Nature Cell Biology最新文献_第5页

An overview of contemporary theories of ageing 当代老龄化理论概述

IF 21.3 1区生物学

Nature Cell Biology Pub Date : 2025-07-01 DOI: 10.1038/s41556-025-01698-7

João Pedro de Magalhães

引用次数: 0

Autophagy-targeted NBR1–p62/SQSTM1 complexes promote breast cancer metastasis by sequestering ITCH 靶向自噬的NBR1-p62 /SQSTM1复合物通过隔离瘙痒促进乳腺癌转移

IF 21.3 1区生物学

Nature Cell Biology Pub Date : 2025-06-27 DOI: 10.1038/s41556-025-01689-8

Gourish Mondal, Hugo Gonzalez, Timothy Marsh, Andrew M. Leidal, Ariadne Vlahakis, Pravin R. Phadatare, Sofı́a Bustamante Eguiguren, Michael Bruck, Akul Naik, Mark Jesus M. Magbanua, Laura A. Huppert, Arun P. Wiita, Jeroen P. Roose, Jennifer M. Rosenbluth, Jayanta Debnath

{"title":"Autophagy-targeted NBR1–p62/SQSTM1 complexes promote breast cancer metastasis by sequestering ITCH","authors":"Gourish Mondal, Hugo Gonzalez, Timothy Marsh, Andrew M. Leidal, Ariadne Vlahakis, Pravin R. Phadatare, Sofı́a Bustamante Eguiguren, Michael Bruck, Akul Naik, Mark Jesus M. Magbanua, Laura A. Huppert, Arun P. Wiita, Jeroen P. Roose, Jennifer M. Rosenbluth, Jayanta Debnath","doi":"10.1038/s41556-025-01689-8","DOIUrl":"https://doi.org/10.1038/s41556-025-01689-8","url":null,"abstract":"Autophagy deficiency in breast cancer promotes metastasis through the accumulation of the autophagy cargo receptor NBR1. Here we show that autophagy normally suppresses breast cancer metastasis by enabling the clearance of NBR1–p62/SQSTM1 complexes that instruct p63-mediated pro-metastatic basal differentiation programmes. When autophagy is inhibited, the autophagy cargo receptors NBR1 and p62/SQSTM1 accumulate within biomolecular condensates in cells, which drives basal differentiation in both mouse and human breast cancer models. Mechanistically, these NBR1–p62/SQSTM1 complexes sequester ITCH, a ubiquitin ligase that degrades and negatively regulates p63 in breast cancer cells, thereby stabilizing and activating p63. Accordingly, mutant forms of NBR1 unable to sequester ITCH into NBR1–p62/SQSTM1 complexes do not promote basal differentiation and metastasis in vivo. Overall, our findings illuminate how proteostatic defects arising in the setting of therapeutic autophagy inhibition modulate epithelial lineage fidelity and metastatic progression.","PeriodicalId":18977,"journal":{"name":"Nature Cell Biology","volume":"50 1","pages":""},"PeriodicalIF":21.3,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144500405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

REM transcription factors and GDE1 shape the DNA methylation landscape through the recruitment of RNA polymerase IV transcription complexes REM转录因子和GDE1通过募集RNA聚合酶IV转录复合物来塑造DNA甲基化景观

IF 21.3 1区生物学

Nature Cell Biology Pub Date : 2025-06-27 DOI: 10.1038/s41556-025-01691-0

Zhongshou Wu, Yan Xue, Shuya Wang, Yuan-Hsin Shih, Zhenhui Zhong, Suhua Feng, Jonathan Draper, Allen Lu, Carsten A. Hoeke, Jihui Sha, Lu Li, James Wohlschlegel, Keqiang Wu, Steven E. Jacobsen

{"title":"REM transcription factors and GDE1 shape the DNA methylation landscape through the recruitment of RNA polymerase IV transcription complexes","authors":"Zhongshou Wu, Yan Xue, Shuya Wang, Yuan-Hsin Shih, Zhenhui Zhong, Suhua Feng, Jonathan Draper, Allen Lu, Carsten A. Hoeke, Jihui Sha, Lu Li, James Wohlschlegel, Keqiang Wu, Steven E. Jacobsen","doi":"10.1038/s41556-025-01691-0","DOIUrl":"https://doi.org/10.1038/s41556-025-01691-0","url":null,"abstract":"In plants, the maintenance of DNA methylation is controlled by several self-reinforcing loops involving histone methylation and non-coding RNAs. However, how methylation is initially patterned at specific genomic loci is largely unknown. Here we describe four Arabidopsis REM transcription factors, VDD, VAL, REM12 and REM13, that recognize specific sequence regions and, together with the protein GENETICS DETERMINES EPIGENETICS1 (GDE1), recruit RNA polymerase IV transcription complexes. This targeted recruitment leads to the production of 24-nucleotide small interfering RNAs that guide DNA methylation to specific genomic sites in plant female reproductive tissues. In the absence of GDE1, polymerase IV transcription complexes are directed to loci bound by an alternative transcription factor, REM8, highlighting the role of REM transcription factors and GDE1 proteins as positional cues for epigenetic modulation. These findings establish a direct connection between sequence-specific transcription factors and the spatial regulation of siRNA production and DNA methylation, offering new insights into the genetic control of epigenetic patterning.","PeriodicalId":18977,"journal":{"name":"Nature Cell Biology","volume":"18 1","pages":""},"PeriodicalIF":21.3,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144500407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A lysosomal surveillance response to stress extends healthspan 对压力的溶酶体监测反应延长了健康寿命

IF 21.3 1区生物学

Nature Cell Biology Pub Date : 2025-06-26 DOI: 10.1038/s41556-025-01693-y

Terytty Yang Li, Arwen W. Gao, Rendan Yang, Yu Sun, Yuxuan Lei, Xiaoxu Li, Lin Chen, Yasmine J. Liu, Rachel N. Arey, Kimberly Morales, Raya B. Liu, Wenzheng Wang, Ang Zhou, Tong-jin Zhao, Weisha Li, Amélia Lalou, Qi Wang, Tanes Lima, Riekelt H. Houtkooper, Johan Auwerx

{"title":"A lysosomal surveillance response to stress extends healthspan","authors":"Terytty Yang Li, Arwen W. Gao, Rendan Yang, Yu Sun, Yuxuan Lei, Xiaoxu Li, Lin Chen, Yasmine J. Liu, Rachel N. Arey, Kimberly Morales, Raya B. Liu, Wenzheng Wang, Ang Zhou, Tong-jin Zhao, Weisha Li, Amélia Lalou, Qi Wang, Tanes Lima, Riekelt H. Houtkooper, Johan Auwerx","doi":"10.1038/s41556-025-01693-y","DOIUrl":"https://doi.org/10.1038/s41556-025-01693-y","url":null,"abstract":"Lysosomes are cytoplasmic organelles central for the degradation of macromolecules to maintain cellular homoeostasis and health. However, how lysosomal activity can be boosted to counteract ageing and ageing-related diseases remains elusive. Here we reveal that silencing specific vacuolar H+-ATPase subunits (for example, vha-6), which are essential for intestinal lumen acidification in Caenorhabditis elegans, extends lifespan by ~60%. This longevity phenotype can be explained by an adaptive transcriptional response typified by induction of a set of transcripts involved in lysosomal function and proteolysis, which we termed the lysosomal surveillance response (LySR). LySR activation is characterized by boosted lysosomal activity and enhanced clearance of protein aggregates in worm models of Alzheimer’s disease, Huntington’s disease and amyotrophic lateral sclerosis, thereby improving fitness. The GATA transcription factor ELT-2 governs the LySR programme and its associated beneficial effects. Activating the LySR pathway may therefore represent an attractive mechanism to reduce proteotoxicity and, as such, potentially extend healthspan.","PeriodicalId":18977,"journal":{"name":"Nature Cell Biology","volume":"24 1","pages":""},"PeriodicalIF":21.3,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144488383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SEL1L–HRD1-mediated ERAD in mammals sel1l - hrd1介导的哺乳动物ERAD

IF 21.3 1区生物学

Nature Cell Biology Pub Date : 2025-06-25 DOI: 10.1038/s41556-025-01690-1

Huilun Helen Wang, Ida Biunno, Shengyi Sun, Ling Qi

引用次数: 0

Author Correction: A two-step mechanism for epigenetic specification of centromere identity and function 作者更正：着丝粒身份和功能的两步表观遗传规范机制

IF 21.3 1区生物学

Nature Cell Biology Pub Date : 2025-06-23 DOI: 10.1038/s41556-025-01718-6

Daniele Fachinetti, H. Diego Folco, Yael Nechemia-Arbely, Luis P. Valente, Kristen Nguyen, Alex J. Wong, Quan Zhu, Andrew J. Holland, Arshad Desai, Lars E. T. Jansen, Don W. Cleveland

引用次数: 0

Organelle conversations drive ferroptosis 细胞器对话驱动铁下垂

IF 21.3 1区生物学

Nature Cell Biology Pub Date : 2025-06-19 DOI: 10.1038/s41556-025-01694-x

Ancély Ferreira dos Santos, José Pedro Friedmann Angeli

引用次数: 0

Crossover patterning through condensation and coarsening of pro-crossover factors 交叉模式通过凝聚和粗化的前交叉因素

IF 21.3 1区生物学

Nature Cell Biology Pub Date : 2025-06-19 DOI: 10.1038/s41556-025-01688-9

Liangyu Zhang, Weston Stauffer, Chenshu Liu, Hengyi Shao, Noor Abuzahriyeh, Rui Jiang, David Zwicker, Xing Liu, Xuebiao Yao, Abby F. Dernburg

{"title":"Crossover patterning through condensation and coarsening of pro-crossover factors","authors":"Liangyu Zhang, Weston Stauffer, Chenshu Liu, Hengyi Shao, Noor Abuzahriyeh, Rui Jiang, David Zwicker, Xing Liu, Xuebiao Yao, Abby F. Dernburg","doi":"10.1038/s41556-025-01688-9","DOIUrl":"https://doi.org/10.1038/s41556-025-01688-9","url":null,"abstract":"Meiotic recombination mixes genetic information from parental genomes, creating unique combinations of alleles. During meiotic prophase, each homologue pair must undergo at least one crossover to segregate faithfully. Only a few recombination intermediates become crossovers, and these are widely spaced or limited to one per chromosome pair. Mechanisms that regulate crossover number and spacing remain poorly understood. Here we show that, in Caenorhabditis elegans, ‘recombination nodules’, protein assemblies that stabilize recombination intermediates and promote crossover formation, assemble in part through biomolecular condensation and are stabilized by CDK-2 kinase activity. We further demonstrate that essential components of these nodules move along the synaptonemal complex (SC) and do not freely exchange between SCs in the same nucleus. Our findings reveal that recombination nodules behave as active droplets and support a model in which coarsening of these droplets via protein translocation along liquid crystalline SCs underlies crossover patterning.","PeriodicalId":18977,"journal":{"name":"Nature Cell Biology","volume":"44 1","pages":""},"PeriodicalIF":21.3,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144319683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Grow up, beta cells 长大吧，细胞

IF 21.3 1区生物学

Nature Cell Biology Pub Date : 2025-06-17 DOI: 10.1038/s41556-025-01705-x

Angela R. Parrish

引用次数: 0

Light microscopy reporting for reproducibility 光学显微镜报告再现性

IF 21.3 1区生物学

Nature Cell Biology Pub Date : 2025-06-17 DOI: 10.1038/s41556-025-01704-y

引用次数: 0