Nano Biomedicine and Engineering最新文献

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Ratiometric SERS platform of dual bioprobes for stable detection of circulating tumor cells 双生物探针稳定检测循环肿瘤细胞的比率SERS平台
Nano Biomedicine and Engineering Pub Date : 2025-12-31 DOI: 10.1016/j.nbe.2025.100019
Xinyu Miao, Z C Zhang, Xinda Cai, Yujiao Xie, Chenyang Gao, Aochi Liu, Xiawei Li Qingyuan Xu Jing Zhang Tianyi Zhang Qian Yu Lu Sheng Dong Xu, Li Sun, Zhiwei Hou, Aiguo Wu, Jie Xia Lin
{"title":"Ratiometric SERS platform of dual bioprobes for stable detection of circulating tumor cells","authors":"Xinyu Miao, Z C Zhang, Xinda Cai, Yujiao Xie, Chenyang Gao, Aochi Liu, Xiawei Li Qingyuan Xu Jing Zhang Tianyi Zhang Qian Yu Lu Sheng Dong Xu, Li Sun, Zhiwei Hou, Aiguo Wu, Jie Xia Lin","doi":"10.1016/j.nbe.2025.100019","DOIUrl":"https://doi.org/10.1016/j.nbe.2025.100019","url":null,"abstract":"Circulating tumor cells (CTCs) serve as crucial biomarkers for non-invasive cancer diagnostics through liquid biopsy. Surface-enhanced Raman spectroscopy (SERS) bioprobes offer high detection sensitivity of rare CTCs. However, SERS signals often suffer from poor reproducibility due to strong background interference and experimental fluctuations. To address these challenges, we developed a novel ratiometric SERS platform using dual functionalized bioprobes: titanium dioxide nanoparticles conjugated with crystal violet and folic acid (TiO 2 -CV-rBSA-FA), and iron oxide nanoparticles modified with acridine red and an EpCAM antibody (IO–AR–PDA-EpCAM). The ratiometric platform achieves an exceptional limit of detection (LOD) as low as 5 × 10 −7 M. The individual bioprobes demonstrate low signal variability, with relative standard deviation (RSD) values of 7.99 % (TiO₂-CV-rBSA-FA) and 9.00 % (IO-AR-PDA-EpCAM), ensuring consistent performance across repeated measurements. This system operates through coordinated mechanisms where IO-AR-EpCAM bioprobe simultaneously concentrate CTCs through magnetic enrichment while providing AR-based internal calibration signals, whereas TiO 2 -CV-rBSA-FA bioprobe generates CV signals specifically amplified at surfaces of CTCs. The ratiometric measurement (I CV /I AR ) effectively eliminates nonspecific adsorption interference while maintaining excellent reproducibility (relative standard deviation <10 %) and biosafety (cell viability >90 %). This approach established a stable and reliable platform for sensitive CTCs detection.","PeriodicalId":18971,"journal":{"name":"Nano Biomedicine and Engineering","volume":"18 2","pages":"100019-100019"},"PeriodicalIF":0.0,"publicationDate":"2025-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147890922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application of Liposome Encapsulation Drug in Inhibiting Ferroptosis and Reducing Radiation Damage During Radiotherapy 脂质体包封药物在抑制铁下垂和减轻放射治疗中辐射损伤中的应用
Nano Biomedicine and Engineering Pub Date : 2025-06-12 DOI: 10.26599/nbe.2025.9290124
Yongkang Zhou, Xuan Ding, Genwu Guo, Yuan Zhuang, Yixing Chen, Fuquan Zhang, Jianying He, Yunan Gao
{"title":"Application of Liposome Encapsulation Drug in Inhibiting Ferroptosis and Reducing Radiation Damage During Radiotherapy","authors":"Yongkang Zhou, Xuan Ding, Genwu Guo, Yuan Zhuang, Yixing Chen, Fuquan Zhang, Jianying He, Yunan Gao","doi":"10.26599/nbe.2025.9290124","DOIUrl":"https://doi.org/10.26599/nbe.2025.9290124","url":null,"abstract":"To alleviate the side effects of radiotherapy, amifostine, as the first FDA-approved radiation protectant, can be used to eliminate free radicals and regulate redox reactions. However, its application is limited by toxic side effects. Liposomes, as drug carriers, can efficiently encapsulate drugs and increase their concentration in tumor sites through passive targeting, reducing damage to normal tissues. Liposomes encapsulating antioxidant drugs can significantly inhibit ferroptosis caused by radiotherapy and alleviate lung and intestinal damage. Therefore, we prepared a novel nanomedicine with less toxic and highly effective radiation protectants based on liposome-encapsulated amifostine. By precisely regulating the ferroptosis pathway, it shows good radiation protection effects, providing a new strategy for the treatment of radiation pneumonitis and intestinal injury, and is expected to improve the quality of life and treatment outcomes of patients.","PeriodicalId":18971,"journal":{"name":"Nano Biomedicine and Engineering","volume":"17 4","pages":"517-528"},"PeriodicalIF":0.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sciopen.com/article_pdf/1933344543270879234.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147877882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Gold-Nanoframework@CuSe Mediated Near-Infrared-II Laser-Triggered Chemodynamic Therapy and Photothermal Synergistic Antibacterial therapy Gold-Nanoframework@CuSe介导的近红外激光触发化学动力学治疗和光热协同抗菌治疗
Nano Biomedicine and Engineering Pub Date : 2025-05-29 DOI: 10.26599/nbe.2025.9290127
Jinfeng Cai, Ao Wu, Shuai Pan, Zhaoqin Zhu, Fuguang Li
{"title":"Gold-Nanoframework@CuSe Mediated Near-Infrared-II Laser-Triggered Chemodynamic Therapy and Photothermal Synergistic Antibacterial therapy","authors":"Jinfeng Cai, Ao Wu, Shuai Pan, Zhaoqin Zhu, Fuguang Li","doi":"10.26599/nbe.2025.9290127","DOIUrl":"https://doi.org/10.26599/nbe.2025.9290127","url":null,"abstract":"The treatment of multidrug-resistant bacteria is a difficult problem in clinical practice. These drug-resistant bacteria have reduced sensitivity to antibiotics, which contributes to the high incidence and mortality of bacterial infections worldwide. Photothermal therapy and chemodynamic therapy are advanced nanomaterial-based medical treatment methods and are widely used in tumor and antibacterial therapies due to their precision and rapidity. To overcome the limitations of conventional treatment for bacterial resistance, this study developed a near-infrared-II (NIR-II) responsive nanomaterial, a gold nanoframework coated with copper selenide (GNF@CS). This nanomaterial simultaneously triggers both chemodynamic therapy and photothermal therapy, while further promoting the chemodynamic process through <i>in-situ</i> heat generation. Ultimately, it shows significant antibacterial effects against both <i>Staphylococcus aureus</i> and <i>Escherichia coli</i>, providing a new non-antibiotic-dependent treatment strategy for clinically relevant bacterial infections.","PeriodicalId":18971,"journal":{"name":"Nano Biomedicine and Engineering","volume":"17 2","pages":"304-314"},"PeriodicalIF":0.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciopen.com/local/article_pdf/10.26599/NBE.2025.9290127.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147920460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Donor–Acceptor–Donor Structured Dyes with Balanced Photothermal Conversion Efficiency and Fluorescence Quantum Yield for Near-Infrared–II Mild-Temperature Photothermal Therapy 具有平衡光热转换效率和荧光量子产率的给体-受体-给体结构染料用于近红外- ii温和光热治疗
Nano Biomedicine and Engineering Pub Date : 2025-04-09 DOI: 10.26599/nbe.2025.9290120
Xuan Sun, Zuyuan Zhang, Chunbai Xiang, Tianhe Qiao, Xin Wang, Gongcheng Ma, Dan Ding
{"title":"Donor–Acceptor–Donor Structured Dyes with Balanced Photothermal Conversion Efficiency and Fluorescence Quantum Yield for Near-Infrared–II Mild-Temperature Photothermal Therapy","authors":"Xuan Sun, Zuyuan Zhang, Chunbai Xiang, Tianhe Qiao, Xin Wang, Gongcheng Ma, Dan Ding","doi":"10.26599/nbe.2025.9290120","DOIUrl":"https://doi.org/10.26599/nbe.2025.9290120","url":null,"abstract":"Effective mild-temperature photothermal therapy (MTPTT) requires photothermal agents with high photothermal conversion efficiency (PCE) and balanced fluorescence quantum yield to enable efficient tumor treatment while minimizing damage to surrounding healthy tissues. In this study, we designed donor–acceptor–donor structured dyes, 4,4’-((6,7-di(thiophen-2-yl)-[1,2,5]thiadiazolo[3,4-g]quinoxaline-4,9-diyl)bis(thiophene-5,2-diyl))bis(N,N-bis(4-methoxyphenyl)aniline) (IT-STPA) and 4,4’-((6,7-di(furan-2-yl)-[1,2,5]thiadiazolo[3,4-g]quinoxaline-4,9-diyl)bis(thiophene-5,2-diyl))bis(N,N-bis(4-methoxyphenyl)aniline) (IT-OTPA), featuring furan-modified thiadiazolo-quinoxaline for near-infrared–II (NIR-II) fluorescence imaging and enhanced PCE. The furan and thiophene modifications promoted aggregation-induced emission, resulting in strong fluorescence emission (1 000–1 400 nm) while maintaining a high PCE of 48.5%. IT-OTPA was encapsulated into nanoparticles for improved aqueous dispersion and combined with the HSP70 inhibitor apoptozole (APZ) to form OTAPZ nanoparticles. The efficacy of this combination was evaluated both <i>in vitro</i> and <i>in vivo</i>, showing efficient tumor targeting and effective MTPTT under NIR laser irradiation. This study presents a promising approach for enhancing MTPTT through balanced photothermal and fluorescence properties, offering new possibilities for cancer treatment.","PeriodicalId":18971,"journal":{"name":"Nano Biomedicine and Engineering","volume":"17 2","pages":"248-262"},"PeriodicalIF":0.0,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciopen.com/local/article_pdf/10.26599/NBE.2025.9290120.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147912933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
A Device for the Removal of Peripheral Blood Circulating Tumor Cells and Inhibiting Their Biodistribution 一种清除外周血循环肿瘤细胞并抑制其生物分布的装置
Nano Biomedicine and Engineering Pub Date : 2025-02-25 DOI: 10.26599/nbe.2025.9290114
Jun Luo, Lei Xing, Ming‐Tao Yu, Ying Sun, Wenjia Wang, Xing Wan, Xiaojie Wang, Yuan Ji, Yi Wang, Tian‐Jiao Zhou, Hu‐Lin Jiang
{"title":"A Device for the Removal of Peripheral Blood Circulating Tumor Cells and Inhibiting Their Biodistribution","authors":"Jun Luo, Lei Xing, Ming‐Tao Yu, Ying Sun, Wenjia Wang, Xing Wan, Xiaojie Wang, Yuan Ji, Yi Wang, Tian‐Jiao Zhou, Hu‐Lin Jiang","doi":"10.26599/nbe.2025.9290114","DOIUrl":"https://doi.org/10.26599/nbe.2025.9290114","url":null,"abstract":"Circulating tumor cells (CTCs) significantly impact the overall survival and progression-free survival of cancer patients. However, the current strategies for CTC separation and enrichment are limited as they analyze only small-volume blood samples, which is insufficient to comprehensively profile the distribution of CTCs in the blood and eliminate them. To address this issue, we developed a peripheral blood CTC removal device (PBCRD) inspired by hemoperfusion. It comprises systems for CTC-capturing and returning purified blood into circulation. The CTC capturing system consists of antibody-modified functional microspheres (AFMPs), while the purified blood returning system includes a peristaltic circulation pump for clinical blood perfusion and catheters. The PBCRD can efficiently capture, enrich, and remove CTCs from peripheral circulation in real-time, effectively inhibiting their biodistribution. The high biocompatibility of AFMPs ensures that PBCRD is safe and does not cause injuries. Overall, this work provides a new class of ideas for the effective capture and removal of CTCs from the peripheral circulation, which is expected to be an effective strategy to assist in the clinical treatment of tumors and inhibit metastasis.","PeriodicalId":18971,"journal":{"name":"Nano Biomedicine and Engineering","volume":"17 3","pages":"386-401"},"PeriodicalIF":0.0,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciopen.com/local/article_pdf/10.26599/NBE.2025.9290114.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147921872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Highly Sensitive Detection and Molecular Subtyping of Breast Cancer Cells Using Machine Learning-assisted SERS Technology 利用机器学习辅助SERS技术对乳腺癌细胞进行高灵敏度检测和分子分型
Nano Biomedicine and Engineering Pub Date : 2025-02-18 DOI: 10.26599/nbe.2025.9290113
Xinyu Miao, Lei Xu, Li Xian Sun, Yujiao Xie, Jiahao Zhang, Xiawei Xu, Yue Hu, Zhouxu Zhang, Aochi Liu, Zhiwei Hou, Aiguo Wu, Jie Lin
{"title":"Highly Sensitive Detection and Molecular Subtyping of Breast Cancer Cells Using Machine Learning-assisted SERS Technology","authors":"Xinyu Miao, Lei Xu, Li Xian Sun, Yujiao Xie, Jiahao Zhang, Xiawei Xu, Yue Hu, Zhouxu Zhang, Aochi Liu, Zhiwei Hou, Aiguo Wu, Jie Lin","doi":"10.26599/nbe.2025.9290113","DOIUrl":"https://doi.org/10.26599/nbe.2025.9290113","url":null,"abstract":"Breast cancer has always been a research hotspot in the medical field due to its highest incidence and mortality rates among women worldwide. However, the significant molecular heterogeneity of breast cancer presents major challenges for its diagnosis and treatment. Surface-enhanced Raman spectroscopy (SERS) has gained considerable attention for its capability in trace detection and molecular analysis. To accurately identify different breast cancer cell subtypes, constructing reliable SERS bioprobes is essential. Therefore, a specific highly expressed receptor, human epidermal growth factor receptor 2 (HER-2), was employed to explore SERS bioprobes in this study. Two bioprobes capable of targeting breast cancer cells, Au NPs@4-MBA@PDA@aHER-2 and Au NPs@4-MPY@PDA@aHER-2, were synthesized. SERS performance testing indicated that the Au NPs were able to detect and trace molecules at concentrations as low as 2 × 10<sup>–9</sup> mol/L. Additionally, the two bioprobes exhibited good spectral stability with a relative standard deviation (RSD) of 9.58%. Moreover, by constructing a “symphonic SERS spectra” of the two bioprobes with prominent component analysis-linear discriminant analysis (PCA-LDA), the classification accuracy of distinguishing white blood cells (WBCs) and two breast cancer cell subtypes (SK-BR-3 and MDA-MB-231) reached up to 97.33%. The integration of machine learning with SERS detection provides a novel technological pathway for the early diagnosis and personalized treatment of breast cancer.","PeriodicalId":18971,"journal":{"name":"Nano Biomedicine and Engineering","volume":"17 1","pages":"129-142"},"PeriodicalIF":0.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciopen.com/local/article_pdf/10.26599/NBE.2025.9290113.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147912698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 27
NIR-IIb-emitted Er-coordination Polymer for Logic Gates and Optical Anticounterfeiting nir - iib发射铒配位聚合物用于逻辑门和光学防伪
Nano Biomedicine and Engineering Pub Date : 2024-12-17 DOI: 10.26599/nbe.2024.9290107
Yanling Yang, Fengyue Wang, Shan Zhang, Hongxin Zhang, Zhen Yang
{"title":"NIR-IIb-emitted Er-coordination Polymer for Logic Gates and Optical Anticounterfeiting","authors":"Yanling Yang, Fengyue Wang, Shan Zhang, Hongxin Zhang, Zhen Yang","doi":"10.26599/nbe.2024.9290107","DOIUrl":"https://doi.org/10.26599/nbe.2024.9290107","url":null,"abstract":"The second near-infrared window in a 1 500–1 700 nm region (known as the NIR-IIb region) presents low autofluorescence and a deep penetration depth, enabling a potential technology for effective imaging and anticounterfeiting applications. However, existing NIR-IIb-emitted fluorescence materials remain limited and possess low luminescent properties. In implementing the enhanced ~1 525 nm emission of the Er (III) complex in a nonorganic solvent, an amphiphilic diblock copolymer (PEG<sub>112</sub>–PAA<sub>12</sub>) was initially synthesized to coordinate with Er (III), and then certain Yb (III) was doped to form the PEG–PAA–Er/Yb complex. The complex shows a dramatic fluorescent enhancement of ~250-fold at ~1 525 nm in D<sub>2</sub>O than that in H<sub>2</sub>O under 980-nm laser irradiation, which is ascribed to the following factors: (1) The substitution of H<sub>2</sub>O by D<sub>2</sub>O can suppress the quenching effect of H<sub>2</sub>O at ~1 470 nm to achieve the emission of PEG–PAA–Er; (2) the doping of Yb (III) enables the co-luminescence effect to PEG–PAA–Er to improve NIR-IIb emission. Notably, the PEG–PAA–Er/Yb complex can construct molecular logic gates with logic functions and optical anticounterfeiting by using the abovementioned fluorescence changes.","PeriodicalId":18971,"journal":{"name":"Nano Biomedicine and Engineering","volume":"17 1","pages":"143-150"},"PeriodicalIF":0.0,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciopen.com/local/article_pdf/10.26599/NBE.2024.9290107.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147332682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Plant Ash/Polylactic Acid Electrospun Fiber Dressing Promotes Wound Healing Through pH Regulation 植物灰/聚乳酸静电纺纤维敷料通过调节pH值促进伤口愈合
Nano Biomedicine and Engineering Pub Date : 2024-12-01 DOI: 10.26599/nbe.2024.9290108
Yixuan Cai, Zhifeng Liao, Zhihao Xue, Zhaowen Xue, Jiayi Mei, Lin Zhou, Guojin Zhang, Wenyi Gan
{"title":"Plant Ash/Polylactic Acid Electrospun Fiber Dressing Promotes Wound Healing Through pH Regulation","authors":"Yixuan Cai, Zhifeng Liao, Zhihao Xue, Zhaowen Xue, Jiayi Mei, Lin Zhou, Guojin Zhang, Wenyi Gan","doi":"10.26599/nbe.2024.9290108","DOIUrl":"https://doi.org/10.26599/nbe.2024.9290108","url":null,"abstract":"Wound healing has always been a focal point in medicine and fabrication of biomaterials. Nanofibers made from polylactic acid (PLA) promote wound healing and possess antibacterial properties. However, the acidic byproducts of PLA can hinder the wound-healing process. Plant ash, being mildly alkaline, has the potential to neutralize these acidic compounds. A nanofiber film combining PLA and plant ash can create a neutral environment conducive to cell growth. Additionally, the growth-promoting components of plant ash can further accelerate wound healing. In this study, we combined PLA with plant ash and electrospun the mixture into nanofibers, ultimately developing a pH-regulating wound dressing. We prepared a mixed emulsion containing grass and wood ash, PLA powder, and a polymer surfactant to fabricate the dressing. The emulsion was then frozen to reduce the solubility of the solvent, facilitating the precipitation of the plant ash/PLA mixture. Subsequently, nanofibers were produced from the precipitated powder through electrospinning, which were employed to create the wound dressing. We evaluated the degradation of the dressing in normal saline and monitored the pH changes over two weeks. The pH remained stable at 7–8, indicating a neutral to mildly alkaline state. This result confirms an optimal environment for wound healing.","PeriodicalId":18971,"journal":{"name":"Nano Biomedicine and Engineering","volume":"16 4","pages":"588-600"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciopen.com/local/article_pdf/10.26599/NBE.2024.9290108.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147909613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
The Novel MoS 2/MnO 2–BSA Nanocomposite Significantly Enhances Antitumour Efficacy through Synergistic Photothermal Therapy/Hemodynamic Therapy 新型mno2 / mno2 - bsa纳米复合材料通过协同光热治疗/血流动力学治疗显著增强抗肿瘤疗效
Nano Biomedicine and Engineering Pub Date : 2024-11-22 DOI: 10.26599/nbe.2024.9290105
Lingle Zhang, Xiaoqing Qian, Yingying Yang, Tingting Xiang, Jinrong SiTu, Hongzhang Yan, Kai Yang
{"title":"The Novel MoS <sub>2</sub>/MnO <sub>2</sub>–BSA Nanocomposite Significantly Enhances Antitumour Efficacy through Synergistic Photothermal Therapy/Hemodynamic Therapy","authors":"Lingle Zhang, Xiaoqing Qian, Yingying Yang, Tingting Xiang, Jinrong SiTu, Hongzhang Yan, Kai Yang","doi":"10.26599/nbe.2024.9290105","DOIUrl":"https://doi.org/10.26599/nbe.2024.9290105","url":null,"abstract":"Cellular photothermal and chemical kinetic therapy has recently been acknowledged as an effective cancer treatment method. Photothermal therapy (PTT) works by transforming light energy into heat through the photothermal effects triggered by near-infrared (NIR) laser exposure. The employment of nanomaterials as carriers for PTT agents or as PTT agents themselves offers improved therapeutic outcomes with fewer side effects through enhanced photothermal conversion efficiency, accumulation of the PTT agents in the tumor tissue. In this work, we synthesized new MoS<sub>2</sub>/MnO<sub>2</sub> nanomaterials modified with bovine serum protein to enhance the effectiveness of the Fenton-like reaction between MoS<sub>2</sub> and MnO<sub>2</sub> to produce •OH through photothermolysis excitation using a near-infrared (NIR) 808 nm laser. <i>In vitro</i> measurements further confirmed the exceptional ability of MoS<sub>2</sub>/MnO<sub>2</sub>–modified bovine hemoglobin (BSA) to destroy cancer cells. We believe that photothermal therapy can offer new insights into cancer therapy and greatly enhance the efficacy of chemotherapeutic tumor treatments.","PeriodicalId":18971,"journal":{"name":"Nano Biomedicine and Engineering","volume":"17 2","pages":"277-286"},"PeriodicalIF":0.0,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciopen.com/local/article_pdf/10.26599/NBE.2024.9290105.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147911659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Azadirachta indica-based Green Fabrication of Metal Oxide Nanoparticles: A State-of-the-Art Review 基于杜鹃花的金属氧化物纳米颗粒绿色制造:最新技术综述
Nano Biomedicine and Engineering Pub Date : 2024-03-01 DOI: 10.26599/nbe.2024.9290070
Zille Huma, Musfira Arain, Muhammad Hammad Parvaiz, Sana Ullah, Khan Gul, Roohul Amin, Waheed Rehman, Faiq Saeed, Samia Arain
{"title":"Azadirachta indica-based Green Fabrication of Metal Oxide Nanoparticles: A State-of-the-Art Review","authors":"Zille Huma, Musfira Arain, Muhammad Hammad Parvaiz, Sana Ullah, Khan Gul, Roohul Amin, Waheed Rehman, Faiq Saeed, Samia Arain","doi":"10.26599/nbe.2024.9290070","DOIUrl":"https://doi.org/10.26599/nbe.2024.9290070","url":null,"abstract":"","PeriodicalId":18971,"journal":{"name":"Nano Biomedicine and Engineering","volume":"8 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140400237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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