Nano Biomedicine and Engineering最新文献_第2页

An Enhancing Diabetic Retinopathy Classification and Segmentation based on TaNet 基于 TaNet 的增强型糖尿病视网膜病变分类和分割技术

Nano Biomedicine and Engineering Pub Date : 2023-10-01 DOI: 10.26599/nbe.2023.9290041

Koneru Suvarna Vani, Puppala Praneeth, Vivek Kommareddy, Parasa Rishi Kumar, Madala Sarath, Shaik Hussain, Potluri Ravikiran

引用次数: 0

The Impact of Modified Metallic Nanoparticles on Thermomechanical Properties of PMMA Soft Liner 改性金属纳米颗粒对PMMA软衬热力学性能的影响

Nano Biomedicine and Engineering Pub Date : 2023-10-01 DOI: 10.26599/nbe.2023.9290040

Ban Saad Jasim, Hasanain K.A. Alalwan, Abdalbseet A. Fatalla, Manar E. Al-Samaray

{"title":"The Impact of Modified Metallic Nanoparticles on Thermomechanical Properties of PMMA Soft Liner","authors":"Ban Saad Jasim, Hasanain K.A. Alalwan, Abdalbseet A. Fatalla, Manar E. Al-Samaray","doi":"10.26599/nbe.2023.9290040","DOIUrl":"https://doi.org/10.26599/nbe.2023.9290040","url":null,"abstract":"The acrylic-based heat-cured soft denture lining material is the most commonly used in relining dentures. This material has poor thermomechanical properties which is a disadvantage. This research aimed to study the effect of the addition of modified metallic nanoparticles on glass transition, modulus of elasticity, and coefficient of thermal expansion and contraction of the acrylic soft liner. Alumina nanoparticles were first modified by a silane coupling agent and then added to a soft denture liner powder in different weight percentages (0, 0.5, 1, and 1.5 wt%) using a probe ultrasonication machine for mixing. 120 samples of acrylic-based soft liner were constructed and divided into four groups G1–G4 (n = 30). Each group was in turn subdivided into 3 subgroups (n = 10) according to the test performed. The mean value, SD, Kruskal-Wallis test, and Dunn’s Multiple Comparison tests were used to analyze the results statistically. Incorporating 0.5% by weight alumina nano-fillers into acrylic-based heat-cured soft denture lining material, increased the glass transition temperature significantly (p ≤ 0.01). Additionally, it significantly reduced the coefficient of thermal expansion and contraction, especially at 30 ºC, compared to the control group. The E-modulus was also reduced, especially at 50 ºC, compared to the control group. According to the reported results, the polymer nanocomposites possess distinctive material properties that distinguish them from unmodified acrylic-base soft denture lining materials. Nanocomposites have more thermal and mechanical stability than unmodified acrylic-base soft denture lining material especially when incorporating 0.5 wt% Al2O3.","PeriodicalId":18971,"journal":{"name":"Nano Biomedicine and Engineering","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136198639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Silver Nanoparticles Synthesized by Cold Plasma as an Antibiofilm Agent against Staphylococcus epidermidis Isolated from Acne 用冷等离子体合成的银纳米粒子作为抗生物膜剂对抗从痤疮中分离出来的表皮葡萄球菌

Nano Biomedicine and Engineering Pub Date : 2023-10-01 DOI: 10.26599/nbe.2023.9290042

Heba K. Tawfeeq, N. Abdalameer, R. Jassim, Maryam M. Shehab

引用次数: 0

Nanoparticles-assisted Wound Healing: A Review 纳米颗粒辅助伤口愈合:综述

Nano Biomedicine and Engineering Pub Date : 2023-10-01 DOI: 10.26599/nbe.2023.9290039

Sarah Habeeb Hamed, Ebaa Adnan Azooz, Emad Abbas Jaffar Al-Mulla

{"title":"Nanoparticles-assisted Wound Healing: A Review","authors":"Sarah Habeeb Hamed, Ebaa Adnan Azooz, Emad Abbas Jaffar Al-Mulla","doi":"10.26599/nbe.2023.9290039","DOIUrl":"https://doi.org/10.26599/nbe.2023.9290039","url":null,"abstract":"Poor wound treatment impacts millions of humans worldwide, increasing deaths and costs. Wounds have three key complications: (a) a lack of an adequate environment for cell migration, proliferation, and angiogenesis; (b) microbial infection; and (c) unstable and prolonged inflammation.Regrettably, contemporary therapeutic treatments have not entirely tackled these basic difficulties and thus have insufficient medical accomplishment. The incorporation of the extraordinary capabilities of nanomaterials in wound healing has achieved major successes over the years. Nanomaterials can promote a variety of cellular and molecular processes that assist in the wound microenvironment through antibacterial, anti-inflammatory, and angiogenic activities, potentially shifting the surroundings from nonhealing to healing. The current review focuses on novel techniques, with a particular focus on recent revolutionary wound healing and infection control tactics based on nanomaterials, such as nanoparticles, nanocomposites, and scaffolds, which are discussed in depth. Furthermore, the effectiveness of nanoparticles as carriers for therapeutic compounds in wound-healing applications has been investigated which provide researchers an up-to-date sources on the use of nanomaterials and their creative ways that can improve wound-healing uses.","PeriodicalId":18971,"journal":{"name":"Nano Biomedicine and Engineering","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136199742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acetylcholinesterase Activity in the Brain of Rats: Presence of an Inhibitor of Enzymatic Activity in Heliotropium eichwaldi L. Induced Silver/Gold Allied Bimetallic Nanoparticles 大鼠脑内乙酰胆碱酯酶活性:一种抑制银/金联合双金属纳米颗粒酶活性的抑制剂的存在

Nano Biomedicine and Engineering Pub Date : 2023-09-01 DOI: 10.26599/nbe.2023.9290034

Naila Sher, Mushtaq Ahmed, Nadia Mushtaq, Rahmat Ali khan

{"title":"Acetylcholinesterase Activity in the Brain of Rats: Presence of an Inhibitor of Enzymatic Activity in Heliotropium eichwaldi L. Induced Silver/Gold Allied Bimetallic Nanoparticles","authors":"Naila Sher, Mushtaq Ahmed, Nadia Mushtaq, Rahmat Ali khan","doi":"10.26599/nbe.2023.9290034","DOIUrl":"https://doi.org/10.26599/nbe.2023.9290034","url":null,"abstract":"A simple green method for the production of silver/gold bimetallic nanoparticles (Ag/Au BNPs) using a Heliotropium eichwaldi L. (HE) extract was designed in this study. The reduction of Ag/Au metals to stable Ag/Au BNPs within 24 h at pH 5 using 1 mL of HE at 40 °C signifies a greater rate of reaction compared with chemically elaborated synthesis. The confirmation of the synthesis and the examination of the size, shape, and elemental composition of these BNPs were performed using visible absorption spectroscopy, Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy dispersive X-ray spectroscopy (EDX). Stable, irregular-rod-shaped, and crystalline Ag/Au BNPs with a well-defined 6-nm diameter and a blue shift λmax of 532 nm were synthesized using the HE extract. Moreover, the anti-cholinesterase (anti-AChE) potential of the Ag/Au BNPs was tested as a treatment for Alzheimer’s disease (AD). An excellent anti-AChE activity (IC50, 71.2 ± 0.22 μg/mL) was observed for these biogenic-synthesized NPs. A statistical analysis revealed that Ag/Au BNPs inhibited AChE competitively, according to a Lineweaver–Burk plot, with Km increasing from 0.019 to 0.063 (288%–1185.7%) and Vmax remaining constant. The Ag/Au BNPs also caused an increase in KIapp, from 128 to 1184 (236%–828%), whereas they did not affect Vmaxiapp. The Km, KI, and Ki values were also calculated to be 0.0053 mmol/L, 595.25 µg, and 80 µg, respectively. Therefore, it is concluded that small-size, stable, and potent Ag/Au BNPs were synthesized successfully from HE extracts that exhibited anti-AChE activity, which renders them a significant remedy for AD.","PeriodicalId":18971,"journal":{"name":"Nano Biomedicine and Engineering","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135688225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection of the Anticancer and Genotoxic Activities of Heliotropium eichwaldi L.-fabricated Silver Nanoparticles on BHK-21 Cells and Human Blood Lymphocytes Using MTT and Comet Assays MTT法和Comet法检测银纳米粒子对BHK-21细胞和人血淋巴细胞的抗癌和遗传毒性活性

Nano Biomedicine and Engineering Pub Date : 2023-09-01 DOI: 10.26599/nbe.2023.9290037

Naila Sher, Mushtaq Ahmed, Nadia Mushtaq, Rahmat Ali Khan

{"title":"Detection of the Anticancer and Genotoxic Activities of Heliotropium eichwaldi L.-fabricated Silver Nanoparticles on BHK-21 Cells and Human Blood Lymphocytes Using MTT and Comet Assays","authors":"Naila Sher, Mushtaq Ahmed, Nadia Mushtaq, Rahmat Ali Khan","doi":"10.26599/nbe.2023.9290037","DOIUrl":"https://doi.org/10.26599/nbe.2023.9290037","url":null,"abstract":"The possible treatment of cancer with nanoparticles (NPs) would be carried out via inoculation into the veins; as a result, the NPs would come into contact with white blood cells (WBCs) and red blood cells (RBCs) prior to reaching the target cancerous cells. In the current study, the genotoxicity and cytotoxicity potential of silver NPs (AgNPs) against human blood lymphocytes and baby hamster kidney-21 (BHK-21) cells was tested using comet and 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) assays, respectively. First, AgNPs were created using a Heliotropium eichwaldi L. (HE) extract. These AgNPs were then confirmed by ultraviolet–visible (UV–Vis) spectroscopy, which yielded a sharp peak at 416 nm with a maximum absorbance of 1.92. Moreover, an X-ray diffraction (XRD) analysis confirmed the crystalline nature and particle size (19.79 nm) of AgNPs, whereas scanning electron microscopy (SEM) revealed their irregular morphology and size of 30 nm. In turn, an EDX analysis indicated that AgNPs had an appreciable composition of Ag ions (30.68%). According to the comet assay, the HE-AgNPs, and standard H2O2 caused highly significant damage to DNA compared with HE extract. The comet assay was reported in terms of the total comet score (TCS). In the case of the MTT assay, a dose-dependent cytotoxicity was noted, in which doxorubicin, and AgNPs were more potent against BHK-21 cells compared with a plant extract. From these results, it is evident that the green-synthesized AgNPs interacted with blood lymphocytes and BHK-21 cells, caused damage to DNA via oxidative stress, and finally triggered cell death (apoptosis). However, further studies aimed at reducing their potential threats are recommended.","PeriodicalId":18971,"journal":{"name":"Nano Biomedicine and Engineering","volume":"94 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135738329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of Artificial Intelligence in the Exploration and Optimization of Biomedical Nanomaterials 人工智能在生物医用纳米材料探索与优化中的应用

Nano Biomedicine and Engineering Pub Date : 2023-09-01 DOI: 10.26599/nbe.2023.9290035

Xiaoyang Zhu, Yan Li, Ning Gu

引用次数: 0

The Effects of Nano Magnetic Graphene Oxide on In Vivo Maturation of Oocyte 纳米磁性氧化石墨烯对卵母细胞体内成熟的影响

Nano Biomedicine and Engineering Pub Date : 2023-09-01 DOI: 10.26599/nbe.2023.9290036

Mitra Rahimi, Tahereh Foroutan, Fatemeh Eini

{"title":"The Effects of Nano Magnetic Graphene Oxide on In Vivo Maturation of Oocyte","authors":"Mitra Rahimi, Tahereh Foroutan, Fatemeh Eini","doi":"10.26599/nbe.2023.9290036","DOIUrl":"https://doi.org/10.26599/nbe.2023.9290036","url":null,"abstract":"Graphene oxide (GO) and Fe3O4 super paramagnetic material are good candidate for some applications such as drug delivery. It has been shown that combining Fe3O4 with graphene oxide increases the biological efficiency of GO. The use of novel assisted reproductive technologies such as gonadotropins injection has been able to help the fertility of infertile people, but the side effects of these methods and high costs are still problems. The aim of the present study was to investigate the effect of magnetic graphene oxide (MGO) on the in vivo maturation of mouse oocytes. Thirty 6–8-week old female Naval Medical Research Institute (NMRI) mice were treated with intra peritoneal (I.P) injection of MGO mixed with hormones. 12 h after I.P. injection of MGO mixed with PMSG and HCG, the number of metaphase II (MII) oocytes obtained from the left fallopian tubes was counted in each group. Also, immuno-cytochemical staining of glutathione and morphometric analysis of ovaries were studied. The results of this study showed that the simultaneous use of MGO, pregnant mare serum gonadotropin (PMSG), and human chorionic gonadotrophin (HCG) increases the number of MII oocytes and helps to increase maturation of oocytes. It could be concluded that MGO can increase the efficiency of super ovulating hormones due to increase in adsorption of serum hormones and growth factors.","PeriodicalId":18971,"journal":{"name":"Nano Biomedicine and Engineering","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135737777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of Ag 2O Nanoparticles via Fresh Pomegranate Peel Extract for Bioapplications 新鲜石榴皮提取物合成Ag2O纳米粒子及其生物应用

Nano Biomedicine and Engineering Pub Date : 2023-08-01 DOI: 10.26599/nbe.2023.9290032

Wedian K. Abad, A. N. Abd, N. Habubi

引用次数: 0

Biosynthesis of Zinc Oxide Nanoparticles Using Punica granatum L. Waste Peel Extract, and Assessment of Antioxidant and Catalytic Activity 石榴皮废料提取物生物合成氧化锌纳米粒子及其抗氧化和催化活性评价

Nano Biomedicine and Engineering Pub Date : 2023-08-01 DOI: 10.26599/nbe.2023.9290030

M. H. Meshkatalsadat, Alireza Momeni, Mohammad Reza Abdollahzadeh

引用次数: 0