Nature metabolism最新文献

{"title":"Author Correction: A glucose-like metabolite deficient in diabetes inhibits cellular entry of SARS-CoV-2","authors":"Liangqin Tong, Xiaoping Xiao, Min Li, Shisong Fang, Enhao Ma, Xi Yu, Yibin Zhu, Chunli Wu, Deyu Tian, Fan Yang, Jing Sun, Jing Qu, Nianzhen Zheng, Shumin Liao, Wanbo Tai, Shengyong Feng, Liming Zhang, Yuhan Li, Lin Wang, Xuelian Han, Shihui Sun, Long Yang, Hui Zhong, Jincun Zhao, Wenjun Liu, Xiaohui Liu, Penghua Wang, Liang Li, Guangyu Zhao, Renli Zhang, Gong Cheng","doi":"10.1038/s42255-026-01634-5","DOIUrl":"10.1038/s42255-026-01634-5","url":null,"abstract":"","PeriodicalId":19038,"journal":{"name":"Nature metabolism","volume":"8 10","pages":"2199-2199"},"PeriodicalIF":27.5,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s42255-026-01634-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148977259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author Correction: Human gut microbial aromatic amino acid and related metabolites prevent obesity through intestinal immune control","authors":"Zengliang Jiang, Liuqing He, Diyin Li, Laibao Zhuo, Lingjun Chen, Rui-Qi Shi, Jianhua Luo, Yuhui Feng, Yuhui Liang, Danyang Li, Xiao Congmei, Yuanqing Fu, Yu-ming Chen, Ju-Sheng Zheng, Liang Tao","doi":"10.1038/s42255-026-01632-7","DOIUrl":"10.1038/s42255-026-01632-7","url":null,"abstract":"","PeriodicalId":19038,"journal":{"name":"Nature metabolism","volume":"8 10","pages":"2203-2203"},"PeriodicalIF":27.5,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s42255-026-01632-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148977306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author Correction: Asparagine deprivation enhances T cell antitumour response in patients via ROS-mediated metabolic and signal adaptations","authors":"Hsuan-Chia Chang, Chung-Ying Tsai, Cheng-Lung Hsu, Tzong-Shyuan Tai, Mei-Ling Cheng, Yu-Ming Chuang, Hsiang-Yu Tang, Kun-Ju Lin, Jia-Jin Chen, Szu-Han Chang, Yi-Ching Ko, Yu-Wen Chi, Hsuan Liu, Bertrand Chin-Ming Tan, Chia-Rui Shen, Chih-Wei Yang, Ping-Chih Ho, Huang-Yu Yang","doi":"10.1038/s42255-026-01633-6","DOIUrl":"10.1038/s42255-026-01633-6","url":null,"abstract":"","PeriodicalId":19038,"journal":{"name":"Nature metabolism","volume":"8 10","pages":"2202-2202"},"PeriodicalIF":27.5,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s42255-026-01633-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148977247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pick and choose","authors":"","doi":"10.1038/s42255-026-01623-8","DOIUrl":"10.1038/s42255-026-01623-8","url":null,"abstract":"Great science comes in all shapes and sizes. Choosing the most suitable article type is key to managing the expectations of readers, editors and reviewers alike.","PeriodicalId":19038,"journal":{"name":"Nature metabolism","volume":"8 9","pages":"1-2"},"PeriodicalIF":27.5,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s42255-026-01623-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148945035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Argininosuccinate signalling drives carbon replenishment in B cell acute lymphoblastic leukaemia","authors":"","doi":"10.1038/s42255-026-01593-x","DOIUrl":"10.1038/s42255-026-01593-x","url":null,"abstract":"Argininosuccinate synthase 1 (ASS1) phosphorylation is elevated in samples from patients with B cell acute lymphoblastic leukaemia and in leukaemic cells. As ASS1-derived argininosuccinate was found to activate cytosolic NT5C2 to promote purine nucleoside biosynthesis and replenish cellular carbon sources, ASS1 and NT5C2 are potential therapeutic targets for tyrosine kinase-driven haematological malignancies.","PeriodicalId":19038,"journal":{"name":"Nature metabolism","volume":"8 9","pages":"1839-1840"},"PeriodicalIF":27.5,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148944954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Childhood proteomic signatures that predict adult cardiometabolic disease","authors":"","doi":"10.1038/s42255-026-01588-8","DOIUrl":"10.1038/s42255-026-01588-8","url":null,"abstract":"Early signs of cardiovascular–kidney–metabolic disease (CKMD) emerge before 20 years of age, but methods to identify CKMD risk in children are limited. We identified a proteomic and phenotypic signature of CKMD in children that is strongly associated with the development and clinical outcomes of CKMD in adulthood.","PeriodicalId":19038,"journal":{"name":"Nature metabolism","volume":"8 9","pages":"1837-1838"},"PeriodicalIF":27.5,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148944995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paediatric proteomic signatures of cardiometabolic disease-associated traits predict adult disease outcomes","authors":"Joshua M. Landman, Heather M. Highland, Andrew S. Perry, Annie G. Howard, Quanhu Sheng, Anna Lorenz, Alexandra B. Palmer, Shilin Zhao, Wanying Zhu, Xinruo Zhang, Victoria L. Buchanan, Elizabeth G. Frankel, Rashedeh Roshani, Alyssa Scartozzi, Eric H. Farber-Eger, Mohammad Y. Anwar, Jessica K. Sprinkles, Ash Breidenbach, Ting-Chen Wang, Christine A. Ballard, Matthew Nayor, Jaclyn Tamaroff, Absalon Gutierrez, Lauren E. Petty, Alexander S. Petty, Benjamin Lippi, Lindsay Fernandez-Rhodes, Hung-Hsin Chen, Mohanraj Krishnan, Mariaelisa Graff, Katie A. Meyer, Miryoung Lee, Kristin L. Young, Quinn Wells, Kahraman Tanriverdi, Jane E. Freedman, Eric R. Gamazon, Joseph B. McCormick, Susan P. Fisher-Hoch, Penny Gordon-Larsen, Jennifer E. Below, Kari E. North, Ravi V. Shah","doi":"10.1038/s42255-026-01589-7","DOIUrl":"10.1038/s42255-026-01589-7","url":null,"abstract":"While the earliest pathological signs of cardiovascular–kidney–metabolic disease (CKMD) emerge before age 20, current adult-based risk thresholds fail to identify a substantial fraction of children at high risk. With increasing childhood obesity, early, sensitive detection of CKMD risk is critical to timely intervention. We linked 25 CKMD phenotypes spanning liver, adipose, vascular and dysglycaemia traits to the circulating proteome in 273 Hispanic or Latino children and adolescents (13.1 ± 2.7 years; 53% female). Here we show that proteome signatures of CKMD in children are strongly associated with clinical CKMD outcomes in adults. In 685 adults from the same community and 28,256 adults from UK Biobank, we observe high concordance between the paediatric and adult CKMD phenotype–proteome relationships, related to pancreatic beta-cell health and insulin sensitivity, liver homeostasis, inflammation and cholesterol metabolism. Many proteins linked to paediatric CKMD were modifiable with glucagon-like peptide-1 receptor agonist therapy in adults and are linked to genetic liability to CKMD. These findings support an early origin of CKMD disease liability embedded in the human proteome in children, underscoring the value of precision prevention to forestall metabolic disease long before its clinical manifestation. By linking cardiovascular–kidney–metabolic disease (CKMD) phenotypes to the proteome of children and adolescents, the authors show that paediatric CKMD proteomic signatures predict cardiometabolic disease outcomes in adulthood.","PeriodicalId":19038,"journal":{"name":"Nature metabolism","volume":"8 9","pages":"2007-2022"},"PeriodicalIF":27.5,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s42255-026-01589-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148932498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ALKBH5 activates creatine-driven thermogenesis by stabilizing CKB mRNA in response to cold","authors":"Yinliang Zhang, Chunyuan Du, Wei Qiao, Ping Qiu, Chaofan Xu, Xiaohan Yang, Jingran Hao, Dong Zhao, Xiaochen Gai, Yongsheng Chang","doi":"10.1038/s42255-026-01592-y","DOIUrl":"10.1038/s42255-026-01592-y","url":null,"abstract":"Non-shivering thermogenesis contributes to increased energy expenditure and can be a potential therapy to combat obesity. Here we show that the adipose tissue N6-methyladenosine (m6A) demethylase ALKBH5 responds to cold and adrenergic stimulation to induce non-shivering thermogenesis independent of UCP1. Fat-specific Alkbh5 knockout reduces thermogenic capacity, increases susceptibility to obesity and disrupts glucose homoeostasis in both male and female mice. Conversely, Alkbh5 overexpression in thermogenic fat increases energy expenditure and improves systemic metabolism. Furthermore, fat ALKBH5 expression inversely correlates with obesity in humans. Mechanistically, ALKBH5 is transcriptionally induced by the cAMP/PKA/CREB pathway in response to thermogenic stimuli. ALKBH5 demethylates m6A on CKB mRNA and prevents its degradation mediated by YTHDF2, thereby enhancing creatine metabolism-mediated thermogenesis in both wild-type and Ucp1-knockout mice. These findings suggest that ALKBH5 transduces thermogenic signalling towards creatine-driven thermogenesis, serving as a potential target for the treatment of obesity. Adipose tissue ALKBH5 responds to cold and adrenergic stimulation and improves stability of CKB mRNA by m6A demethylation, leading to increased energy expenditure and thermogenesis independent of UCP1 in mice.","PeriodicalId":19038,"journal":{"name":"Nature metabolism","volume":"8 9","pages":"1990-2006"},"PeriodicalIF":27.5,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148930610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author Correction: Lac-Phe induces hypophagia by inhibiting AgRP neurons in mice.","authors":"Hailan Liu, Veronica L Li, Qingzhuo Liu, Yao Liu, Cunjin Su, Hueyxian Wong, Na Yin, Hesong Liu, Xing Fang, Kristine M McDermott, Hueyzhong Wong, Meng Yu, Longlong Tu, Jonathan C Bean, Yongxiang Li, Mengjie Wang, Yue Deng, Yuhan Shi, Olivia Z Ginnard, Yuxue Yang, Junying Han, Megan E Burt, Sanika V Jossy, Chunmei Wang, Yongjie Yang, Benjamin R Arenkiel, Dong Kong, Yang He, Jonathan Z Long, Yong Xu","doi":"10.1038/s42255-026-01624-7","DOIUrl":"https://doi.org/10.1038/s42255-026-01624-7","url":null,"abstract":"","PeriodicalId":19038,"journal":{"name":"Nature metabolism","volume":" ","pages":""},"PeriodicalIF":27.5,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148920837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GVC-Calc enables large-scale analysis of continuous glucose monitoring data","authors":"Diana M. Thomas, Ethan Collins, Karoline Hood, Leanne M. Redman, Kaja Falkenhain, Sarah Berry, Kate Bermingham, Andrew Lee, Antonio Mastroberardino, Austin Semmel, Rachel Gidaro, Zoe Winston, David S. Ludwig, Cara B. Ebbeling, Andrew P. Koutnik, Mason Crow, Dympna Gallagher, Maxine Ashby-Thompson, Kelsey M. Power, G. J. LaPorte","doi":"10.1038/s42255-026-01611-y","DOIUrl":"10.1038/s42255-026-01611-y","url":null,"abstract":"","PeriodicalId":19038,"journal":{"name":"Nature metabolism","volume":"8 10","pages":"2039-2041"},"PeriodicalIF":27.5,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148920822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}