Neurogastroenterology & Motility最新文献

{"title":"Letter in response to Black et al. (2020): Authors’ Reply","authors":"C. Black, A. Ford","doi":"10.1111/nmo.14388","DOIUrl":"https://doi.org/10.1111/nmo.14388","url":null,"abstract":"To the editor; We are grateful to Trindade et al. 1 for their interest in our paper, which examined the factor structure of the visceral sensitivity index (VSI) among 811 individuals with Rome IV irritable bowel syndrome (IBS) from the UK.2 The VSI is a measure of gastrointestinal symptomspecific anxiety that had not been validated in the UK population. The original validation study from the USA reported an unifactorial structure,3 whereas our analysis identified three separate factors. Moreover, we found no evidence that VSI mediated the relationship between measures of generalized anxiety and symptom severity in IBS. In their analysis of 424 Swedish patients with IBS, Trindade et al. report a singlefactor structure in agreement with the original VSI study.1 They discuss that cultural and linguistic differences between studies may have influenced the responses to the VSI, but this seems unlikely. The original VSI was developed in English, and while differences in spelling and usage exist between the UK and the USA, there is nothing that should affect understanding of the VSI in the UK population. Whether Trindade et al. translated the VSI into Swedish is unclear. However, this is unlikely to explain the differences between their results and ours, given the similarity between their findings and those from the USA. The cultural concepts discussed in the VSI, such as eating out in restaurants, will be familiar to people from any Westernized society. Consequently, methodological differences between the studies are likely to be of greater relevance to understanding the contrasting results. The original validation study involved only 96 individuals who selfidentified with IBS, of whom 85% met Rome II criteria.3 We also recruited individuals who selfidentified with IBS, but our study cohort was much larger, and we only included those who met diagnostic criteria for IBS. Moreover, we defined IBS using the current Rome IV criteria.4 These are more specific for diagnosing IBS compared with previous iterations,5,6 but they also select for patients who have more severe symptoms and greater psychological comorbidity.7,8 This may explain why analysis of the VSI in our study yielded a different factor structure than was originally described. Trindade et al. recruited patients referred to a tertiary center among whom reporting gastrointestinal symptomspecific anxiety may conceivably be more homogeneous. Furthermore, it is unclear how they defined IBS in their study. Importantly, their results are not fully published, limiting comparison with our study; however, we agree that further work to validate and refine the VSI is warranted.","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85343174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabotropic 5‐HT receptor‐mediated effects in the human submucous plexus","authors":"A. Annaházi, T. Berger, I. Demir, F. Zeller, M. Müller, Markus Anneser, A. Skerra, K. Michel, M. Schemann","doi":"10.1111/nmo.14380","DOIUrl":"https://doi.org/10.1111/nmo.14380","url":null,"abstract":"Serotonin (5‐HT) is an important mediator in the gastrointestinal tract, acting on different neuronal 5‐HT receptors. The ionotropic 5‐HT3 receptor mediates immediate but transient spike discharge in human enteric neurons. We studied the role of the metabotropic 5‐HT1P, 5‐HT4, and 5‐HT7 receptors to activate human submucous neurons.","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"105 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86628849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic stress increases DNA methylation of the GR promoter in the central nucleus of the amygdala of female rats","authors":"T. Louwies, B. Greenwood-Van Meerveld","doi":"10.1111/nmo.14377","DOIUrl":"https://doi.org/10.1111/nmo.14377","url":null,"abstract":"The central pathophysiological mechanisms underlying irritable bowel syndrome (IBS), a female‐predominant gastrointestinal disorder characterized by abdominal pain and abnormal bowel habits, remain poorly understood. IBS patients often report that chronic stress exacerbates their symptoms. Brain imaging studies have revealed that the amygdala, a stress‐responsive brain region, of IBS patients is overactive when compared to healthy controls. Previously, we demonstrated that downregulation of the glucocorticoid receptor (GR) in the central nucleus of the amygdala (CeA) underlies stress‐induced visceral hypersensitivity in female rats. In the current study, we aimed to evaluate in the CeA of female rats whether chronic water avoidance stress (WAS) alters DNA methylation of the GR exon 17 promoter region, a region homologous to the human GR promoter. As histone deacetylase (HDAC) inhibitors are able to change DNA methylation, we also evaluated whether administration of the HDAC inhibitor trichostatin A (TSA) directly into the CeA prevented WAS‐induced increases in DNA methylation of the GR exon 17 promoter. We found that WAS increased overall and specific CpG methylation of the GR promoter in the CeA of female rats, which persisted for up to 28 days. Administration of the TSA directly into the CeA prevented these stress‐induced changes of DNA methylation at the GR promoter. Our results suggest that, in females, changes in DNA methylation are involved in the regulation of GR expression in the CeA. These changes in DNA methylation may contribute to the central mechanisms responsible for stress‐induced visceral hypersensitivity.","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84935585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction and identification of an immortalized rat intestinal smooth muscle cell line","authors":"Huiling Chen, Xiaoli Li, Li-yun Gao, Dekui Zhang, Tiyun Han","doi":"10.1111/nmo.14359","DOIUrl":"https://doi.org/10.1111/nmo.14359","url":null,"abstract":"Although intestinal smooth muscle cells (ISMCs) play an important role in the remodeling of the intestinal structure, considerably less is known about the molecular mechanisms that mediate the development and growth of ISMCs. A possible reason for this lag is the lack of cell lines that recapitulate ISMCs in vivo.","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77721826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pictograms are more effective than verbal descriptors in Spanish for bloating and distension","authors":"Ruth E. Rabago, Alejandro Bonilla, Ernesto Escamilla-Diego, M. D. F. Higuera de la Tijera, M. Schmulson","doi":"10.1111/nmo.14364","DOIUrl":"https://doi.org/10.1111/nmo.14364","url":null,"abstract":"There is no translation for bloating in Spanish, and distension is very technical.","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87026217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Duodenal cholinergic tuft cell number is increased in functional dyspepsia","authors":"Xinyi Huang, T. Oshima, Y. Akiba, Takanori Yoshimoto, Junji Chen, M. Taki, T. Tomita, H. Fukui, J. Kaunitz, H. Miwa","doi":"10.1111/nmo.14378","DOIUrl":"https://doi.org/10.1111/nmo.14378","url":null,"abstract":"Low‐grade duodenal inflammation has recently been identified in patients with functional dyspepsia (FD). Chemosensory tuft cells were reported to be associated with gastrointestinal diseases. We therefore assessed duodenal tuft cell density and microinflammation in patients with FD to determine whether these measures could serve as useful biomarkers, and also correlated tuft cell density and microinflammation in FD patients.","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75166642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Clinical value of brain‐gut behavioral therapies for functional esophageal disorders and symptoms","authors":"Yuying Luo, L. Keefer","doi":"10.1111/nmo.14373","DOIUrl":"https://doi.org/10.1111/nmo.14373","url":null,"abstract":"Functional esophageal disorders (functional chest pain, functional heartburn, reflux hypersensitivity, globus, and functional dysphagia) are the disorders of gut‐brain interactions (DGBI) and present with esophageal symptoms not associated with a structural, major motility or underlying inflammatory condition. Notably, many patients with the latter conditions may still experience esophageal symptoms beyond what could be attributed to their underlying disorders. Esophageal visceral hypersensitivity and hypervigilance are the two pathways which drive functional esophageal disorders and symptoms. These functional esophageal symptoms may be severe, leaving patients with impaired quality of life and inadequate treatment outcomes. Neuromodulators are the foundation of the pharmacologic approach of many of the functional esophageal disorders and symptoms, modulating both peripheral and central hyperalgesia. There is also emerging evidence for brain‐gut behavioral therapies (BGBT) such as gut‐directed hypnotherapy and cognitive behavior therapy for the treatment of a variety of DGBIs. In this issue of Neurogastroenterology and Motility, Hurtte et al. add to the literature on the effectiveness of BGBT in treating functional esophageal symptoms, showing multimodal therapy with pharmacologic and non‐pharmacologic approaches led to improvement in health‐related quality of life. In this review, we outline the mechanistic underpinnings of BGBT and review the existing evidence for BGBT for functional esophageal disorders and symptoms. We also highlight the future research directions and challenges for scaling these therapies.","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89643969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A double‐blind randomized, multicenter, placebo‐controlled study of itopride in functional dyspepsia postprandial distress syndrome","authors":"F. Carbone, A. Vandenberghe, L. Holvoet, H. Piessevaux, J. Arts, P. Caenepeel, D. Staessen, P. Vergauwe, P. Maldague, T. De Ronde, F. Wuestenberghs, V. Lamy, V. Lefebvre, P. Latour, T. Vanuytsel, Michael Jones, J. Tack","doi":"10.1111/nmo.14337","DOIUrl":"https://doi.org/10.1111/nmo.14337","url":null,"abstract":"Itopride, a mixed D2 antagonist and cholinesterase inhibitor, has prokinetic effects on gastric motility. The Leuven Postprandial Distress Scale is a validated patient‐reported outcome instrument for functional dyspepsia (FD) postprandial distress syndrome (PDS). We aimed to use the LPDS to assess treatment outcome in PDS and PDS/EPS (epigastric pain syndrome).","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87095794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral and central pathophysiological changes in a new rat model of acid reflux combined with mental stress","authors":"Ting-ting Xu, Li Li, Lin Geng, Bingduo Zhou, Shengliang Zhu","doi":"10.1111/nmo.14360","DOIUrl":"https://doi.org/10.1111/nmo.14360","url":null,"abstract":"Mental stress is an important risk factor for gastroesophageal reflux disease (GERD), which interacts with acid reflux and affects the efficacy of single acid suppression treatment. However, the specific mechanism remains elusive, and there is a lack of available models for further support.","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81801884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Model for multi‐disciplinary, multi‐institutional virtual learning: The Stanford Esophageal Virtual Collaborative Conference on benign esophageal diseases","authors":"Afrin N. Kamal, G. Triadafilopoulos, C. Gyawali, L. Nguyen, G. Sayuk, D. Azagury, R. Tatum, J. Clarke","doi":"10.1111/nmo.14369","DOIUrl":"https://doi.org/10.1111/nmo.14369","url":null,"abstract":"","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"61 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85683249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}