发布求助
文献互助 智能选刊 最新文献

Neurogastroenterology & Motility最新文献

筛选
英文 中文
Metabotropic 5‐HT receptor‐mediated effects in the human submucous plexus 代谢5 - HT受体在人粘膜下神经丛中的介导作用
Neurogastroenterology & Motility Pub Date : 2022-04-19 DOI: 10.1111/nmo.14380
A. Annaházi, T. Berger, I. Demir, F. Zeller, M. Müller, Markus Anneser, A. Skerra, K. Michel, M. Schemann
{"title":"Metabotropic 5‐HT receptor‐mediated effects in the human submucous plexus","authors":"A. Annaházi, T. Berger, I. Demir, F. Zeller, M. Müller, Markus Anneser, A. Skerra, K. Michel, M. Schemann","doi":"10.1111/nmo.14380","DOIUrl":"https://doi.org/10.1111/nmo.14380","url":null,"abstract":"Serotonin (5‐HT) is an important mediator in the gastrointestinal tract, acting on different neuronal 5‐HT receptors. The ionotropic 5‐HT3 receptor mediates immediate but transient spike discharge in human enteric neurons. We studied the role of the metabotropic 5‐HT1P, 5‐HT4, and 5‐HT7 receptors to activate human submucous neurons.","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"105 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86628849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Chronic stress increases DNA methylation of the GR promoter in the central nucleus of the amygdala of female rats 慢性应激增加雌性大鼠杏仁核中央核GR启动子的DNA甲基化
Neurogastroenterology & Motility Pub Date : 2022-04-11 DOI: 10.1111/nmo.14377
T. Louwies, B. Greenwood-Van Meerveld
{"title":"Chronic stress increases DNA methylation of the GR promoter in the central nucleus of the amygdala of female rats","authors":"T. Louwies, B. Greenwood-Van Meerveld","doi":"10.1111/nmo.14377","DOIUrl":"https://doi.org/10.1111/nmo.14377","url":null,"abstract":"The central pathophysiological mechanisms underlying irritable bowel syndrome (IBS), a female‐predominant gastrointestinal disorder characterized by abdominal pain and abnormal bowel habits, remain poorly understood. IBS patients often report that chronic stress exacerbates their symptoms. Brain imaging studies have revealed that the amygdala, a stress‐responsive brain region, of IBS patients is overactive when compared to healthy controls. Previously, we demonstrated that downregulation of the glucocorticoid receptor (GR) in the central nucleus of the amygdala (CeA) underlies stress‐induced visceral hypersensitivity in female rats. In the current study, we aimed to evaluate in the CeA of female rats whether chronic water avoidance stress (WAS) alters DNA methylation of the GR exon 17 promoter region, a region homologous to the human GR promoter. As histone deacetylase (HDAC) inhibitors are able to change DNA methylation, we also evaluated whether administration of the HDAC inhibitor trichostatin A (TSA) directly into the CeA prevented WAS‐induced increases in DNA methylation of the GR exon 17 promoter. We found that WAS increased overall and specific CpG methylation of the GR promoter in the CeA of female rats, which persisted for up to 28 days. Administration of the TSA directly into the CeA prevented these stress‐induced changes of DNA methylation at the GR promoter. Our results suggest that, in females, changes in DNA methylation are involved in the regulation of GR expression in the CeA. These changes in DNA methylation may contribute to the central mechanisms responsible for stress‐induced visceral hypersensitivity.","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84935585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Construction and identification of an immortalized rat intestinal smooth muscle cell line 永生化大鼠肠平滑肌细胞系的构建与鉴定
Neurogastroenterology & Motility Pub Date : 2022-04-11 DOI: 10.1111/nmo.14359
Huiling Chen, Xiaoli Li, Li-yun Gao, Dekui Zhang, Tiyun Han
{"title":"Construction and identification of an immortalized rat intestinal smooth muscle cell line","authors":"Huiling Chen, Xiaoli Li, Li-yun Gao, Dekui Zhang, Tiyun Han","doi":"10.1111/nmo.14359","DOIUrl":"https://doi.org/10.1111/nmo.14359","url":null,"abstract":"Although intestinal smooth muscle cells (ISMCs) play an important role in the remodeling of the intestinal structure, considerably less is known about the molecular mechanisms that mediate the development and growth of ISMCs. A possible reason for this lag is the lack of cell lines that recapitulate ISMCs in vivo.","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77721826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Pictograms are more effective than verbal descriptors in Spanish for bloating and distension 在西班牙语中，对于腹胀和腹胀，象形图比口头描述更有效
Neurogastroenterology & Motility Pub Date : 2022-04-08 DOI: 10.1111/nmo.14364
Ruth E. Rabago, Alejandro Bonilla, Ernesto Escamilla-Diego, M. D. F. Higuera de la Tijera, M. Schmulson
{"title":"Pictograms are more effective than verbal descriptors in Spanish for bloating and distension","authors":"Ruth E. Rabago, Alejandro Bonilla, Ernesto Escamilla-Diego, M. D. F. Higuera de la Tijera, M. Schmulson","doi":"10.1111/nmo.14364","DOIUrl":"https://doi.org/10.1111/nmo.14364","url":null,"abstract":"There is no translation for bloating in Spanish, and distension is very technical.","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87026217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Duodenal cholinergic tuft cell number is increased in functional dyspepsia 十二指肠胆碱能丛细胞数目在功能性消化不良时增加
Neurogastroenterology & Motility Pub Date : 2022-04-06 DOI: 10.1111/nmo.14378
Xinyi Huang, T. Oshima, Y. Akiba, Takanori Yoshimoto, Junji Chen, M. Taki, T. Tomita, H. Fukui, J. Kaunitz, H. Miwa
{"title":"Duodenal cholinergic tuft cell number is increased in functional dyspepsia","authors":"Xinyi Huang, T. Oshima, Y. Akiba, Takanori Yoshimoto, Junji Chen, M. Taki, T. Tomita, H. Fukui, J. Kaunitz, H. Miwa","doi":"10.1111/nmo.14378","DOIUrl":"https://doi.org/10.1111/nmo.14378","url":null,"abstract":"Low‐grade duodenal inflammation has recently been identified in patients with functional dyspepsia (FD). Chemosensory tuft cells were reported to be associated with gastrointestinal diseases. We therefore assessed duodenal tuft cell density and microinflammation in patients with FD to determine whether these measures could serve as useful biomarkers, and also correlated tuft cell density and microinflammation in FD patients.","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75166642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
The Clinical value of brain‐gut behavioral therapies for functional esophageal disorders and symptoms 脑肠行为疗法治疗功能性食道疾病及其症状的临床价值
Neurogastroenterology & Motility Pub Date : 2022-04-02 DOI: 10.1111/nmo.14373
Yuying Luo, L. Keefer
{"title":"The Clinical value of brain‐gut behavioral therapies for functional esophageal disorders and symptoms","authors":"Yuying Luo, L. Keefer","doi":"10.1111/nmo.14373","DOIUrl":"https://doi.org/10.1111/nmo.14373","url":null,"abstract":"Functional esophageal disorders (functional chest pain, functional heartburn, reflux hypersensitivity, globus, and functional dysphagia) are the disorders of gut‐brain interactions (DGBI) and present with esophageal symptoms not associated with a structural, major motility or underlying inflammatory condition. Notably, many patients with the latter conditions may still experience esophageal symptoms beyond what could be attributed to their underlying disorders. Esophageal visceral hypersensitivity and hypervigilance are the two pathways which drive functional esophageal disorders and symptoms. These functional esophageal symptoms may be severe, leaving patients with impaired quality of life and inadequate treatment outcomes. Neuromodulators are the foundation of the pharmacologic approach of many of the functional esophageal disorders and symptoms, modulating both peripheral and central hyperalgesia. There is also emerging evidence for brain‐gut behavioral therapies (BGBT) such as gut‐directed hypnotherapy and cognitive behavior therapy for the treatment of a variety of DGBIs. In this issue of Neurogastroenterology and Motility, Hurtte et al. add to the literature on the effectiveness of BGBT in treating functional esophageal symptoms, showing multimodal therapy with pharmacologic and non‐pharmacologic approaches led to improvement in health‐related quality of life. In this review, we outline the mechanistic underpinnings of BGBT and review the existing evidence for BGBT for functional esophageal disorders and symptoms. We also highlight the future research directions and challenges for scaling these therapies.","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89643969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
A double‐blind randomized, multicenter, placebo‐controlled study of itopride in functional dyspepsia postprandial distress syndrome 一项双盲、随机、多中心、安慰剂对照研究:依托必利治疗功能性消化不良餐后窘迫综合征
Neurogastroenterology & Motility Pub Date : 2022-03-31 DOI: 10.1111/nmo.14337
F. Carbone, A. Vandenberghe, L. Holvoet, H. Piessevaux, J. Arts, P. Caenepeel, D. Staessen, P. Vergauwe, P. Maldague, T. De Ronde, F. Wuestenberghs, V. Lamy, V. Lefebvre, P. Latour, T. Vanuytsel, Michael Jones, J. Tack
{"title":"A double‐blind randomized, multicenter, placebo‐controlled study of itopride in functional dyspepsia postprandial distress syndrome","authors":"F. Carbone, A. Vandenberghe, L. Holvoet, H. Piessevaux, J. Arts, P. Caenepeel, D. Staessen, P. Vergauwe, P. Maldague, T. De Ronde, F. Wuestenberghs, V. Lamy, V. Lefebvre, P. Latour, T. Vanuytsel, Michael Jones, J. Tack","doi":"10.1111/nmo.14337","DOIUrl":"https://doi.org/10.1111/nmo.14337","url":null,"abstract":"Itopride, a mixed D2 antagonist and cholinesterase inhibitor, has prokinetic effects on gastric motility. The Leuven Postprandial Distress Scale is a validated patient‐reported outcome instrument for functional dyspepsia (FD) postprandial distress syndrome (PDS). We aimed to use the LPDS to assess treatment outcome in PDS and PDS/EPS (epigastric pain syndrome).","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87095794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Peripheral and central pathophysiological changes in a new rat model of acid reflux combined with mental stress 胃酸反流合并精神应激新模型大鼠外周和中枢病理生理变化
Neurogastroenterology & Motility Pub Date : 2022-03-30 DOI: 10.1111/nmo.14360
Ting-ting Xu, Li Li, Lin Geng, Bingduo Zhou, Shengliang Zhu
{"title":"Peripheral and central pathophysiological changes in a new rat model of acid reflux combined with mental stress","authors":"Ting-ting Xu, Li Li, Lin Geng, Bingduo Zhou, Shengliang Zhu","doi":"10.1111/nmo.14360","DOIUrl":"https://doi.org/10.1111/nmo.14360","url":null,"abstract":"Mental stress is an important risk factor for gastroesophageal reflux disease (GERD), which interacts with acid reflux and affects the efficacy of single acid suppression treatment. However, the specific mechanism remains elusive, and there is a lack of available models for further support.","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81801884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Model for multi‐disciplinary, multi‐institutional virtual learning: The Stanford Esophageal Virtual Collaborative Conference on benign esophageal diseases 多学科、多机构的虚拟学习模式:斯坦福食管良性食管疾病虚拟协作会议
Neurogastroenterology & Motility Pub Date : 2022-03-27 DOI: 10.1111/nmo.14369
Afrin N. Kamal, G. Triadafilopoulos, C. Gyawali, L. Nguyen, G. Sayuk, D. Azagury, R. Tatum, J. Clarke
{"title":"Model for multi‐disciplinary, multi‐institutional virtual learning: The Stanford Esophageal Virtual Collaborative Conference on benign esophageal diseases","authors":"Afrin N. Kamal, G. Triadafilopoulos, C. Gyawali, L. Nguyen, G. Sayuk, D. Azagury, R. Tatum, J. Clarke","doi":"10.1111/nmo.14369","DOIUrl":"https://doi.org/10.1111/nmo.14369","url":null,"abstract":"","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"61 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85683249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Overlap of heartburn, functional dyspepsia, and irritable bowel syndrome in a population sample: Prevalence, temporal stability, and associated comorbidities 人群样本中胃灼热、功能性消化不良和肠易激综合征的重叠:患病率、时间稳定性和相关合并症
Neurogastroenterology & Motility Pub Date : 2022-03-16 DOI: 10.1111/nmo.14349
Michael P. Jones, Ayesha Shah, M. Walker, N. Koloski, G. Holtmann, N. Talley
{"title":"Overlap of heartburn, functional dyspepsia, and irritable bowel syndrome in a population sample: Prevalence, temporal stability, and associated comorbidities","authors":"Michael P. Jones, Ayesha Shah, M. Walker, N. Koloski, G. Holtmann, N. Talley","doi":"10.1111/nmo.14349","DOIUrl":"https://doi.org/10.1111/nmo.14349","url":null,"abstract":"Co‐occurring (overlapping) irritable bowel syndrome (IBS), functional dyspepsia (FD), and heartburn has been observed. However, whether it is a distinct entity has not been established, nor what clinical, demographic, lifestyle, and psychological traits are associated with it. This study sought to estimate the prevalence and temporal stability of this overlap and to identify features specific to it in order to gain some insights into the potential etiopathogenesis.","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74976823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信