Neuropsychopharmacology最新文献_第5页

Abnormal ventromedial-to-dorsolateral hierarchical topography of striatal circuits in cocaine use disorder and its modulations by brain stimulation 可卡因使用障碍患者纹状体回路的腹内侧至背外侧分层结构异常及其脑刺激的调节作用。

IF 6.6 1区医学

Neuropsychopharmacology Pub Date : 2025-04-01 DOI: 10.1038/s41386-025-02098-z

Ran Zhang, Xiang Xiao, Debo Dong, Ting Xu, Yuzheng Hu, Feng Zhou, Tianye Zhai, Yawei Qi, Yihong Yang, Qinghua He

{"title":"Abnormal ventromedial-to-dorsolateral hierarchical topography of striatal circuits in cocaine use disorder and its modulations by brain stimulation","authors":"Ran Zhang, Xiang Xiao, Debo Dong, Ting Xu, Yuzheng Hu, Feng Zhou, Tianye Zhai, Yawei Qi, Yihong Yang, Qinghua He","doi":"10.1038/s41386-025-02098-z","DOIUrl":"10.1038/s41386-025-02098-z","url":null,"abstract":"Cocaine use disorder (CUD) has been linked to cortico-striatal dysfunctions, particularly within the prefrontal-striatal circuitry. However, previous studies have typically focused on discrete parcellations of the striatum, overlooking its continuous variations of neural organization. Moreover, while repetitive transcranial magnetic stimulation (rTMS) has shown benefits in CUD treatment, the neural effects of rTMS on striatal dysfunction in CUD remain poorly understood. Using connectome gradient-mapping techniques on three resting-state functional magnetic resonance imaging datasets, we derived the ventromedial-to-dorsolateral striatal functional topography. We identified specific alterations in this topography in the discovery cohort (41 CUD patients and 44 controls), validated findings in an independent cohort (53 CUD patients and 45 controls), and examined whether rTMS targeting the left dorsolateral prefrontal cortex (dlPFC) could normalize abnormalities in the rTMS-treatment cohort (44 patients). Across all datasets, we found a positive correlation between gradient variation and drug dependence severity in CUD. Compared to controls, CUD in both the discovery and replication cohorts exhibited elevated gradient values in the ventral striatum, while decreased values in the dorsal striatum were observed only in the discovery cohort. Furthermore, in the rTMS-treatment cohort, 5-Hz rTMS targeting the left dlPFC significantly normalized the aberrant gradient values in the ventral striatum, and these changes also related to cocaine craving changes. Overall, our study provides novel evidence of specific alterations in the ventromedial-to-dorsolateral functional topography of the striatum in CUD patients and highlights the impact of rTMS on striatal circuits through prefrontal modulation.","PeriodicalId":19143,"journal":{"name":"Neuropsychopharmacology","volume":"50 9","pages":"1354-1363"},"PeriodicalIF":6.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Four dimensions of individualization in brain stimulation for psychiatric disorders: context, target, dose, and timing 精神疾病脑刺激个体化的四个维度：情境、目标、剂量和时机。

IF 6.6 1区医学

Neuropsychopharmacology Pub Date : 2025-03-27 DOI: 10.1038/s41386-025-02094-3

Ghazaleh Soleimani, Michael A. Nitsche, Colleen A. Hanlon, Kelvin O. Lim, Alexander Opitz, Hamed Ekhtiari

{"title":"Four dimensions of individualization in brain stimulation for psychiatric disorders: context, target, dose, and timing","authors":"Ghazaleh Soleimani, Michael A. Nitsche, Colleen A. Hanlon, Kelvin O. Lim, Alexander Opitz, Hamed Ekhtiari","doi":"10.1038/s41386-025-02094-3","DOIUrl":"10.1038/s41386-025-02094-3","url":null,"abstract":"Non-invasive Brain Stimulation (NIBS) technologies, including transcranial electrical (tES) and magnetic (TMS) stimulation, have emerged as promising interventions for various psychiatric disorders. FDA-approved TMS protocols in depression, OCD and nicotine use disorder provide a meaningful improvement. Treatment efficacy however remains inconsistent across individuals, and one relevant reason is intervention effect variability based on individual factors. There is a growing effort to develop individualized interventions, reinforced recently by FDA approval of a new TMS protocol that includes individualized fMRI-based targeting along with other modifications with higher reported effect size than previous “one size fits all” protocols. This paper discusses the dimensions for individualizing tES/TMS protocols to enhance therapeutic efficacy. We propose a multifaceted approach to personalizing NIBS, considering four levels: (1) context, (2) target, (3) dose, and (4) timing. By addressing inter- and intra-individual variability, we highlight a path toward precision medicine using individualized Brain Stimulation to treat psychiatric diseases. Despite challenges and limitations, this approach encourages broader and more systematic adoption of personalized Brain Stimulation techniques to improve clinical outcomes.","PeriodicalId":19143,"journal":{"name":"Neuropsychopharmacology","volume":"50 6","pages":"857-870"},"PeriodicalIF":6.6,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early-life adversity alters adult nucleus incertus neurons: implications for neuronal mechanisms of increased stress and compulsive behavior vulnerability 早期生活的逆境改变了成年的中核神经元：对增加压力和强迫行为脆弱性的神经元机制的影响。

IF 6.6 1区医学

Neuropsychopharmacology Pub Date : 2025-03-21 DOI: 10.1038/s41386-025-02089-0

Anna Gugula, Patryk Sambak, Aleksandra Trenk, Sylwia Drabik, Aleksandra Nogaj, Zbigniew Soltys, Andrew L. Gundlach, Anna Blasiak

{"title":"Early-life adversity alters adult nucleus incertus neurons: implications for neuronal mechanisms of increased stress and compulsive behavior vulnerability","authors":"Anna Gugula, Patryk Sambak, Aleksandra Trenk, Sylwia Drabik, Aleksandra Nogaj, Zbigniew Soltys, Andrew L. Gundlach, Anna Blasiak","doi":"10.1038/s41386-025-02089-0","DOIUrl":"10.1038/s41386-025-02089-0","url":null,"abstract":"Early-life stress (ELS) arising from physical and emotional abuse disrupts normal brain development and impairs hypothalamic–pituitary–adrenal axis function, increasing the risk of psychopathological disorders and compulsive behaviors in adulthood. However, the underlying neural mechanisms remain unclear. The brainstem nucleus incertus (NI) is a highly stress-sensitive locus, involved in behavioral activation and stress-induced reward (food/alcohol) seeking, but its sensitivity to ELS remains unexplored. We used neonatal maternal separation stress in rats as a model for ELS and examined its impact on stress-related mRNA and neuropeptide expression in the NI, using fluorescent in situ hybridization and immunohistochemistry, respectively. Using whole-cell, patch-clamp recordings we determined the influence of ELS on the synaptic activity, excitability, and electrophysiological properties of NI neurons. Using c-Fos protein expression we also assessed the impact of ELS on the sensitivity of NI neurons to acute restraint stress in adulthood. ELS weakened the acute stress responsiveness of NI neurons, and caused dendritic shrinkage, impaired synaptic transmission and altered electrophysiological properties of NI neurons in a cell-type-specific manner. Additionally, ELS increased the expression of mRNA encoding corticotropin-releasing hormone receptor type 1 and the nerve-growth factor receptor, TrkA in adult NI. The multiple, cell-type specific changes in the expression of neuropeptides and molecules associated with stress and substance abuse in the NI, as well as impairments in NI neuron morphology and electrophysiology caused by ELS and observed in the adult brain, may contribute to the increased susceptibility to stress and compulsive behaviors observed in individuals with a history of ELS.","PeriodicalId":19143,"journal":{"name":"Neuropsychopharmacology","volume":"50 9","pages":"1406-1419"},"PeriodicalIF":6.6,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41386-025-02089-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Central Med23 deficiency leads to malformation of dentate gyrus and ADHD-like behaviors in mice 中枢性Med23缺乏导致小鼠齿状回畸形和adhd样行为。

IF 6.6 1区医学

Neuropsychopharmacology Pub Date : 2025-03-20 DOI: 10.1038/s41386-025-02088-1

Bing-Yao Zhou, Ze-Xuan Li, Yi-Wei Li, Jin-Nan Li, Wei-Tang Liu, Xi-Yue Liu, Zhi-Bin Hu, Li Zhao, Jia-Yin Chen, Ling Hu, Ning-Ning Song, Xue Feng, Gang Wang, Lin Xu, Yu-Qiang Ding

{"title":"Central Med23 deficiency leads to malformation of dentate gyrus and ADHD-like behaviors in mice","authors":"Bing-Yao Zhou, Ze-Xuan Li, Yi-Wei Li, Jin-Nan Li, Wei-Tang Liu, Xi-Yue Liu, Zhi-Bin Hu, Li Zhao, Jia-Yin Chen, Ling Hu, Ning-Ning Song, Xue Feng, Gang Wang, Lin Xu, Yu-Qiang Ding","doi":"10.1038/s41386-025-02088-1","DOIUrl":"10.1038/s41386-025-02088-1","url":null,"abstract":"Attention-deficit hyperactivity disorder (ADHD) is a prevalent psychiatric disorder with high heritability, while its etiology and pathophysiology remain unclear. Med23 is a subunit of the Mediator complex, a key regulator of gene expression by linking transcription factors to RNA polymerase II. The mutations of Med23 are associated with several brain diseases including microcephaly, epilepsy and intellectual disability, but its biological roles in brain development and possible behavioral consequence have not been explored in the animal model. In this study, Emx1-Cre mice were used to generate Med23 conditional knockout (Med23 CKO) mice that showed severe hypoplasia of the dentate gyrus (DG) with malformation of the dendritic tree and spines along with impaired short-term synaptic plasticity. Interestingly, Med23 CKO mice exhibited ADHD-like behaviors as shown by hyperactivity, inattention and impulsivity, as well as impaired sensory gating and working memory. Importantly, methylphenidate (MPH), a common drug for ADHD ameliorated these deficits in the CKO mice. Furthermore, we also revealed that the impaired synaptic plasticity was partially restored by MPH in an N-methyl-d-aspartate (NMDA) receptor-dependent way. Collectively, our data demonstrate Med23 deficiency causes DG malformation and ADHD-like behaviors, suggesting a novel mechanism underlying relevant brain diseases.","PeriodicalId":19143,"journal":{"name":"Neuropsychopharmacology","volume":"50 8","pages":"1224-1236"},"PeriodicalIF":6.6,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41386-025-02088-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preregistered multi-site preclinical randomized controlled trials: the beginning of a new day in reverse translational science? 预注册多中心临床前随机对照试验：逆向转化科学新一天的开始？

IF 6.6 1区医学

Neuropsychopharmacology Pub Date : 2025-03-20 DOI: 10.1038/s41386-025-02090-7

Lorenzo Leggio, Giancarlo Colombo

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Correction: Neuropsychopharmacology Volume 50 Issue 1 修正：神经精神药理学第50卷第1期。

IF 6.6 1区医学

Neuropsychopharmacology Pub Date : 2025-03-19 DOI: 10.1038/s41386-025-02087-2

引用次数: 0

Grey matter morphometry in young adult e-cigarette users, tobacco cigarette users & non-using controls 年轻成人电子烟使用者、烟草烟使用者和非使用者对照组的灰质形态测量。

IF 6.6 1区医学

Neuropsychopharmacology Pub Date : 2025-03-19 DOI: 10.1038/s41386-025-02086-3

Kanwar Boparai, Hsiang-Yuan Lin, Peter Selby, Laurie Zawertailo

{"title":"Grey matter morphometry in young adult e-cigarette users, tobacco cigarette users & non-using controls","authors":"Kanwar Boparai, Hsiang-Yuan Lin, Peter Selby, Laurie Zawertailo","doi":"10.1038/s41386-025-02086-3","DOIUrl":"10.1038/s41386-025-02086-3","url":null,"abstract":"Despite the rise in electronic cigarette use in recent years, the neurobiological effects of daily e-cigarette use versus smoking cigarettes in young adults remains unknown. This study aimed to investigate the impact of regular, exclusive e-cigarette use on grey matter morphometry in young adults, age 18–25. Structural MRI data were collected from 3 distinct groups of participants (n = 78): daily, exclusive e-cigarette users; tobacco cigarette users; and non-using controls, to assess grey matter volume (GMV) differences. Voxel-based morphometry revealed significant GMV reductions in tobacco cigarette users in the left fusiform gyrus (FG), left and right inferior temporal gyrus (IFG), right middle temporal gyri, and right middle cingulate gyrus (MCG), compared to controls, as well as the anterior cingulate cortex (ACC), compared to both e-cigarette users and controls, even after adjusting for nicotine exposure history. Partial correlation analyses revealed that in tobacco cigarette users, GMV in the FG, ITG, MTG, and MCG displayed a strong, negative association with exposure history but not with nicotine dependence. GMV of the ACC was not associated with duration of use or nicotine dependence score, suggesting distinct relationships between ACC volume and smoking status and FG/ITG/MTG/MCG volume and smoking status. This indicates a distinct difference between regular tobacco cigarette and e-cigarette use, perhaps a relatively safer profile of e-cigarette use on GMV. These findings suggest that factors beyond nicotine, such as other toxicants in tobacco cigarette smoke, may contribute to the observed brain atrophy, or imply potential pre-existing vulnerabilities that might predispose individuals to take up smoking.","PeriodicalId":19143,"journal":{"name":"Neuropsychopharmacology","volume":"50 9","pages":"1455-1463"},"PeriodicalIF":6.6,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41386-025-02086-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of sex in the association between cannabis use disorder and resting-state functional connectivity 性在大麻使用障碍和静息状态功能连接之间的关联中的作用。

IF 6.6 1区医学

Neuropsychopharmacology Pub Date : 2025-03-18 DOI: 10.1038/s41386-025-02078-3

Janna Cousijn, Yara J. Toenders, Anne Marije Kaag, Francesca Filbey, Emese Kroon

{"title":"The role of sex in the association between cannabis use disorder and resting-state functional connectivity","authors":"Janna Cousijn, Yara J. Toenders, Anne Marije Kaag, Francesca Filbey, Emese Kroon","doi":"10.1038/s41386-025-02078-3","DOIUrl":"10.1038/s41386-025-02078-3","url":null,"abstract":"While Cannabis use disorder (CUD) is twice as prevalent in males, females transition more quickly from heavy use to CUD and experience more severe withdrawal. These clinically relevant sex differences contrast the lack of knowledge about the underlying brain mechanisms. This study investigated the relationship between CUD and resting-state functional brain connectivity (RSFC), assessing potential sex differences herein. RSFC of the Salience Network (SN), Basal Ganglia Network (BGN), Executive Control Network (ECN), and Default Mode Network (DMN) was compared between 152 individuals (76 males) with CUD and 114 matched controls (47 males). Within the CUD group, relationships between RSFC and heaviness of cannabis use, age of onset, and CUD symptom severity, along with their associations with sex, were investigated. CUD and control groups showed similar RSFC across all networks, regardless of sex. In the CUD group, heavier cannabis use correlated with higher RSFC across all networks and earlier age of onset was related to higher RSFC in the anterior SN, BGN, left ECN, and dorsal DMN. These associations were similar for males and females. CUD severity was related to higher RSFC in the anterior SN, which was moderated by sex, with a positive association seen only in males. In conclusion, CUD may not necessarily be associated with altered RSFC. Individual use characteristics such age of onset and severity of use may determine the potential impact of cannabis use on RSFC in a largely similar way in males and females.","PeriodicalId":19143,"journal":{"name":"Neuropsychopharmacology","volume":"50 6","pages":"991-999"},"PeriodicalIF":6.6,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DRN-SNc serotonergic circuit drives stress-induced motor deficits and Parkinson’s disease vulnerability DRN-SNc血清素能回路驱动应激诱导的运动障碍和帕金森病易感性。

IF 6.6 1区医学

Neuropsychopharmacology Pub Date : 2025-03-17 DOI: 10.1038/s41386-025-02080-9

Yibo Yao, Chi Cui, Yulong Shi, Jie Lei, Tongxia Li, Ming Li, Xiang Peng, Xueke Yang, Kun Ren, Jian Yang, Gangan Luo, Junsong Du, Sitong Chen, Pei Zhang, Bo Tian

{"title":"DRN-SNc serotonergic circuit drives stress-induced motor deficits and Parkinson’s disease vulnerability","authors":"Yibo Yao, Chi Cui, Yulong Shi, Jie Lei, Tongxia Li, Ming Li, Xiang Peng, Xueke Yang, Kun Ren, Jian Yang, Gangan Luo, Junsong Du, Sitong Chen, Pei Zhang, Bo Tian","doi":"10.1038/s41386-025-02080-9","DOIUrl":"10.1038/s41386-025-02080-9","url":null,"abstract":"Stress is a recognized risk factor for Parkinson’s disease (PD), but the mechanisms by which stress exacerbates PD symptoms through the serotonergic system are not fully understood. This study investigates the role of serotonergic (5-HT) neurons in the dorsal raphe nucleus (DRN) in mediating stress-induced motor deficits and PD progression. Acute and chronic stress were induced in mice using an elevated platform (EP) and combined with MPTP administration to model early-stage PD. Acute EP stress caused transient motor deficits and significant activation of DRN5-HT neurons projecting to substantia nigra compacta (SNc) dopaminergic (DA) neurons. Manipulating the DRN-SNc pathway with optogenetics and chemogenetics confirmed its critical role in stress-induced motor deficits. Activation of the SNc 5-HT2C receptor with an agonist replicated these deficits, while receptor inhibition prevented them, underscoring its importance. Chronic EP stress worsened MPTP-induced deficits and caused significant SNcDA neurons loss, suggesting it accelerates PD progression. Prolonged chemogenetic inhibition of the DRN-SNc circuit mitigated chronic stress effects in MPTP-treated mice. These findings highlight the crucial role of the DRN-SNc serotonergic circuit and 5-HT2C receptors in stress-related motor deficits, suggesting potential targets for therapies aimed at treating both stress-related motor disorders and Parkinson’s disease.","PeriodicalId":19143,"journal":{"name":"Neuropsychopharmacology","volume":"50 7","pages":"1051-1062"},"PeriodicalIF":6.6,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41386-025-02080-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapid hippocampal synaptic potentiation induced by ketamine metabolite (2R,6R)-hydroxynorketamine persistently primes synaptic plasticity 氯胺酮代谢物（2R,6R）-羟基炔诺酮胺诱导的快速海马突触电位可持续激发突触可塑性。

IF 6.6 1区医学

Neuropsychopharmacology Pub Date : 2025-03-17 DOI: 10.1038/s41386-025-02085-4

Kyle A. Brown, Musa I. Ajibola, Todd D. Gould

{"title":"Rapid hippocampal synaptic potentiation induced by ketamine metabolite (2R,6R)-hydroxynorketamine persistently primes synaptic plasticity","authors":"Kyle A. Brown, Musa I. Ajibola, Todd D. Gould","doi":"10.1038/s41386-025-02085-4","DOIUrl":"10.1038/s41386-025-02085-4","url":null,"abstract":"The pharmacologically active (R,S)-ketamine (ketamine) metabolite (2 R,6 R)-hydroxynorketamine (HNK) maintains ketamine’s preclinical antidepressant profile without adverse effects. While hypotheses have been proposed to explain how ketamine and its metabolites initiate their antidepressant-relevant effects, it remains unclear how sustained therapeutic actions arise following drug elimination. To distinguish the physiological mechanisms involved in the rapid from sustained actions of HNK, we utilized extracellular electrophysiology combined with pharmacology to develop an in vitro hippocampal slice incubation model that exhibited pharmacological fidelity to the 1) rapid synaptic potentiation induced by HNK at the Schaffer collateral-CA1 (SC-CA1) synapse during bath-application to slices collected from mice, and 2) maintenance of metaplastic (priming) activity that enhanced N-methyl-D-aspartate receptor (NMDAR) activation-dependent long-term potentiation (LTP) hours after in vivo dosing. We used this model to reveal novel mechanisms engaged in HNK’s temporally-sensitive antidepressant-relevant synaptic actions, finding that the induction of synaptic potentiation by HNK did not require NMDAR activity, but NMDAR activity was necessary to maintain synaptic priming. HNK required protein kinase A (PKA) activity to rapidly potentiate SC-CA1 neurotransmission to facilitate synaptic priming that persistently promoted LTP formation. HNK’s rapid actions were blocked by inhibitors of adenylyl cyclase 1 (AC1), but not an AC5 inhibitor. We conclude that HNK rapidly potentiates SC-CA1 synaptic efficacy, which then stimulates priming mechanisms that persistently favor plasticity. Targeting such priming mechanisms may be an effective antidepressant strategy, and our incubation model may aid in revealing novel pharmacological targets.","PeriodicalId":19143,"journal":{"name":"Neuropsychopharmacology","volume":"50 6","pages":"928-940"},"PeriodicalIF":6.6,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0