Muscle & Nerve最新文献_第5页

AAOS 2024 CTS Guidelines-Comments by Members of AANEM CTS Severity Scale Workgroup. AAOS 2024 CTS指南- AANEM CTS严重性量表工作组成员的意见。

IF 3.1 3区医学

Muscle & Nerve Pub Date : 2025-10-01 Epub Date: 2025-08-08 DOI: 10.1002/mus.28477

Jeremy Bland, Devon Rubin, Lawrence Robinson, Michael Cartwright, Michael Andary, John Kincaid, Zainab Al-Lawati, Peter Grant

引用次数: 0

Proceedings of the 24^th Annual Meeting of the Northeast ALS Consortium. 第24届东北渐冻症联盟年会论文集。

IF 3.1 3区医学

Muscle & Nerve Pub Date : 2025-10-01 DOI: 10.1002/mus.70018

引用次数: 0

Examining Complication Rates to Inform the Consent Process in Needle Electromyography: A Quality Improvement Project. 检查并发症率以告知针肌电图的同意过程：一个质量改进项目。

IF 3.1 3区医学

Muscle & Nerve Pub Date : 2025-10-01 Epub Date: 2025-07-22 DOI: 10.1002/mus.28472

Jihong Min, Bharathi Swaminathan, Amtul Farheen, Rahila Ansari, Ileana Howard

{"title":"Examining Complication Rates to Inform the Consent Process in Needle Electromyography: A Quality Improvement Project.","authors":"Jihong Min, Bharathi Swaminathan, Amtul Farheen, Rahila Ansari, Ileana Howard","doi":"10.1002/mus.28472","DOIUrl":"10.1002/mus.28472","url":null,"abstract":"Introduction/aims: Verbal informed consent prior to electrodiagnostic (EDx) studies, including nerve conduction study and needle electromyography (EMG), is considered the standard of care to counsel the patient of risks and benefits of the procedure. However, there is a paucity of population-based studies evaluating the actual occurrence of complications. We aim to improve the informed consent process for EMGs by accurately understanding rates of adverse events.Methods: A rapid cycle quality improvement approach was used to assess complication rates for EMGs at a US Veterans Administration tertiary medical center. Potential complications were compared to actual complications following 24,718 EMG procedures performed over a 14-year period. The occurrence of serious complications in the month following EMG was queried from the electronic health record.Results: About 35% of the patients used anticoagulants or antiplatelet agents, yet no cases of hematoma were recorded. Three reports of cellulitis occurred in patients on aspirin. No pneumothoraces were recorded. These findings were then used to update informed consent guidelines to more closely align with actual complication rates.Discussion: This study underscores the safety of EMGs, even in the setting of anticoagulation use, and helps guide the informed consent process. Taking into consideration the findings of prior studies, caution must still be exercised when performing EMGs in muscles with a high risk of pneumothorax. Based on our findings, anticoagulants and antiplatelet agents do not appear to increase the risk of bleeding-related complications. Cellulitis in the three patients on aspirin was most likely due to medical comorbidities.","PeriodicalId":18968,"journal":{"name":"Muscle & Nerve","volume":" ","pages":"632-635"},"PeriodicalIF":3.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Less Social Contact During the Pandemic Could Explain the Lower Prevalence of GBS During This Time. 大流行期间较少的社会接触可以解释这段时间GBS患病率较低的原因。

IF 3.1 3区医学

Muscle & Nerve Pub Date : 2025-10-01 Epub Date: 2025-06-11 DOI: 10.1002/mus.28457

Josef Finsterer

引用次数: 0

Quantitative Muscle Ultrasound: A Non-Invasive Biomarker for Monitoring Duchenne Muscular Dystrophy. 定量肌肉超声：一种监测杜氏肌营养不良的非侵入性生物标志物。

IF 3.1 3区医学

Muscle & Nerve Pub Date : 2025-10-01 Epub Date: 2025-07-16 DOI: 10.1002/mus.28469

Yu Jin Im, Yumi Choe, Jiwon Lee, Jeehun Lee, Jong Geol Do, Jeong-Yi Kwon

{"title":"Quantitative Muscle Ultrasound: A Non-Invasive Biomarker for Monitoring Duchenne Muscular Dystrophy.","authors":"Yu Jin Im, Yumi Choe, Jiwon Lee, Jeehun Lee, Jong Geol Do, Jeong-Yi Kwon","doi":"10.1002/mus.28469","DOIUrl":"10.1002/mus.28469","url":null,"abstract":"Introduction/aims: Quantitative muscle ultrasound (QMUS) shows promise as a non-invasive biomarker for monitoring functional status in Duchenne muscular dystrophy (DMD). We evaluated the correlation between QMUS in various muscles and functional capacity assessments. Additionally, we compared the utility of composite QMUS scores as a comprehensive measure of disease progression to that of single-muscle analyses.Methods: We analyzed baseline data from an ongoing prospective study involving 23 patients with DMD (aged 5-18 years; mean 10.7; SD 4.2). High-resolution ultrasound scans of muscle groups across the upper and lower limbs, head and neck, and diaphragm were assessed for muscle echogenicity using mean grayscale values (MGV). Functional capacity assessments included the 6-min walk test (6MWT), North Star Ambulatory Assessment (NSAA), Performance of Upper Limb (PUL) module, timed function tests, quantitative muscle strength tests, and respiratory muscle strength tests.Results: The composite MGV for upper and lower limbs demonstrated moderate to strong negative correlations with the 6MWT and NSAA scores (correlation coefficient [CC]: -0.44 to -0.74; p < 0.01) and strong to very strong positive correlations with rise-from-floor, 4-stair climb, and 10-m walk/run times (CC: 0.65 to 0.87; p < 0.01). For upper limb function, the MGV of the flexor carpi radialis muscle was negatively correlated with PUL scores (CC = -0.35, p = 0.02). However, no significant correlations were observed between QMUS parameters and muscle strength test (p > 0.05).Discussion: QMUS offers a non-invasive method for assessing muscle changes and tracking disease progression in DMD.Trial registration: ClinicalTrials.gov identifier: NCT05249361.","PeriodicalId":18968,"journal":{"name":"Muscle & Nerve","volume":" ","pages":"606-615"},"PeriodicalIF":3.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12435151/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in MicroRNAs in Pathophysiology of Duchenne Muscular Dystrophy. 杜氏肌营养不良病理生理中的微rna研究进展。

IF 3.1 3区医学

Muscle & Nerve Pub Date : 2025-10-01 Epub Date: 2025-07-18 DOI: 10.1002/mus.28482

Jose Emilio Galeazzi Aguilar, Tomas Almeida-Becerril, Maricela Rodríguez-Cruz

{"title":"Advances in MicroRNAs in Pathophysiology of Duchenne Muscular Dystrophy.","authors":"Jose Emilio Galeazzi Aguilar, Tomas Almeida-Becerril, Maricela Rodríguez-Cruz","doi":"10.1002/mus.28482","DOIUrl":"10.1002/mus.28482","url":null,"abstract":"Duchenne muscular dystrophy (DMD) is a severe, progressive muscle disorder caused by pathogenic variants in the DMD gene, which encodes dystrophin, a protein essential for maintaining muscle integrity. Reduced or absent dystrophin expression results in sarcolemmal instability, chronic inflammation, oxidative stress, impaired muscle regeneration, and fibrosis. MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression post-transcriptionally and significantly influence multiple pathological processes in DMD. Specific miRNAs, including miR-146a, miR-155, miR-378, and miR-711, modulate inflammation primarily through the NF-κB signaling pathway. Others, such as miR-21, miR-31, miR-128, miR-144, and miR-379, regulate oxidative stress responses via the NRF2 antioxidant pathway. Muscle-specific miRNAs (myomiRs), notably miR-1, miR-133a/b, miR-206, miR-486, and miR-499, are critical for muscle regeneration, and their dysregulation impairs satellite cell function and muscle repair. Additionally, miRNAs such as miR-21, miR-29a/c, and miR-199a-5p play significant roles in fibrosis development. The dysregulation of these miRNAs contributes to the complex pathophysiology of DMD, underscoring their potential as biomarkers for disease progression and therapeutic response. Understanding the specific roles of these miRNAs provides valuable insights into the molecular mechanisms underlying DMD and may facilitate the identification of novel therapeutic targets.","PeriodicalId":18968,"journal":{"name":"Muscle & Nerve","volume":" ","pages":"541-555"},"PeriodicalIF":3.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Environmental Awareness in Electrodiagnostic Medicine. 电诊断医学中的环境意识。

IF 3.1 3区医学

Muscle & Nerve Pub Date : 2025-10-01 Epub Date: 2025-07-28 DOI: 10.1002/mus.28483

引用次数: 0

Reply: "Letter to the Editors; Less Social Contact During the Pandemic Could Explain the Lower Prevalence of GBS During This Time". 回复：“给编辑的信；大流行期间较少的社会接触可以解释这段时间GBS患病率较低的原因。”

IF 3.1 3区医学

Muscle & Nerve Pub Date : 2025-10-01 Epub Date: 2025-08-18 DOI: 10.1002/mus.70005

Toshiyuki Hayashi, Tatsushi Toda, Atsuro Chiba, Nobutaka Hattori, Masahiro Sonoo, Hideto Nakajima, Takanori Yokota, Yasuyuki Iguchi, Hidetomo Murakami, Haruhisa Kato, Osamu Kano, Kazuo Kitagawa, Satoshi Kitagawa, Hiroshi Nagayama, Kazumi Kimura

引用次数: 0

Isograft Obtained From ZDF (Obese Fa/Fa) Rats Does Not Impair Nerve Regeneration Compared to Healthy Isograft. 与健康同种异体移植相比，肥胖Fa/Fa大鼠的同种异体移植不损害神经再生。

IF 3.1 3区医学

Muscle & Nerve Pub Date : 2025-09-29 DOI: 10.1002/mus.70028

Mackenzie Grasso, Moe Al-Tekreeti, Ananya Gomatam, Elizabeth Zielinski, Geetanjali Bendale, Jonathan Isaacs

{"title":"Isograft Obtained From ZDF (Obese Fa/Fa) Rats Does Not Impair Nerve Regeneration Compared to Healthy Isograft.","authors":"Mackenzie Grasso, Moe Al-Tekreeti, Ananya Gomatam, Elizabeth Zielinski, Geetanjali Bendale, Jonathan Isaacs","doi":"10.1002/mus.70028","DOIUrl":"https://doi.org/10.1002/mus.70028","url":null,"abstract":"Introduction/aims: Both Nerve Autograft and Processed Nerve Allograft (PNA) are Acceptable Options for Reconstructing Nerve Defects. While Small Animal Models Suggest That Autograft Has Superior Neuro-Regenerative Properties, This Advantage Has Not Been Demonstrated in Clinical Outcomes. We Believe That in Some Cases Human Autograft May Be Adversely Affected by Pathologic States Such as Diabetes. We Sought an Appropriate Small Animal Model to Test This Theory.Methods: 10 male ZDF rats (Obese Fa/Fa) genetically predisposed to have type 2 diabetes were used as donors. 10 male ZDF rats (Lean +/?) were utilized as a healthy control. Sciatic nerves harvested bilaterally from the compromised and control groups were utilized to reconstruct a 15 mm defect in 40 ZDF rats (Lean +/?). At 16 weeks, motor testing and nerve histology were performed.Results: There was no statistically significant difference in axonal counts between the diabetic-derived (6031 ± 3848) and healthy-derived control groups (5813 ± 2535). The average twitch force in the diabetic donor group reached 82% ± 33% of the twitch force of the normal contralateral limb, compared to 67% ± 28% in the healthy graft group. Tetanic force in the diabetic donor group reached 89% ± 30% normalized force compared to 74% ± 29% for the healthy control graft group. Muscle mass and girth ratio were 78% ± 4% and 79% ± 12% for the diabetic donor group, compared to 74% ± 18% and 78% ± 11% for the healthy group.Discussion: Isograft obtained from a diabetic donor rat did not demonstrate inferior nerve regeneration compared with \"normal\" healthy isograft.","PeriodicalId":18968,"journal":{"name":"Muscle & Nerve","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145186365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reply to: "Beyond Prevalence: The Importance of Multifactorial Assessment in Cancer Risk Among Myotonic Dystrophy Patients". 回复：“超越流行：多因素评估在肌强直性营养不良患者癌症风险中的重要性”。

IF 3.1 3区医学

Muscle & Nerve Pub Date : 2025-09-29 DOI: 10.1002/mus.70034

Wanfang Zhang, Suzanne McDermott

引用次数: 0