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Nature Reviews. Drug Discovery最新文献

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Comprehensive measurement of biopharmaceutical R&D investment 全面衡量生物制药研发投资
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2024-08-06 DOI: 10.1038/d41573-024-00131-2
Amitabh Chandra,  John Drum,  Michael Daly,  Henry Mirsberger,  Samuel Spare,  Ulrich Neumann,  Silas Martin,  Noam Kirson
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引用次数: 0
Per-patient approach to calculating drug development costs yields lower estimate 按患者人数计算药物开发成本的方法得出了较低的估算值
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2024-08-05 DOI: 10.1038/d41573-024-00130-3
Asher Mullard
{"title":"Per-patient approach to calculating drug development costs yields lower estimate","authors":"Asher Mullard","doi":"10.1038/d41573-024-00130-3","DOIUrl":"10.1038/d41573-024-00130-3","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"23 9","pages":"650-650"},"PeriodicalIF":122.7,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141891732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anti-IL-11 antibody shows anti-ageing properties 抗 IL-11 抗体具有抗衰老特性。
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2024-08-01 DOI: 10.1038/d41573-024-00132-1
Alex Eccleston
{"title":"Anti-IL-11 antibody shows anti-ageing properties","authors":"Alex Eccleston","doi":"10.1038/d41573-024-00132-1","DOIUrl":"10.1038/d41573-024-00132-1","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"23 9","pages":"658-658"},"PeriodicalIF":122.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141875448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chinese innovative drug R&D trends in 2024 2024 年中国创新药物研发趋势
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2024-07-31 DOI: 10.1038/d41573-024-00120-5
Zimeng Chen,  Hui Zhong,  Hongxi Hu,  Fanpu Kong,  Wannian Liang,  Guanqiao Li
{"title":"Chinese innovative drug R&D trends in 2024","authors":"Zimeng Chen, \u0000 Hui Zhong, \u0000 Hongxi Hu, \u0000 Fanpu Kong, \u0000 Wannian Liang, \u0000 Guanqiao Li","doi":"10.1038/d41573-024-00120-5","DOIUrl":"10.1038/d41573-024-00120-5","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"23 11","pages":"810-811"},"PeriodicalIF":122.7,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141857795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Muscarinic drugs breathe new life into schizophrenia pipeline 毒蕈碱类药物为精神分裂症的治疗注入了新的活力。
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2024-07-30 DOI: 10.1038/d41573-024-00129-w
Katie Kingwell
{"title":"Muscarinic drugs breathe new life into schizophrenia pipeline","authors":"Katie Kingwell","doi":"10.1038/d41573-024-00129-w","DOIUrl":"10.1038/d41573-024-00129-w","url":null,"abstract":"Karuna and Bristol Myers Squibb’s muscarinic agonist KarXT looks set to offer the first new drug mechanism for patients with schizophrenia in over 70 years. Karuna and Bristol Myers Squibb’s muscarinic agonist KarXT looks set to offer the first new drug mechanism for patients with schizophrenia in over 70 years.","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"23 9","pages":"647-649"},"PeriodicalIF":122.7,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141856093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TCR-boosted T cell therapy yields proof-of-principle clinical data in solid cancer TCR 增强型 T 细胞疗法在实体瘤治疗中获得原则性临床数据。
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2024-07-29 DOI: 10.1038/d41573-024-00121-4
Asher Mullard
{"title":"TCR-boosted T cell therapy yields proof-of-principle clinical data in solid cancer","authors":"Asher Mullard","doi":"10.1038/d41573-024-00121-4","DOIUrl":"10.1038/d41573-024-00121-4","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"23 9","pages":"651-651"},"PeriodicalIF":122.7,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oral miniproteins treat IBD 口服小蛋白治疗 IBD。
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2024-07-25 DOI: 10.1038/d41573-024-00126-z
Sarah Crunkhorn
{"title":"Oral miniproteins treat IBD","authors":"Sarah Crunkhorn","doi":"10.1038/d41573-024-00126-z","DOIUrl":"10.1038/d41573-024-00126-z","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"23 9","pages":"660-660"},"PeriodicalIF":122.7,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141760006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Proteogenomics identifies anticancer targets 蛋白质基因组学确定抗癌目标。
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2024-07-25 DOI: 10.1038/d41573-024-00127-y
Sarah Crunkhorn
{"title":"Proteogenomics identifies anticancer targets","authors":"Sarah Crunkhorn","doi":"10.1038/d41573-024-00127-y","DOIUrl":"10.1038/d41573-024-00127-y","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"23 9","pages":"660-660"},"PeriodicalIF":122.7,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141760007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Opioid antidote gets a boost 阿片类药物解毒剂得到加强。
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2024-07-25 DOI: 10.1038/d41573-024-00125-0
Sarah Crunkhorn
{"title":"Opioid antidote gets a boost","authors":"Sarah Crunkhorn","doi":"10.1038/d41573-024-00125-0","DOIUrl":"10.1038/d41573-024-00125-0","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"23 9","pages":"658-658"},"PeriodicalIF":122.7,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141760005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epigenetic editor silences prion protein 表观遗传编辑器使朊病毒蛋白沉默。
IF 122.7 1区 医学
Nature Reviews. Drug Discovery Pub Date : 2024-07-25 DOI: 10.1038/d41573-024-00128-x
Sarah Crunkhorn
{"title":"Epigenetic editor silences prion protein","authors":"Sarah Crunkhorn","doi":"10.1038/d41573-024-00128-x","DOIUrl":"10.1038/d41573-024-00128-x","url":null,"abstract":"","PeriodicalId":19068,"journal":{"name":"Nature Reviews. Drug Discovery","volume":"23 9","pages":"660-660"},"PeriodicalIF":122.7,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141760004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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