Nature metabolism最新文献_第5页

Publisher Correction: Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function. 出版者更正：冷诱导的截断腺苷酸环化酶3的表达对棕色脂肪的功能起变阻器作用。

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Nature metabolism Pub Date : 2025-04-01 DOI: 10.1038/s42255-025-01292-z

Sajjad Khani, Hande Topel, Ronja Kardinal, Ana Rita Tavanez, Ajeetha Josephrajan, Bjørk Ditlev Marcher Larsen, Michael James Gaudry, Philipp Leyendecker, Nadia Meincke Egedal, Aylin Seren Güller, Natasa Stanic, Phillip M M Ruppert, Isabella Gaziano, Nils Rouven Hansmeier, Elena Schmidt, Paul Klemm, Lara-Marie Vagliano, Rainer Stahl, Fraser Duthie, Jens-Henning Krause, Ana Bici, Christoph Andreas Engelhard, Sabrina Gohlke, Peter Frommolt, Thorsten Gnad, Alvaro Rada-Iglesias, Marta Pradas-Juni, Tim Julius Schulz, Frank Thomas Wunderlich, Alexander Pfeifer, Alexander Bartelt, Martin Jastroch, Dagmar Wachten, Jan-Wilhelm Kornfeld

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Author Correction: Glycolytic neutrophils accrued in the spleen compromise anti-tumour T cell immunity in breast cancer. 作者更正：脾脏中积累的糖酵解中性粒细胞损害乳腺癌的抗肿瘤T细胞免疫。

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Nature metabolism Pub Date : 2025-04-01 DOI: 10.1038/s42255-025-01279-w

Yu Wang, Muhan Xu, Jian Sun, Xiaoxiao Li, Huazheng Shi, Xuefeng Wang, Benming Liu, Tao Zhang, Xu Jiang, Liangyu Lin, Qing Li, Yin Huang, Yong Liang, Mingyuan Hu, Fanjun Zheng, Fengyu Zhang, Jian Sun, Yufang Shi, Ying Wang

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Publisher Correction: A subset of dopamine receptor-expressing neurons in the nucleus accumbens controls feeding and energy homeostasis 出版商更正：阿坎本斯核中表达多巴胺受体的神经元亚群控制进食和能量平衡

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Nature metabolism Pub Date : 2025-04-01 DOI: 10.1038/s42255-025-01285-y

Yiqiong Liu, Ying Wang, Zheng-dong Zhao, Guoguang Xie, Chao Zhang, Renchao Chen, Yi Zhang

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Non-caloric sweetener effects on brain appetite regulation in individuals across varying body weights 无热量甜味剂对不同体重个体大脑食欲调节的影响

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Nature metabolism Pub Date : 2025-03-26 DOI: 10.1038/s42255-025-01227-8

Sandhya P. Chakravartti, Kay Jann, Ralf Veit, Hanyang Liu, Alexandra G. Yunker, Brendan Angelo, John R. Monterosso, Anny H. Xiang, Stephanie Kullmann, Kathleen A. Page

{"title":"Non-caloric sweetener effects on brain appetite regulation in individuals across varying body weights","authors":"Sandhya P. Chakravartti, Kay Jann, Ralf Veit, Hanyang Liu, Alexandra G. Yunker, Brendan Angelo, John R. Monterosso, Anny H. Xiang, Stephanie Kullmann, Kathleen A. Page","doi":"10.1038/s42255-025-01227-8","DOIUrl":"10.1038/s42255-025-01227-8","url":null,"abstract":"Sucralose, a widely used non-caloric sweetener, provides sweet taste without calories. Some studies suggest that non-caloric sweeteners stimulate appetite, possibly owing to the delivery of a sweet taste without the post-ingestive metabolic signals that normally communicate with the hypothalamus to suppress hunger. In a randomized crossover trial (ClinicalTrials.gov identifier: NCT02945475 ), 75 young adults (healthy weight, overweight or with obesity) consumed a drink containing sucralose, sweetness-matched sucrose or water. We show that acute consumption of sucralose versus sucrose stimulates hypothalamic blood flow (P < 0.018) and greater hunger responses (P < 0.001). Sucralose versus water also increases hypothalamic blood flow (P < 0.019) but produces no difference in hunger ratings. Sucrose, but not sucralose, increases peripheral glucose levels, which are associated with reductions in medial hypothalamic blood flow (P < 0.007). Sucralose, compared to sucrose and water, results in increased functional connections between the hypothalamus and brain regions involved in motivation and somatosensory processing. These findings suggest that non-caloric sweeteners could affect key mechanisms in the hypothalamus responsible for appetite regulation. In a randomized, crossover clinical trial in healthy young adults with varying weights, sucralose increased hypothalamic blood flow and its functional connections with brain regions involved in motivation and somatosensory processing.","PeriodicalId":19038,"journal":{"name":"Nature metabolism","volume":"7 3","pages":"574-585"},"PeriodicalIF":18.9,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143707711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Haem biosynthesis regulates BCAA catabolism and thermogenesis in brown adipose tissue 血红素生物合成调节棕色脂肪组织BCAA分解代谢和产热

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Nature metabolism Pub Date : 2025-03-25 DOI: 10.1038/s42255-025-01253-6

Dylan J. Duerre, Julia K. Hansen, Steven V. John, Annie Jen, Noah D. Carrillo, Hoang Bui, Yutong Bao, Matias Fabregat, J. Leon Catrow, Li-Yu Chen, Katherine A. Overmyer, Evgenia Shishkova, Quentinn Pearce, Mark P. Keller, Richard A. Anderson, Vincent L. Cryns, Alan D. Attie, James E. Cox, Joshua J. Coon, Jing Fan, Andrea Galmozzi

{"title":"Haem biosynthesis regulates BCAA catabolism and thermogenesis in brown adipose tissue","authors":"Dylan J. Duerre, Julia K. Hansen, Steven V. John, Annie Jen, Noah D. Carrillo, Hoang Bui, Yutong Bao, Matias Fabregat, J. Leon Catrow, Li-Yu Chen, Katherine A. Overmyer, Evgenia Shishkova, Quentinn Pearce, Mark P. Keller, Richard A. Anderson, Vincent L. Cryns, Alan D. Attie, James E. Cox, Joshua J. Coon, Jing Fan, Andrea Galmozzi","doi":"10.1038/s42255-025-01253-6","DOIUrl":"https://doi.org/10.1038/s42255-025-01253-6","url":null,"abstract":"<p>The distinctive colour of brown adipose tissue (BAT) is attributed to its high content of haem-rich mitochondria. However, the mechanisms by which BAT regulates intracellular haem levels remain largely unexplored. Here we demonstrate that haem biosynthesis is the primary source of haem in brown adipocytes. Inhibiting haem biosynthesis results in an accumulation of the branched-chain amino acids (BCAAs) valine and isoleucine, owing to a haem-associated metabolon that channels BCAA-derived carbons into haem biosynthesis. Haem synthesis-deficient brown adipocytes display reduced mitochondrial respiration and lower UCP1 levels than wild-type cells. Although exogenous haem supplementation can restore intracellular haem levels and mitochondrial function, UCP1 downregulation persists. This sustained UCP1 suppression is linked to epigenetic regulation induced by the accumulation of propionyl-CoA, a byproduct of disrupted haem synthesis. Finally, disruption of haem biosynthesis in BAT impairs thermogenic response and, in female but not male mice, hinders the cold-induced clearance of circulating BCAAs in a sex-hormone-dependent manner. These findings establish adipose haem biosynthesis as a key regulator of thermogenesis and sex-dependent BCAA homeostasis.</p>","PeriodicalId":19038,"journal":{"name":"Nature metabolism","volume":"61 1","pages":""},"PeriodicalIF":20.8,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143695623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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A BCAA–haem axis regulates brown fat function bcaa -血红素轴调节棕色脂肪的功能

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Nature metabolism Pub Date : 2025-03-25 DOI: 10.1038/s42255-025-01266-1

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Reversible reduction in brain myelin content upon marathon running 马拉松运动后脑髓磷脂含量的可逆减少

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Nature metabolism Pub Date : 2025-03-24 DOI: 10.1038/s42255-025-01244-7

Pedro Ramos-Cabrer, Alberto Cabrera-Zubizarreta, Daniel Padro, Mario Matute-González, Alfredo Rodríguez-Antigüedad, Carlos Matute

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Reversible reduction in brain myelin content after endurance exercise 耐力运动后脑髓磷脂含量可逆减少

IF 20.8 1区医学