Mariana Lopes Martins , Melyssa Kellyane Cavalcanti Galdino , Daniel Soares Ferreira Silva , Eliza Carolina Dantas Valença , Mariana Braz dos Santos , Jessica Figueiredo de Medeiros , Daniel Gomes da Silva Machado , Marine Raquel Diniz da Rosa
{"title":"Standalone tDCS for tinnitus treatment: Is it a good choice?","authors":"Mariana Lopes Martins , Melyssa Kellyane Cavalcanti Galdino , Daniel Soares Ferreira Silva , Eliza Carolina Dantas Valença , Mariana Braz dos Santos , Jessica Figueiredo de Medeiros , Daniel Gomes da Silva Machado , Marine Raquel Diniz da Rosa","doi":"10.1016/j.neucli.2024.103035","DOIUrl":"10.1016/j.neucli.2024.103035","url":null,"abstract":"","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 1","pages":"Article 103035"},"PeriodicalIF":2.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Laura Tassi , Veronica Pelliccia , Francesca Bisulli , Matteo Martinoni , Lorenzo Ferri , Flavio Giordano , Federico Melani , Luca de Palma , Nicola Specchio , Carlo Efisio Marras , Francesco Cardinale , Carmen Barba
{"title":"Stereo-EEG around the world: State of the art in Italy","authors":"Laura Tassi , Veronica Pelliccia , Francesca Bisulli , Matteo Martinoni , Lorenzo Ferri , Flavio Giordano , Federico Melani , Luca de Palma , Nicola Specchio , Carlo Efisio Marras , Francesco Cardinale , Carmen Barba","doi":"10.1016/j.neucli.2024.103041","DOIUrl":"10.1016/j.neucli.2024.103041","url":null,"abstract":"<div><div>Stereo-EEG is not just a diagnostic examination but a complex methodology, requiring an accurate synthesis of many data (anatomical, clinical, neurophysiological, cognitive, metabolic, and genetic). The implantation scheme is decided based on a hypothesis (or hypotheses) of epileptogenic zone localization. Subsequently, intracerebral electrical stimulation is used to define the extent of highly functional cortical regions and to reproduce the clinical symptoms and signs associated with seizures. Finally, stereo-EEG-guided thermocoagulation is used, with the dual purpose of stopping/reducing the seizures and determining the prognosis of possible resective (curative) surgery. The centers in Italy that use stereo-EEG derive from the French school of Bancaud and Talairach. Nevertheless, each one has interpreted, on the basis of its own specificity and talent, a new methodology and philosophy of implantation. The present work presents the state of the art of stereo-EEG use in Italy, with detail of the stereo-EEG program of the Munari center in Milano, as well as those of Florence, Bologna and Rome.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 1","pages":"Article 103041"},"PeriodicalIF":2.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Letter in response to Martins et al., tDCS for tinnitus modulation","authors":"Hinpetch Daungsupawong , Viroj Wiwanitkit","doi":"10.1016/j.neucli.2024.103034","DOIUrl":"10.1016/j.neucli.2024.103034","url":null,"abstract":"","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 1","pages":"Article 103034"},"PeriodicalIF":2.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tingting Ying , Wenxiang Zhong , Yan Yuan, Li Zhou, Shiting Li
{"title":"Application of neurophysiological monitoring in differentiation of hemifacial spasm and post-facial paralysis synkinesis","authors":"Tingting Ying , Wenxiang Zhong , Yan Yuan, Li Zhou, Shiting Li","doi":"10.1016/j.neucli.2024.103019","DOIUrl":"10.1016/j.neucli.2024.103019","url":null,"abstract":"<div><h3>Objective</h3><div>The aims of this study were to investigate the electrophysiological features of hemifacial spasm (HFS) and post-facial paralysis synkinesis (PFPS) that contribute to differential diagnosis.</div></div><div><h3>Methods</h3><div>This study was designed as a retrospective analysis, focusing on 132 patients diagnosed with HFS and 78 patients with PFPS between May and October 2023. Patient data were collected from existing medical records. The study aimed to analyze pre-existing electrophysiological data, including abnormal muscle response (AMR) and facial synkinesis, focusing on parameters such as AMR latency, amplitude, and duration.</div></div><div><h3>Results</h3><div>In the HFS group, AMR could be induced in all patients, with synkinesis present in 31.8 %. In the PFPS group, AMR and synkinesis were induced in 79.5 % and 100 % of patients, respectively. Compared with the PFPS group, the HFS group had a shorter AMR latency and higher amplitude (<em>P</em> < 0.05). The duration of the AMR did not significantly differ between the two groups (<em>P</em> > 0.05). Synkinesis in the HFS group was typically accompanied or followed by an involuntary spasm episode, but not every eye closure or pouting led to synkinesis. In contrast, synkinesis in the PFPS group occurred with every voluntary movement and was synchronized with these movements.</div></div><div><h3>Conclusions</h3><div>Patients with HFS and PFPS may exhibit similar clinical symptoms. Neurophysiological tests, particularly electromyography, provide valuable information for the differential diagnosis of HFS and PFPS.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 2","pages":"Article 103019"},"PeriodicalIF":2.7,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Neurophysiology of adaptative and maladaptive stress: Relations with psychology of stress","authors":"Marion Trousselard","doi":"10.1016/j.neucli.2024.103036","DOIUrl":"10.1016/j.neucli.2024.103036","url":null,"abstract":"<div><h3>Objectives</h3><div>The stress reaction is an integrated response to a change in the environment that enables each individual to adapt to demand. While this response is physiologically coordinated by the brain, its phenomenology is expressed in the field of psychology and psychopathology. This interrelation between neurophysiological mechanisms and psychological processes is complex as dynamic interpersonal, biological, and psychocognitive systems interact with contextual and environmental factors to shape adaptation over the life constraints.</div></div><div><h3>Method</h3><div>This article aims to present the actors of the adjusted stress response, such as coping and coping flexibility, mindfulness and resilience, and their respective neurophysiology.</div></div><div><h3>Results</h3><div>A model of the relationship between resilience, mindfulness and coping was proposed for optimizing adaptation to stress response.</div></div><div><h3>Discussion</h3><div>These focuses are prerequisites for understanding and supporting human adaptation in the everyday environment and promoting efficient management of stress for mental and physical health.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"55 2","pages":"Article 103036"},"PeriodicalIF":2.7,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The epileptogenic network concept: Applications in the SEEG exploration of lesional focal epilepsies","authors":"Fabrice Bartolomei","doi":"10.1016/j.neucli.2024.103023","DOIUrl":"10.1016/j.neucli.2024.103023","url":null,"abstract":"<div><div>The advent of advanced brain imaging techniques has significantly enhanced the understanding and treatment of focal epilepsies, with identifiable brain lesions present in 80 % of cases. Despite this, surgical outcomes remain varied, often influenced by lesion type and location. Traditional lesion-centric approaches may overlook the complex organization of the epileptogenic zone (EZ), which often extends beyond the visible lesion, emphasizing the need for comprehensive presurgical evaluations like stereo-electroencephalography (SEEG) in some cases. This article delves into the concept of epileptogenic networks, moving beyond the notion of a lesional epileptic focus. Through SEEG, three primary network types have been identified: the Epileptogenic Zone Network (EZN), characterized by regions with heightened epileptogenicity and seizure initiation; the Propagation Zone Network (PZN), involving regions with delayed and less intense epileptic activity; and Non-Involved networks (NI). Quantitative measures, such as the epileptogenicity index (EI), aid in delineating these networks, revealing that EZN can be focal or networked, with the latter being more prevalent.</div><div>The relationship between epilepsy-associated lesions and network organization is complex. Intrinsically epileptogenic lesions, like focal cortical dysplasia and periventricular nodular heterotopias, often generate epileptiform activities but may still involve broader epileptogenic networks. Non-intrinsically epileptogenic lesions, such as cavernomas and post-stroke lesions, typically lack inherent neuronal activity but can facilitate the development of extensive epileptogenic networks.</div><div>Understanding the intricacies of these networks is crucial for optimizing surgical interventions. Recognizing that lesions may represent just one node within a broader epileptogenic network underscores the importance of comprehensive SEEG evaluations to achieve better surgical outcomes.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"54 6","pages":"Article 103023"},"PeriodicalIF":2.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142552812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"F-waves responses derived from low-intensity electrical stimulation: A method to explore split-hand pathogenesis","authors":"Miguel Lopes , Michael Swash , Mamede de Carvalho","doi":"10.1016/j.neucli.2024.103018","DOIUrl":"10.1016/j.neucli.2024.103018","url":null,"abstract":"<div><h3>Objectives</h3><div>The “split-hand syndrome” is a common clinical sign in amyotrophic lateral sclerosis (ALS), being characterized by more severe atrophy of the hand muscles on the radial side of the hand compared to the ulnar side. We aimed to investigate possible physiological differences between relevant hand muscles using low-intensity F-wave stimulation to assess spinal motoneuron excitability.</div></div><div><h3>Methods</h3><div>We recruited 36 healthy volunteers. F-waves were recorded from the abductor pollicis brevis (APB), first dorsal interosseous (FDI) and abductor digiti minimi (ADM), using 20 supramaximal stimuli followed by 20 stimuli at a low-intensity required to obtain M-waves with 10 % amplitude of maximal CMAP. We evaluated the following F-wave parameters: F-M latency, chronodispersion, persistence, amplitude, F/CMAP amplitude ratio and number of F-wave repeaters (with low-intensity). In 10 subjects, low-intensity stimulation F-waves were compared after 20 and 50 stimuli in each muscle.</div></div><div><h3>Results</h3><div>Low-intensity stimulation resulted in lower F-wave amplitude and persistence and higher F/CMAP amplitude ratios. There were no significant differences in F-wave latencies and chronodispersion. When comparing the three muscles, we found higher F-wave persistence and F/CMAP amplitude ratios when recording over the ADM and APB compared to the FDI. We also found a higher number of F-wave repeaters in the ADM with low-intensity stimulation. Results from 20 to 50 low-intensity stimuli were similar.</div></div><div><h3>Discussion</h3><div>A small number of low-intensity stimuli is appropriate to study F-wave latencies and chronodispersion. We found differences in some physiological properties of the ADM spinal motoneuron pool compared to other hand muscles.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"54 6","pages":"Article 103018"},"PeriodicalIF":2.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142566361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Transcranial MEPs predict clinical outcome during minimally invasive dorsal decompression for cervical spondylotic myelopathy","authors":"Fares Komboz , Fabian Kück , Silvia Hernández-Durán , Ingo Fiss , Xenia Hautmann , Dorothee Mielke (Prof.) , Veit Rohde (Prof.) , Tammam Abboud","doi":"10.1016/j.neucli.2024.103022","DOIUrl":"10.1016/j.neucli.2024.103022","url":null,"abstract":"<div><h3>Objectives</h3><div>Motor evoked potential (MEP) monitoring is a reliable method for real-time assessment of corticospinal tract integrity. However, the potential benefits of MEP monitoring during degenerative spine surgery remain controversial. This study aims to determine the role of MEP monitoring during surgery for cervical spondylotic myelopathy (CSM) in prediction of prognosis.</div></div><div><h3>Methods</h3><div>Transcranial electrical stimulation was performed to elicit MEPs during dorsal decompression for the treatment of CSM. MEP-threshold levels were assessed separately at the beginning and end of the surgery in upper extremity muscles corresponding to nerve roots at the level of/distal to the decompression site. Clinical outcome was measured using the modified Japanese Orthopedic Association score (mJOA).</div></div><div><h3>Results</h3><div>The study included 47 patients. 31 patients (66 %) showed improvements in neurological function at discharge. A measurable improvement in the majority of tested muscles, or in at least one muscle group, in a given patient highly correlated with mJOA score increase at discharge (<em>p</em> < 0.001) with an odds ratio of 10.3 (CI:2.6–34.4) and 11.4 (CI:2.8–41.3), respectively. Conversely, MEP deterioration was not associated with worse clinical outcome, nor was it predictive of failure to recover.</div></div><div><h3>Conclusion</h3><div>MEP improvement during CSM surgery seems to be highly predictive of early postoperative neurological recovery and could indicate subclinically enhanced signal conduction. This highlights the potential of MEP monitoring as an intraoperative, real-time predictive tool for clinical recovery after decompression in patients with CSM.</div></div>","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"54 6","pages":"Article 103022"},"PeriodicalIF":2.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142587277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Twenty years of SIRPIDs: What have we learned?","authors":"Michael W.K. Fong , Lawrence J. Hirsch","doi":"10.1016/j.neucli.2024.103024","DOIUrl":"10.1016/j.neucli.2024.103024","url":null,"abstract":"","PeriodicalId":19134,"journal":{"name":"Neurophysiologie Clinique/Clinical Neurophysiology","volume":"54 6","pages":"Article 103024"},"PeriodicalIF":2.7,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142535199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}