Journal of Controversies in Obstetrics & Gynecology and Pediatrics最新文献

{"title":"What do we know about kisspeptin?","authors":"N. Akgün, B. Dilbaz","doi":"10.51271/jcogp-0012","DOIUrl":"https://doi.org/10.51271/jcogp-0012","url":null,"abstract":"Kisspeptins are a group of peptide fragments that are expressed by the neurons of the hypothalamus mainly in the arcuate, dorsal-medial and antero ventricular, periventricular nuclei of the hypothalamus besides the amygdala.1 Initially, Kisspeptin via its G protein-coupled receptor 54 (GPR54) was introduced to have an important role in cancer biology with its metastasis suppression effect. In light of recent research, Kisspeptin is found to have a major role in the neuroendocrine \u0000reproductive axis through the Kisspeptin 1 (KISS1) gene. The KISS1 gene that encodes Kisspeptin was first discovered \u0000in 1996 by researchers from the United States of America. Kisspeptinreceptors are also expressed by the same neurons. \u0000Kisspeptin has a pivotal role in reproduction through the hypothalamic-hypophysial axis while exerting an extra \u0000hypothalamic function on sexual and emotional behavior.","PeriodicalId":190423,"journal":{"name":"Journal of Controversies in Obstetrics & Gynecology and Pediatrics","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130154784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of umbilical artery Doppler analysis in estimating perinatal morbidity and mortality in hypertensive pregnancy","authors":"Tanju Demirören, A. Yüksel","doi":"10.51271/jcogp-0009","DOIUrl":"https://doi.org/10.51271/jcogp-0009","url":null,"abstract":"Aims: Uteroplacental (uterine artery systolic/diastolic (S/D) ratio) and fetal circulation changes (umbilical artery pulsatility\u0000Index (PI) value) can be evaluated non-invasively by using Doppler ultrasonography spectral analysis. The present study aimed to demonstrate how Doppler ultrasonography should be combined with classical well-being tests to detect perinatal morbidity and mortality in hypertensive pregnancy.\u0000Methods: This prospective research was carried out with 88 pregnant women diagnosed with high-risk pregnancy and\u0000hypertension between April 1992 and May 1994. A non-stress test (NST) was performed in all cases, and fetal distress was\u0000evaluated by a biophysical profile (BP) and/or a contraction stress test (CST) subsequent to a non-reactive NST. Following the diagnosis of hypertension, longitudinal maternal (uterine artery) and fetal (umbilical artery) Doppler analyses were initiated at 7–10-day intervals. In the study, the Acuson 128 XP 10 device (Research project No. 515/080555592 was funded by the İstanbul University Research Fund) and a 3.5-5 MHz curvilinear probe were used. No Doppler pathology was considered solely in the timing of delivery.\u0000Results: There was no case of perinatal loss, antepartum and intrapartum fetal distress, neonatal asphyxia, and\u0000oligohydramnios in the group with normal uterine and umbilical artery Doppler analyses. There was one case with umbilical\u0000artery Doppler flow pathology only, which was delivered by preterm cesarean section with the diagnosis of antepartum fetal\u0000distress. Fetus diagnosed to have a fetal growth restriction (FGR) and the findings of fetal distress, FGR, and cesarean delivery were concordant with the literature. There was also increased perinatal mortality (9.1%) among patients with pathological uterine artery Doppler and normal umbilical artery Doppler group, but there was no case of oligohydramnios in this group and the rate of neonatal asphyxia (5.min Apgar score <7) was 21.7%. The antepartum loss was 27%, the neonatal loss was 23.8%, and perinatal mortality was 44.8% in the group with pathological uterine and umbilical artery Doppler findings, and this group had all cases of oligohydramnios.\u0000Conclusion: Overall, it seems reasonable to identify any pathologies with Doppler ultrasonography in hypertensive\u0000pregnant women in the early pregnancy and to follow them up with classical fetal antepartum surveillance tests at appropriate intervals related to their umbilical artery Doppler pathologies.","PeriodicalId":190423,"journal":{"name":"Journal of Controversies in Obstetrics &amp; Gynecology and Pediatrics","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116839571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Menopausal period and homeopathy: a review","authors":"A. Uluocak","doi":"10.51271/jcogp-0011","DOIUrl":"https://doi.org/10.51271/jcogp-0011","url":null,"abstract":"Homeopathy, rather than suppressing existing disease symptoms; is a natural, side effect-free, safe, and inexpensive treatment method based on activating this natural healing power that has been impaired. In this method, which is based on the principle of similarity (like heals like), the person is evaluated individually and holistically. For example, not every woman is treated the same for the menopausal condition. Each woman is treated individually, considering all her symptoms. \u0000Therefore, instead of trying to eliminate the symptoms, the patient's treatment is targeted. Medicines used in homeopathic treatment are called remedies. Remedies include: plants, minerals, animal tissue and other sources that are all found in nature, 70% of which are obtained from plant sources. Today, there are around 8000 remedies that are available. Remedies are obtained by diluting these substances with water. Dilution process; it prevents side effects and increases the effect. By applying the shaking method, the power is increased. Remedial information; It is obtained as a result of studies called proving that are made by using healthy people. Animal experiments are not used. Within the scope of this review, it is aimed to give information about the remedies that can be used for homeopathic purposes in the menopausal period and the selection of the appropriate remedy.","PeriodicalId":190423,"journal":{"name":"Journal of Controversies in Obstetrics &amp; Gynecology and Pediatrics","volume":"82 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126041675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}