来自神经管的外周神经干细胞有助于多器官神经发生

IF 17.3 1区生物学 Q1 CELL BIOLOGY

Nature Cell Biology Pub Date : 2025-04-11 DOI:10.1038/s41556-025-01649-2

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引用次数: 0

摘要

我们发现多能性神经干细胞（NSCs）存在于外周，并且可以从多个外周组织中分离出来。外周神经干细胞（pNSCs）由源自神经上皮细胞而非神经嵴细胞的SOX1+细胞组成，与脑NSCs具有相同的特征，并在早期发育过程中参与外周神经发生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Peripheral neural stem cells from the neural tube contribute to multi-organ neurogenesis

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Peripheral neural stem cells from the neural tube contribute to multi-organ neurogenesis

We show that multipotent neural stem cells (NSCs) exist in the periphery and can be isolated from multiple peripheral tissues. Peripheral NSCs (pNSCs) are composed of SOX1+ cells that originate from neuroepithelial cells and not neural crest cells, share features with brain NSCs and contribute to peripheral neurogenesis during early development.

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来源期刊

Nature Cell Biology 生物-细胞生物学

CiteScore

28.40

自引率

0.90%

发文量

219

审稿时长

3 months

期刊介绍： Nature Cell Biology, a prestigious journal, upholds a commitment to publishing papers of the highest quality across all areas of cell biology, with a particular focus on elucidating mechanisms underlying fundamental cell biological processes. The journal's broad scope encompasses various areas of interest, including but not limited to: -Autophagy -Cancer biology -Cell adhesion and migration -Cell cycle and growth -Cell death -Chromatin and epigenetics -Cytoskeletal dynamics -Developmental biology -DNA replication and repair -Mechanisms of human disease -Mechanobiology -Membrane traffic and dynamics -Metabolism -Nuclear organization and dynamics -Organelle biology -Proteolysis and quality control -RNA biology -Signal transduction -Stem cell biology