SIRT5通过减轻炎症来减缓骨骼肌老化

IF 18.9 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Nature metabolism Pub Date : 2025-03-14 DOI:10.1038/s42255-025-01228-7

Vera Gorbunova, Andrei Seluanov

引用次数: 0

摘要

骨骼肌减少症是老年人丧失独立性的主要原因之一。一项灵长类动物研究表明，sirt5介导的TBK1 Lys137去琥珀酰化抑制TBK1的激活及其下游的促炎反应，从而保护骨骼肌免于衰老。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

SIRT5 slows skeletal muscle ageing by alleviating inflammation

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SIRT5 slows skeletal muscle ageing by alleviating inflammation

Sarcopenia is one of the main contributors to the loss of independence in older adults. A study in primates demonstrates that SIRT5-mediated desuccinylation of TBK1 at Lys137 inhibits the activation of TBK1 and its downstream pro-inflammatory responses, thereby protecting skeletal muscle from ageing.

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来源期刊

Nature metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

27.50

自引率

2.40%

发文量

170

期刊介绍： Nature Metabolism is a peer-reviewed scientific journal that covers a broad range of topics in metabolism research. It aims to advance the understanding of metabolic and homeostatic processes at a cellular and physiological level. The journal publishes research from various fields, including fundamental cell biology, basic biomedical and translational research, and integrative physiology. It focuses on how cellular metabolism affects cellular function, the physiology and homeostasis of organs and tissues, and the regulation of organismal energy homeostasis. It also investigates the molecular pathophysiology of metabolic diseases such as diabetes and obesity, as well as their treatment. Nature Metabolism follows the standards of other Nature-branded journals, with a dedicated team of professional editors, rigorous peer-review process, high standards of copy-editing and production, swift publication, and editorial independence. The journal has a high impact factor, has a certain influence in the international area, and is deeply concerned and cited by the majority of scholars.