Neuropsychopharmacology最新文献_第3页

Quality over quantity: powering neuroimaging samples in psychiatry. 质量重于数量：为精神病学的神经成像样本提供动力。

IF 6.6 1区医学

Neuropsychopharmacology Pub Date : 2024-11-01 Epub Date: 2024-06-20 DOI: 10.1038/s41386-024-01893-4

Carolina Makowski, Thomas E Nichols, Anders M Dale

{"title":"Quality over quantity: powering neuroimaging samples in psychiatry.","authors":"Carolina Makowski, Thomas E Nichols, Anders M Dale","doi":"10.1038/s41386-024-01893-4","DOIUrl":"10.1038/s41386-024-01893-4","url":null,"abstract":"Neuroimaging has been widely adopted in psychiatric research, with hopes that these non-invasive methods will provide important clues to the underpinnings and prediction of various mental health symptoms and outcomes. However, the translational impact of neuroimaging has not yet reached its promise, despite the plethora of computational methods, tools, and datasets at our disposal. Some have lamented that too many psychiatric neuroimaging studies have been underpowered with respect to sample size. In this review, we encourage this discourse to shift from a focus on sheer increases in sample size to more thoughtful choices surrounding experimental study designs. We propose considerations at multiple decision points throughout the study design, data modeling and analysis process that may help researchers working in psychiatric neuroimaging boost power for their research questions of interest without necessarily increasing sample size. We also provide suggestions for leveraging multiple datasets to inform each other and strengthen our confidence in the generalization of findings to both population-level and clinical samples. Through a greater emphasis on improving the quality of brain-based and clinical measures rather than merely quantity, meaningful and potentially translational clinical associations with neuroimaging measures can be achieved with more modest sample sizes in psychiatry.","PeriodicalId":19143,"journal":{"name":"Neuropsychopharmacology","volume":" ","pages":"58-66"},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11525971/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141432396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synaptic changes in psychiatric and neurological disorders: state-of-the art of in vivo imaging. 精神和神经疾病中的突触变化：活体成像技术的最新进展。

IF 6.6 1区医学

Neuropsychopharmacology Pub Date : 2024-11-01 Epub Date: 2024-08-12 DOI: 10.1038/s41386-024-01943-x

Oliver Howes, Julia Marcinkowska, Federico E Turkheimer, Richard Carr

{"title":"Synaptic changes in psychiatric and neurological disorders: state-of-the art of in vivo imaging.","authors":"Oliver Howes, Julia Marcinkowska, Federico E Turkheimer, Richard Carr","doi":"10.1038/s41386-024-01943-x","DOIUrl":"10.1038/s41386-024-01943-x","url":null,"abstract":"Synapses are implicated in many neuropsychiatric illnesses. Here, we provide an overview of in vivo techniques to index synaptic markers in patients. Several positron emission tomography (PET) tracers for synaptic vesicle glycoprotein 2 A (SV2A) show good reliability and selectivity. We review over 50 clinical studies including over 1700 participants, and compare findings in healthy ageing and across disorders, including addiction, schizophrenia, depression, posttraumatic stress disorder, and neurodegenerative disorders, including tauopathies, Huntington's disease and α-synucleinopathies. These show lower SV2A measures in cortical brain regions across most of these disorders relative to healthy volunteers, with the most well-replicated findings in tauopathies, whilst changes in Huntington's chorea, Parkinson's disease, corticobasal degeneration and progressive supranuclear palsy are predominantly subcortical. SV2A PET measures are correlated with functional connectivity across brain networks, and a number of other measures of brain function, including glucose metabolism. However, the majority of studies found no relationship between grey matter volume measured with magnetic resonance imaging and SV2A PET measures. Cognitive dysfunction, in domains including working memory and executive function, show replicated inverse relationships with SV2A measures across diagnoses, and initial findings also suggest transdiagnostic relationships with mood and anxiety symptoms. This suggests that synaptic abnormalities could be a common pathophysiological substrate underlying cognitive and, potentially, affective symptoms. We consider limitations of evidence and future directions; highlighting the need to develop postsynaptic imaging markers and for longitudinal studies to test causal mechanisms.","PeriodicalId":19143,"journal":{"name":"Neuropsychopharmacology","volume":" ","pages":"164-183"},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11525650/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141971530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroimaging in psychiatry: toward mechanistic insights and clinical utility. 精神病学中的神经影像学研究：探索机理和临床实用性。

IF 6.6 1区医学

Neuropsychopharmacology Pub Date : 2024-11-01 Epub Date: 2024-10-11 DOI: 10.1038/s41386-024-01984-2

Deanna Barch, Conor Liston

引用次数: 0

Developmental neuroplasticity and adversity-related risk for psychopathology. 发育神经可塑性和与逆境相关的精神病理学风险。

IF 6.6 1区医学

Neuropsychopharmacology Pub Date : 2024-11-01 DOI: 10.1038/s41386-024-01950-y

Lucinda M Sisk, Dylan G Gee

引用次数: 0

Current best practices and future opportunities for reproducible findings using large-scale neuroimaging in psychiatry. 利用精神病学大规模神经成像技术再现研究结果的当前最佳实践和未来机遇。

IF 6.6 1区医学

Neuropsychopharmacology Pub Date : 2024-11-01 Epub Date: 2024-08-08 DOI: 10.1038/s41386-024-01938-8

Neda Jahanshad, Petra Lenzini, Janine Bijsterbosch

引用次数: 0

Leveraging large-scale brain networks in rats to understand neurological and psychiatric disorders in humans. 利用大鼠的大规模大脑网络了解人类的神经和精神疾病。

IF 6.6 1区医学

Neuropsychopharmacology Pub Date : 2024-11-01 DOI: 10.1038/s41386-024-01952-w

Hanbing Lu, Yihong Yang

引用次数: 0

Virtual reality exposure therapy advances and potential for clinical and experimental use. 虚拟现实暴露疗法的进展及临床和实验应用潜力。

IF 6.6 1区医学

Neuropsychopharmacology Pub Date : 2024-11-01 DOI: 10.1038/s41386-024-01930-2

Barbara O Rothbaum, Jacob O Rothbaum

引用次数: 0

Environmental and neurodevelopmental contributors to youth mental illness. 青少年精神疾病的环境和神经发育因素。

IF 6.6 1区医学

Neuropsychopharmacology Pub Date : 2024-11-01 Epub Date: 2024-07-19 DOI: 10.1038/s41386-024-01926-y

Sarah Whittle, Lu Zhang, Divyangana Rakesh

{"title":"Environmental and neurodevelopmental contributors to youth mental illness.","authors":"Sarah Whittle, Lu Zhang, Divyangana Rakesh","doi":"10.1038/s41386-024-01926-y","DOIUrl":"10.1038/s41386-024-01926-y","url":null,"abstract":"While a myriad of factors likely contribute to the development of mental illness in young people, the social environment (including early adverse experiences) in concert with neurodevelopmental alterations is undeniably important. A number of influential theories make predictions about how and why neurodevelopmental alterations may mediate or moderate the effects of the social environment on the emergence of mental illness. Here, we discuss current evidence supporting each of these theories. Although this area of research is rapidly growing, the body of evidence is still relatively limited. However, there exist some consistent findings, including increased striatal reactivity during positive affective processing and larger hippocampal volumes being associated with increased vulnerability or susceptibility to the effects of social environments on internalizing symptoms. Limited longitudinal work has investigated neurodevelopmental mechanisms linking the social environment with mental health. Drawing from human research and insights from animal studies, we propose an integrated mediation-moderation model and outline future research directions to advance the field.","PeriodicalId":19143,"journal":{"name":"Neuropsychopharmacology","volume":" ","pages":"201-210"},"PeriodicalIF":6.6,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11526094/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141727586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Post-traumatic stress comorbidity in substance use disorder: machine learning analyses of phenotypic drivers. 药物使用障碍中的创伤后应激合并症：表型驱动因素的机器学习分析。

IF 6.6 1区医学

Neuropsychopharmacology Pub Date : 2024-11-01 DOI: 10.1038/s41386-024-01969-1

David C Houghton, Heidi M Spratt

引用次数: 0

Memory engram stability and flexibility. 记忆刻痕的稳定性和灵活性

IF 6.6 1区医学

Neuropsychopharmacology Pub Date : 2024-11-01 Epub Date: 2024-09-18 DOI: 10.1038/s41386-024-01979-z

Yosif Zaki, Denise J Cai

引用次数: 0