Neurophysiologie Clinique/Clinical Neurophysiology最新文献

{"title":"Evaluation of cortical excitability with transcranial magnetic stimulation in patients with obstructive sleep apnea syndrome","authors":"Tuğçe Akçadağ Çaman ,&nbsp;İnan Özdemir ,&nbsp;Mahmut Bilal Çaman ,&nbsp;Serkan Aksu ,&nbsp;Semai Bek ,&nbsp;Gülnihal Kutlu","doi":"10.1016/j.neucli.2025.103111","DOIUrl":"10.1016/j.neucli.2025.103111","url":null,"abstract":"<div><h3>Objectives</h3><div>Cognitive impairment constitutes one of the most prevalent sequelae associated with obstructive sleep apnea (OSA). Given the established correlation between chronic hypoxia in patients with OSA and the deterioration of cortical functions, this study hypothesize that levels of cortical excitability diminish in direct relation to the severity of hypoxic episodes.</div></div><div><h3>Methods</h3><div>A cohort of 102 individuals diagnosed with OSA participated. Patients exhibiting a T90 value of ≥30 % were categorized into the desaturated cohort, whereas those with a T90 value of &lt;30 % were designated as the non-desaturated cohort. To evaluate alterations in cortical excitability, Transcranial Magnetic Stimulation (TMS) was employed to quantify various parameters including resting muscle motor evoked potential (MEP) latency and amplitude, resting motor threshold, active muscle MEP latency andamplitude, and active motor threshold in both the dominant and non-dominant abductor pollicis brevis (APB) muscles.</div></div><div><h3>Results</h3><div>The findings indicated that resting dominant APB muscle MEP latency (<em>t</em>=-2.659; <em>p</em> = 0.009), active dominant APB muscle MEP latency (<em>Z</em>=-2.322; <em>p</em> = 0.020), resting non-dominant APB muscle MEP latency (<em>Z</em>=-2.666; <em>p</em> = 0.008), and active motor threshold for dominant APB (<em>Z</em>=-2.410; <em>p</em> = 0.016) were significantly elevated in the desaturated cohort compared to the non-desaturated cohort.</div></div><div><h3>Conclusion</h3><div>This study showed that chronic hypoxia in patients with OSA is associated with modifications in cortical excitability as assessed through TMS. A marked decrease in cortical excitability was identified in the desaturated cohort. It is hypothesized that a disturbance in gamma-aminobutyric acid (GABA) and glutamate transmission could be crucial to understanding OSA and cortical excitability.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 6","pages":"Article 103111"},"PeriodicalIF":2.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145245025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vestibular evoked myogenic potentials beyond oVEMP and cVEMP: exploring new recording sites","authors":"Quentin Legois ,&nbsp;Mathieu Marx ,&nbsp;Antoine Paul ,&nbsp;Fabrice Giraudet","doi":"10.1016/j.neucli.2025.103115","DOIUrl":"10.1016/j.neucli.2025.103115","url":null,"abstract":"","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 6","pages":"Article 103115"},"PeriodicalIF":2.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145346339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamics of sleep-wake cycles and architecture in anti-NMDAR encephalitis","authors":"Lina Jeantin ,&nbsp;Louis Cousyn ,&nbsp;Vincent Navarro ,&nbsp;Vi-Huong Nguyen-Michel","doi":"10.1016/j.neucli.2025.103119","DOIUrl":"10.1016/j.neucli.2025.103119","url":null,"abstract":"<div><div>Sleep disturbances in anti-NMDAR encephalitis evolve dynamically across disease phases. We monitored a patient longitudinally from the acute phase through remission, relapse, and recovery, using video-EEG and polysomnography. No sleep complaints were reported during the prodromal phase, whereas coma was characterized by rhythmic theta-delta activity devoid of sleep patterns. Sleep stages gradually emerged after teratoma removal and immunotherapy, paralleling clinical improvement. A second teratoma caused relapse with severe sleep disruption and <em>agrypnia excitata</em>, then residual <em>status dissociatus</em> persisted before normalization. Sleep changes mirrored disease progression, suggesting that sleep patterns may serve as biomarkers and potential therapeutic targets in anti-NMDAR encephalitis.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 6","pages":"Article 103119"},"PeriodicalIF":2.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145415603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is the decrement pattern in myasthenia gravis due to muscle-specific kinase antibodies different to that due to acetylcholine receptor antibodies?","authors":"Antoine Pegat ,&nbsp;Antoine Gavoille ,&nbsp;Maxime Bonjour ,&nbsp;Florent Cluse ,&nbsp;Martin Moussy ,&nbsp;Juliette Svahn ,&nbsp;Ludivine Kouton ,&nbsp;Aude-Marie Grapperon ,&nbsp;Annie Verschueren ,&nbsp;Emilien Delmont ,&nbsp;Emmanuelle Salort-Campana ,&nbsp;Shahram Attarian ,&nbsp;Etienne Fortanier ,&nbsp;Françoise Bouhour","doi":"10.1016/j.neucli.2025.103092","DOIUrl":"10.1016/j.neucli.2025.103092","url":null,"abstract":"<div><h3>Objective</h3><div>A decrement on repetitive nerve stimulation (RNS) is essential for the diagnosis of myasthenia gravis (MG). The decrement pattern is typically “U-shaped” in MG caused by acetylcholine receptor antibodies (AChR-MG) but is less well described in MG caused by muscle-specific kinase antibodies (MuSK-MG). The aim of this study was to investigate RNS abnormalities in MuSK-MG, and to describe the differences in the decrement pattern as compared to AChR-MG.</div></div><div><h3>Methods</h3><div>This retrospective case-control study included patients diagnosed with generalized MuSK-MG, compared to a control group of generalized AChR-MG. The five most frequently explored nerve-muscle pairs in RNS were analyzed: radial-anconeus, fibular nerve–tibialis anterior (TA), XI-trapezius, XII/V-submental complex (SMC), and VII-orbicularis oculi (OO). Decreased amplitude between the 1st and 4th responses (early decrement) and the late/early ratio were calculated (late/early ratio &lt;100 %=<em>U</em>-shaped pattern, and ≥100 %=progressive pattern).</div></div><div><h3>Results</h3><div>For MuSK-MG, 25 patients were included and compared to 35 AChR-MG patients. An early decrement was present in 38/83 (54.2 %) muscles in MuSK-MG compared to 88/130 (67.7 %) muscles in AChR-MG; and in MuSK-MG was less frequently found in anconeus (4/22 [18.2 %] <em>vs</em> 27/31 [87.1 %], <em>p</em> &lt; 0.001) and in TA (0/12 [0.0 %] <em>vs</em> 9/30 [30 %], <em>p</em> = 0.04). A progressive pattern was more frequent in MuSK-MG (19/38 [50.0 %] of muscles <em>vs</em> 15/88 [17.0 %], <em>p</em> &lt; 0.001). The late/early ratio was greater in MuSK-MG (median value was 98.4 % [IQR, 86.8–106.8] <em>vs</em> 89.7 % [IQR, 79.5–96.5]). The first response with minimal amplitude during the RNS (Amin) was significantly different between the two groups (<em>p</em> &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>Compared to AChR-MG, RNS in MuSK-MG showed fewer affected muscles, with less frequent involvement of anconeus and TA in particular; and a more progressive decrement pattern.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 6","pages":"Article 103092"},"PeriodicalIF":2.4,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144738987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-interval intracortical inhibition (SICI): effect of target tracking on variability of responses for 1 mV and 200µV test-alone targets","authors":"Gaia Fanella ,&nbsp;Hugh Bostock ,&nbsp;Gintaute Samusyte ,&nbsp;Anna Bystrup Jacobsen ,&nbsp;James Howells ,&nbsp;Bülent Cengiz ,&nbsp;Hasan Kılınç ,&nbsp;Martin Koltzenburg ,&nbsp;Agessandro Abrahao ,&nbsp;Lorne Zinman ,&nbsp;Benjamin Bardel ,&nbsp;Jean-Pascal Lefaucheur ,&nbsp;Lucía Del Valle ,&nbsp;José Manuel Matamala ,&nbsp;Hatice Tankisi","doi":"10.1016/j.neucli.2025.103091","DOIUrl":"10.1016/j.neucli.2025.103091","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate whether continuously tracking unconditioned thresholds for maintaining constant motor-evoked potential (MEP) amplitudes improves the variability of amplitude-based short-interval intracortical inhibition (SICI) measurements.</div></div><div><h3>Methods</h3><div>Fifty-five healthy subjects were tested twice on two days with six SICI protocols. Conditioning stimulus (CS) intensity was set to 70 % of the resting motor threshold for a 200µV target (RMT200), while test stimulus (TS) intensity targeted MEP of either 1 mV or 200µV. Protocols included conventional A-SICI (fixed CS and TS), hybrid A-SICI (fixed CS and updated TS by threshold tracking); tracked A-SICI (both CS and TS updated by threshold tracking). Variability in unconditioned and conditioned responses was analyzed across interstimulus intervals (ISIs) of 1, 2.5, and 3 ms.</div></div><div><h3>Results</h3><div>Threshold-tracking reduced variability of the unconditioned responses measured by geometric standard deviation (expressed as a factor) for 1 mV (×/÷1.61 to 1.39; <em>p</em>&lt;0.0001) and 200µV targets (×/÷2.21 to 1.30; <em>p</em>&lt;0.0001). However, variability of inhibition measures did not differ significantly across protocols. Inhibition with the 200µV MEP target was significantly less than with 1 mV across all ISIs (<em>p</em>&lt;0.001). The A-SICI 200µV tracked protocol showed reliability comparable to A-SICI fixed 1 mV, suggesting it may be a practical alternative in clinical populations where achieving a 1 mV MEP is challenging, such as in patients with severe muscle denervation.</div></div><div><h3>Conclusions</h3><div>While threshold-tracking enhances unconditioned MEP reproducibility, it does not reduce the variability of SICI, which is highly dependent on target MEP size. These findings point towards two distinct mechanisms underlying conditioned and unconditioned responses and refine understanding of SICI variability.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 5","pages":"Article 103091"},"PeriodicalIF":2.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144580663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protocol considerations for single and paired pulse transcranial magnetic stimulation in Parkinson’s disease","authors":"Anjali Sivaramakrishnan ,&nbsp;Harry T. Jordan ,&nbsp;Cathy M. Stinear","doi":"10.1016/j.neucli.2025.103097","DOIUrl":"10.1016/j.neucli.2025.103097","url":null,"abstract":"","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 5","pages":"Article 103097"},"PeriodicalIF":2.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144887028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transforming spontaneous premature neonatal EEG to spontaneous fetal MEG using a novel machine learning approach","authors":"Alban Gallard ,&nbsp;Benoit Brebion ,&nbsp;Katrin Sippel ,&nbsp;Amer Zaylaa ,&nbsp;Hubert Preissl ,&nbsp;Sahar Moghimi ,&nbsp;Yael Fregier ,&nbsp;Fabrice Wallois","doi":"10.1016/j.neucli.2025.103086","DOIUrl":"10.1016/j.neucli.2025.103086","url":null,"abstract":"<div><h3>Objectives</h3><div>The spontaneous neural activity of premature neonates has been characterized with electroencephalography (EEG). However, evaluation of normal and pathological fetal brain development is still largely unknown. Fetal magnetoencephalography (fMEG) is currently the only available technique to record fetal neural activity. Benefiting from progress in machine learning and artificial intelligence, we aimed to transfer premature EEG to fMEG, to characterize the manifestation of spontaneous activity using the knowledge obtained from premature EEG.</div></div><div><h3>Methods</h3><div>In this study, 30 high-resolution EEG recordings from premature newborns and 44 fMEG recordings were used to develop a transfer function to predict the spontaneous neural activity of the fetus. After preprocessing, bursts of spontaneous activity were detected using the non-linear energy operator. Next, we proposed a CycleGAN-based model to transform the premature EEG to fMEG and evaluated its performance with both time and frequency measurements.</div></div><div><h3>Results</h3><div>In the time domain, the values were similar for the mean square error (&lt; 5 %) and correlation (0.91 ± 0.05 and 0.89 ± 0.08) for both transformations between the original data and that generated by CycleGAN. However, considering the frequency content, the CycleGAN-based model modulated the frequency content of EEG to MEG transformed signals relative to the original signals by increasing the power, on average, in all frequency bands, except for the slow delta frequency band.</div></div><div><h3>Conclusion</h3><div>Our developed model showed promising potential to generate a priori signatures of fMEG manifestations related to spontaneous neural activity. Collectively, this study represents the first steps toward identifying neurobiomarkers of fetal brain development.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 5","pages":"Article 103086"},"PeriodicalIF":2.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144261829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is segmenting ECG features a viable tool for seizure detection?","authors":"Ewan S. Nurse ,&nbsp;Mark J. Cook","doi":"10.1016/j.neucli.2025.103099","DOIUrl":"10.1016/j.neucli.2025.103099","url":null,"abstract":"","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 5","pages":"Article 103099"},"PeriodicalIF":2.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144911423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing repeater F waves using the compound muscle action potential scan and machine learning techniques","authors":"Xiaoyan Li ,&nbsp;Maoqi Chen ,&nbsp;Paul E. Barkhaus ,&nbsp;Sanjeev D. Nandedkar ,&nbsp;Marek Cierny ,&nbsp;Caitlin Moore ,&nbsp;Ping Zhou","doi":"10.1016/j.neucli.2025.103076","DOIUrl":"10.1016/j.neucli.2025.103076","url":null,"abstract":"<div><h3>Objectives</h3><div>The purpose of this study is to introduce a new analytical technique on repeater F waves (RFws) using compound muscle action potential (CMAP) scan and new features to differentiate the nerves innervating hand muscles.</div></div><div><h3>Methods</h3><div>Twenty-four healthy subjects participated in the CMAP scan study. Tests were performed on the abductor pollicis brevis (APB) and abductor digit minimi (ADM) muscles. RFws were extracted using unsupervised machine learning and analyzed through conventional characteristics such as amplitude, latency, indices of F repeaters and total F repeaters, as well by new variables, including relative stimulus intensity (ReSI), relative F/M ratio (RF/MR), and range of stimulation intensity (RaSI).</div></div><div><h3>Results</h3><div>Significantly higher indices of F repeaters (APB: 18.42±4.92 %, ADM: 13.58±4.68 %, <em>p</em> &lt; 0.005) and total F repeaters (APB: 34.75±7.8 %, ADM: 26.67±8.56 %, <em>p</em> &lt; 0.005) were observed in the APB compared with the ADM muscles. The ReSI (<em>Z</em> = 13.81, <em>p</em> &lt; 0.001) and RaSI (<em>Z</em>=-2.46, <em>p</em> &lt; 0.05) showed significant differences between the two muscles.</div></div><div><h3>Discussion and Conclusion</h3><div>This study provides normative data for RFws based on the CMAP scan recording and identifies different characteristics of repeaters between APB and ADM muscles. Findings of the study improve understanding of motoneuron physiological properties in hand muscles. The CMAP scan-based F wave analysis can be combined with motor unit number estimation technique to provide insights into surviving motoneuron function in neurological disorders.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 5","pages":"Article 103076"},"PeriodicalIF":2.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143923421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Reticular formation: An integrative network for postural control","authors":"FJF Viseux ,&nbsp;M Simoneau ,&nbsp;GM Pamboris ,&nbsp;N Sturbois-Nachef ,&nbsp;CT Bonnet ,&nbsp;M Martinez Carrasco ,&nbsp;L Defebvre ,&nbsp;M Billot ,&nbsp;A Delval","doi":"10.1016/j.neucli.2025.103100","DOIUrl":"10.1016/j.neucli.2025.103100","url":null,"abstract":"<div><div>The reticular formation (RF), a complex network within the brainstem, plays a pivotal role in postural control, by integrating multisensory information and coordinating motor responses, to maintain balance and stability. This theoretical review synthesizes current knowledge on the anatomical and functional organization of the RF, highlighting its contributions to muscle tone regulation, anticipatory postural adjustments (APA), and gaze stability. Anatomically divided into median, paramedian, and lateral columns, the RF operates through both ascending and descending pathways. The ascending reticular activating system (ARAS) regulates arousal and alertness, while the descending reticulospinal tracts modulate postural muscle tone and motor coordination. Functionally, the RF maintains baseline muscle tone via excitatory and inhibitory pathways and supports APA by preparing the body for movement-induced perturbations. Moreover, the RF is integral to the coordination of eye and head movements, ensuring visual stability during motion. Collectively, these mechanisms position the RF as a central integrator of posture and movement, with implications for understanding motor control and informing interventions in neurorehabilitation and movement optimization.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 5","pages":"Article 103100"},"PeriodicalIF":2.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145026678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}