Tiago A Mestre, Glenn T Stebbins, Sheng Luo, Christopher G Goetz
{"title":"Tremor is Commonly Responsive to Levodopa Along the Natural History of Parkinson's Disease.","authors":"Tiago A Mestre, Glenn T Stebbins, Sheng Luo, Christopher G Goetz","doi":"10.1002/mdc3.70162","DOIUrl":"https://doi.org/10.1002/mdc3.70162","url":null,"abstract":"","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alex J Berry, Harry Costello, Silvia Jesús, Gary Price, Ashwani Jha
{"title":"Management of Anxiety in Parkinson's Disease.","authors":"Alex J Berry, Harry Costello, Silvia Jesús, Gary Price, Ashwani Jha","doi":"10.1002/mdc3.70144","DOIUrl":"https://doi.org/10.1002/mdc3.70144","url":null,"abstract":"<p><strong>Background: </strong>Anxiety is a common, distressing, hard-to-diagnose and hard-to-treat symptom in Parkinson's disease. No formal guidelines exist to assist management.</p><p><strong>Objective: </strong>We provide a pragmatic guide to detecting and managing anxiety in Parkinson's disease.</p><p><strong>Methods: </strong>In this educational review, we describe the phenomenology, diagnostic challenges, hypothesized neurobiology, and the rationale for treatments for anxiety in Parkinson's disease. We review the major drug-classes and non-pharmacological treatment approaches in current use. We also present a meta-analysis of pharmacological treatments of anxiety derived from previously published systematic reviews of RCTs for depression in Parkinson's disease in which anxiety was a secondary outcome.</p><p><strong>Results: </strong>In our meta-analysis, anxiolytic medications showed a moderate overall anxiolytic effect compared to placebo (standardized mean difference: -0.45 [95% CI: -0.78, -0.12], p = 0.02). There were significant limitations with the studies included in this meta-analysis, with studies generally having small cohort sizes, and each specific pharmacotherapy was not studied in more than one randomized control trial. We also describe a pragmatic algorithm for individualized pharmacological management, based on our own experience of selecting treatments to optimize side-effect profile and treatment of comorbid symptoms.</p><p><strong>Conclusions: </strong>Detecting and treating anxiety likely benefits people with Parkinson's disease, though the current evidence-base for specific treatments or specific pharmacotherapy remains limited. Further work is needed to investigate the different evidence-based approaches for managing anxiety in Parkinson's disease.</p>","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144497532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Changing Face of Dystonia-Enhancing Diagnosis by Moving Beyond Traditional Clinical Phenotyping.","authors":"Niroshan Jeyakumar, Kishore R Kumar","doi":"10.1002/mdc3.70189","DOIUrl":"https://doi.org/10.1002/mdc3.70189","url":null,"abstract":"","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144506881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Case of Vertical Diplopia after Thalamic Deep Brain Stimulation for Essential Tremor.","authors":"Rena Far, Suresh Subramaniam, Camila Aquino, Fady Girgis","doi":"10.1002/mdc3.70191","DOIUrl":"https://doi.org/10.1002/mdc3.70191","url":null,"abstract":"","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144485185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Justus Chun-Yu Chen, Renato P Munhoz, Anthony E Lang, Peer Briken, Christos Ganos
{"title":"A Pragmatic Approach to Sexual Health in Movement Disorders.","authors":"Justus Chun-Yu Chen, Renato P Munhoz, Anthony E Lang, Peer Briken, Christos Ganos","doi":"10.1002/mdc3.70198","DOIUrl":"https://doi.org/10.1002/mdc3.70198","url":null,"abstract":"<p><strong>Background: </strong>A satisfying sexual life is essential for maintaining good quality of life and healthy relationships for all individuals, including those with movement disorders and their partners. However, its significance is often overlooked in neurological clinics.</p><p><strong>Methods: </strong>We review the literature and draw from our own experience to offer a practical approach for assessing and managing sexual health issues in patients with movement disorders.</p><p><strong>Results: </strong>We begin by introducing fundamental concepts of sexual medicine, emphasizing models of sexual response that offer useful frameworks for diagnostic classification and management practices. We then address the most common sexual problems and disorders, including sexual dysfunction, sexual pain disorders, sexual compulsivity, and paraphilic behaviors, and their connections to different movement disorders. Next, we discuss assessment approaches that encompass biological, psychological, and social factors related to sexual health, including investigations for structural, vascular, or hormonal causes. Brief assessment questionnaires are also discussed. In addition to specific sexual therapeutic practices and supportive psychotherapy, we cover adjustments to pharmacological treatments related to movement disorders, as well as the use of mechanical devices. We also address the need for individualized management in specific cases, such as for patients undergoing deep brain stimulation surgery.</p><p><strong>Conclusion: </strong>Neurologists can play a key role in addressing sexual health concerns, considering the impact of both the disorder and its treatments. A comprehensive approach includes assessing biological, psychological, and sociocultural factors, with interventions like sexual therapy, supportive psychotherapy, pharmacological treatments and medical devices. Further research is needed to establish evidence-based treatments in this population.</p>","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144497531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Karlo J Lizarraga, Petra Pavelekova, Robert Chen, Mark Hallett
{"title":"Neurophysiological Testing to Diagnose Stiff-Person Spectrum Disorder.","authors":"Karlo J Lizarraga, Petra Pavelekova, Robert Chen, Mark Hallett","doi":"10.1002/mdc3.70194","DOIUrl":"https://doi.org/10.1002/mdc3.70194","url":null,"abstract":"","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144485186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Systematic Approach to Evaluating and Addressing Disparities in Deep Brain Stimulation.","authors":"Anthony Bishay, Natasha Hughes, Sarah K Bick","doi":"10.1002/mdc3.70193","DOIUrl":"https://doi.org/10.1002/mdc3.70193","url":null,"abstract":"","PeriodicalId":19029,"journal":{"name":"Movement Disorders Clinical Practice","volume":" ","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144476107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}