International Journal of Experimental Research and Review最新文献

{"title":"Solubility enhancement and evaluation of Cilnidipine using solid Dispersion techniques","authors":"S. Mankar, Arpita Tupe","doi":"10.52756/ijerr.2023.v32.030","DOIUrl":"https://doi.org/10.52756/ijerr.2023.v32.030","url":null,"abstract":"The poor solubility of Cilnidipine leads to low bioavailability and limits its therapeutic efficacy. To develop a dosage form that is stable, effective and has a higher bioavailability. It is necessary to increase the solubility of such medications. The present study aimed to improve the solubility by solid dispersion technique of Cilnidipine by solid dispersion techniques. Solvent evaporation and melt fusion methods were used to prepare solid dispersions of the drug cilnidipine with various polymers. The solubility of these prepared solid dispersions was evaluated by FT-IR spectroscopy, Differential Scanning Colorimetry and X-ray diffraction. The greatest solubility, of 21.07 µg/mL, was found in the solid dispersion that was developed by solvent evaporation technique employing a combination of Cilnidipine and Poloxamer 188 in a 1:9 ratio. The current investigation showed that solid dispersion using Poloxamer 188 can be a potentially effective method to increase the solubility and rate of dissolution of cilnidipine.","PeriodicalId":190842,"journal":{"name":"International Journal of Experimental Research and Review","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133929821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-cancer Properties of Dietary Supplement CELNORM against Colon and Lung Cancer: An in vitro preliminary study","authors":"Vijay Mehta, Amit Dey, Nandita Thakkar, Keerthana Prabhakar, Ganesan Jothimani, A. Banerjee","doi":"10.52756/ijerr.2023.v32.001","DOIUrl":"https://doi.org/10.52756/ijerr.2023.v32.001","url":null,"abstract":"Cancer is a complex disease characterized by a cascade of events that culminate in the accumulation of several genetic alterations. Because of the high incidence and mortality rate, scientists began seeking novel medications that were harmful to cancer cells but not to healthy cells. This study aimed to investigate the effect of CELNORM and its various components individually in colon and lung cancer cells. Based on the LD50 value, colon and lung cancer cells were treated with two different dosages of curcumin, pepper, carrot and cucumber extracts, individually and CELNORM (formulation with all four ingredients). The cytotoxicity of each compound has been checked through morphological analysis and cell viability assay by using the CCK8 kit and statistically analyzed. qPCR-based Gene expression study has also been done to further validate the anti-cancerous properties of the compounds.  Curcumin extract decreased cancer cell growth, as evidenced by cytotoxicity and morphological analyses, but pepper, carrot, and cucumber extracts showed a less significant reduction in cancer cell growth. CELNORM, on the other hand, had the highest significant effect in suppressing cell proliferation, indicating the novel health supplement CELNORM renders more efficacy than individual components. Gene expression analysis also verifies the anti-cancerous properties of CELNORM, though some gene expressions are not in the expected line. The morphological analysis and cell viability result has shown the efficacy of the CELNORM over the individual compounds of the CELNORM and gene expression analysis of proliferative genes such as Cyclin D, CDK6, PCNA and BCL-2 further validates the anti-cancerous properties of CELNORM and all four components.","PeriodicalId":190842,"journal":{"name":"International Journal of Experimental Research and Review","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129860430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Technology adoption of digital banking and women consumers: An empirical investigation","authors":"Bimaldeep Kaur, Narinder Kaur Batra","doi":"10.52756/ijerr.2023.v32.024","DOIUrl":"https://doi.org/10.52756/ijerr.2023.v32.024","url":null,"abstract":"Digital banking services have gained much attention in recent years due to their enormous advantages, like convenience, flexibility, and time-savings compared to traditional banking services. However, the low awareness, perceived risk, and security concerns with online banking services led Indian women to deposit their savings in banks, mostly in accounts operated by the husband or a male family member. This study examines women consumers' awareness and intentions to use digital banking during post-demonetization. The study has analyzed the technology adoption model and established a relationship between perceived usefulness, ease of use, trust, risk and behaviour (independent variables) and intentions to use (dependent variable). We have carried out a primary survey and collected 180 responses from the national capital regions of India. The findings show a positive significant influence of perceived usefulness, ease of use, and behaviour over the intentions to use digital banking. According to the outcome, women consumers are ready to adopt digital banking. The results of this study may be utilized to improve financial services, particularly digital banking, and as part of a marketing campaign to promote its usage. It has been difficult to visit the bank physically during epidemics; thus, using digital banking is strongly advised.","PeriodicalId":190842,"journal":{"name":"International Journal of Experimental Research and Review","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126002843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative physico-chemical, phytochemical and spectroscopic analysis of two medicinal plants belongs to Euphorbiaceae family: Acalypha indica L. and Euphorbia hirta L. growing in Paschim Medinipur District, West Bengal, India","authors":"Manna De, Lata Sharma","doi":"10.52756/ijerr.2023.v32.018","DOIUrl":"https://doi.org/10.52756/ijerr.2023.v32.018","url":null,"abstract":"Plants belong to Euphorbiaceae family, bearing enormous Medicinal potential due to the presence of various pharmacologically important secondary metabolites. Now a days, with the help of various tools and techniques like FTIR, GCMS researchers are engaged to systematically find out various biologically active phytoconstituents. The present study investigated Acalypha indica L. and Euphorbia hirta L. leaf to establish the fact. Physico-chemical parameters of the experimental plants have been investigated. The result shows that Acalypha indica possesses maximum values on Swelling index, volatile matter, ash contents, fixed carbon, higher heat value, hydrogen content, oxygen content, carbon content, hemicellulose content, lignin content and extractive values. In contrast, the percentage composition of bulk density, carbon content, and nitrogen content is higher in Euphorbia hirta. In the present investigation, the FTIR analysis reveals that Acalypha indica L. possessed different chemical classes like Sulfoxide, Alkene, Carbon Dioxide, Alkane, Alcohol etc., whereas FTIR analysis reveals the presence Alkene, Secondary Alcohol, Conjugated Alkene, Carbon Dioxide, Alkene, Alcohol in Euphorbia hirta L. The methanolic leaf extracts of two different plants have been screened through GC-MS, revealing many important bioactive phytoconstituents. Acalypha indica L. possesses Cyclotrisiloxane, Hexamethyl-, cis-2,4-dimethylamine, S, S-dioxide, 1- nonadecanamine, n, n-dimethyl-, tridecane, 2,2,4,10,12,12-hexamethyl-7-(3,5,5-trimethylsilyl)-, dodecane, 1-fluoro-, whereas, Euphorbia hirta L. possesses myo- inositol, 4-c-methyl-, z,z-6,28-heptatriactontadien-2-one, phytylpalmitate, hexasiloxane, 1,1,3,3,5,5,7,7,9,9,11,11-dodecamethyl-, 4-tert-octylphenol, TMS derivative. Both these plants have chemical substances that have proven bioactivity in human welfare. The GC-MS of leaf methanolic extract reveals that the phytochemical cis-2,4-dimethylthiane, S, S-dioxide have Anticancer (stomach) activities, 1-nonadecanamine, N, N-dimethyl bears Antitumor (nasopharynx) activities, myo-inositol, 4-C- methyl bearing Myo-neuro-stimulant activities and Z, Z-6,28-heptatriactontadien-2-one having Increase zinc bioavailability activities. These activities of individual phytoconstituents have been proven through Dr. Duke's Phytochemical and Ethno-botanical Databases: U.S. Department of Agriculture. This information might be helpful to the pharmacologists, chemists, etc., for future novel drug discovery.","PeriodicalId":190842,"journal":{"name":"International Journal of Experimental Research and Review","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131763485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extraction, isolation and chromatographic estimation of Aloe-Emodin and Physcion from Cassia Fistula root","authors":"Beldar Shamshad Bee, R. Jat, Sufiyan Ahmad","doi":"10.52756/ijerr.2023.v32.026","DOIUrl":"https://doi.org/10.52756/ijerr.2023.v32.026","url":null,"abstract":"The large and untapped resources of chemical compounds with significant medical potential found in medicinal plant species make them valuable as sources for biomedicine. Traditional medical systems like Ayurveda and Chinese Traditional Medicine are just two of the many that use the essential medicinal plant Cassia fistula L. It is a medium-sized tree that loses its leaves in the autumn. Its name is from its beautiful yellow flowers and long, rod-shaped seeds with pulp inside. The plant's roots were extracted using petroleum ether, chloroform, alcohol, and water in that order, and the products were looked at for preliminary phytochemical screening and antioxidant activity. Analysis of phytochemicals like alkaloids, flavonoids, carbohydrates, glycosides, protein, amino acids, saponins, and triterpenoids showed that most elements were present. Furthermore, this work concentrated on isolating and purifying aloe-emodin and Physcionusing column chromatography and then determining their purity using HPTLC. Different extraction solvents were tested, and ethanolic produced the highest yield of both. Toluene: Ethyl acetate: Methanol at 5:4:1 (v/v) showed superior resolution of Rf values at 0.7 and 0.9 as aloe-emodin and Physcion, respectively. Different solvents with different polarities were tried before using TLC to separate aloe-emodin and Physcion. The Toluene-ethyl acetate-formic acid ratio was increased when the silica gel column chromatography polarity was applied to the alcohol extract.","PeriodicalId":190842,"journal":{"name":"International Journal of Experimental Research and Review","volume":" 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132125039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-Time Face Recognition System with Enhanced Security Features using Deep Learning","authors":"Mukta Banerjee, Riya Goyal, Pragati Gupta, Ashish Tripathi","doi":"10.52756/ijerr.2023.v32.011","DOIUrl":"https://doi.org/10.52756/ijerr.2023.v32.011","url":null,"abstract":"\u0000 \u0000 \u0000 \u0000Abstract: Identification of people and mask detection has long been a captivating topic, in terms of research and business. This topic has received increasing attention in recent phases due to the speedy advancement of Artificial Intelligence (AI). Nowadays, a lot of applications, including phone unlocking systems, criminal identification systems, and even home security systems, use face recognition as a common technique. Due to the fact that this method only requires a facial image instead of other dependencies like a key or card, it is more secure. Face detection and face identification are often the first two elements of a human recognition system. Even during COVID-19, it is considered the best way to stop the spread of the COVID-19 virus is by wearing a face mask. The risk of contracting the virus can be reduced by almost 70% only by wearing a face mask. In order to promote community health. This Study aims to produce a highly precise and real-time method that can effectively recognize people and identify non-mask faces in public. When a person stands in front of the device, this application detects the human face automatically using detection, extraction, and recognition algorithms. The proposed work applies the Viola-Jones algorithm for face recognition and the YOLOv5 algorithm for mask detection and classification. When the proposed work is tested, this shows higher accuracy in mask detection which is 92.8%. \u0000 \u0000 \u0000 \u0000","PeriodicalId":190842,"journal":{"name":"International Journal of Experimental Research and Review","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115892952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Popping balls papaya extract: Preparation of pediatric dosages in therapeutic formulations for therapeutic usage in dengue and malaria","authors":"Hrutuja Wagh, Avinash Bhosale, Vishal Girbane, Shravanee Bhosale, Manish Bhise, Mahesh Deshpande, Piyush Chandra, Rakesh Ranjan","doi":"10.52756/ijerr.2023.v32.016","DOIUrl":"https://doi.org/10.52756/ijerr.2023.v32.016","url":null,"abstract":"Spherification is a cutting-edge molecular gastronomy method that has just emerged in the realm of food science and technology, and it may be used to produce foods with superior sensory qualities and a high level of consumer acceptance and satisfaction. This method is excellent for making semi-solid spheres with a membrane coating so thin that it is barely discernible when placed in the mouth. This experiment used a simple spherification method to turn papaya extract into popping balls with sodium alginate. Intraventricular haemorrhage is a potentially fatal consequence of thrombocytopenia in the newborn period. Extracts from papaya leaves show promise as a treatment for refractory cases of newborn thrombocytopenia. This research aims to learn how to make popping balls out of papaya extract that are both safe to eat and tasty by adding jaggery as a sweetener. Physical parameters such as pH, viscosity, and stability of the prepared balls were studied in in-vitro, 30-day time frame. The findings revealed that papaya-popping balls are homogeneous and have a low viscosity. The expected drug release was 91%. Papaya popping balls were subjected to a three-month stability study. According to the results, there was no variation in colour, pH, or viscosity during the study. All the particles in the formulation were round so that it may be given to kids as an alternative to oral solid dose forms.","PeriodicalId":190842,"journal":{"name":"International Journal of Experimental Research and Review","volume":"603 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116452155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimation Features by Transformed Bernstein kind Polynomials","authors":"Ravendra Kumar Mishra, Sudesh Kumar Garg, Rupa Rani Sharma, Priyanka Sharma","doi":"10.52756/ijerr.2023.v32.008","DOIUrl":"https://doi.org/10.52756/ijerr.2023.v32.008","url":null,"abstract":"In our extensive study of literature, we delved into the multifarious manifestations of discrete operator transformations. These transformations are pivotal in mathematical analysis, especially concerning Lebesgue integral equations. Our investigation led us to corroborate the findings of Acu, Heilmann and Lorentz particularly in the context of functions normed under the L1-norm. Generalization was a key facet of our research, wherein we probed deeper into these operators' behaviors. This endeavor yielded a profound result: the derivation of a global asymptotic formula, providing invaluable insight into the long-term trends exhibited by these operators. Such formulae are instrumental in predicting the operators' behaviors over an extended span. Furthermore, our exploration unveiled a plethora of findings related to these generalized operators. We meticulously computed various moments, shedding light on the statistical characteristics of these transformations. This included an investigation into convergence properties, essential for understanding the stability and reliability of the operators in question. One of the most noteworthy contributions of our study is the elucidation of pointwise approximation and direct results. These findings offer practical applications, allowing for precise and efficient approximations in practical scenarios. This is particularly significant in fields where these operators are routinely employed, such as signal processing, numerical analysis, and scientific computing. In essence, our research has not only confirmed the foundational work of Acu, Heilmann and Lorentz but has also expanded the horizons of knowledge surrounding discrete operator transformations, offering a wealth of insights and practical implications for a wide range of mathematical and computational applications.","PeriodicalId":190842,"journal":{"name":"International Journal of Experimental Research and Review","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126703999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A retrospective, non-randomized, clinical review on the effect of single-dose biosimilar Razumab injection in diabetic macular edema","authors":"Arul Balasubramanian, Jeyaprakash Balasubramanian, Atchaya Pugazhenthi, Chandru Balasivaraman, Divya Murugadass, Kothai Ramalingam","doi":"10.52756/ijerr.2023.v32.010","DOIUrl":"https://doi.org/10.52756/ijerr.2023.v32.010","url":null,"abstract":"Diabetic macular edema (DME) is one of the microvascular complications of diabetes and also coexists with diabetic retinopathy. The present study aims to investigate the effectiveness of single-dose biosimilar Razumab injection in diabetic macular edema. In this retrospective, non-randomized, clinical review on patients (n=50), 50 eyes with diabetic macular edema were selected and treated with a single dose of 2.3mg/0.23mL Razumab injection intravitreally. Visual acuity (VA) and macular thickness (MT), were evaluated for a period of up to 45 days after injecting biosimilar Razumab and were used to assess the effectiveness after treatment for 45 days. The results of the study showed that there was a significant increase in visual acuity and a marked reduction in macular thickness and the intraocular pressure (IOP) and anterior segment (AS) examination reverted to normal after the injection (Day 45). This study concludes that a single dose of biosimilar Razumab injection was effective in improving visual acuity and reducing macular thickness with no ocular concerns in diabetic macular edema patients.","PeriodicalId":190842,"journal":{"name":"International Journal of Experimental Research and Review","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123485477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preclinical evaluation of the diabetic wound healing activity of phytoconstituents extracted from Ficus racemosa Linn. leaves","authors":"Sadhana Pawar, Kajal Pawade, Sonali Nipate, Aishawarya Balap, B. Pimple, Vijay Wagh, R. Kachave","doi":"10.52756/ijerr.2023.v32.032","DOIUrl":"https://doi.org/10.52756/ijerr.2023.v32.032","url":null,"abstract":"Human body has several multi-layered organs, but skin is one of biggest and easiest to access. It serves as body's primary line of defense alongside various skin diseased conditions. Despite receiving sufficient and appropriate care, diabetes wounds heal slowly and may take a week to complete. A progression of connective tissue patch up is the body's natural defense against tissue damage. Fresh leaves of Ficus racemosa were utilized for the study. In this study, two distinct models were employed to compare how well different Ficus racemosa leaf extracts healed wounds. Excision wounds healed more quickly and to a greater extent after being treated with a flavonoid and tannin fraction of Ficus racemosa leaf extract, suggesting improved epithelization. The extract-treated groups also experienced an increase in breaking potency of incision wounds made; higher breaking strength indicates better wound healing. Complete closure of wound of flavonoid fraction and in fraction of Ficus racemosa extract occurred in 16 and 17 days respectively. Standard treatment increased tensile strength in the diabetic linear incision wound model, followed by treatment with the flavonoid fraction and tannin fraction of Ficus racemosa leaves extract. Ultimate finding and outcome of the present study experimentally demonstrates that extracts of the flavonoid and tannin fractions of Ficus racemosa have wound-healing properties and are effective in treating diabetic wounds. From this study, we state that Ficus racemosa flavonoid fraction and tannin fraction extract has a beneficial effect on blood glucose levels, which shows hypoglycaemic activity.","PeriodicalId":190842,"journal":{"name":"International Journal of Experimental Research and Review","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125600736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}