代谢5 - HT受体在人粘膜下神经丛中的介导作用

Neurogastroenterology & Motility Pub Date : 2022-04-19 DOI:10.1111/nmo.14380

A. Annaházi, T. Berger, I. Demir, F. Zeller, M. Müller, Markus Anneser, A. Skerra, K. Michel, M. Schemann

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引用次数: 4

摘要

5 -羟色胺(5 - HT)是胃肠道中重要的介质，作用于不同的神经元5 - HT受体。嗜离子性5‐HT3受体介导人类肠神经元的即时但短暂的峰放电。我们研究了代谢5‐HT1P、5‐HT4和5‐HT7受体在激活人粘膜下神经元中的作用。

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Metabotropic 5‐HT receptor‐mediated effects in the human submucous plexus

Serotonin (5‐HT) is an important mediator in the gastrointestinal tract, acting on different neuronal 5‐HT receptors. The ionotropic 5‐HT3 receptor mediates immediate but transient spike discharge in human enteric neurons. We studied the role of the metabotropic 5‐HT1P, 5‐HT4, and 5‐HT7 receptors to activate human submucous neurons.

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Neurogastroenterology & Motility

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