NeuropsychopharmacologyPub Date : 2024-11-01Epub Date: 2024-08-28DOI: 10.1038/s41386-024-01976-2
Satoka Fujimoto, Atsushi Fujimoto, Catherine Elorette, Ki Sueng Choi, Helen Mayberg, Brian Russ, Peter Rudebeck
{"title":"What can neuroimaging of neuromodulation reveal about the basis of circuit therapies for psychiatry?","authors":"Satoka Fujimoto, Atsushi Fujimoto, Catherine Elorette, Ki Sueng Choi, Helen Mayberg, Brian Russ, Peter Rudebeck","doi":"10.1038/s41386-024-01976-2","DOIUrl":"10.1038/s41386-024-01976-2","url":null,"abstract":"<p><p>Neuromodulation is increasingly becoming a therapeutic option for treatment resistant psychiatric disorders. These non-invasive and invasive therapies are still being refined but are clinically effective and, in some cases, provide sustained symptom reduction. Neuromodulation relies on changing activity within a specific brain region or circuit, but the precise mechanisms of action of these therapies, is unclear. Here we review work in both humans and animals that has provided insight into how therapies such as deep brain and transcranial magnetic stimulation alter neural activity across the brain. We focus on studies that have combined neuromodulation with neuroimaging such as PET and MRI as these measures provide detailed information about the distributed networks that are modulated and thus insight into both the mechanisms of action of neuromodulation but also potentially the basis of psychiatric disorders. Further we highlight work in nonhuman primates that has revealed how neuromodulation changes neural activity at different scales from single neuron activity to functional connectivity, providing key insight into how neuromodulation influences the brain. Ultimately, these studies highlight the value of combining neuromodulation with neuroimaging to reveal the mechanisms through which these treatments influence the brain, knowledge vital for refining targeted neuromodulation therapies for psychiatric disorders.</p>","PeriodicalId":19143,"journal":{"name":"Neuropsychopharmacology","volume":" ","pages":"184-195"},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11526173/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142093634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeuropsychopharmacologyPub Date : 2024-11-01Epub Date: 2024-06-28DOI: 10.1038/s41386-024-01903-5
Emily C Wright, Erin Scott, Lin Tian
{"title":"Applications of functional neurotransmitter release imaging with genetically encoded sensors in psychiatric research.","authors":"Emily C Wright, Erin Scott, Lin Tian","doi":"10.1038/s41386-024-01903-5","DOIUrl":"10.1038/s41386-024-01903-5","url":null,"abstract":"<p><p>Psychiatric research encompasses diverse methodologies to understand the complex interplay between neurochemistry and behavior in mental health disorders. Despite significant advancements in pharmacological interventions, there remains a critical gap in understanding the precise functional changes underlying psychiatric conditions and the mechanisms of action of therapeutic agents. Genetically encoded sensors have emerged as powerful tools to address these challenges by enabling real-time monitoring of neurochemical dynamics in specific neuronal populations. This prospective explores the utility of neurotransmitter binding genetically encoded sensors in uncovering the nature of neuronal dysregulation underpinning mental illness, assessing the impact of pharmaceutical interventions, and facilitating the discovery of novel treatments.</p>","PeriodicalId":19143,"journal":{"name":"Neuropsychopharmacology","volume":" ","pages":"269-273"},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11525779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141469689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Brain-based graph-theoretical predictive modeling: a novel approach to prospectively map psychiatric symptoms.","authors":"Rotem Dan, Diego A Pizzagalli","doi":"10.1038/s41386-024-01924-0","DOIUrl":"10.1038/s41386-024-01924-0","url":null,"abstract":"","PeriodicalId":19143,"journal":{"name":"Neuropsychopharmacology","volume":" ","pages":"322-323"},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11525576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141627205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Transcranial photobiomodulation: an emerging therapeutic method to enhance brain bioenergetics.","authors":"Naomi L Gaggi, Dan V Iosifescu","doi":"10.1038/s41386-024-01929-9","DOIUrl":"10.1038/s41386-024-01929-9","url":null,"abstract":"","PeriodicalId":19143,"journal":{"name":"Neuropsychopharmacology","volume":" ","pages":"314-315"},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11525996/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141724096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeuropsychopharmacologyPub Date : 2024-11-01Epub Date: 2024-06-19DOI: 10.1038/s41386-024-01900-8
S Andrea Wijtenburg, Laura M Rowland, Aleksandra Vicentic, Andrew F Rossi, Linda S Brady, Joshua A Gordon, Sarah H Lisanby
{"title":"NIMH perspectives on future directions in neuroimaging for mental health.","authors":"S Andrea Wijtenburg, Laura M Rowland, Aleksandra Vicentic, Andrew F Rossi, Linda S Brady, Joshua A Gordon, Sarah H Lisanby","doi":"10.1038/s41386-024-01900-8","DOIUrl":"10.1038/s41386-024-01900-8","url":null,"abstract":"<p><p>NIMH's mission is to transform the understanding and treatment of mental illnesses through basic and clinical research, paving the way for prevention, recovery, and cure. New imaging techniques hold great promise for improving our understanding of the pathophysiology of mental illnesses, stratifying patients for treatment selection, and developing a personalized medicine approach. Here, we highlight emerging and promising new technologies that are likely to be vital in helping NIMH accomplish its mission, the potential for utilizing multimodal approaches to study mental illness, and considerations for data analytics and data sharing.</p>","PeriodicalId":19143,"journal":{"name":"Neuropsychopharmacology","volume":" ","pages":"294-297"},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11525989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141427302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Correction: Identifying dysfunctional cell types and circuits in animal models for psychiatric disorders with calcium imaging.","authors":"Mark M Gergues, Lahin K Lalani, Mazen A Kheirbek","doi":"10.1038/s41386-024-01982-4","DOIUrl":"10.1038/s41386-024-01982-4","url":null,"abstract":"","PeriodicalId":19143,"journal":{"name":"Neuropsychopharmacology","volume":" ","pages":"305"},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11525901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Biomarker development for menstrual cycle affective change: the need for greater temporal, mechanistic, and phenotypic specificity.","authors":"Jordan C Barone, Tory A Eisenlohr-Moul","doi":"10.1038/s41386-024-01931-1","DOIUrl":"10.1038/s41386-024-01931-1","url":null,"abstract":"","PeriodicalId":19143,"journal":{"name":"Neuropsychopharmacology","volume":" ","pages":"353-354"},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11525718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141724093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Precision functional mapping for target engagement in drug development.","authors":"Joshua S Siegel","doi":"10.1038/s41386-024-01945-9","DOIUrl":"10.1038/s41386-024-01945-9","url":null,"abstract":"","PeriodicalId":19143,"journal":{"name":"Neuropsychopharmacology","volume":" ","pages":"339-340"},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11525882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Multisystem stress response biotypes: a precision psychiatry approach to identifying and treating multidimensional risk factors for anhedonia in adolescence.","authors":"Danielle S Roubinov, Aysenil Belger","doi":"10.1038/s41386-024-01953-9","DOIUrl":"10.1038/s41386-024-01953-9","url":null,"abstract":"","PeriodicalId":19143,"journal":{"name":"Neuropsychopharmacology","volume":" ","pages":"318-319"},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11525919/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141907232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Distributed circuits regulating defensive state transitions: freezing, flight and fight.","authors":"Chandrashekhar D Borkar, Jonathan P Fadok","doi":"10.1038/s41386-024-01965-5","DOIUrl":"10.1038/s41386-024-01965-5","url":null,"abstract":"","PeriodicalId":19143,"journal":{"name":"Neuropsychopharmacology","volume":" ","pages":"320-321"},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11526118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141996215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}