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Neurogastroenterology & Motility最新文献

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Nigral overexpression of α‐synuclein in a rat Parkinson’s disease model indicates alterations in the enteric nervous system and the gut microbiome α -突触核蛋白在大鼠帕金森病模型中的过度表达表明肠道神经系统和肠道微生物组的改变
Neurogastroenterology & Motility Pub Date : 2020-01-01 DOI: 10.1111/nmo.13726
Sarah M O'Donovan, Erin K. Crowley, J. Brown, Ó. O’Sullivan, O. O'Leary, Suzanne Timmons, Y. Nolan, D. Clarke, N. Hyland, S. Joyce, A. Sullivan, C. O'Neill
{"title":"Nigral overexpression of α‐synuclein in a rat Parkinson’s disease model indicates alterations in the enteric nervous system and the gut microbiome","authors":"Sarah M O'Donovan, Erin K. Crowley, J. Brown, Ó. O’Sullivan, O. O'Leary, Suzanne Timmons, Y. Nolan, D. Clarke, N. Hyland, S. Joyce, A. Sullivan, C. O'Neill","doi":"10.1111/nmo.13726","DOIUrl":"https://doi.org/10.1111/nmo.13726","url":null,"abstract":"A hallmark feature of Parkinson's disease (PD) is the build‐up of α‐synuclein protein aggregates throughout the brain; however α‐synuclein is also expressed in enteric neurons. Gastrointestinal (GI) symptoms and pathology are frequently reported in PD, including constipation, increased intestinal permeability, glial pathology, and alterations to gut microbiota composition. α‐synuclein can propagate through neuronal systems but the site of origin of α‐synuclein pathology, whether it be the gut or the brain, is still unknown. Physical exercise is associated with alleviating symptoms of PD and with altering the composition of the gut microbiota.","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85994113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 53
Enteric cholinergic neuropathy in patients with diabetes: Non‐invasive assessment with positron emission tomography 糖尿病患者肠胆碱能神经病:正电子发射断层扫描无创评估
Neurogastroenterology & Motility Pub Date : 2020-01-01 DOI: 10.1111/nmo.13731
M. Klinge, P. Borghammer, Sten Lund, T. Fedorova, K. Knudsen, A. Haase, J. Christiansen, K. Krogh
{"title":"Enteric cholinergic neuropathy in patients with diabetes: Non‐invasive assessment with positron emission tomography","authors":"M. Klinge, P. Borghammer, Sten Lund, T. Fedorova, K. Knudsen, A. Haase, J. Christiansen, K. Krogh","doi":"10.1111/nmo.13731","DOIUrl":"https://doi.org/10.1111/nmo.13731","url":null,"abstract":"11C‐Donepezil positron emission tomography (PET) allows non‐invasive assessment of cholinergic innervation of visceral organs. We aimed to compare cholinergic innervation in the gut in patients with diabetes mellitus (DM) and in healthy controls (HC).","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82474165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Impaired gastric mucosal integrity identified by confocal endomicroscopy in Helicobacter pylori‐negative functional dyspepsia 在幽门螺杆菌阴性的功能性消化不良患者中，共聚焦内镜下发现胃粘膜完整性受损
Neurogastroenterology & Motility Pub Date : 2020-01-01 DOI: 10.1111/nmo.13719
Rui Ji, Peng Wang, Guan-jun Kou, X. Zuo, Xiao Wang, Yan-Qing Li
{"title":"Impaired gastric mucosal integrity identified by confocal endomicroscopy in Helicobacter pylori‐negative functional dyspepsia","authors":"Rui Ji, Peng Wang, Guan-jun Kou, X. Zuo, Xiao Wang, Yan-Qing Li","doi":"10.1111/nmo.13719","DOIUrl":"https://doi.org/10.1111/nmo.13719","url":null,"abstract":"Low‐grade inflammation may be involved in the pathogenesis of functional dyspepsia (FD). We hypothesis that altered gastric permeability is involved in the onset and persistence of this disorder. Therefore, our aim was to evaluate gastric mucosal integrity and mast cell numbers in patients with FD.","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74754147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Functional involvement of acid‐sensing ion channel 3 in the swallowing reflex in rats 酸感离子通道3在大鼠吞咽反射中的功能参与
Neurogastroenterology & Motility Pub Date : 2020-01-01 DOI: 10.1111/nmo.13728
M. Z. Hossain, Hiroshi Ando, S. Unno, T. Nakamoto, Junichi Kitagawa
{"title":"Functional involvement of acid‐sensing ion channel 3 in the swallowing reflex in rats","authors":"M. Z. Hossain, Hiroshi Ando, S. Unno, T. Nakamoto, Junichi Kitagawa","doi":"10.1111/nmo.13728","DOIUrl":"https://doi.org/10.1111/nmo.13728","url":null,"abstract":"Difficulty swallowing represents a major health problem. Swallowing function is improved by incorporating weak acids in suspensions/food boluses, implicating acid‐sensing ion channels (ASICs) in the swallowing reflex. However, the functional involvement of ASICs in the swallowing reflex has not been fully elucidated.","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73958277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Enterocolic increase of cannabinoid receptor type 1 and type 2 and clinical improvement after probiotic administration in dogs with chronic signs of colonic dysmotility without mucosal inflammatory changes 无黏膜炎症改变的慢性结肠运动障碍犬，服用益生菌后肠结肠1型和2型大麻素受体增加及临床改善
Neurogastroenterology & Motility Pub Date : 2020-01-01 DOI: 10.1111/nmo.13717
G. Rossi, G. Gioacchini, G. Pengo, J. Suchodolski, A. Jergens, K. Allenspach, A. Gavazza, S. Scarpona, S. Berardi, L. Galosi, G. Bassotti, M. Cerquetella
{"title":"Enterocolic increase of cannabinoid receptor type 1 and type 2 and clinical improvement after probiotic administration in dogs with chronic signs of colonic dysmotility without mucosal inflammatory changes","authors":"G. Rossi, G. Gioacchini, G. Pengo, J. Suchodolski, A. Jergens, K. Allenspach, A. Gavazza, S. Scarpona, S. Berardi, L. Galosi, G. Bassotti, M. Cerquetella","doi":"10.1111/nmo.13717","DOIUrl":"https://doi.org/10.1111/nmo.13717","url":null,"abstract":"Colonic dysmotility in dogs can cause different GI signs. Sometimes, histology of enterocolic biopsies does not reveal inflammatory infiltrates or mucosal lesions that are typically associated with clinical disease activity. It is speculated that, similarly to humans, colonic dysmotility may be anxiety‐based, although recent data demonstrate that irritable bowel syndrome (IBS) could result from acute infectious enteritis. Specific Lactobacillus spp. strains administered orally in humans induced the expression of μ‐opioid and cannabinoid receptors in mucosal enterocytes, modulating intestinal morphine‐like analgesic functions. We investigated the potential association of GI signs caused by colonic dysmotility and mucosal expression of cannabinoid receptors in intestinal epithelial cells and the number of mucosal mast cells.","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84800552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Implementation of the low FODMAP diet in functional gastrointestinal symptoms: A real‐world experience 在功能性胃肠道症状中实施低FODMAP饮食:一个真实世界的经验
Neurogastroenterology & Motility Pub Date : 2020-01-01 DOI: 10.1111/nmo.13730
C. Tuck, D. Reed, J. Muir, S. Vanner
{"title":"Implementation of the low FODMAP diet in functional gastrointestinal symptoms: A real‐world experience","authors":"C. Tuck, D. Reed, J. Muir, S. Vanner","doi":"10.1111/nmo.13730","DOIUrl":"https://doi.org/10.1111/nmo.13730","url":null,"abstract":"The low FODMAP (fermentable oligo‐, di‐, monosaccharides, and polyols) diet reduces functional gastrointestinal symptoms (FGID) when implemented by dietitian‐delivered education in clinical trials, but it is unknown how well the diet is followed in routine clinical care and if differences exist when implemented by physician or dietitian. This study aimed to evaluate the real‐world experience of patients recommended the diet.","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"69 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91100321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 49
Association between allelic variants in the glucagon‐like peptide 1 and cholecystokinin receptor genes with gastric emptying and glucose tolerance 胰高血糖素样肽1和胆囊收缩素受体基因等位变异与胃排空和葡萄糖耐量的关系
Neurogastroenterology & Motility Pub Date : 2020-01-01 DOI: 10.1111/nmo.13724
B. Anderson, P. Carlson, Marcello C. Laurenti, A. Vella, M. Camilleri, Anshuman C. Desai, Kelly J. Feuerhak, A. Bharucha
{"title":"Association between allelic variants in the glucagon‐like peptide 1 and cholecystokinin receptor genes with gastric emptying and glucose tolerance","authors":"B. Anderson, P. Carlson, Marcello C. Laurenti, A. Vella, M. Camilleri, Anshuman C. Desai, Kelly J. Feuerhak, A. Bharucha","doi":"10.1111/nmo.13724","DOIUrl":"https://doi.org/10.1111/nmo.13724","url":null,"abstract":"Nutrient‐mediated release of cholecystokinin and glucagon‐like peptide‐1 (GLP‐1) regulates gastric emptying (GE) via duodenogastric feedback mechanisms; GLP‐1 also regulates postprandial insulin secretion. Some patients with functional upper gastrointestinal symptoms have impaired glucose tolerance during enteral dextrose infusion. Our hypothesis was that variants in CCK, GLP‐1, and TCF7L2 (transcription factor 7‐like 2 locus), which is associated with greatest genetic risk for development of type 2 diabetes mellitus, are associated with GE and independently with glucose tolerance. Our aims were to evaluate the associations between these GE, glucose tolerance, and these single nucleotide polymorphisms (SNPs).","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85049834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Characterization of gastrointestinal pathologies in the dystonia musculorum mouse model for hereditary sensory and autonomic neuropathy type VI 遗传性感觉和自主神经病变VI型肌张力障碍小鼠模型的胃肠病理特征
Neurogastroenterology & Motility Pub Date : 2019-12-09 DOI: 10.1111/nmo.13773
Anisha Lynch-Godrei, Y. De Repentigny, R. Yaworski, Sabrina Gagnon, J. Butcher, J. Manoogian, A. Stintzi, R. Kothary
{"title":"Characterization of gastrointestinal pathologies in the dystonia musculorum mouse model for hereditary sensory and autonomic neuropathy type VI","authors":"Anisha Lynch-Godrei, Y. De Repentigny, R. Yaworski, Sabrina Gagnon, J. Butcher, J. Manoogian, A. Stintzi, R. Kothary","doi":"10.1111/nmo.13773","DOIUrl":"https://doi.org/10.1111/nmo.13773","url":null,"abstract":"Dystonia musculorum (Dstdt) is a murine disease caused by recessive mutations in the dystonin (Dst) gene. Loss of dorsal root ganglion (DRG) sensory neurons, ataxia, and dystonic postures before death by postnatal day 18 (P18) is a hallmark feature. Recently we observed gas accumulation and discoloration in the small intestine and cecum in Dstdt mice by P15. The human disease resulting from dystonin loss‐of‐function, known as hereditary sensory and autonomic neuropathy type VI (HSAN‐VI), has also been associated with gastrointestinal (GI) symptoms including chronic diarrhea and abdominal pain. As neuronal dystonin isoforms are expressed in the GI tract, we hypothesized that dystonin loss‐of‐function in Dstdt‐27J enteric nervous system (ENS) neurons resulted in neurodegeneration associated with the GI abnormalities.","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73130451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of O‐1602 and CBD on TNBS‐induced colonic disturbances O - 1602和CBD对TNBS诱导的结肠紊乱的影响
Neurogastroenterology & Motility Pub Date : 2019-12-04 DOI: 10.1111/nmo.13756
DanDan Wei, HuiChao Wang, JingNan Yang, ZhiFeng Dai, Ruilin Yang, ShuangShuang Meng, Yongyu Li, Xuhong Lin
{"title":"Effects of O‐1602 and CBD on TNBS‐induced colonic disturbances","authors":"DanDan Wei, HuiChao Wang, JingNan Yang, ZhiFeng Dai, Ruilin Yang, ShuangShuang Meng, Yongyu Li, Xuhong Lin","doi":"10.1111/nmo.13756","DOIUrl":"https://doi.org/10.1111/nmo.13756","url":null,"abstract":"This study attempted to provide the effects and mechanisms of two cannabinoids, O‐1602 and cannabidiol (CBD), on colonic motility of 2,4,6‐trinitro‐benzene sulfonic acid (TNBS) colitis.","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"79 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76832666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Chronic ingestion of deoxynivalenol‐contaminated diet dose‐dependently decreases the area of myenteric neurons and gliocytes of rats 长期摄入脱氧雪腐镰刀菌醇污染的饮食剂量依赖性地减少了大鼠的肌肠神经元和胶质细胞的面积
Neurogastroenterology & Motility Pub Date : 2019-12-03 DOI: 10.1111/nmo.13770
Débora Furlan Rissato, Ana Paula de Santi Rampazzo, S. Borges, F. C. Sousa, C. Busso, N. Buttow, M. Natali
{"title":"Chronic ingestion of deoxynivalenol‐contaminated diet dose‐dependently decreases the area of myenteric neurons and gliocytes of rats","authors":"Débora Furlan Rissato, Ana Paula de Santi Rampazzo, S. Borges, F. C. Sousa, C. Busso, N. Buttow, M. Natali","doi":"10.1111/nmo.13770","DOIUrl":"https://doi.org/10.1111/nmo.13770","url":null,"abstract":"Deoxynivalenol (DON), a mycotoxin produced by Fusarium spp., is commonly found in cereals ingested by humans and animals. Its ingestion is correlated with hepatic, hematologic, renal, splenic, cardiac, gastrointestinal, and neural damages, according to dose, duration of exposure and species. In this work, the effects of the ingestion of DON‐contaminated diet at concentrations considered tolerable for human and animal intake were assessed.","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83015333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
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