inclusion disease 神经元核内包涵体病的免疫系统参与

IF 5 2区医学

Neuropathology and Applied Neurobiology Pub Date : 2024-04-05 DOI: 10.1111/nan.12976

Lei Bao, Dandan Zuo, Xiaoying Qu, Yingying Cui, Keke Li, Jing Dong, Renjin Chen, Zunsheng Zhang, Guiyun Cui, Hao Chen

引用次数: 0

Response letter: Complexities in pericyte markers 回信：周细胞标记的复杂性

IF 5 2区医学

Neuropathology and Applied Neurobiology Pub Date : 2024-04-03 DOI: 10.1111/nan.12975

Peter T. Nelson, Andras Sziraki, Junyue Cao

引用次数: 0

Targeting the EGFR pathway: An alternative strategy for the treatment of tuberous sclerosis complex? 靶向表皮生长因子受体通路：治疗结节性硬化症复合体的另一种策略？

IF 5 2区医学

Neuropathology and Applied Neurobiology Pub Date : 2024-04-01 DOI: 10.1111/nan.12974

Julia Schachenhofer, Victoria-Elisabeth Gruber, Stefanie Valerie Fehrer, Carmen Haider, Sarah Glatter, Ewa Liszewska, Romana Höftberger, Eleonora Aronica, Karl Rössler, Jacek Jaworski, Theresa Scholl, Martha Feucht

{"title":"Targeting the EGFR pathway: An alternative strategy for the treatment of tuberous sclerosis complex?","authors":"Julia Schachenhofer, Victoria-Elisabeth Gruber, Stefanie Valerie Fehrer, Carmen Haider, Sarah Glatter, Ewa Liszewska, Romana Höftberger, Eleonora Aronica, Karl Rössler, Jacek Jaworski, Theresa Scholl, Martha Feucht","doi":"10.1111/nan.12974","DOIUrl":"10.1111/nan.12974","url":null,"abstract":"Introduction: Tuberous sclerosis complex (TSC) is caused by variants in TSC1/TSC2, leading to constitutive activation of the mammalian target of rapamycin (mTOR) complex 1. Therapy with everolimus has been approved for TSC, but variations in success are frequent. Recently, caudal late interneuron progenitor (CLIP) cells were identified as a common origin of the TSC brain pathologies such as subependymal giant cell astrocytomas (SEGA) and cortical tubers (CT). Further, targeting the epidermal growth factor receptor (EGFR) with afatinib, which is expressed in CLIP cells, reduces cell growth in cerebral TSC organoids. However, investigation of clinical patient-derived data is lacking.Aims: Observation of EGFR expression in SEGA, CT and focal cortical dysplasia (FCD) 2B human brain specimen and investigation of whether its inhibition could be a potential therapeutic intervention for these patients.Methods: Brain specimens of 23 SEGAs, 6 CTs, 20 FCD2Bs and 17 controls were analysed via immunohistochemistry to characterise EGFR expression, cell proliferation (via Mib1) and mTOR signalling. In a cell-based assay using primary patient-derived cells (CT n = 1, FCD2B n = 1 and SEGA n = 4), the effects of afatinib and everolimus on cell proliferation and cell viability were observed.Results: EGFR overexpression was observed in histological sections of SEGA, CT and FCD2B patients. Both everolimus and afatinib decreased the proliferation and viability in primary SEGA, tuber and FCD2B cells.Conclusion: Our study demonstrates that EGFR suppression might be an effective alternative treatment option for SEGAs and tubers, as well as other mTOR-associated malformations of cortical development, including FCD2B.","PeriodicalId":19151,"journal":{"name":"Neuropathology and Applied Neurobiology","volume":"50 2","pages":"e12974"},"PeriodicalIF":5.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140336324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanisms of COVID-19-associated olfactory dysfunction. COVID-19 相关嗅觉功能障碍的机理。

IF 4 2区医学

Neuropathology and Applied Neurobiology Pub Date : 2024-04-01 DOI: 10.1111/nan.12960

Koping Chang, Thomas Zaikos, Nicholas Kilner-Pontone, Cheng-Ying Ho

{"title":"Mechanisms of COVID-19-associated olfactory dysfunction.","authors":"Koping Chang, Thomas Zaikos, Nicholas Kilner-Pontone, Cheng-Ying Ho","doi":"10.1111/nan.12960","DOIUrl":"10.1111/nan.12960","url":null,"abstract":"Olfactory dysfunction is one of the most common symptoms of COVID-19. In the first 2 years of the pandemic, it was frequently reported, although its incidence has significantly decreased with the emergence of the Omicron variant, which has since become the dominant viral strain. Nevertheless, many patients continue to suffer from persistent dysosmia and dysgeusia, making COVID-19-associated olfactory dysfunction an ongoing health concern. The proposed pathogenic mechanisms of COVID-19-associated olfactory dysfunction are complex and likely multifactorial. While evidence suggests that infection of sustentacular cells and associated mucosal inflammation may be the culprit of acute, transient smell loss, alterations in other components of the olfactory system (e.g., olfactory receptor neuron dysfunction, olfactory bulb injury and alterations in the olfactory cortex) may lead to persistent, long-term olfactory dysfunction. This review aims to provide a comprehensive summary of the epidemiology, clinical manifestations and current understanding of the pathogenic mechanisms of COVID-19-associated olfactory dysfunction.","PeriodicalId":19151,"journal":{"name":"Neuropathology and Applied Neurobiology","volume":"50 2","pages":"e12960"},"PeriodicalIF":4.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10906737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139990727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Argyrophilic grain disease and co-pathologies in an older patient with a rapidly progressive neuropsychiatric syndrome. 一名患有快速进展性神经精神综合征的老年患者的霰粒肿和并发症。

IF 5 2区医学

Neuropathology and Applied Neurobiology Pub Date : 2024-04-01 DOI: 10.1111/nan.12973

Camilla N Clark, Norman Poole, Jeremy D Isaacs, Andrew D MacKinnon, Philip Rich, Leslie R Bridges, Zane Jaunmuktane, Elizabeth Caruana Galizia

引用次数: 0

Chronic traumatic encephalopathy neuropathologic change in former Australian rugby players 前澳大利亚橄榄球运动员的慢性创伤性脑病神经病理变化

IF 5 2区医学

Neuropathology and Applied Neurobiology Pub Date : 2024-03-19 DOI: 10.1111/nan.12972

Claire E. Shepherd, Heather McCann, Catriona A. McLean, Grant L. Iverson, Andrew J. Gardner

{"title":"Chronic traumatic encephalopathy neuropathologic change in former Australian rugby players","authors":"Claire E. Shepherd, Heather McCann, Catriona A. McLean, Grant L. Iverson, Andrew J. Gardner","doi":"10.1111/nan.12972","DOIUrl":"https://doi.org/10.1111/nan.12972","url":null,"abstract":"AimsWe applied the 2021 consensus criteria for both chronic traumatic encephalopathy neuropathological change and traumatic encephalopathy syndrome in a small case series of six former elite‐level Australian rugby code players.MethodsNeuropathological assessment of these cases was carried out at the Sydney and Victorian Brain Banks. Clinical data were collected via clinical interviews and health questionnaires completed by the participants and/or their next of kin, and neuropsychological testing was conducted with participants who were capable of completing this testing.ResultsAll cases exhibited progressive cognitive impairment during life. Chronic traumatic encephalopathy neuropathological change was identified in four out of the six cases. However, coexisting neuropathologies were common, with limbic‐predominant age‐related TDP‐43 encephalopathy and ageing‐related tau astrogliopathy seen in all cases, intermediate or high Alzheimer's disease neuropathological change seen in four cases and hippocampal sclerosis seen in two of the six cases.ConclusionThe presence of multiple neuropathologies in these cases complicates clinical diagnostic efforts for traumatic encephalopathy syndrome. It will be important for further clinicopathological studies on larger groups to report all neuropathological comorbidities found in cases diagnosed with either chronic traumatic encephalopathy neuropathological change and/or traumatic encephalopathy syndrome.","PeriodicalId":19151,"journal":{"name":"Neuropathology and Applied Neurobiology","volume":"1152 1","pages":""},"PeriodicalIF":5.0,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140169079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in the locus coeruleus during the course of Alzheimer's disease and their relationship to cortical pathology 阿尔茨海默氏症病程中神经节的变化及其与大脑皮层病理学的关系

IF 5 2区医学

Neuropathology and Applied Neurobiology Pub Date : 2024-02-05 DOI: 10.1111/nan.12965

Rebecca Beardmore, Matthew Durkin, Faizan Zayee-Mellick, Laurie C. Lau, James A. R. Nicoll, Clive Holmes, Delphine Boche

引用次数: 0

Diagnostic value of CSF chromogranin A to discriminate between Alzheimer's disease and dementia with Lewy bodies 脑脊液嗜铬粒蛋白 A 在区分阿尔茨海默病和路易体痴呆症方面的诊断价值

IF 5 2区医学

Neuropathology and Applied Neurobiology Pub Date : 2024-02-01 DOI: 10.1111/nan.12961

Olivier Bousiges, Thomas Lavaux, Catherine Demuynck, Caroline Schaeffer-Agalède, Nathalie Philippi, Candice Muller, Benjamin Cretin, Frédéric Blanc

引用次数: 0