Paediatric respiratory epidemiology最新文献_第9页

Exercise induced dyspnea among adolescents – prevalence and incidence, a five-year follow-up 运动引起的青少年呼吸困难-患病率和发病率，为期五年的随访

Paediatric respiratory epidemiology Pub Date : 2018-09-15 DOI: 10.1183/13993003.CONGRESS-2018.PA4679

H. Johansson, M. Emtner, C. Janson, A. Malinovschi, Katarina Norlander, L. Nordang

引用次数: 1

Do changes in spirometric indices and FeNO predict asthma outcomes in children? An individual patient data analysis using results from seven FeNO trials 肺活量指数和FeNO的变化能否预测儿童哮喘结局?使用7个FeNO试验结果的个体患者数据分析

Paediatric respiratory epidemiology Pub Date : 2018-09-15 DOI: 10.1183/13993003.CONGRESS-2018.PA5011

S. Turner, S. Fielding, M. Pijnenburg, J. D. Jongste, K. Pike, G. Roberts, H. Petsky, A. Chang, M. Fritsch, T. Frischer, S. Szefler, P. Gergen, F. Vermeulen, R. Vael

{"title":"Do changes in spirometric indices and FeNO predict asthma outcomes in children? An individual patient data analysis using results from seven FeNO trials","authors":"S. Turner, S. Fielding, M. Pijnenburg, J. D. Jongste, K. Pike, G. Roberts, H. Petsky, A. Chang, M. Fritsch, T. Frischer, S. Szefler, P. Gergen, F. Vermeulen, R. Vael","doi":"10.1183/13993003.CONGRESS-2018.PA5011","DOIUrl":"https://doi.org/10.1183/13993003.CONGRESS-2018.PA5011","url":null,"abstract":"Introduction: Guidelines recommend spirometry and/or fractional exhaled nitric oxide (FeNO) as objective measurements to guide asthma management. Our hypothesis was that falling FEV1, FEV1/FVC ratio or FEF25-75 or rising FeNO measurements are associated with future adverse asthma outcomes. Methods: Data were obtained from 7 trials using FeNO to guide asthma treatment. Predictors were change in % FEV1, FEV1/FVC ratio or FEF25-75 and % change in FeNO between baseline and 3 months. Loss of asthma control and asthma attack between 3 and 6 months were the outcomes. A one-stage individual patient data meta-analysis was conducted using a mixed effects logistic model, including a random effect for study. Results: Data were available in 1112 children (58% male, mean age 12.6 years [SD 3.1]) from seven trials. A reduction of 10% FEV1 was associated with increased risk for future attack (OR 1.28 [1.02, 1.58]) and for loss of control (OR 1.21 [1, 1.45]), and a reduction of 10% FVC with increased risk for future attack (OR 1.40 [1.04, 1.88]). Changes in %FEF25-75 and %FEV1/FVC ratio were not linked to future outcomes. Each 20% increase in FeNO was associated with increased risk for future loss of control (OR 1.041 [1.000, 1.062]). Baseline %FEV1/FVC was associated with increased risk for attack over the next three months (OR per % predicted reduction 1.037 [1.007, 1.067]). Otherwise no measurement at baseline was associated with later outcome. Conclusions: Change in %FEV1 over a three month period may be useful as part of dynamic risk assessment. Whether a large change in FeNO may also be useful for dynamic risk assessment remains uncertain.","PeriodicalId":190855,"journal":{"name":"Paediatric respiratory epidemiology","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116083966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

First year of life respiratory symptoms in premature born children 出生后第一年的早产儿呼吸系统症状

Paediatric respiratory epidemiology Pub Date : 2018-09-15 DOI: 10.1183/13993003.CONGRESS-2018.PA1343

Nikki Edelbroek, A. Kamerbeek, G. Tramper

引用次数: 0

The impact of chronic non-specific cough on children and their families 慢性非特异性咳嗽对儿童及其家庭的影响

Paediatric respiratory epidemiology Pub Date : 2018-09-15 DOI: 10.1183/13993003.CONGRESS-2018.PA1339

Gill Waring, S. Kirk, D. Fallon

引用次数: 0

Metabolomics in the prediction of recurrent wheezing: a longitudinal healthy birth cohort study 代谢组学预测复发性喘息:一项纵向健康出生队列研究

Paediatric respiratory epidemiology Pub Date : 2018-09-15 DOI: 10.1183/13993003.CONGRESS-2018.PA1355

V. Ferraro, E. Baraldi, M. Stocchero, S. Bozzetto, M. Maretti, G. Giordano, P. Pirillo, S. Zanconato, S. Carraro

引用次数: 0

Combining supervised and unsupervised models to characterize asthma phenotypes in children 结合监督和非监督模型表征儿童哮喘表型

Paediatric respiratory epidemiology Pub Date : 2018-09-15 DOI: 10.1183/13993003.CONGRESS-2018.PA4684

Bronwyn K Brew, F. Chiesa, C. Lundholm, C. Almqvist

{"title":"Combining supervised and unsupervised models to characterize asthma phenotypes in children","authors":"Bronwyn K Brew, F. Chiesa, C. Lundholm, C. Almqvist","doi":"10.1183/13993003.CONGRESS-2018.PA4684","DOIUrl":"https://doi.org/10.1183/13993003.CONGRESS-2018.PA4684","url":null,"abstract":"Background: Asthma is not a single disease and a number of phenotypes are now recognized. Characterizing these phenotypes aids in better management of asthma for individuals in the pursuit of personalized medicine. Aim: To identify and characterize the asthma phenotypes in an asthma-rich population of children. Methods: The study population included 752 twins, aged 9-14, selected from a larger twin study. Parents answered questions on symptoms, risk factors and medication use. Clinical tests assessed lung function and immunological biomarkers. A latent class analysis (LCA) using current and historical symptom data was used to generate asthma phenotypes (unsupervised). Multinomial regression was then applied to characterize these phenotypes further based on medication use, risk factors, biomarkers and lung function (supervised). Results: The LCA identified five phenotypes; healthy (61%), early transient wheeze (15%), persistent wheeze (5%), mild asthma (9%) and severe asthma (10%). All wheeze and asthma phenotypes were found to have reduced lung function, however early transient wheeze did not show reversibility with bronchodilators. Persistent wheeze was identified as an at-risk group as they had wheeze and sensitization but no asthma diagnosis and only used controller medication intermittently. Those with severe asthma were more likely to have used preventer medication and β2 agonists in the last year than those with mild asthma. They were also more likely to have a family history of asthma and an allergic profile. Conclusion: Characterizing asthma using supervised and unsupervised methods we have been able to identify several phenotypes that may improve the clinical management of asthma.","PeriodicalId":190855,"journal":{"name":"Paediatric respiratory epidemiology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129736078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical features & management of 334 children with primary ciliary dyskinesia in the English National Cohort 英国国家队列334例原发性纤毛运动障碍患儿的临床特点及处理

Paediatric respiratory epidemiology Pub Date : 2018-09-15 DOI: 10.1183/13993003.CONGRESS-2018.PA5024

B. Rubbo, Sunayna Best, R. Hirst, F. Gahleitner, S. Carr, P. Chetcuti, C. Hogg, P. Kenia, J. Lucas, E. Moya, M. Narayanan, C. O’Callaghan, M. Williamson, W. Walker

引用次数: 0

An observational study of incident diagnoses of children’s diffuse parenchymal lung disease (ChILDEU) 儿童弥漫性肺实质疾病(ChILDEU)偶发诊断的观察研究

Paediatric respiratory epidemiology Pub Date : 2018-09-15 DOI: 10.1183/13993003.congress-2018.pa5027

S. Cunningham, C. Graham, M. Maclean, P. Aurora, M. Ashworth, A. Calder, A. Clément, Meike Hengste, N. Kiper, K. Krenke, J. Lange, A. Nicholson, S. Reu, D. Snijders, A. Bush, N. Schwerk, M. Griese

引用次数: 0

Challenges facing parents/caregivers of children with interstitial lung disease (chILD): international survey 间质性肺病(chILD)患儿父母/照顾者面临的挑战:国际调查

Paediatric respiratory epidemiology Pub Date : 2018-09-15 DOI: 10.1183/13993003.CONGRESS-2018.PA4680

Jeanette Boyd, S. Cunningham, N. Schwerk, C. Gilbert, P. Powell, Mareike Schamberger

{"title":"Challenges facing parents/caregivers of children with interstitial lung disease (chILD): international survey","authors":"Jeanette Boyd, S. Cunningham, N. Schwerk, C. Gilbert, P. Powell, Mareike Schamberger","doi":"10.1183/13993003.CONGRESS-2018.PA4680","DOIUrl":"https://doi.org/10.1183/13993003.CONGRESS-2018.PA4680","url":null,"abstract":"Introduction: The ERS Clinical Research Collaboration (CRC) for chILD aims to develop critical interest in these rare diseases among early career clinicians, researchers, scientists and industry. Patient involvement is integral and through partnering with the chILD Lung Foundation, Starke Lunge Foundation and European Lung Foundation, patient/parent contacts globally are being strengthened. Methods: To understand challenges that parents face and to inform activities, a mixed methods survey was devised and made available online in 9 languages from August - November 2017. Results: 156 respondents from 13 countries responded relating to the following chILD conditions: neuroendocrine cell hyperplasia (NEHI) (39%), undiagnosed/unknown (20%), bronchiolitis obliterans (15%), surfactant dysfunction mutations (SPC, ABCA3) (13%), pulmonary interstitial glycogenosis (PIG) (6%) and other (7%). Described by one responder as ‘a very lonely disease’, the most challenging aspects were: not knowing how the disease will progress (82%), anxiety/depression (74%), time management (67%), daily activities (64%) and feeding issues (60%). On rating aspects of treatment and care, 100% wanted better clinicians working interaction; 94% to know how to get a second opinion and 80% the option for genetic counselling. More availability of online information was requested by 95%. Future research direction included causes, genetics, risk factors, diagnostics and new treatments and reduction of impact of the condition on patients over the long-term. Conclusion: These findings will inform CRC activities and research going forward. Online information, clinical networks and industry links are in active development","PeriodicalId":190855,"journal":{"name":"Paediatric respiratory epidemiology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131250757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Severity of air pollution in New Delhi and burden of paediatric respiratory illnesses - An Ecological Study 新德里空气污染的严重程度和儿童呼吸系统疾病的负担——一项生态学研究

Paediatric respiratory epidemiology Pub Date : 2018-09-15 DOI: 10.1183/13993003.congress-2018.pa1352

C. Kohli, B. Banerjee, S. Garg

引用次数: 0