Nature metabolismPub Date : 2025-02-28DOI: 10.1038/s42255-025-01239-4
Yasin El Abiead, Adriano Rutz, Simone Zuffa, Bashar Amer, Shipei Xing, Corinna Brungs, Robin Schmid, Mario S. P. Correia, Andres Mauricio Caraballo-Rodriguez, Amir Zarrinpar, Helena Mannochio-Russo, Michael Witting, Ipsita Mohanty, Tomáš Pluskal, Wout Bittremieux, Rob Knight, Andrew D. Patterson, Justin J. J. van der Hooft, Sebastian Böcker, Warwick B. Dunn, Roger G. Linington, David S. Wishart, Jean-Luc Wolfender, Oliver Fiehn, Nicola Zamboni, Pieter C. Dorrestein
{"title":"Discovery of metabolites prevails amid in-source fragmentation","authors":"Yasin El Abiead, Adriano Rutz, Simone Zuffa, Bashar Amer, Shipei Xing, Corinna Brungs, Robin Schmid, Mario S. P. Correia, Andres Mauricio Caraballo-Rodriguez, Amir Zarrinpar, Helena Mannochio-Russo, Michael Witting, Ipsita Mohanty, Tomáš Pluskal, Wout Bittremieux, Rob Knight, Andrew D. Patterson, Justin J. J. van der Hooft, Sebastian Böcker, Warwick B. Dunn, Roger G. Linington, David S. Wishart, Jean-Luc Wolfender, Oliver Fiehn, Nicola Zamboni, Pieter C. Dorrestein","doi":"10.1038/s42255-025-01239-4","DOIUrl":"10.1038/s42255-025-01239-4","url":null,"abstract":"","PeriodicalId":19038,"journal":{"name":"Nature metabolism","volume":"7 3","pages":"435-437"},"PeriodicalIF":18.9,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143518772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nature metabolismPub Date : 2025-02-25DOI: 10.1038/s42255-025-01256-3
Hongmei Fu, Juho Vuononvirta, Silvia Fanti, Fabrizia Bonacina, Antonio D’Amati, Guosu Wang, Thanushiyan Poobalasingam, Maria Fankhaenel, Davide Lucchesi, Rachel Coleby, David Tarussio, Bernard Thorens, Robert J. Hearnden, M. Paula Longhi, Paul Grevitt, Madeeha H. Sheikh, Egle Solito, Susana A. Godinho, Michele Bombardieri, David M. Smith, Dianne Cooper, Asif J. Iqbal, Jeffrey C. Rathmell, Samuel Schaefer, Valle Morales, Katiuscia Bianchi, Giuseppe Danilo Norata, Federica M. Marelli-Berg
{"title":"Publisher Correction: The glucose transporter 2 regulates CD8+ T cell function via environment sensing","authors":"Hongmei Fu, Juho Vuononvirta, Silvia Fanti, Fabrizia Bonacina, Antonio D’Amati, Guosu Wang, Thanushiyan Poobalasingam, Maria Fankhaenel, Davide Lucchesi, Rachel Coleby, David Tarussio, Bernard Thorens, Robert J. Hearnden, M. Paula Longhi, Paul Grevitt, Madeeha H. Sheikh, Egle Solito, Susana A. Godinho, Michele Bombardieri, David M. Smith, Dianne Cooper, Asif J. Iqbal, Jeffrey C. Rathmell, Samuel Schaefer, Valle Morales, Katiuscia Bianchi, Giuseppe Danilo Norata, Federica M. Marelli-Berg","doi":"10.1038/s42255-025-01256-3","DOIUrl":"10.1038/s42255-025-01256-3","url":null,"abstract":"","PeriodicalId":19038,"journal":{"name":"Nature metabolism","volume":"7 3","pages":"634-634"},"PeriodicalIF":18.9,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s42255-025-01256-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143502683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nature metabolismPub Date : 2025-02-24DOI: 10.1038/s42255-025-01223-y
{"title":"Mitochondrial superoxide regulates pro-inflammatory macrophages","authors":"","doi":"10.1038/s42255-025-01223-y","DOIUrl":"10.1038/s42255-025-01223-y","url":null,"abstract":"Pro-inflammatory macrophages produce mitochondria-derived reactive oxygen species (mtROS) such as superoxide, but it is not understood how it is produced or how it affects macrophage effector functions. We show that mitochondrial superoxide is produced by reverse electron transport at complex I of the respiratory chain and regulates pro-inflammatory cytokine production.","PeriodicalId":19038,"journal":{"name":"Nature metabolism","volume":"7 3","pages":"452-453"},"PeriodicalIF":18.9,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143477694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nature metabolismPub Date : 2025-02-21DOI: 10.1038/s42255-025-01226-9
Stephanie Kullmann, Lore Wagner, Robert Hauffe, Anne Kühnel, Leontine Sandforth, Ralf Veit, Corinna Dannecker, Jürgen Machann, Andreas Fritsche, Nobert Stefan, Hubert Preissl, Nils B. Kroemer, Martin Heni, André Kleinridders, Andreas L. Birkenfeld
{"title":"A short-term, high-caloric diet has prolonged effects on brain insulin action in men","authors":"Stephanie Kullmann, Lore Wagner, Robert Hauffe, Anne Kühnel, Leontine Sandforth, Ralf Veit, Corinna Dannecker, Jürgen Machann, Andreas Fritsche, Nobert Stefan, Hubert Preissl, Nils B. Kroemer, Martin Heni, André Kleinridders, Andreas L. Birkenfeld","doi":"10.1038/s42255-025-01226-9","DOIUrl":"10.1038/s42255-025-01226-9","url":null,"abstract":"Brain insulin responsiveness is linked to long-term weight gain and unhealthy body fat distribution. Here we show that short-term overeating with calorie-rich sweet and fatty foods triggers liver fat accumulation and disrupted brain insulin action that outlasted the time-frame of its consumption in healthy weight men. Hence, brain response to insulin can adapt to short-term changes in diet before weight gain and may facilitate the development of obesity and associated diseases. Short-term overeating with calorie-rich snacks is shown to disrupt insulin action in the brain of men, which outlasted the time-frame of overeating.","PeriodicalId":19038,"journal":{"name":"Nature metabolism","volume":"7 3","pages":"469-477"},"PeriodicalIF":18.9,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s42255-025-01226-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143462435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nature metabolismPub Date : 2025-02-19DOI: 10.1038/s42255-025-01224-x
Alva M. Casey, Dylan G. Ryan, Hiran A. Prag, Suvagata Roy Chowdhury, Eloïse Marques, Keira Turner, Anja V. Gruszczyk, Ming Yang, Dane M. Wolf, Jan Lj. Miljkovic, Joyce Valadares, Patrick F. Chinnery, Richard C. Hartley, Christian Frezza, Julien Prudent, Michael P. Murphy
{"title":"Pro-inflammatory macrophages produce mitochondria-derived superoxide by reverse electron transport at complex I that regulates IL-1β release during NLRP3 inflammasome activation","authors":"Alva M. Casey, Dylan G. Ryan, Hiran A. Prag, Suvagata Roy Chowdhury, Eloïse Marques, Keira Turner, Anja V. Gruszczyk, Ming Yang, Dane M. Wolf, Jan Lj. Miljkovic, Joyce Valadares, Patrick F. Chinnery, Richard C. Hartley, Christian Frezza, Julien Prudent, Michael P. Murphy","doi":"10.1038/s42255-025-01224-x","DOIUrl":"10.1038/s42255-025-01224-x","url":null,"abstract":"Macrophages stimulated by lipopolysaccharide (LPS) generate mitochondria-derived reactive oxygen species (mtROS) that act as antimicrobial agents and redox signals; however, the mechanism of LPS-induced mitochondrial superoxide generation is unknown. Here we show that LPS-stimulated bone-marrow-derived macrophages produce superoxide by reverse electron transport (RET) at complex I of the electron transport chain. Using chemical biology and genetic approaches, we demonstrate that superoxide production is driven by LPS-induced metabolic reprogramming, which increases the proton motive force (∆p), primarily as elevated mitochondrial membrane potential (Δψm) and maintains a reduced CoQ pool. The key metabolic changes are repurposing of ATP production from oxidative phosphorylation to glycolysis, which reduces reliance on F1FO-ATP synthase activity resulting in a higher ∆p, while oxidation of succinate sustains a reduced CoQ pool. Furthermore, the production of mtROS by RET regulates IL-1β release during NLRP3 inflammasome activation. Thus, we demonstrate that ROS generated by RET is an important mitochondria-derived signal that regulates macrophage cytokine production. Casey et al. explore the basic mechanisms of mitochondrial superoxide production and its impact on interleukin-1β production in LPS-treated macrophages.","PeriodicalId":19038,"journal":{"name":"Nature metabolism","volume":"7 3","pages":"493-507"},"PeriodicalIF":18.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s42255-025-01224-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143443304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nature metabolismPub Date : 2025-02-18DOI: 10.1038/s42255-025-01219-8
Lars O. Dragsted, Henrik M. Roager, Catalina Cuparencu
{"title":"Querying stool for dietary information","authors":"Lars O. Dragsted, Henrik M. Roager, Catalina Cuparencu","doi":"10.1038/s42255-025-01219-8","DOIUrl":"10.1038/s42255-025-01219-8","url":null,"abstract":"Accurately determining food intake remains a substantial challenge in nutrition research. This issue of Nature Metabolism introduces a methodology for assessing dietary intake, using stool metagenomic data to detect food DNA from a broad range of foods.","PeriodicalId":19038,"journal":{"name":"Nature metabolism","volume":"7 3","pages":"450-451"},"PeriodicalIF":18.9,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143435145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nature metabolismPub Date : 2025-02-18DOI: 10.1038/s42255-025-01220-1
Christian Diener, Hannah D. Holscher, Klara Filek, Karen D. Corbin, Christine Moissl-Eichinger, Sean M. Gibbons
{"title":"Metagenomic estimation of dietary intake from human stool","authors":"Christian Diener, Hannah D. Holscher, Klara Filek, Karen D. Corbin, Christine Moissl-Eichinger, Sean M. Gibbons","doi":"10.1038/s42255-025-01220-1","DOIUrl":"10.1038/s42255-025-01220-1","url":null,"abstract":"Dietary intake is tightly coupled to gut microbiota composition, human metabolism and the incidence of virtually all major chronic diseases. Dietary and nutrient intake are usually assessed using self-reporting methods, including dietary questionnaires and food records, which suffer from reporting biases and require strong compliance from study participants. Here, we present Metagenomic Estimation of Dietary Intake (MEDI): a method for quantifying food-derived DNA in human faecal metagenomes. We show that DNA-containing food components can be reliably detected in stool-derived metagenomic data, even when present at low abundances (more than ten reads). We show how MEDI dietary intake profiles can be converted into detailed metabolic representations of nutrient intake. MEDI identifies the onset of solid food consumption in infants, shows significant agreement with food frequency questionnaire responses in an adult population and shows agreement with food and nutrient intake in two controlled-feeding studies. Finally, we identify specific dietary features associated with metabolic syndrome in a large clinical cohort without dietary records, providing a proof-of-concept for detailed tracking of individual-specific, health-relevant dietary patterns without the need for questionnaires. Diener et al. present a method that allows the estimation of dietary intake from human stool by detecting food-derived DNA in faecal metagenomes.","PeriodicalId":19038,"journal":{"name":"Nature metabolism","volume":"7 3","pages":"617-630"},"PeriodicalIF":18.9,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s42255-025-01220-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143435495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nature metabolismPub Date : 2025-02-07DOI: 10.1038/s42255-024-01214-5
Theresa V. Rohm, Karina Cunha e Rocha, Jerrold M. Olefsky
{"title":"Metabolic Messengers: small extracellular vesicles","authors":"Theresa V. Rohm, Karina Cunha e Rocha, Jerrold M. Olefsky","doi":"10.1038/s42255-024-01214-5","DOIUrl":"10.1038/s42255-024-01214-5","url":null,"abstract":"Small extracellular vesicles (sEVs) are signalling molecules and biomarkers of cell status that govern a complex intraorgan and interorgan communication system through their cargo. Initially recognized as a waste disposal mechanism, they have emerged as important metabolic regulators. They transfer biological signals to recipient cells through their cargo content, and microRNAs (miRNAs) often mediate their metabolic effects. This review provides a concise overview of sEVs, specifically in the context of obesity-associated chronic inflammation and related metabolic disorders, describing their role as metabolic messengers, identifying their key sites of action and elucidating their mechanisms. We highlight studies that have shaped our understanding of sEV metabolism, address critical questions for future exploration, discuss the use of miRNAs as disease biomarkers and provide insights into the therapeutic potential of sEVs or specific miRNAs for treating metabolic diseases and related disorders in the future. Olefsky, Rohm and Cunha e Rocha provide a concise overview of the role of small extracellular vesicles in metabolic health and discuss their history, role as biomarkers, mechanisms of action and therapeutic potential.","PeriodicalId":19038,"journal":{"name":"Nature metabolism","volume":"7 2","pages":"253-262"},"PeriodicalIF":18.9,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143258569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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