Nature Cell Biology最新文献_第3页

Contracting and fracturing to invade 收缩和破裂入侵

IF 19.1 1区生物学

Nature Cell Biology Pub Date : 2026-04-16 DOI: 10.1038/s41556-026-01942-8

Daryl J. V. David

引用次数: 0

NK progenitors against cancer NK祖细胞抗癌

IF 19.1 1区生物学

Nature Cell Biology Pub Date : 2026-04-16 DOI: 10.1038/s41556-026-01934-8

Stylianos Lefkopoulos

引用次数: 0

GPX1 dictates in vivo ferroptosis GPX1决定体内铁下垂

IF 19.1 1区生物学

Nature Cell Biology Pub Date : 2026-04-16 DOI: 10.1038/s41556-026-01935-7

Zhe Wang

引用次数: 0

Lipid-trap mass spectrometry identifies lipid-protein interactions in cells. 脂质阱质谱法鉴定细胞中的脂质-蛋白相互作用。

IF 21.3 1区生物学

Nature Cell Biology Pub Date : 2026-04-13 DOI: 10.1038/s41556-026-01928-6

Andrea Paquola,Clare E Benson,Smita Eknath Desale,Cagakan Ozbalci,Elisabeth M Storck,Stephen J Terry,Bhagyashree Dasari Rao,Kelechi N Nwite,Federica Ferrentino,Ulrike S Eggert

{"title":"Lipid-trap mass spectrometry identifies lipid-protein interactions in cells.","authors":"Andrea Paquola,Clare E Benson,Smita Eknath Desale,Cagakan Ozbalci,Elisabeth M Storck,Stephen J Terry,Bhagyashree Dasari Rao,Kelechi N Nwite,Federica Ferrentino,Ulrike S Eggert","doi":"10.1038/s41556-026-01928-6","DOIUrl":"https://doi.org/10.1038/s41556-026-01928-6","url":null,"abstract":"Cells actively maintain complex lipidomes that encompass thousands of lipids; however, many of the roles of these lipids remain unexplored. Specific interactions between lipids and membrane proteins are a likely reason for lipidome complexity. Here we report the development of a technique, named lipid-trap mass spectrometry (LTMS), to systematically study lipid-protein interactions directly captured from mammalian cells. LTMS uses immunoprecipitation of GFP-tagged proteins expressed in HeLa cells, followed by lipidomic analysis of lipids bound to the GFP-tagged protein. We applied LTMS to cell division to illustrate the technique. We chose this process because membranes regulate their lipid composition as they undergo major changes during cytokinesis, and many cytokinetic proteins, including RACGAP1 and ESCRT-III components CHMP4B and CHMP2A, are membrane-associated. Using LTMS, we found that RACGAP1 and CHMP4B associate with specific lipid species in dividing compared with non-dividing cells. We expand our understanding of lipid diversity during cell division and present a general approach to explore lipid-protein interactions to further our knowledge of the roles of lipids in mammalian cells.","PeriodicalId":18977,"journal":{"name":"Nature Cell Biology","volume":"21 1","pages":""},"PeriodicalIF":21.3,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147666554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morally relevant features warranting ethical oversight in human stem cell-based embryo models 人类干细胞胚胎模型的道德相关特征需要伦理监督。

IF 19.1 1区生物学

Nature Cell Biology Pub Date : 2026-04-08 DOI: 10.1038/s41556-026-01881-4

Naomi Moris, Alfonso Martinez Arias, Martin Pera, Nicolas Rivron, Karen Sermon, Nienke de Graeff

{"title":"Morally relevant features warranting ethical oversight in human stem cell-based embryo models","authors":"Naomi Moris, Alfonso Martinez Arias, Martin Pera, Nicolas Rivron, Karen Sermon, Nienke de Graeff","doi":"10.1038/s41556-026-01881-4","DOIUrl":"10.1038/s41556-026-01881-4","url":null,"abstract":"Stem cell-based embryo models provide innovative ways to explore the principles of human development but also pose new challenges for regulation. Recent guidelines have argued for case-by-case evaluation of stem cell-based embryo model research but it is still unclear what exactly such oversight should consider. Here we argue that effective review requires the identification of a set of attributes by which to evaluate research proposals. To define these, the underlying ethical values and morally relevant biological features present in embryo models must be identified to enable the practical implementation of oversight. We propose that developmental stage, tissue/organ integrity, fetal potential and the capacity to form neural circuits should be used together for evaluation purposes. We also highlight the importance of the wider context, including the proposed uses of embryo models, public perception and individual researcher responsibilities, and thus provide a general framework for regulatory consideration of human embryo model research. This Perspective presents a set of attributes by which to evaluate human stem cell-based embryo models that not only include morally relevant embryo features but also take into account proposed use of the model and regulatory considerations.","PeriodicalId":18977,"journal":{"name":"Nature Cell Biology","volume":"28 4","pages":"659-664"},"PeriodicalIF":19.1,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147636028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A guide to using embedded ethics in human stem-cell-based embryo model research 在基于人类干细胞的胚胎模型研究中使用嵌入伦理的指南。

IF 19.1 1区生物学

Nature Cell Biology Pub Date : 2026-04-08 DOI: 10.1038/s41556-026-01909-9

Heidi Beate Bentzen, Maxence Gaillard, Iftach Nachman, Daniel Reumann, Nikolaj Gadegaard, Laurent David, Fredrik Lanner, Naomi Moris, Vincent Pasque, Nicolas Rivron, Berna Sozen, Rosario Isasi, Stefan Krauss, Jesse V. Veenvliet

{"title":"A guide to using embedded ethics in human stem-cell-based embryo model research","authors":"Heidi Beate Bentzen, Maxence Gaillard, Iftach Nachman, Daniel Reumann, Nikolaj Gadegaard, Laurent David, Fredrik Lanner, Naomi Moris, Vincent Pasque, Nicolas Rivron, Berna Sozen, Rosario Isasi, Stefan Krauss, Jesse V. Veenvliet","doi":"10.1038/s41556-026-01909-9","DOIUrl":"10.1038/s41556-026-01909-9","url":null,"abstract":"Human stem-cell-based embryo models (hSCBEMs) offer unprecedented opportunities for basic and translational research. However, the rapid pace of scientific developments in the field challenges the slower, traditional modes of ethics evaluation. To facilitate responsible research and governance, and ensure public trust, we propose using ‘embedded ethics’ as a purpose-anchored, dynamic, iterative and integrative approach where ethicists and scientists engage in continuous dialogue to ethically assess ongoing research. We outline a nested benchmarking strategy to periodically evaluate the scientific and ethical status of hSCBEMs within a project, using the human embryo as a reference and weighting criteria along a hierarchy of features that chart embryo-likeness, completeness and the developmental stage modelled. Embedded ethics guides the definition of decision points and ethical boundaries through an iterative assessment of project purpose and ethical and regulatory frameworks, and enables early identification of emerging issues and the co-construction of responsible paths forward. This Perspective proposes the use of an integrative embedded ethics approach to evaluate human stem-cell-based embryo models and outlines a nested benchmarking strategy to periodically evaluate their scientific and ethical status.","PeriodicalId":18977,"journal":{"name":"Nature Cell Biology","volume":"28 4","pages":"665-673"},"PeriodicalIF":19.1,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147636027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aberrant amino acid-sensing promotes immunotherapy resistance via the inflammatory cytokine–ZBTB5–mTORC1 axis 异常的氨基酸感知通过炎症细胞因子- zbtb5 - mtorc1轴促进免疫治疗抵抗

IF 21.3 1区生物学

Nature Cell Biology Pub Date : 2026-04-03 DOI: 10.1038/s41556-026-01926-8

Junyu Xiang, Tao Wang, Shuoran Tian, Jinyang Li, Mengyun Luo, Yuzhu Wang, Aibei Du, Xu Chen, Fanxuan Tian, Lei Wang, Yongchao Zhang, Mengyi Han, Wenqing Hou, Xinyu Wang, Tao Hou, Qin Liu, Dongfeng Chen, Liangzhi Wen, Zhongyi Qin, Xianfeng Li, Cong Jiang, Qiaoqiao Zhang, Pengda Liu, Xiuwu Bian, Wenyi Wei, Bin Wang

引用次数: 0

Programmable macromolecule delivery via engineered trogocytosis 可编程的大分子传递通过工程细胞胞浆

IF 21.3 1区生物学

Nature Cell Biology Pub Date : 2026-04-01 DOI: 10.1038/s41556-026-01920-0

Xinyi Chen, Yinglin Situ, Yuexuan Yang, Luna Lyu, Mengting Han, Lorenzo Magni, Maylin L. Fu, Boxiong Deng, Sui Wang, Lei S. Qi

{"title":"Programmable macromolecule delivery via engineered trogocytosis","authors":"Xinyi Chen, Yinglin Situ, Yuexuan Yang, Luna Lyu, Mengting Han, Lorenzo Magni, Maylin L. Fu, Boxiong Deng, Sui Wang, Lei S. Qi","doi":"10.1038/s41556-026-01920-0","DOIUrl":"https://doi.org/10.1038/s41556-026-01920-0","url":null,"abstract":"Trogocytosis, the transfer of plasma membrane fragments during cell–cell contact, offers potential for macromolecular delivery but is limited by the uncertain fate of trogocytosed molecules, restriction to membrane cargo and unclear generalizability. Here we demonstrate that donor cells engineered with designed receptors specific to surface ligands can transfer proteins to recipient cells through direct contact. We identified key engineering principles for enhancing transfer and ensuring cargo functionalization, including receptor design, pH-responsive membrane fusion, inducible cargo localization and release, and subcellular translocation. The method is broadly applicable across diverse cell types and operates through a dynamin- and endosome acidification-dependent pathway. Exploiting these findings, we developed TRANSFER, a versatile delivery system with programmable cell type specificity and tunability. TRANSFER can sense multiple ligand inputs, deliver large therapeutic protein cargos and mediate genome editing. The study establishes trogocytosis as a programmable, versatile framework for cell-based macromolecular delivery.","PeriodicalId":18977,"journal":{"name":"Nature Cell Biology","volume":"64 1","pages":""},"PeriodicalIF":21.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147585939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mosaic gastruloids reveal a temporal restriction for developmental cell competition. 马赛克类胃原体揭示了发育细胞竞争的时间限制。

IF 21.3 1区生物学

Nature Cell Biology Pub Date : 2026-04-01 DOI: 10.1038/s41556-026-01923-x

Joshua D Frenster,Stephen Babin,Pablo Casani-Galdon,Joel B Josende-Garcia,Pau Pascual-Mas,Gaëlle Robertson,Shlomit Edri,Alexandra E Wehmeyer,Sebastian J Arnold,Jordi Garcia Ojalvo,Alfonso Martinez Arias

{"title":"Mosaic gastruloids reveal a temporal restriction for developmental cell competition.","authors":"Joshua D Frenster,Stephen Babin,Pablo Casani-Galdon,Joel B Josende-Garcia,Pau Pascual-Mas,Gaëlle Robertson,Shlomit Edri,Alexandra E Wehmeyer,Sebastian J Arnold,Jordi Garcia Ojalvo,Alfonso Martinez Arias","doi":"10.1038/s41556-026-01923-x","DOIUrl":"https://doi.org/10.1038/s41556-026-01923-x","url":null,"abstract":"Selective elimination of suboptimal cells is critical for the developmental integrity of early mammalian embryogenesis. Cell competition is a non-autonomous quality control in which 'winner' cells outcompete viable but suboptimal 'loser' cells based on fitness differences. Here we investigate cell competition dynamics using mosaic mouse gastruloids, a 3D embryonic stem cell-based model of gastrulation. Introducing just two Trp53-deficient supercompetitor cells suffices to impair growth in neighbouring wild-type cells through mitochondrial apoptosis. Competition is tightly restricted to a developmental transition stage between primed pluripotency and early gastrulation and involves gene regulatory networks of pluripotency exit. Heterochronic gastruloids from developmental stage-shifted cells, EpiGastruloids, and dynamic p53-degrons reveal that both winners and losers must reside within this permissive stage, during which acute relative p53 protein levels determine competitive outcomes. These findings advance our understanding of cell fitness evaluation and establish gastruloids as a powerful 3D model for investigating developmental stage-specific cell competition in mammalian embryogenesis.","PeriodicalId":18977,"journal":{"name":"Nature Cell Biology","volume":"28 1","pages":""},"PeriodicalIF":21.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147585750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reinvigorating COTL1high NK cells via GITR signalling overcomes immune checkpoint blockade resistance in tsMHC-I-impaired tumours. 通过GITR信号激活cotl1高NK细胞克服tsmhc -i损伤肿瘤的免疫检查点阻断抗性

IF 21.3 1区生物学

Nature Cell Biology Pub Date : 2026-03-30 DOI: 10.1038/s41556-026-01925-9

Wenhua You,Chupeng Hu,Yuhan Zhang,Yedi Huang,Jianzhou Yuan,Cai-Yuan Wu,Deyuan Kong,Mengya Zhao,Yueqing Han,Songmao Li,Ruimin Shan,Jinying Lu,Ming Cheng,Qing Li,Bin Yao,Xiao-Fang Yu,Qing Xia,Wei Chong,Dong-Ming Kuang,Yun Chen

{"title":"Reinvigorating COTL1high NK cells via GITR signalling overcomes immune checkpoint blockade resistance in tsMHC-I-impaired tumours.","authors":"Wenhua You,Chupeng Hu,Yuhan Zhang,Yedi Huang,Jianzhou Yuan,Cai-Yuan Wu,Deyuan Kong,Mengya Zhao,Yueqing Han,Songmao Li,Ruimin Shan,Jinying Lu,Ming Cheng,Qing Li,Bin Yao,Xiao-Fang Yu,Qing Xia,Wei Chong,Dong-Ming Kuang,Yun Chen","doi":"10.1038/s41556-026-01925-9","DOIUrl":"https://doi.org/10.1038/s41556-026-01925-9","url":null,"abstract":"Patients with impaired tumour-specific major histocompatibility complex class I (tsMHC-Iimpaired) often fail to respond to immune checkpoint blockade (ICB), presenting a major clinical challenge. However, through our multicentre investigation, we observed that a subset of patients with tsMHC-Iimpaired remains responsive to ICB, a phenomenon that has not been fully explained. Here we identify a COTL1high natural killer (NK) subset that mediates ICB responsiveness in these patients. Mechanistically, PD-L1+ macrophages coexpress GITRL and engage GITR on COTL1high NK cells, whereas PD-L1 blockade relieves the PD-1-mediated inhibition of GITR signalling and promotes NK cell activation. Activated COTL1high NK cells enhance immunological synapse stability and IFN-γ production via a metabolic-H3K27ac-RBPJ axis, thereby upregulating tsMHC-I expression and reinforcing adaptive anti-tumour immunity. Notably, GITR activation significantly enhances the sensitivity to anti-PD-L1 therapy in tsMHC-Iimpaired models. Our findings identify COTL1high NK cells as key determinants of ICB responsiveness and highlight the GITRL-GITR axis as a promising therapeutic target for tsMHC-Iimpaired tumours.","PeriodicalId":18977,"journal":{"name":"Nature Cell Biology","volume":"62 1","pages":""},"PeriodicalIF":21.3,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147578347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0