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Molecular Therapy: the Journal of the American Society of Gene Therapy最新文献

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The Vascular Disrupting Agent CA4P Improves the Antitumor Efficacy of CAR-T Cells in Preclinical Models of Solid Human Tumors. 血管干扰剂CA4P提高CAR-T细胞在实体人肿瘤临床前模型中的抗肿瘤效果
Molecular Therapy: the Journal of the American Society of Gene Therapy Pub Date : 2020-01-01 DOI: 10.1016/j.ymthe.2019.10.010
Changwen Deng, Jingjing Zhao, Shixin Zhou, Jiebin Dong, Jixiang Cao, Junshuang Gao, Yun Bai, H. Deng
{"title":"The Vascular Disrupting Agent CA4P Improves the Antitumor Efficacy of CAR-T Cells in Preclinical Models of Solid Human Tumors.","authors":"Changwen Deng, Jingjing Zhao, Shixin Zhou, Jiebin Dong, Jixiang Cao, Junshuang Gao, Yun Bai, H. Deng","doi":"10.1016/j.ymthe.2019.10.010","DOIUrl":"https://doi.org/10.1016/j.ymthe.2019.10.010","url":null,"abstract":"","PeriodicalId":19039,"journal":{"name":"Molecular Therapy: the Journal of the American Society of Gene Therapy","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73663500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 31
MicroRNA-411 and Its 5'-IsomiR Have Distinct Targets and Functions and Are Differentially Regulated in the Vasculature under Ischemia. MicroRNA-411及其5'-IsomiR具有不同的靶点和功能，在缺血血管中受到不同的调控。
Molecular Therapy: the Journal of the American Society of Gene Therapy Pub Date : 2020-01-01 DOI: 10.1016/j.ymthe.2019.10.002
R. V. van der Kwast, Tamar Woudenberg, Paul H.A. Quax, A. Nossent
{"title":"MicroRNA-411 and Its 5'-IsomiR Have Distinct Targets and Functions and Are Differentially Regulated in the Vasculature under Ischemia.","authors":"R. V. van der Kwast, Tamar Woudenberg, Paul H.A. Quax, A. Nossent","doi":"10.1016/j.ymthe.2019.10.002","DOIUrl":"https://doi.org/10.1016/j.ymthe.2019.10.002","url":null,"abstract":"","PeriodicalId":19039,"journal":{"name":"Molecular Therapy: the Journal of the American Society of Gene Therapy","volume":"90 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80410180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 45
A Cohesin-Mediated Intrachromosomal Loop Drives Oncogenic ROR lncRNA to Accelerate Tumorigenesis. 内聚蛋白介导的染色体内环驱动致癌ROR lncRNA加速肿瘤发生。
Molecular Therapy: the Journal of the American Society of Gene Therapy Pub Date : 2019-12-01 DOI: 10.1016/j.ymthe.2019.07.020
Jiayan Fan, Yangfan Xu, Xu-yang Wen, S. Ge, Renbing Jia, He Zhang, Xianqun Fan
{"title":"A Cohesin-Mediated Intrachromosomal Loop Drives Oncogenic ROR lncRNA to Accelerate Tumorigenesis.","authors":"Jiayan Fan, Yangfan Xu, Xu-yang Wen, S. Ge, Renbing Jia, He Zhang, Xianqun Fan","doi":"10.1016/j.ymthe.2019.07.020","DOIUrl":"https://doi.org/10.1016/j.ymthe.2019.07.020","url":null,"abstract":"","PeriodicalId":19039,"journal":{"name":"Molecular Therapy: the Journal of the American Society of Gene Therapy","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83742595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Suppression of Zika Virus Infection in the Brain by the Antiretroviral Drug Rilpivirine. 抗逆转录病毒药物利匹韦林抑制脑内寨卡病毒感染。
Molecular Therapy: the Journal of the American Society of Gene Therapy Pub Date : 2019-12-01 DOI: 10.1016/j.ymthe.2019.10.006
I. Sariyer, J. Gordon, T. Burdo, Hassen S Wollebo, Eleonora Gianti, Martina Donadoni, A. Bellizzi, S. Cicalese, Regina Loomis, J. Robinson, V. Carnevale, J. Steiner, M. H. Ozdener, Andrew D. Miller, S. Amini, M. Klein, K. Khalili
{"title":"Suppression of Zika Virus Infection in the Brain by the Antiretroviral Drug Rilpivirine.","authors":"I. Sariyer, J. Gordon, T. Burdo, Hassen S Wollebo, Eleonora Gianti, Martina Donadoni, A. Bellizzi, S. Cicalese, Regina Loomis, J. Robinson, V. Carnevale, J. Steiner, M. H. Ozdener, Andrew D. Miller, S. Amini, M. Klein, K. Khalili","doi":"10.1016/j.ymthe.2019.10.006","DOIUrl":"https://doi.org/10.1016/j.ymthe.2019.10.006","url":null,"abstract":"","PeriodicalId":19039,"journal":{"name":"Molecular Therapy: the Journal of the American Society of Gene Therapy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82332034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 18
Systemic Delivery of CRISPR/Cas9 Targeting HPV Oncogenes Is Effective at Eliminating Established Tumors. 靶向HPV癌基因的CRISPR/Cas9系统递送可有效消除已建立的肿瘤
Molecular Therapy: the Journal of the American Society of Gene Therapy Pub Date : 2019-12-01 DOI: 10.1016/j.ymthe.2019.08.012
Luqman Jubair, Sora Fallaha, N. McMillan
{"title":"Systemic Delivery of CRISPR/Cas9 Targeting HPV Oncogenes Is Effective at Eliminating Established Tumors.","authors":"Luqman Jubair, Sora Fallaha, N. McMillan","doi":"10.1016/j.ymthe.2019.08.012","DOIUrl":"https://doi.org/10.1016/j.ymthe.2019.08.012","url":null,"abstract":"","PeriodicalId":19039,"journal":{"name":"Molecular Therapy: the Journal of the American Society of Gene Therapy","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88924157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 50
Targeted Integration and High-Level Transgene Expression in AAVS1 Transgenic Mice after In Vivo HSC Transduction with HDAd5/35++ Vectors. hdad5 /35++载体体内HSC转导后AAVS1转基因小鼠的靶向整合和高水平转基因表达
Molecular Therapy: the Journal of the American Society of Gene Therapy Pub Date : 2019-12-01 DOI: 10.1016/j.ymthe.2019.08.006
Chang Li, Arpit Mishra, Sucheol Gil, Meng Wang, A. Georgakopoulou, T. Papayannopoulou, R. D. Hawkins, A. Lieber
{"title":"Targeted Integration and High-Level Transgene Expression in AAVS1 Transgenic Mice after In Vivo HSC Transduction with HDAd5/35++ Vectors.","authors":"Chang Li, Arpit Mishra, Sucheol Gil, Meng Wang, A. Georgakopoulou, T. Papayannopoulou, R. D. Hawkins, A. Lieber","doi":"10.1016/j.ymthe.2019.08.006","DOIUrl":"https://doi.org/10.1016/j.ymthe.2019.08.006","url":null,"abstract":"","PeriodicalId":19039,"journal":{"name":"Molecular Therapy: the Journal of the American Society of Gene Therapy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78832809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 29
Fetal Gene Therapy Using a Single Injection of Recombinant AAV9 Rescued SMA Phenotype in Mice. 单次注射重组AAV9挽救小鼠SMA表型的胎儿基因治疗。
Molecular Therapy: the Journal of the American Society of Gene Therapy Pub Date : 2019-12-01 DOI: 10.1016/j.ymthe.2019.08.017
A. Rashnonejad, Gholamhossein Amini Chermahini, Cumhur Gündüz, H. Onay, A. Aykut, B. Durmaz, M. Baka, Q. Su, G. Gao, F. Özkınay
{"title":"Fetal Gene Therapy Using a Single Injection of Recombinant AAV9 Rescued SMA Phenotype in Mice.","authors":"A. Rashnonejad, Gholamhossein Amini Chermahini, Cumhur Gündüz, H. Onay, A. Aykut, B. Durmaz, M. Baka, Q. Su, G. Gao, F. Özkınay","doi":"10.1016/j.ymthe.2019.08.017","DOIUrl":"https://doi.org/10.1016/j.ymthe.2019.08.017","url":null,"abstract":"","PeriodicalId":19039,"journal":{"name":"Molecular Therapy: the Journal of the American Society of Gene Therapy","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74454143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 23
Systemic Exosomal Delivery of shRNA Minicircles Prevents Parkinsonian Pathology. shRNA微环的全身外泌体递送可预防帕金森病病理。
Molecular Therapy: the Journal of the American Society of Gene Therapy Pub Date : 2019-12-01 DOI: 10.1016/j.ymthe.2019.08.010
M. Izco, J. Blesa, M. Schleef, M. Schmeer, Riccardo Porcari, R. Al-Shawi, S. Ellmerich, María de Toro, C. Gardiner, Y. Seow, Alejandro Reinares-Sebastián, R. Forcén, J. Paul Simons, V. Bellotti, J. Mark Cooper, L. Álvarez-Erviti
{"title":"Systemic Exosomal Delivery of shRNA Minicircles Prevents Parkinsonian Pathology.","authors":"M. Izco, J. Blesa, M. Schleef, M. Schmeer, Riccardo Porcari, R. Al-Shawi, S. Ellmerich, María de Toro, C. Gardiner, Y. Seow, Alejandro Reinares-Sebastián, R. Forcén, J. Paul Simons, V. Bellotti, J. Mark Cooper, L. Álvarez-Erviti","doi":"10.1016/j.ymthe.2019.08.010","DOIUrl":"https://doi.org/10.1016/j.ymthe.2019.08.010","url":null,"abstract":"","PeriodicalId":19039,"journal":{"name":"Molecular Therapy: the Journal of the American Society of Gene Therapy","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79187351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 100
Immunogenicity of RNA Replicons Encoding HIV Env Immunogens Designed for Self-Assembly into Nanoparticles. 设计用于自组装成纳米颗粒的HIV Env免疫原RNA复制子的免疫原性
Molecular Therapy: the Journal of the American Society of Gene Therapy Pub Date : 2019-12-01 DOI: 10.1016/J.YMTHE.2019.08.007
M. Melo, E. Porter, Y. Zhang, Murillo Silva, Na Li, Brian S. Dobosh, Alessia Liguori, Patrick D. Skog, E. Landais, S. Menis, D. Sok, D. Nemazee, W. Schief, Ron Weiss, D. Irvine
{"title":"Immunogenicity of RNA Replicons Encoding HIV Env Immunogens Designed for Self-Assembly into Nanoparticles.","authors":"M. Melo, E. Porter, Y. Zhang, Murillo Silva, Na Li, Brian S. Dobosh, Alessia Liguori, Patrick D. Skog, E. Landais, S. Menis, D. Sok, D. Nemazee, W. Schief, Ron Weiss, D. Irvine","doi":"10.1016/J.YMTHE.2019.08.007","DOIUrl":"https://doi.org/10.1016/J.YMTHE.2019.08.007","url":null,"abstract":"","PeriodicalId":19039,"journal":{"name":"Molecular Therapy: the Journal of the American Society of Gene Therapy","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82012755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 47
DGCR8/ZFAT-AS1 Promotes CDX2 Transcription in a PRC2 Complex-Dependent Manner to Facilitate the Malignant Biological Behavior of Glioma Cells. DGCR8/ZFAT-AS1以PRC2复合物依赖的方式促进CDX2转录，促进胶质瘤细胞的恶性生物学行为。
Molecular Therapy: the Journal of the American Society of Gene Therapy Pub Date : 2019-11-20 DOI: 10.1016/j.ymthe.2019.11.015
Fangfang Zhang, Xuelei Ruan, Jun Ma, Xiaobai Liu, Jian Zheng, Yunhui Liu, Libo Liu, S. Shen, Lianqi Shao, Di Wang, Chunqing Yang, H. Cai, Zhen Li, Ziyi Feng, Yixue Xue
{"title":"DGCR8/ZFAT-AS1 Promotes CDX2 Transcription in a PRC2 Complex-Dependent Manner to Facilitate the Malignant Biological Behavior of Glioma Cells.","authors":"Fangfang Zhang, Xuelei Ruan, Jun Ma, Xiaobai Liu, Jian Zheng, Yunhui Liu, Libo Liu, S. Shen, Lianqi Shao, Di Wang, Chunqing Yang, H. Cai, Zhen Li, Ziyi Feng, Yixue Xue","doi":"10.1016/j.ymthe.2019.11.015","DOIUrl":"https://doi.org/10.1016/j.ymthe.2019.11.015","url":null,"abstract":"","PeriodicalId":19039,"journal":{"name":"Molecular Therapy: the Journal of the American Society of Gene Therapy","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84672921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 19
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