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Defining clinically useful biomarkers of immune checkpoint inhibitors in solid tumours 确定实体瘤免疫检查点抑制剂的临床有用生物标记物
IF 72.5 1区 医学
Nature Reviews Cancer Pub Date : 2024-06-12 DOI: 10.1038/s41568-024-00705-7
Ashley M. Holder, Aikaterini Dedeilia, Kailan Sierra-Davidson, Sonia Cohen, David Liu, Aparna Parikh, Genevieve M. Boland
{"title":"Defining clinically useful biomarkers of immune checkpoint inhibitors in solid tumours","authors":"Ashley M. Holder, Aikaterini Dedeilia, Kailan Sierra-Davidson, Sonia Cohen, David Liu, Aparna Parikh, Genevieve M. Boland","doi":"10.1038/s41568-024-00705-7","DOIUrl":"10.1038/s41568-024-00705-7","url":null,"abstract":"Although more than a decade has passed since the approval of immune checkpoint inhibitors (ICIs) for the treatment of melanoma and non-small-cell lung, breast and gastrointestinal cancers, many patients still show limited response. US Food and Drug Administration (FDA)-approved biomarkers include programmed cell death 1 ligand 1 (PDL1) expression, microsatellite status (that is, microsatellite instability-high (MSI-H)) and tumour mutational burden (TMB), but these have limited utility and/or lack standardized testing approaches for pan-cancer applications. Tissue-based analytes (such as tumour gene signatures, tumour antigen presentation or tumour microenvironment profiles) show a correlation with immune response, but equally, these demonstrate limited efficacy, as they represent a single time point and a single spatial assessment. Patient heterogeneity as well as inter- and intra-tumoural differences across different tissue sites and time points represent substantial challenges for static biomarkers. However, dynamic biomarkers such as longitudinal biopsies or novel, less-invasive markers such as blood-based biomarkers, radiomics and the gut microbiome show increasing potential for the dynamic identification of ICI response, and patient-tailored predictors identified through neoadjuvant trials or novel ex vivo tumour models can help to personalize treatment. In this Perspective, we critically assess the multiple new static, dynamic and patient-specific biomarkers, highlight the newest consortia and trial efforts, and provide recommendations for future clinical trials to make meaningful steps forwards in the field. In this Perspective, Holder et al. discuss the limitations of current predictive biomarkers of response to immune checkpoint inhibitors and the need to further explore static, dynamic and patient-specific biomarkers using novel tools, such as machine learning and consortia-level initiatives.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"24 7","pages":"498-512"},"PeriodicalIF":72.5,"publicationDate":"2024-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141308952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Eliminating false positives 消除误报
IF 72.5 1区 医学
Nature Reviews Cancer Pub Date : 2024-06-10 DOI: 10.1038/s41568-024-00716-4
Daniela Senft
{"title":"Eliminating false positives","authors":"Daniela Senft","doi":"10.1038/s41568-024-00716-4","DOIUrl":"10.1038/s41568-024-00716-4","url":null,"abstract":"To establish microbiome-based screening for colorectal cancer, a study published in Nature Medicine tackled two key challenges: utilizing quantitative microbiome profiling and identifying covariates that might obscure the microbiota–colorectal cancer interactions.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"24 7","pages":"444-444"},"PeriodicalIF":72.5,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141298919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Charting spatially resolved cell states with CytoSPACE 利用 CytoSPACE 绘制空间解析细胞状态图
IF 72.5 1区 医学
Nature Reviews Cancer Pub Date : 2024-06-10 DOI: 10.1038/s41568-024-00713-7
Erin L. Brown
{"title":"Charting spatially resolved cell states with CytoSPACE","authors":"Erin L. Brown","doi":"10.1038/s41568-024-00713-7","DOIUrl":"10.1038/s41568-024-00713-7","url":null,"abstract":"In this Tools of the Trade article, Erin Brown describes the development of CytoSPACE, a computational tool that aligns single-cell transcriptomes and spatial transcriptomic data, and highlights its use in identifying spatially resolved cell states in the tumour microenvironment.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"24 9","pages":"593-593"},"PeriodicalIF":72.5,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141298925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bone voyage: immune crosstalk sets sail 骨骼之旅：免疫串联起航。
IF 72.5 1区 医学
Nature Reviews Cancer Pub Date : 2024-06-04 DOI: 10.1038/s41568-024-00712-8
Gabrielle Brewer
{"title":"Bone voyage: immune crosstalk sets sail","authors":"Gabrielle Brewer","doi":"10.1038/s41568-024-00712-8","DOIUrl":"10.1038/s41568-024-00712-8","url":null,"abstract":"Monteran et al. identified key interactions between granulocytes and T cells that promote an immunosuppressive bone microenvironment, enabling breast cancer metastasis.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"24 7","pages":"445-445"},"PeriodicalIF":72.5,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141248173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
No mutation, tumour initiation 无突变，肿瘤初始。
IF 72.5 1区 医学
Nature Reviews Cancer Pub Date : 2024-05-29 DOI: 10.1038/s41568-024-00711-9
Daniela Senft
{"title":"No mutation, tumour initiation","authors":"Daniela Senft","doi":"10.1038/s41568-024-00711-9","DOIUrl":"10.1038/s41568-024-00711-9","url":null,"abstract":"Parreno et al. provide evidence for epigenetically initiated cancers in Drosophila and show that cancer develops after transient loss of Polycomb group proteins in the absence of recurrent mutations.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"24 7","pages":"446-446"},"PeriodicalIF":72.5,"publicationDate":"2024-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141176187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Liquid biopsies for Hodgkin lymphoma 治疗霍奇金淋巴瘤的液体活检技术
IF 72.5 1区 医学
Nature Reviews Cancer Pub Date : 2024-05-23 DOI: 10.1038/s41568-024-00709-3
Sojung Lim, Yoon Kyung Jeon
{"title":"Liquid biopsies for Hodgkin lymphoma","authors":"Sojung Lim, Yoon Kyung Jeon","doi":"10.1038/s41568-024-00709-3","DOIUrl":"10.1038/s41568-024-00709-3","url":null,"abstract":"In this Journal Club, Lim and Jeon discuss a recent study demonstrating the utility of noninvasive genomic profiling for subtyping Hodgkin lymphomas.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"24 8","pages":"522-522"},"PeriodicalIF":72.5,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141085403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author Correction: Developmental origins shape the paediatric cancer genome 作者更正：发育起源决定儿科癌症基因组。
IF 72.5 1区 医学
Nature Reviews Cancer Pub Date : 2024-05-21 DOI: 10.1038/s41568-024-00710-w
Xiaolong Chen, Wentao Yang, Charles W. M. Roberts, Jinghui Zhang
{"title":"Author Correction: Developmental origins shape the paediatric cancer genome","authors":"Xiaolong Chen, Wentao Yang, Charles W. M. Roberts, Jinghui Zhang","doi":"10.1038/s41568-024-00710-w","DOIUrl":"10.1038/s41568-024-00710-w","url":null,"abstract":"","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"24 7","pages":"513-513"},"PeriodicalIF":72.5,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41568-024-00710-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141076274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A guide to artificial intelligence for cancer researchers 癌症研究人员人工智能指南
IF 78.5 1区 医学
Nature Reviews Cancer Pub Date : 2024-05-16 DOI: 10.1038/s41568-024-00694-7
Raquel Perez-Lopez, Narmin Ghaffari Laleh, Faisal Mahmood, Jakob Nikolas Kather
{"title":"A guide to artificial intelligence for cancer researchers","authors":"Raquel Perez-Lopez, Narmin Ghaffari Laleh, Faisal Mahmood, Jakob Nikolas Kather","doi":"10.1038/s41568-024-00694-7","DOIUrl":"10.1038/s41568-024-00694-7","url":null,"abstract":"Artificial intelligence (AI) has been commoditized. It has evolved from a specialty resource to a readily accessible tool for cancer researchers. AI-based tools can boost research productivity in daily workflows, but can also extract hidden information from existing data, thereby enabling new scientific discoveries. Building a basic literacy in these tools is useful for every cancer researcher. Researchers with a traditional biological science focus can use AI-based tools through off-the-shelf software, whereas those who are more computationally inclined can develop their own AI-based software pipelines. In this article, we provide a practical guide for non-computational cancer researchers to understand how AI-based tools can benefit them. We convey general principles of AI for applications in image analysis, natural language processing and drug discovery. In addition, we give examples of how non-computational researchers can get started on the journey to productively use AI in their own work. This Review provides an introductory guide to artificial intelligence (AI)-based tools for non-computational cancer researchers. Here, Perez-Lopez et al. outline the general principles of AI for image analysis, natural language processing and drug discovery, as well as how researchers can get started with each of them.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"24 6","pages":"427-441"},"PeriodicalIF":78.5,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140949490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Finding the truth in science 寻找科学真理
IF 72.5 1区 医学
Nature Reviews Cancer Pub Date : 2024-05-16 DOI: 10.1038/s41568-024-00702-w
Elisabeth M. Bik
{"title":"Finding the truth in science","authors":"Elisabeth M. Bik","doi":"10.1038/s41568-024-00702-w","DOIUrl":"10.1038/s41568-024-00702-w","url":null,"abstract":"In a ‘publish or perish’ culture, some scientists may resort to questionable research practices or even fraud. Scientific paper mills and artificial intelligence increasingly threaten the pursuit of truth in science. Structural changes, including heightened scrutiny of papers and authorship and better funding, are needed to ensure scientific integrity.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"24 8","pages":"516-517"},"PeriodicalIF":72.5,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140949468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Taking a detour 绕道而行
IF 72.5 1区 医学
Nature Reviews Cancer Pub Date : 2024-05-16 DOI: 10.1038/s41568-024-00707-5
Anna Dart
{"title":"Taking a detour","authors":"Anna Dart","doi":"10.1038/s41568-024-00707-5","DOIUrl":"10.1038/s41568-024-00707-5","url":null,"abstract":"Kong et al. have now shown that Knudson’s two-hit hypothesis can be circumvented through the actions of the glycolytic metabolite methylglyoxal, which transiently inactivates the tumour-suppressive functions of BRCA2 leading to episodic mutagenesis and cancer genome evolution.","PeriodicalId":19055,"journal":{"name":"Nature Reviews Cancer","volume":"24 7","pages":"445-445"},"PeriodicalIF":72.5,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140949361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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