What do we know about kisspeptin?

Abstract

Kisspeptins are a group of peptide fragments that are expressed by the neurons of the hypothalamus mainly in the arcuate, dorsal-medial and antero ventricular, periventricular nuclei of the hypothalamus besides the amygdala.1 Initially, Kisspeptin via its G protein-coupled receptor 54 (GPR54) was introduced to have an important role in cancer biology with its metastasis suppression effect. In light of recent research, Kisspeptin is found to have a major role in the neuroendocrine reproductive axis through the Kisspeptin 1 (KISS1) gene. The KISS1 gene that encodes Kisspeptin was first discovered in 1996 by researchers from the United States of America. Kisspeptinreceptors are also expressed by the same neurons. Kisspeptin has a pivotal role in reproduction through the hypothalamic-hypophysial axis while exerting an extra hypothalamic function on sexual and emotional behavior.