Nature Reviews Clinical Oncology最新文献

{"title":"Multidisciplinary management of meningiomas in the era of precision oncology","authors":"Majid Assadi, Malik E. Juweid, Philipp Lohmann, Giuseppe Minniti, Felix Sahm, Jana Ivanidze, Philipp Karschnia, Alexander Landry, Felix M. Mottaghy, Gelareh Zadeh","doi":"10.1038/s41571-026-01148-9","DOIUrl":"10.1038/s41571-026-01148-9","url":null,"abstract":"Meningiomas are the most common type of primary intracranial tumour. Histopathology-based WHO grading remains the standard for guiding management in most institutions, although new molecularly driven classification tools have been shown to improve prognostic accuracy and could guide personalized management decisions. Somatostatin receptor-targeted PET–CT or MRI has improved tumour delineation, enabling earlier diagnosis of residual or recurrent disease and guiding precision delivery of local therapies. Patients with meningioma have been traditionally managed with surgery and radiotherapy, although advances over the past decade have brought about promising novel treatment options. These developments include endoscopic surgery and other forms of minimally invasive surgery that have enabled safer resections, stereotactic radiotherapy platforms and systemic treatment with targeted agents, immune checkpoint inhibitors and targeted radioligands, which are being increasingly considered for patients with meningioma. Despite these advances, challenges remain, particularly in the standardization of classification systems, development of predictive biomarkers and optimization of trial designs. In this comprehensive, state-of-the-art Review we provide an integrated roadmap for meningioma care as well as a framework for ongoing and future research in this field. Patients with meningioma, the most common type of intracranial primary tumour, have been traditionally managed with surgery and radiotherapy, although advances over the past decade have brought about promising novel treatment options. In addition, new molecularly driven classification tools can improve prognostic accuracy and guide personalized management decisions. The authors of this Review provide an integrated roadmap for meningioma care as well as a framework for ongoing and future research in this field.","PeriodicalId":19079,"journal":{"name":"Nature Reviews Clinical Oncology","volume":"23 7","pages":"539-556"},"PeriodicalIF":94.6,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147666511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cultivating the microbiome to enhance cancer immunotherapy","authors":"Erez N. Baruch, Nadim J. Ajami, Jennifer A. Wargo","doi":"10.1038/s41571-026-01146-x","DOIUrl":"10.1038/s41571-026-01146-x","url":null,"abstract":"Three recently published studies demonstrate the feasibility of modulating gut microorganisms using faecal microbiota transplantation (FMT) in patients receiving immune-checkpoint inhibitors (ICIs) in the first-line setting, expanding the evidence that FMT can augment response to ICIs. Herein, we discuss several opportunities for refining these efforts in order to increase the rigour and clinical benefit from microbiota modulation trials in oncology.","PeriodicalId":19079,"journal":{"name":"Nature Reviews Clinical Oncology","volume":"23 6","pages":"394-395"},"PeriodicalIF":82.2,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147641487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A prioritization framework for large-scale cancer screening under resource constraints: three ‘not all’ principles","authors":"Xuesi Dong, Yu Wang, Ni Li","doi":"10.1038/s41571-026-01144-z","DOIUrl":"10.1038/s41571-026-01144-z","url":null,"abstract":"Cancer screening is an effective strategy for reducing cancer mortality, but in resource-constrained settings the key challenge is not simply whether screening works but how its implementation should be prioritized. We propose a framework for prioritizing cancer screening under resource constraints, summarized in three ‘not all’ principles: not all cancers are suitable for screening; not all individuals need screening; and not all high-performance technologies are appropriate for population screening.","PeriodicalId":19079,"journal":{"name":"Nature Reviews Clinical Oncology","volume":"23 6","pages":"391-393"},"PeriodicalIF":82.2,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147518446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In what clinical settings are the MASAI trial results applicable?","authors":"Karla Kerlikowske, Kathryn P. Lowry, Diana L. Miglioretti","doi":"10.1038/s41571-026-01143-0","DOIUrl":"10.1038/s41571-026-01143-0","url":null,"abstract":"This Comment describes the clinical significance of the Mammography Screening with Artificial Intelligence (MASAI) trial, which is, to the best of our knowledge, the first randomized trial of artificial intelligence-supported mammography interpretation to examine interval cancer as an outcome. This trial used artificial intelligence to assign single-reading versus double-reading of mammograms and found that this approach does not increase interval cancers in the Swedish population.","PeriodicalId":19079,"journal":{"name":"Nature Reviews Clinical Oncology","volume":"23 5","pages":"319-320"},"PeriodicalIF":82.2,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147506721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neoadjuvant GOLP is effective in high-risk intrahepatic cholangiocarcinoma","authors":"Diana Romero","doi":"10.1038/s41571-026-01142-1","DOIUrl":"10.1038/s41571-026-01142-1","url":null,"abstract":"","PeriodicalId":19079,"journal":{"name":"Nature Reviews Clinical Oncology","volume":"23 6","pages":"398-398"},"PeriodicalIF":82.2,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147478454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author Correction: Innovative approaches for lung cancer screening and interception","authors":"Jianjun Zhang, Matthew D. Park, Tej Pandya, Elaine Shum, Jia Wu, Simon Heeke, Ramin Salehi-Rad, Thomas U. Marron, Zhubo Wei, Hui Li, Torsten G. Blum, John V. Heymach, Steven M. Dubinett, Pan-Chyr Yang, Charles Swanton, Miriam Merad","doi":"10.1038/s41571-026-01140-3","DOIUrl":"10.1038/s41571-026-01140-3","url":null,"abstract":"","PeriodicalId":19079,"journal":{"name":"Nature Reviews Clinical Oncology","volume":"23 5","pages":"390-390"},"PeriodicalIF":82.2,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41571-026-01140-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147383480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in the management of metastatic gastric cancer: current strategies and emerging therapeutics","authors":"Joan Choo, Amalya Sargsyan, Vahe Khachatryan, Sara Lonardi, Filippo Pietrantonio, Raghav Sundar, Samuel Klempner, Yelena Janjigian","doi":"10.1038/s41571-026-01134-1","DOIUrl":"10.1038/s41571-026-01134-1","url":null,"abstract":"Metastatic gastric cancer remains a major global health challenge with poor long-term outcomes. Over the past 5 years, the treatment landscape has rapidly evolved with the integration of biomarker-informed strategies that guide the use of immune checkpoint inhibitors and targeted therapies in molecularly defined subgroups, including microsatellite unstable, PD-L1-expressing, HER2-positive and claudin 18.2-positive disease. Standard first-line treatment continues to rely on fluoropyrimidine–platinum chemotherapy backbones, with biomarker-driven agents selectively layered on for improved efficacy. Despite these advances, most patients continue to have disease progression, and durable responses are uncommon. In addition to identifying and validating new targets such as FGFR2b, ongoing efforts are focusing on novel strategies involving established targets, including HER2 and claudin 18.2, using next-generation treatment modalities such as antibody–drug conjugates, bispecific antibodies and cellular therapies. Complementary platforms including circulating tumour DNA and theranostic agents are also being explored to better guide treatment selection, facilitate non-invasive monitoring and enable early response assessments. In this Review, we summarize the current standard of care for patients with metastatic gastric cancer and also highlight emerging approaches aimed at improving the outcomes in these patients. The development of immune checkpoint inhibitors and novel targeted therapies and the incorporation of these agents into first-line therapy for biomarker-selected patients with metastatic gastric cancer has improved outcomes. Nonetheless, many challenges remain, including both primary and acquired resistance as well as a lack of relevant biomarkers in certain subgroups. In this Review, the authors describe the current approach to first-line therapy for patients with metastatic gastric cancer as well as emerging approaches that might improve the standard of care in the coming years.","PeriodicalId":19079,"journal":{"name":"Nature Reviews Clinical Oncology","volume":"23 6","pages":"441-458"},"PeriodicalIF":82.2,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147383479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glucagon-like peptide 1 receptor agonists and cancer risk: the good, the bad and the unknown","authors":"Edoardo Mannucci, Ilaria Dicembrini","doi":"10.1038/s41571-026-01135-0","DOIUrl":"10.1038/s41571-026-01135-0","url":null,"abstract":"Glucagon-like peptide 1 receptor agonists (GLP1RAs) are widely used for the treatment of type 2 diabetes mellitus (T2DM) and, at higher doses, obesity. Both T2DM and obesity are associated with a higher risk of cancer, which can be reduced by intentional weight loss, whereas effects of a reduction in hyperglycaemia are uncertain. GLP1RAs might have further direct effects, either beneficial or detrimental, on the development of specific malignancies. Evidence from preclinical and clinical studies suggests heterogeneous effects of GLP1RAs on cancer risk: the incidence of hepatocellular, oesophageal, endometrial, ovarian and prostate cancers might be reduced, whereas safety concerns persist with respect to thyroid (both medullary and non-medullary) carcinomas. Conversely, initial concerns on the risk of pancreatic cancer have not been confirmed. Nonetheless, the interpretation of current data is limited by detection and prescription biases in observational studies as well as insufficient follow-up and number of events in randomized trials. In this Review, we summarize current preclinical and clinical evidence, showing that the risk–benefit profile of GLP1RAs remains favourable in individuals with T2DM and obesity, although caution is warranted in those with a low cardiometabolic risk, for whom the potential risks of cancer might outweigh any expected benefits; conversely, the potential use of GLP1RAs as adjuvant therapies for certain forms of cancer needs to be further investigated. Glucagon-like peptide 1 receptor agonists (GLP1RAs) are widely used by individuals with type 2 diabetes mellitus (T2DM) and/or obesity. Both of these conditions are also associated with an increased risk of certain cancers, and this risk might be ameliorated following intentional weight loss, which can consistently be achieved with GLP1RAs. Conversely, several reports have suggested an increased risk of certain cancers, such as medullary or non-medullary thyroid cancer and pancreatic cancer among those receiving GLP1RAs. In this Review, the authors evaluate these competing risks and the underlying evidence as well as highlighting areas in which evidence is limited and more research will be needed in order to definitively understand the implications of GLP1RAs for cancer risk.","PeriodicalId":19079,"journal":{"name":"Nature Reviews Clinical Oncology","volume":"23 6","pages":"459-470"},"PeriodicalIF":82.2,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147381176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The changing landscape of oncology clinical trials in Latin America","authors":"Andreia Cristina de Melo","doi":"10.1038/s41571-026-01137-y","DOIUrl":"10.1038/s41571-026-01137-y","url":null,"abstract":"Although oncology advances stem from clinical research, <5% of global cancer trials actively recruit patients in Latin America. Herein, I discuss why expanding inclusive trial designs and fostering multisector partnerships are essential to reduce disparities and improve the role of Latin America in global oncology research. I present examples such as the recent regulatory reforms in Brazil that aim to accelerate study approvals, as well as collaborative initiatives between local and international research groups to further strengthen clinical trial capacity.","PeriodicalId":19079,"journal":{"name":"Nature Reviews Clinical Oncology","volume":"23 5","pages":"317-318"},"PeriodicalIF":82.2,"publicationDate":"2026-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147350344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perioperative approaches for patients with biliary tract cancer","authors":"Anudari Zorigtbaatar, Zhihao Li, Christian T. J. Magyar, Laia Aceituno, Anna Saborowski, Arndt Vogel, Robert C. Grant, Grainne M. O’Kane, Gonzalo Sapisochin","doi":"10.1038/s41571-026-01130-5","DOIUrl":"10.1038/s41571-026-01130-5","url":null,"abstract":"Biliary tract cancers, encompassing intrahepatic, perihilar and distal cholangiocarcinoma and gallbladder cancer, are a heterogeneous group of highly aggressive malignancies. Most patients have unresectable disease at first presentation, and even those who undergo surgery are likely to have disease recurrence. Newer approaches have included liver transplantation for selected patients, and the integration of locoregional and systemic therapies has expanded the number of patients who can benefit from surgery. The advent of immune-checkpoint inhibitors and targeted therapies for patients with advanced-stage disease has prompted the exploration of these agents in earlier-stage disease settings. Despite this progress, treatment algorithms remain complex, necessitating a multidisciplinary and individualized approach to patient management. Future research should focus on optimizing patient selection through biomarker-driven strategies, including the integration of molecular profiles to guide the selection of systemic therapy, as well as refining the criteria for surgery and transplantation. These improvements will require global collaboration and novel clinical trial designs. In this Review, we describe evolving perioperative strategies for the management of patients with biliary tract cancers and highlight emerging directions in the field. Cholangiocarcinomas, comprising intrahepatic, extrahepatic and perihilar subtypes as well as gallbladder cancer, are a heterogeneous group of malignancies that necessitates a personalized approach to both surgery and systemic therapy. In this Review, the authors describe progress in the development of personalized perioperative therapy strategies as well as the most promising future research directions in this diverse and often difficult-to-treat group of cancers.","PeriodicalId":19079,"journal":{"name":"Nature Reviews Clinical Oncology","volume":"23 6","pages":"425-440"},"PeriodicalIF":82.2,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147346374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}