Neuroendocrinology最新文献_第9页

Endocrine Aspects of Pain Pathophysiology: Focus on Adipose Tissue. 疼痛病理生理学的内分泌方面：关注脂肪组织。

IF 3.2 2区医学

Neuroendocrinology Pub Date : 2024-01-01 Epub Date: 2024-05-28 DOI: 10.1159/000539531

Mete Ozcan, Ahmet Ayar

{"title":"Endocrine Aspects of Pain Pathophysiology: Focus on Adipose Tissue.","authors":"Mete Ozcan, Ahmet Ayar","doi":"10.1159/000539531","DOIUrl":"10.1159/000539531","url":null,"abstract":"Background: Multiple factors, including neurobiological, hormonal, psychological, and social/cultural norms, influence the manner in which individuals experience pain. Adipose tissue, once considered solely an energy storage site, has been recognized as a significant endocrine organ that produces and releases a range of hormones and cytokines. In recent years, research has highlighted the role of adipose tissue and its endocrine factors in the pathophysiology of pain.Summary: This narrative review aimed to provide a comprehensive overview of the current knowledge on the endocrine aspects of pain pathophysiology, with a specific focus on adipose tissue. We examine the role of adipokines released by adipose tissue, such as leptin, adiponectin, resistin, visfatin, asprosin in pain perception and response. We also explore the clinical implications of these findings, including the potential for personalized pain management based on endocrine factors and adipose tissue.Key messages: Overall, given this background, this review intended to highlight the importance of understanding the endocrine aspects of pain pathophysiology, particularly focusing on the role of adipose tissue, in the development of chronic pain and adipokines. Better understanding the role of adipokines in pain modulation might have therapeutic implications by providing novel targets for addressing underlying mechanism rather than directly focusing on symptoms for chronic pain, particularly in obese individuals.","PeriodicalId":19117,"journal":{"name":"Neuroendocrinology","volume":" ","pages":"894-906"},"PeriodicalIF":3.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141158748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hyperandrogenism Decreases Seizure Threshold in a Rat Model of Polycystic Ovary Syndrome. 高雄激素会降低多囊卵巢综合征大鼠模型的癫痫阈值

IF 3.2 2区医学

Neuroendocrinology Pub Date : 2024-01-01 Epub Date: 2024-07-25 DOI: 10.1159/000540523

Jiaxian Zhang, Wanlin Lai, Yusha Tang, Jing Gao, Xiangyang Zhou, Lei Chen

{"title":"Hyperandrogenism Decreases Seizure Threshold in a Rat Model of Polycystic Ovary Syndrome.","authors":"Jiaxian Zhang, Wanlin Lai, Yusha Tang, Jing Gao, Xiangyang Zhou, Lei Chen","doi":"10.1159/000540523","DOIUrl":"10.1159/000540523","url":null,"abstract":"Introduction: In women of childbearing age with epilepsy, 30% experience the comorbidity of polycystic ovary syndrome (PCOS), which is marked by a higher prevalence of hyperandrogenism. Our recent clinical observations indicate the potential contribution of hyperandrogenism-induced PCOS to epilepsy susceptibility, and this study aimed to unravel the underlying factors that increase the susceptibility of females to epilepsy.Methods: A letrozole-induced PCOS rat model was employed to simulate endogenous hyperandrogenism. The threshold of seizure was assessed through seizure kindling rates using pentetrazol and electroencephalogram recordings. Additionally, the role of androgens in epilepsy was verified through interventions using Diane-35.Results: This study revealed that letrozole-induced elevated testosterone levels and PCOS-related changes in female rats. PCOS rats, through pentetrazol-kindling, exhibited a reduced seizure threshold compared with controls. Elevated testosterone levels were observed in both the hippocampal and frontal brain tissues, accompanied by changes in circulation. Two weeks of Diane-35 intervention showed a tendency to alleviate these changes, modifying testosterone levels in both the plasma and brain tissue. Western blotting and immunohistochemistry revealed increased expression of GABA-A receptor in the hippocampus and decreased AMPA receptor expression in the frontal cortex, correlating with antiepileptic status in PCOS rats.Conclusion: This study delves into the impact of elevated androgen levels on seizure threshold, providing crucial insights into the underpinnings of the comorbidity between PCOS and epilepsy. These findings significantly contribute to the evolving field of epilepsy research, emphasizing the imperative consideration of hormonal influences for the development of targeted therapeutic interventions in individuals with epilepsy and PCOS.","PeriodicalId":19117,"journal":{"name":"Neuroendocrinology","volume":" ","pages":"1005-1017"},"PeriodicalIF":3.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141760040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Glutamine-Glutamate Cycle Contributes to Behavioral Feminization in Female Rats. 谷氨酰胺-谷氨酸循环有助于雌性大鼠的行为女性化

IF 3.2 2区医学

Neuroendocrinology Pub Date : 2024-01-01 Epub Date: 2024-08-23 DOI: 10.1159/000541102

Shu-Ling Liang, Rou-Shayn Chen

{"title":"The Glutamine-Glutamate Cycle Contributes to Behavioral Feminization in Female Rats.","authors":"Shu-Ling Liang, Rou-Shayn Chen","doi":"10.1159/000541102","DOIUrl":"10.1159/000541102","url":null,"abstract":"Introduction: In perinatal female rats, the glutamine (Gln)-glutamate cycle (GGC) constitutively supplies Gln to neurons of the ventral lateral ventromedial nucleus of the hypothalamus (vlVMH) to sustain glutamatergic synaptic transmission (GST). In contrast, male pups may use Gln only during periods of elevated neuronal activity. Perinatal disruption of the GGC has sex-specific effects on the GST and morphology of vlVMH neurons during adulthood. Since (vl)VMH neuronal activities regulate mating behavior expression, we hypothesize that maintaining a perinatal intact GGC may be essential for the sexual differentiation of reproductive behaviors.Methods: Using perinatal rats of both sexes, we pharmacologically killed astrocytes or blocked the GGC and supplemented them with exogenous Gln. Mating behavior, an open-field test and protein levels of GGC enzymes were examined during adulthood.Results: Killing astrocytes reduced mating behavior expression by 38-48% and 71-72% in male and female rats, respectively. Any blocker targeting the GGC consistently reduced female lordosis behavior by 52-73% and increased glutaminase protein levels in the hypothalamus, but blockers had no effect on the expression of or motivation for copulatory behavior in males. Exogenous Gln supplementation partly rescued the decline in Gln synthetase inhibitor-mediated sex behavior in females. Perinatal interruption of the GGC did not increase induced expression of female sexual behavior in hormone-primed castrated male rats or affect locomotion or anxiety-like behavior in either sex.Conclusion: The intact GGC is necessary for behavioral feminization in female rats and may play little or no role in behavioral masculinization or defeminization in males.","PeriodicalId":19117,"journal":{"name":"Neuroendocrinology","volume":" ","pages":"1045-1065"},"PeriodicalIF":3.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11548894/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142056153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Somatostatin Receptor Imaging in Mice with Difference Positive Rate of SSTR2. SSTR2阳性率不同小鼠的生长抑素受体显像。

IF 3.2 2区医学

Neuroendocrinology Pub Date : 2024-01-01 Epub Date: 2023-11-04 DOI: 10.1159/000535037

Qing Xie, Wenyuan Zhou, Xiangxi Meng, Jin Ding, Dan Li, Ming Lu, Zhi Yang, Jiangyuan Yu

{"title":"Somatostatin Receptor Imaging in Mice with Difference Positive Rate of SSTR2.","authors":"Qing Xie, Wenyuan Zhou, Xiangxi Meng, Jin Ding, Dan Li, Ming Lu, Zhi Yang, Jiangyuan Yu","doi":"10.1159/000535037","DOIUrl":"10.1159/000535037","url":null,"abstract":"Introduction: Imaging with [68Ga]Ga-DOTA-TATE, [68Ga]Ga-DOTA-JR11, and [18F]AlF-NOTA-JR11 was performed to analyze differences among the three probes and to analyze the correlation between the image and pathology parameters.Method: Tumor-bearing mice with different positive rates of somatostatin receptor II (SSTR2) were established with HEK293-SSTR2 and HEK293 cells, and imaging was performed on the same mouse with [68Ga]Ga-DOTA-TATE, [68Ga]Ga-DOTA-JR11, and [18F]AlF-NOTA-JR11 at 20, 60, and 120 min. The image parameters were obtained, including the maximum standard uptake value (SUVmax), mean standard uptake value (SUVmean), standard deviation of SUVmean, tumor volume, and coefficient of variation (CoV). Immunohistochemistry (IHC) of the tumor was performed after imaging to obtain positive rate of SSTR2. Statistical analysis was performed to analyze the differences among the three imaging techniques and the correlations between the relative imaging parameter and IHC.Result: The SUVmax of [18F]AlF-NOTA-JR11 at 20 min and 60 min was higher than that of [68Ga]Ga-DOTA-TATE (p = 0.0015, 0.0035) and [68Ga]Ga-DOTA-JR11 (p = 0.033, 0.019), and no significant difference was found in the other groups (p > 0.05). There was a significant positive correlation between the positive rate and SUVmean of tumors with three tracers (p < 0.05). However, a significant negative correlation between the positive rate and CoV was found only in the [68Ga]Ga-DOTA-TATE group at 60 min and 120 min (p = 0.048, 0.026).Conclusion: [18F]AlF-NOTA-JR11 is more suitable for SSTR imaging within an hour than other two tracers. SUVmean of whole tumor can become an indicator for evaluating the positive rate of IHC, and the higher SUVmean of three tracers means a higher positive rate. However, the CoV is not applicable to the two antagonist tracers for evaluating the positive rate.","PeriodicalId":19117,"journal":{"name":"Neuroendocrinology","volume":" ","pages":"848-855"},"PeriodicalIF":3.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71484227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alteration of Thyroid Hormones in Mouse Models of Alzheimer's Disease and Aging. 阿尔茨海默病和衰老小鼠模型中甲状腺激素的变化。

IF 3.2 2区医学

Neuroendocrinology Pub Date : 2024-01-01 Epub Date: 2024-01-16 DOI: 10.1159/000536089

Siyuan Zhu, Yidan Pang, Xiangwei Zhang, Chunying Yang, Junjie Gao, Ping Fang, Yaohui Zhang, Yunjin Yao, Fangyu Ju, Fang Ye, Hongyi Zhu, Peng Liao, Lufeng Yao, Lulu Dai, Jun Xu, Bo Wu, Jun Pan, Yijun Wu

{"title":"Alteration of Thyroid Hormones in Mouse Models of Alzheimer's Disease and Aging.","authors":"Siyuan Zhu, Yidan Pang, Xiangwei Zhang, Chunying Yang, Junjie Gao, Ping Fang, Yaohui Zhang, Yunjin Yao, Fangyu Ju, Fang Ye, Hongyi Zhu, Peng Liao, Lufeng Yao, Lulu Dai, Jun Xu, Bo Wu, Jun Pan, Yijun Wu","doi":"10.1159/000536089","DOIUrl":"10.1159/000536089","url":null,"abstract":"Introduction: Aging is characterized by the deterioration of a wide range of functions in tissues and organs, and Alzheimer's disease (AD) is a neurodegenerative disease characterized by cognitive impairment. Hypothyroidism occurs when there is insufficient production of thyroid hormones (THs) by the thyroid. The relationship between hypothyroidism and aging as well as AD is controversial at present.Methods: We established an animal model of AD (FAD4T) with mutations in the APP and PSEN1 genes, and we performed a thyroid function test and RNA sequencing (RNA-Seq) of the thyroid from FAD4T and naturally aging mice. We also studied gene perturbation correlation in the FAD4T mouse thyroid, bone marrow, and brain by further single-cell RNA sequencing (scRNA-seq) data of the bone marrow and brain.Results: In this study, we found alterations in THs in both AD and aging mice. RNA-seq data showed significant upregulation of T-cell infiltration- and cell proliferation-related genes in FAD4T mouse thyroid. In addition, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses revealed that upregulated genes were enriched in the functional gene modules of activation of immune cells. Downregulated energy metabolism-related genes were prominent in aging thyroids, which reflected the reduction in THs. GSEA showed a similar enrichment tendency in both mouse thyroids, suggesting their analogous inflammation state. In addition, the regulation of leukocyte activation and migration was a common signature between the thyroid, brain, and bone marrow of FAD4T mice.Conclusions: Our findings identified immune cell infiltration of the thyroid as the potential underlying mechanism of the alteration of THs in AD and aging.","PeriodicalId":19117,"journal":{"name":"Neuroendocrinology","volume":" ","pages":"411-422"},"PeriodicalIF":3.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139479020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enucleation for Sporadic Nonfunctioning Pancreatic Neuroendocrine Tumors Larger than 2 Centimeters Is Associated with Equivalent Morbidity and Survival Compared to Smaller Tumors: A Multi-Institutional Study. 对大于 2 厘米的散发性无功能胰腺神经内分泌肿瘤进行去核手术，其发病率和生存率与较小肿瘤相当：一项多机构研究。

IF 3.2 2区医学

Neuroendocrinology Pub Date : 2024-01-01 Epub Date: 2024-08-23 DOI: 10.1159/000541078

Elias Karam, Alexandra Nassar, Sara Elkurdi, Guillaume Péré, Thomas Freville, Edouard Wasielewski, Anaïs Palen, Julie Périnel, Jean-Christophe Lifante, Emilie Lermite, Ugo Marchese, Mustapha Adham, Olivier Turrini, Laurent Sulpice, Nicolas Régenet, Nicolas Carrère, Sébastien Gaujoux, François Pattou, Alain Sauvanet

{"title":"Enucleation for Sporadic Nonfunctioning Pancreatic Neuroendocrine Tumors Larger than 2 Centimeters Is Associated with Equivalent Morbidity and Survival Compared to Smaller Tumors: A Multi-Institutional Study.","authors":"Elias Karam, Alexandra Nassar, Sara Elkurdi, Guillaume Péré, Thomas Freville, Edouard Wasielewski, Anaïs Palen, Julie Périnel, Jean-Christophe Lifante, Emilie Lermite, Ugo Marchese, Mustapha Adham, Olivier Turrini, Laurent Sulpice, Nicolas Régenet, Nicolas Carrère, Sébastien Gaujoux, François Pattou, Alain Sauvanet","doi":"10.1159/000541078","DOIUrl":"10.1159/000541078","url":null,"abstract":"Introduction: Nonfunctioning pancreatic neuroendocrine tumor (NF-PanNET) ≤2 cm can be observed or resected. Surgery remains recommended for NF-PanNET >2 cm but its extent, enucleation (EN) versus formal resection, remains controversial.Methods: Multicentric retrospective cohort of sporadic NF-PanNET patients treated with EN. Short- and long-term outcomes were compared according to tumor size on imaging ≤2 cm versus >2 cm.Results: 131 patients underwent EN for NF-PanNET, including 103 (79.0%) ≤2 cm and 28 (21.0%) >2 cm (extremes, 4-55 mm). Patients' characteristics were comparable, and tumor characteristics only differed in their diameter. Clavien III-IV complications were similar (18.4% vs. 17.9%, p = 1.00) with one death in NF-PanNET ≤2 cm. Grade B/C pancreatic fistula were comparable (16.5% vs. 10.7%, p = 0.850). In NF-PanNET >2 cm there were more pT2/3 stage tumors (85.7% vs. 21.4%, p < 0.001), similar rates of grade G2/3 tumors (25% vs. 16.5%, p = 0.408) with a median Ki67 of 2 (interquartile range: 1-3), and of lymphovascular and perineural invasions. Lymph node picking was done in 46 (35.1%) patients, with a higher median number of harvested lymph nodes in NF-PanNET >2 cm (4 vs. 3, p = 0.01). All were pN0. R0 resection rate (78.6% vs. 82.5%, respectively; p = 0.670) was equivalent. Five-year overall (100% vs. 99%, p = 0.602) and 10-year disease-free (96% vs. 92%, respectively; p = 0.532) survivals were comparable.Conclusions: EN for selected NF-PanNET >2 cm carries equivalent morbidity, overall and disease-free survivals compared to those observed with NF-PanNET ≤2 cm.","PeriodicalId":19117,"journal":{"name":"Neuroendocrinology","volume":" ","pages":"1034-1044"},"PeriodicalIF":3.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142056151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum. 勘误。

IF 3.2 2区医学

Neuroendocrinology Pub Date : 2024-01-01 Epub Date: 2024-05-06 DOI: 10.1159/000538845

引用次数: 0

Single-Cell RNA Sequencing and Its Applications in Pituitary Research. 单细胞 RNA 测序及其在垂体研究中的应用。

IF 3.2 2区医学

Neuroendocrinology Pub Date : 2024-01-01 Epub Date: 2024-07-25 DOI: 10.1159/000540352

Shuangjian Yang, Congcong Deng, Changqin Pu, Xuexue Bai, Chenxin Tian, Mengqi Chang, Ming Feng

{"title":"Single-Cell RNA Sequencing and Its Applications in Pituitary Research.","authors":"Shuangjian Yang, Congcong Deng, Changqin Pu, Xuexue Bai, Chenxin Tian, Mengqi Chang, Ming Feng","doi":"10.1159/000540352","DOIUrl":"10.1159/000540352","url":null,"abstract":"Background: Mounting evidence underscores the significance of cellular diversity within the endocrine system and the intricate interplay between different cell types and tissues, essential for preserving physiological balance and influencing disease trajectories. The pituitary gland, a central player in the endocrine orchestra, exemplifies this complexity with its assortment of hormone-secreting and nonsecreting cells.Summary: The pituitary gland houses several types of cells responsible for hormone production, alongside nonsecretory cells like fibroblasts and endothelial cells, each playing a crucial role in the gland's function and regulatory mechanisms. Despite the acknowledged importance of these cellular interactions, the detailed mechanisms by which they contribute to pituitary gland physiology and pathology remain largely uncharted. The last decade has seen the emergence of groundbreaking technologies such as single-cell RNA sequencing, offering unprecedented insights into cellular heterogeneity and interactions. However, the application of this advanced tool in exploring the pituitary gland's complexities has been scant. This review provides an overview of this methodology, highlighting its strengths and limitations, and discusses future possibilities for employing it to deepen our understanding of the pituitary gland and its dysfunction in disease states.Key message: Single-cell RNA sequencing technology offers an unprecedented means to study the heterogeneity and interactions of pituitary cells, though its application has been limited thus far. Further utilization of this tool will help uncover the complex physiological and pathological mechanisms of the pituitary, advancing research and treatment of pituitary diseases.","PeriodicalId":19117,"journal":{"name":"Neuroendocrinology","volume":" ","pages":"875-893"},"PeriodicalIF":3.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11460981/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141760041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Programmed Cell Death Ligand 1 Expression in Pituitary Tumours: Lessons from the Current Literature. 垂体瘤中 PD-L1 表达的作用：从现有文献中汲取的教训。

IF 3.2 2区医学

Neuroendocrinology Pub Date : 2024-01-01 Epub Date: 2024-05-16 DOI: 10.1159/000539345

Mariana Lopes-Pinto, Ema Lacerda-Nobre, Ana Luísa Silva, Francisco Tortosa, Pedro Marques

{"title":"The Role of Programmed Cell Death Ligand 1 Expression in Pituitary Tumours: Lessons from the Current Literature.","authors":"Mariana Lopes-Pinto, Ema Lacerda-Nobre, Ana Luísa Silva, Francisco Tortosa, Pedro Marques","doi":"10.1159/000539345","DOIUrl":"10.1159/000539345","url":null,"abstract":"Background: Programmed cell death-1 (PD-1) and PD ligand-1 (PD-L1) expression predict the biological behaviour, aggressiveness, and response to immune checkpoint inhibitors in different cancers. We reviewed the published data on PD-L1 expression in pituitary tumours from the perspective of its biological role and prognostic usefulness.Summary: A literature review focused on PD-L1 expression in pituitary tumours was performed. Six immunohistochemistry-based studies which assessed PD-L1 positivity in pituitary tumours were included, encompassing 704 patients. The cohort consisted of 384 (54.5%) nonfunctioning tumours and 320 (43.5%) functioning pituitary tumours. PD-L1 expression was positive in 248 cases (35.2%). PD-L1 positivity rate was higher in functioning than in nonfunctioning tumours (46.3% vs. 26.0%; p < 0.001) but also higher in growth hormone-secreting tumours (56.7%) and prolactinomas (53.6%) than in thyrotroph (33.3%) or corticotroph tumours (20.6%). While proliferative pituitary tumours showed higher rate of PD-L1 positivity than non-proliferative tumours (p < 0.001), no association with invasion or recurrence was found.Key messages: PD-L1 is expressed in a substantial number of pituitary tumours, predominantly in the functioning ones. PD-L1 positivity rates were significantly higher in proliferative pituitary tumours in comparison to non-proliferative tumours, but no differences were found concerning invasive or recurrent pituitary tumours. More studies following homogeneous and standardised methodologies are needed to fully elucidate the role and usefulness of PD-L1 expression in pituitary tumours.","PeriodicalId":19117,"journal":{"name":"Neuroendocrinology","volume":" ","pages":"709-720"},"PeriodicalIF":3.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140958595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response of Neuropeptides to Hunger Signals in Teleost. 神经肽对鱼类饥饿信号的反应

IF 3.2 2区医学

Neuroendocrinology Pub Date : 2024-01-01 Epub Date: 2023-12-24 DOI: 10.1159/000535611

Xiaozheng Yu, Jiaqi Li, Yixuan Guo, Yang Yu, Ran Cai, Benliang Chen, Minyao Chen, Caiyun Sun, Wensheng Li

{"title":"Response of Neuropeptides to Hunger Signals in Teleost.","authors":"Xiaozheng Yu, Jiaqi Li, Yixuan Guo, Yang Yu, Ran Cai, Benliang Chen, Minyao Chen, Caiyun Sun, Wensheng Li","doi":"10.1159/000535611","DOIUrl":"10.1159/000535611","url":null,"abstract":"Introduction: The perception of hunger is a complex physiological process that requires precise coordination between the central and peripheral tissues.Methods: In this study, tilapia fasted for 24 h was chosen to establish a hunger model to study the mechanism of homeostasis recovery under the joint regulation of the central nervous system (CNS) and peripheral tissues.Results: The gastric and intestinal contents of tilapia were predominantly depleted after a fasting period of 9 h and 24 h, respectively. The serum glucose level significantly decreased at the 9-h and 24-h fasting, respectively, and the glucokinase-dependent glucosensing mechanism in the liver was identified as well as the significant activation of phospho-AMPK. However, fasting for 24 h did not activate glucosensing mechanisms and AMPK signaling pathways in the hypothalamus. On the other hand, significant reductions were observed in the mRNA levels of the lipid synthesis-related genes fas and accα, and the serum triglyceride levels as well. The mRNA levels of npy, agrp, pomc, and cart in the hypothalamus fluctuated during the fasting period without significant differences. With in situ hybridization npy signals upregulated in the ventral zone of posterior periventricular nucleus after 24-h fasting, pomc signals enhanced in the lateral tuberal nucleus. Based on the serum metabolomic analysis, the levels of branched-chain amino acids, butyrate, and short-chain acylcarnitine decreased, while those of medium- and long-chain acylcarnitine increased.Conclusion: Fasting for 24 h resulted in changes in npy and pomc signals within the hypothalamus and triggered the glucosensing mechanism in the liver of tilapia. This study is beneficial for elucidating the response of neuropeptides in the CNS to the changes of nutritional factors when hungry.","PeriodicalId":19117,"journal":{"name":"Neuroendocrinology","volume":" ","pages":"365-385"},"PeriodicalIF":3.2,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139032480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0