Neuropsychopharmacology最新文献

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What can neuroimaging of neuromodulation reveal about the basis of circuit therapies for psychiatry? 神经调控的神经影像学能揭示精神病学回路疗法的基础是什么?
IF 6.6 1区 医学
Neuropsychopharmacology Pub Date : 2024-11-01 Epub Date: 2024-08-28 DOI: 10.1038/s41386-024-01976-2
Satoka Fujimoto, Atsushi Fujimoto, Catherine Elorette, Ki Sueng Choi, Helen Mayberg, Brian Russ, Peter Rudebeck
{"title":"What can neuroimaging of neuromodulation reveal about the basis of circuit therapies for psychiatry?","authors":"Satoka Fujimoto, Atsushi Fujimoto, Catherine Elorette, Ki Sueng Choi, Helen Mayberg, Brian Russ, Peter Rudebeck","doi":"10.1038/s41386-024-01976-2","DOIUrl":"10.1038/s41386-024-01976-2","url":null,"abstract":"<p><p>Neuromodulation is increasingly becoming a therapeutic option for treatment resistant psychiatric disorders. These non-invasive and invasive therapies are still being refined but are clinically effective and, in some cases, provide sustained symptom reduction. Neuromodulation relies on changing activity within a specific brain region or circuit, but the precise mechanisms of action of these therapies, is unclear. Here we review work in both humans and animals that has provided insight into how therapies such as deep brain and transcranial magnetic stimulation alter neural activity across the brain. We focus on studies that have combined neuromodulation with neuroimaging such as PET and MRI as these measures provide detailed information about the distributed networks that are modulated and thus insight into both the mechanisms of action of neuromodulation but also potentially the basis of psychiatric disorders. Further we highlight work in nonhuman primates that has revealed how neuromodulation changes neural activity at different scales from single neuron activity to functional connectivity, providing key insight into how neuromodulation influences the brain. Ultimately, these studies highlight the value of combining neuromodulation with neuroimaging to reveal the mechanisms through which these treatments influence the brain, knowledge vital for refining targeted neuromodulation therapies for psychiatric disorders.</p>","PeriodicalId":19143,"journal":{"name":"Neuropsychopharmacology","volume":" ","pages":"184-195"},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11526173/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142093634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Applications of functional neurotransmitter release imaging with genetically encoded sensors in psychiatric research. 利用基因编码传感器进行功能性神经递质释放成像在精神病学研究中的应用。
IF 6.6 1区 医学
Neuropsychopharmacology Pub Date : 2024-11-01 Epub Date: 2024-06-28 DOI: 10.1038/s41386-024-01903-5
Emily C Wright, Erin Scott, Lin Tian
{"title":"Applications of functional neurotransmitter release imaging with genetically encoded sensors in psychiatric research.","authors":"Emily C Wright, Erin Scott, Lin Tian","doi":"10.1038/s41386-024-01903-5","DOIUrl":"10.1038/s41386-024-01903-5","url":null,"abstract":"<p><p>Psychiatric research encompasses diverse methodologies to understand the complex interplay between neurochemistry and behavior in mental health disorders. Despite significant advancements in pharmacological interventions, there remains a critical gap in understanding the precise functional changes underlying psychiatric conditions and the mechanisms of action of therapeutic agents. Genetically encoded sensors have emerged as powerful tools to address these challenges by enabling real-time monitoring of neurochemical dynamics in specific neuronal populations. This prospective explores the utility of neurotransmitter binding genetically encoded sensors in uncovering the nature of neuronal dysregulation underpinning mental illness, assessing the impact of pharmaceutical interventions, and facilitating the discovery of novel treatments.</p>","PeriodicalId":19143,"journal":{"name":"Neuropsychopharmacology","volume":" ","pages":"269-273"},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11525779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141469689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Brain-based graph-theoretical predictive modeling: a novel approach to prospectively map psychiatric symptoms. 基于大脑的图论预测建模:前瞻性绘制精神病症状图的新方法。
IF 6.6 1区 医学
Neuropsychopharmacology Pub Date : 2024-11-01 DOI: 10.1038/s41386-024-01924-0
Rotem Dan, Diego A Pizzagalli
{"title":"Brain-based graph-theoretical predictive modeling: a novel approach to prospectively map psychiatric symptoms.","authors":"Rotem Dan, Diego A Pizzagalli","doi":"10.1038/s41386-024-01924-0","DOIUrl":"10.1038/s41386-024-01924-0","url":null,"abstract":"","PeriodicalId":19143,"journal":{"name":"Neuropsychopharmacology","volume":" ","pages":"322-323"},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11525576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141627205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transcranial photobiomodulation: an emerging therapeutic method to enhance brain bioenergetics. 经颅光生物调制:增强大脑生物能的新兴治疗方法。
IF 6.6 1区 医学
Neuropsychopharmacology Pub Date : 2024-11-01 DOI: 10.1038/s41386-024-01929-9
Naomi L Gaggi, Dan V Iosifescu
{"title":"Transcranial photobiomodulation: an emerging therapeutic method to enhance brain bioenergetics.","authors":"Naomi L Gaggi, Dan V Iosifescu","doi":"10.1038/s41386-024-01929-9","DOIUrl":"10.1038/s41386-024-01929-9","url":null,"abstract":"","PeriodicalId":19143,"journal":{"name":"Neuropsychopharmacology","volume":" ","pages":"314-315"},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11525996/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141724096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
NIMH perspectives on future directions in neuroimaging for mental health. NIMH 对神经影像学在心理健康领域未来发展方向的展望。
IF 6.6 1区 医学
Neuropsychopharmacology Pub Date : 2024-11-01 Epub Date: 2024-06-19 DOI: 10.1038/s41386-024-01900-8
S Andrea Wijtenburg, Laura M Rowland, Aleksandra Vicentic, Andrew F Rossi, Linda S Brady, Joshua A Gordon, Sarah H Lisanby
{"title":"NIMH perspectives on future directions in neuroimaging for mental health.","authors":"S Andrea Wijtenburg, Laura M Rowland, Aleksandra Vicentic, Andrew F Rossi, Linda S Brady, Joshua A Gordon, Sarah H Lisanby","doi":"10.1038/s41386-024-01900-8","DOIUrl":"10.1038/s41386-024-01900-8","url":null,"abstract":"<p><p>NIMH's mission is to transform the understanding and treatment of mental illnesses through basic and clinical research, paving the way for prevention, recovery, and cure. New imaging techniques hold great promise for improving our understanding of the pathophysiology of mental illnesses, stratifying patients for treatment selection, and developing a personalized medicine approach. Here, we highlight emerging and promising new technologies that are likely to be vital in helping NIMH accomplish its mission, the potential for utilizing multimodal approaches to study mental illness, and considerations for data analytics and data sharing.</p>","PeriodicalId":19143,"journal":{"name":"Neuropsychopharmacology","volume":" ","pages":"294-297"},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11525989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141427302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Identifying dysfunctional cell types and circuits in animal models for psychiatric disorders with calcium imaging. 更正:利用钙成像技术识别精神疾病动物模型中功能失调的细胞类型和回路。
IF 6.6 1区 医学
Neuropsychopharmacology Pub Date : 2024-11-01 DOI: 10.1038/s41386-024-01982-4
Mark M Gergues, Lahin K Lalani, Mazen A Kheirbek
{"title":"Correction: Identifying dysfunctional cell types and circuits in animal models for psychiatric disorders with calcium imaging.","authors":"Mark M Gergues, Lahin K Lalani, Mazen A Kheirbek","doi":"10.1038/s41386-024-01982-4","DOIUrl":"10.1038/s41386-024-01982-4","url":null,"abstract":"","PeriodicalId":19143,"journal":{"name":"Neuropsychopharmacology","volume":" ","pages":"305"},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11525901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biomarker development for menstrual cycle affective change: the need for greater temporal, mechanistic, and phenotypic specificity. 月经周期情感变化的生物标志物开发:需要更强的时间、机制和表型特异性。
IF 6.6 1区 医学
Neuropsychopharmacology Pub Date : 2024-11-01 DOI: 10.1038/s41386-024-01931-1
Jordan C Barone, Tory A Eisenlohr-Moul
{"title":"Biomarker development for menstrual cycle affective change: the need for greater temporal, mechanistic, and phenotypic specificity.","authors":"Jordan C Barone, Tory A Eisenlohr-Moul","doi":"10.1038/s41386-024-01931-1","DOIUrl":"10.1038/s41386-024-01931-1","url":null,"abstract":"","PeriodicalId":19143,"journal":{"name":"Neuropsychopharmacology","volume":" ","pages":"353-354"},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11525718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141724093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Precision functional mapping for target engagement in drug development. 为药物开发中的目标参与绘制精确的功能图谱。
IF 6.6 1区 医学
Neuropsychopharmacology Pub Date : 2024-11-01 DOI: 10.1038/s41386-024-01945-9
Joshua S Siegel
{"title":"Precision functional mapping for target engagement in drug development.","authors":"Joshua S Siegel","doi":"10.1038/s41386-024-01945-9","DOIUrl":"10.1038/s41386-024-01945-9","url":null,"abstract":"","PeriodicalId":19143,"journal":{"name":"Neuropsychopharmacology","volume":" ","pages":"339-340"},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11525882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multisystem stress response biotypes: a precision psychiatry approach to identifying and treating multidimensional risk factors for anhedonia in adolescence. 多系统应激反应生物型:一种识别和治疗青少年厌学症多维风险因素的精准精神病学方法。
IF 6.6 1区 医学
Neuropsychopharmacology Pub Date : 2024-11-01 DOI: 10.1038/s41386-024-01953-9
Danielle S Roubinov, Aysenil Belger
{"title":"Multisystem stress response biotypes: a precision psychiatry approach to identifying and treating multidimensional risk factors for anhedonia in adolescence.","authors":"Danielle S Roubinov, Aysenil Belger","doi":"10.1038/s41386-024-01953-9","DOIUrl":"10.1038/s41386-024-01953-9","url":null,"abstract":"","PeriodicalId":19143,"journal":{"name":"Neuropsychopharmacology","volume":" ","pages":"318-319"},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11525919/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141907232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Distributed circuits regulating defensive state transitions: freezing, flight and fight. 调节防御状态转换的分布式回路:冻结、逃跑和战斗。
IF 6.6 1区 医学
Neuropsychopharmacology Pub Date : 2024-11-01 DOI: 10.1038/s41386-024-01965-5
Chandrashekhar D Borkar, Jonathan P Fadok
{"title":"Distributed circuits regulating defensive state transitions: freezing, flight and fight.","authors":"Chandrashekhar D Borkar, Jonathan P Fadok","doi":"10.1038/s41386-024-01965-5","DOIUrl":"10.1038/s41386-024-01965-5","url":null,"abstract":"","PeriodicalId":19143,"journal":{"name":"Neuropsychopharmacology","volume":" ","pages":"320-321"},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11526118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141996215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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