南方医科大学学报杂志最新文献

{"title":"[Aerobic exercise produces cardioprotective effects in mice by regulating the oxidative stress-inflammation-Hippo/YAP signaling axis].","authors":"Guodong Zhang, Siang Wei, Hong Wang, Yanli Xie, Hui He, Rong Li","doi":"10.12122/j.issn.1673-4254.2026.04.04","DOIUrl":"https://doi.org/10.12122/j.issn.1673-4254.2026.04.04","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the mechanism by which aerobic exercise improves transverse aortic constriction (TAC)-induced heart failure in mice.</p><p><strong>Methods: </strong>Thirty male C57BL/6J mice were randomized into sham-operated group, TAC model group, and TAC with aerobic exercise (TACE) group. The mice in TACE group underwent a 4-week progressive treadmill training starting on day 3 following TAC modeling. Echocardiography and Masson's trichrome staining were used to assess cardiac function and myocardial fibrosis of the mice, respectively, and serum levels of BNP, TNF-α, IL-6, IL-1β, MDA, SOD, and GSH-Px were measured using ELISA. The mRNA and protein expressions of Hippo-YAP pathway components in the myocardial tissue were detected using RT‑PCR and Western blotting, respectively. Bioinformatics analysis was performed to explore the correlations among the measured indicators.</p><p><strong>Results: </strong>Compared with those in TAC group, the mice in TACE group showed significantly reduced heart weight and heart weight/body weight ratio, increased left ventricular ejection fraction, left ventricular fractional shortening, and E/A ratio, reduced myocardial fibrosis, decreased BNP expression in both the serum and myocardial tissue, lowered serum levels of TNF‑α, IL‑6, IL‑1β, and MDA, and increased SOD and GSH-Px activities. The mRNA expressions of Mst1, Lats1, Lats2, and YAP1 were significantly downregulated in TACE group as compared with those in TAC group. Western blotting revealed decreased total protein expressions of Mst1/2, Lats1/2, and YAP and increased expression levels of phosphorylated Lats1/2 and phosphorylated YAP in TACE group. Correlation analysis suggested significant associations of oxidative stress markers and inflammatory factors with the expressions of the Hippo-YAP pathway components.</p><p><strong>Conclusions: </strong>Aerobic exercise improves cardiac function and attenuates cardiac remodeling in mice with TAC-induced heart failure possibly by suppressing oxidative stress and inflammation and modulating the Hippo-YAP pathway.</p>","PeriodicalId":18962,"journal":{"name":"南方医科大学学报杂志","volume":"46 4","pages":"753-760"},"PeriodicalIF":0.0,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13120991/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147776512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Key determinants of global burden of non-alcoholic fatty liver disease: machine learning combined with Mendelian randomization analysis based on GBD data].","authors":"Hao Chen, Zhenhan Li, Mengjia Ji, Xincheng Wang, Bofeng Chen, Qian Guan, Man Wu, Linming Lu","doi":"10.12122/j.issn.1673-4254.2026.04.06","DOIUrl":"https://doi.org/10.12122/j.issn.1673-4254.2026.04.06","url":null,"abstract":"<p><strong>Objectives: </strong>To analyze the global trends, drivers, and health inequalities of non-alcoholic fatty liver disease (NAFLD) burden to identify key predictors of NAFLD-related mortality.</p><p><strong>Methods: </strong>Using data from the Global Burden of Disease (GBD) Study 2021, we extracted global measures of NAFLD from 1990 to 2021, and the trends were analyzed using joinpoint regression. Decomposition analysis was used to quantify the contributions of population growth, aging, and epidemiological changes. The health inequality was assessed using the concentration index. Using XGBoost-SHAP machine learning, the mortality predictors were identified, and two-sample Mendelian randomization was employed to test the causality for the key factors. All the analyses were conducted with data stratification by sex and the socio-demographic index (SDI).</p><p><strong>Results: </strong>The global age-standardized disability-adjusted life years (DALYs) rate showed an increasing trend in both males (average annual percentage change [AAPC]=+0.34%) and females (AAPC=+0.05%). Decomposition analysis revealed that population growth was the primary driver of the global increase in DALYs, while population aging contributed to 52.37% of male deaths in high-SDI regions. Health inequality analysis showed a concentration index of -0.05 for DALYs in 2021, indicating a concentration of burden among low-SDI populations. Machine learning identified smoking (relative importance=100%) and advanced age (70-74 years: 60%) as the most critical predictors of mortality, and the model demonstrated good fit on the test set (<i>R</i>²=0.98). SDI-stratified analysis showed smoking and aging are the top two predictors across all SDI regions. Mendelian randomization further confirmed positive causal associations of smoking initiation (OR=1.35, <i>P</i><0.05) and aging (proxied by frailty index, OR=2.01, <i>P</i><0.05) with NAFLD risk.</p><p><strong>Conclusions: </strong>NAFLD burden is heavy globally with significant sex and socioeconomic inequalities. Smoking and advanced age are key risk factors for NAFLD, calling for integrated interventions for tobacco control, geriatric health management, and health equity promotion.</p>","PeriodicalId":18962,"journal":{"name":"南方医科大学学报杂志","volume":"46 4","pages":"770-784"},"PeriodicalIF":0.0,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13120990/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147776674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Scutellarin improves metabolic dysfunction-associated steatotic liver disease in rats by regulating MMP7 and LCN2].","authors":"Yang Ma, Longhui Guo, Jinguo Wang, Wenpin Xiao, Yuncheng Lv, Xiaoming Fan","doi":"10.12122/j.issn.1673-4254.2026.04.19","DOIUrl":"https://doi.org/10.12122/j.issn.1673-4254.2026.04.19","url":null,"abstract":"<p><strong>Objectives: </strong>To identify the therapeutic targets and signaling pathways that mediate the therapeutic effect of scutellarin against metabolic dysfunction-associated steatotic liver disease (MASLD).</p><p><strong>Methods: </strong>The differentially expressed genes (DEGs) in liver tissues of MASLD patients and healthy individuals were obtained from the GSE89632 dataset. The potential targets of scutellarin were screened using the PharmMapper database, and a drug-target network was constructed using Cytoscape. Functional enrichment analysis was performed using GO and KEGG pathway analysis. The intersection of scutellarin's target genes and the DEGs formed the potential therapeutic (PT) genes. Protein-protein interaction (PPI) networks were constructed using STRING to identify the key therapeutic (KT) genes. Molecular docking and dynamics simulations were used to assess the drug-target relationship. In a rat model of MASLD treated with different doses of scutellarin, the changes in serum biochemical parameters and liver pathology were analyzed.</p><p><strong>Results: </strong>A total of 810 DEGs and 12 PT genes were identified, and GO and KEGG analyses suggested their involvement in inflammation regulation, cytokine response, fibrosis, and metabolism. In the rat models of MASLD, treatment with scutellarin significantly improved insulin resistance, liver function, lipid levels, inflammation, and hepatic pathology in a dose-dependent manner, and high-dose scutellarin produced better therapeutic effects than simvastatin. Scutellarin treatment significantly upregulated MMP7 and downregulated LCN2 expression in the mouse livers.</p><p><strong>Conclusions: </strong>Scutellarin ameliorates MASLD in rats possibly by modulating hepatic MMP7 and LCN2 expressions.</p>","PeriodicalId":18962,"journal":{"name":"南方医科大学学报杂志","volume":"46 4","pages":"907-922"},"PeriodicalIF":0.0,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13120984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147776699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Patient and family predictors of group intervention outcomes in children with attention-deficit/hyperactivity disorder: a multidimensional model analysis].","authors":"Xinmei Yang, Yongqi Wang, Xiaohua Mo, Zhihang Zhu, Danping Hong, Yingzi Hu, Kaiqi Peng, Yixuan Xu, Jinlan Liu, Wenjuan Guo, Qiwen Lin, Junjie Mai, Siming Mai, Jingjie Lu, Chanjuan Yang, Yanling Zhou, Daomeng Cheng, Meng Yu, Weizhen Yin","doi":"10.12122/j.issn.1673-4254.2026.04.08","DOIUrl":"https://doi.org/10.12122/j.issn.1673-4254.2026.04.08","url":null,"abstract":"<p><strong>Objectives: </strong>To explore individual and family characteristics associated with children's response to group interventions for attention-deficit/hyperactivity disorder (ADHD) based on multidimensional indicators of intervention outcomes.</p><p><strong>Methods: </strong>A total of 62 children with ADHD aged 6-9 years participating in an intervention program at the Affiliated Brain Hospital of Guangzhou Medical University from July 2023 to January 2025 were enrolled. All the participants received a standardized group intervention consisting of 8 sessions delivered over 4-6 weeks, focusing on attention training and emotion regulation training. Pre- and post-intervention data were collected using the General Information Questionnaire, the Difficulties in Emotion Regulation Scale (DERS), the Affective Reactivity Index (ARI), the Matson Evaluation of Social Skills with Youngsters (MESSY), and the parent-rated Swanson, Nolan, and Pelham Rating Scale-IV (SNAP-IV). Given the consistency in intervention format and structure between the two groups, data were pooled for modeling analyses. Changes in emotion regulation, inattention, and social skills were used as the outcome indicators. LASSO regression was used to screen 18 baseline variables (8 psychosocial characteristics and 10 demographic and family-background variables), followed by multiple linear regression to identify stable predictors.</p><p><strong>Results: </strong>Across the models predicting changes in inattention, irritability, emotion-regulation difficulties, and inappropriately assertive/overconfident, the baseline score of each outcome was a significant positive predictor (β=0.462-0.669, <i>P</i>_BH<0.05). Higher baseline hostile scores predicted less improvement in emotion-regulation difficulties (β=-0.326, <i>P</i>_BH<0.01) and inappropriate assertiveness/overconfidence (β=-0.543, <i>P</i>_BH<0.05).</p><p><strong>Conclusions: </strong>This study provides preliminary evidence that baseline symptoms and hostility traits may predict response to group interventions for ADHD, which may help to estimate treatment outcomes before intervention and provide support to precision intervention for children with ADHD.</p>","PeriodicalId":18962,"journal":{"name":"南方医科大学学报杂志","volume":"46 4","pages":"794-802"},"PeriodicalIF":0.0,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13120987/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147776733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Ophiopogonin D alleviates doxorubicin-induced myocardial hypertrophy in mice by activating the β-catenin/FUNDC1/mitophagy axis].","authors":"Yanping Lei, Jiasheng Song, Lewu Xu, Rui Liu, Yue Zhao","doi":"10.12122/j.issn.1673-4254.2026.04.09","DOIUrl":"https://doi.org/10.12122/j.issn.1673-4254.2026.04.09","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate whether ophiopogonin D (OD) alleviates doxorubicin (Dox)‑induced myocardial hypertrophy in mice by regulating the β‑catenin/FUNDC1/mitophagy signaling axis.</p><p><strong>Methods: </strong>Thirty C57BL/6J mice were randomized equally into control group, Dox treatment group, Dox with OD treatment group, Dox treatment group with injection of adeno-associated virus (AAV) vector carrying β‑catenin, and Dox treatment group with injection of AAV vector. RNA sequencing analysis was used to identify differentially expressed genes in cultured mouse cardiac cells following Dox treatment. Western blotting was performed to examine the protein levels of β‑catenin, active β‑catenin, FUNDC1, LC3, p62, β‑myosin heavy chain (β-MHC), and α‑actin; immunohistochemistry and immunofluorescence staining were used to assess the localization and expression of β-catenin and FUNDC1. Transmission electron microscopy was employed to evaluate mitochondrial damage in the cardiac myocytes. Chromatin immunoprecipitation and dual-luciferase reporter gene assays were used to investigate the transcriptional regulation of FUNDC1 by β‑catenin.</p><p><strong>Results: </strong>Dox treatment significantly inhibited β‑catenin signaling and FUNDC1-mediated mitophagy, leading to cardiomyocyte hypertrophy and mitochondrial damage. OD treatment obviously reversed these effects, restored β‑catenin signaling, enhanced FUNDC1 transcription and expression, and promoted mitophagy. Overexpression of β‑catenin or FUNDC1 mimicked the cardioprotective effect of OD, while knockdown of β‑catenin aggravated myocardial hypertrophy, which was reversed by FUNDC1 overexpression. Mechanistically, β‑catenin directly bound to the FUNDC1 promoter and activated its transcription.</p><p><strong>Conclusions: </strong>OD alleviates Dox-induced myocardial hypertrophy in mice by activating the β‑catenin/FUNDC1/mitophagy axis and enhancing mitochondrial quality control.</p>","PeriodicalId":18962,"journal":{"name":"南方医科大学学报杂志","volume":"46 4","pages":"803-815"},"PeriodicalIF":0.0,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13120926/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147776691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[<i>Jianpi Zishen</i> Formula improves renal damage in mice with systemic lupus erythematosus by inhibiting p53-MDM2 signaling axis-mediated ferroptosis].","authors":"Yunfei Li, Chuanbing Huang, Lijun Pang, Ziheng Zhu, Ming Li","doi":"10.12122/j.issn.1673-4254.2026.04.07","DOIUrl":"https://doi.org/10.12122/j.issn.1673-4254.2026.04.07","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the therapeutic mechanism of <i>Jianpi Ziren</i> Formula (JPZS) for ameliorating renal injury in mice with systemic lupus erythematosus (SLE).</p><p><strong>Methods: </strong>Thirty MRL/lpr lupus mice were randomly divided into model group, JPZS treatment group, and prednisone treatment group, with 10 C57BL/6 mice as the control group. After treatment with daily gavage with normal saline, JPZS (7.8 g/kg) or prednisone (5 mg/kg) for 8 consecutive weeks, the mice were examined for changes in serum levels of anti-ds DNA, C3 and Scr, 24-h urine protein (24hPRO) and renal Fe²⁺ content, MDA level, SOD activity, GSH level, and ROS level. Renal histopathological changes and ultrastructural changes were observed with HE staining and transmission electron microscopy. The changes in renal expressions of p53, MDM2, GPX4, SLC7A11, ACSL4, Bax, Bcl-2, and caspase-3 mRNAs and proteins were detected using RT-qPCR and Western blotting.</p><p><strong>Results: </strong>Compared with the normal control mice, the mouse models of SLE had significantly elevated levels of dsDNA, Scr, 24hPRO, Fe²⁺, MDA, and ROS, increased renal expressions of p53, MDM2, ACSL4, Bax, and caspase-3, lowered levels of C3, SOD, and GSH, and reduced renal expressions of GPX4, SLC7A11, and Bcl-2 at both the mRNA and protein levels. Treatment with JPZS and prednisone both significantly ameliorated these abnormalities in the mouse models.</p><p><strong>Conclusions: </strong>JPZS can reduce renal ferroptosis in lupus mice, ameliorate kidney injury, and promote renal function repair possibly by inhibiting the p53-MDM2 signaling axis, which is closely associated with regulation of glomerular podocyte ferroptosis.</p>","PeriodicalId":18962,"journal":{"name":"南方医科大学学报杂志","volume":"46 4","pages":"785-793"},"PeriodicalIF":0.0,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13120920/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147775841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[A Transformer-based model using laboratory indicators efficiently differentiates ovarian cancer].","authors":"Shunqian Tan, Li Zhuo, Min Zeng, Fangjun Huang, Jun Zhu, Guangyao Cai, Xin Zhen","doi":"10.12122/j.issn.1673-4254.2026.04.22","DOIUrl":"https://doi.org/10.12122/j.issn.1673-4254.2026.04.22","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the diagnostic performance of a Transformer-based deep learning model that integrates real-world laboratory test indicators for differential diagnosis of ovarian cancer.</p><p><strong>Methods: </strong>The clinical data and 99 laboratory test indicators were retrospectively collected from patients with ovarian cancer and benign ovarian lesions admitted to Department of Obstetrics and Gynecology of Tongji Hospital between January 1, 2012 and April 4, 2021. A feature selection algorithm based on ANOVA F-test was used on the training set to identify 20 key features. Each case was then converted into a unified embedded vector using a tabular data Transformer. An improved stacked Transformer model was then trained to encode these feature vectors. The proposed model was compared with multiple traditional machine learning methods. The evaluation metrics included the area under the receiver operating characteristic curve (AUC), accuracy, sensitivity, and specificity. Five-fold cross-validation was performed to assess the generalization ability and robustness of the model.</p><p><strong>Results: </strong>Five-fold cross-validation showed that the Transformer-based deep learning model achieved the best performance in predicting ovarian cancer with an AUC of 0.931, an accuracy of 0.813, a sensitivity of 0.833, and a specificity of 0.865.</p><p><strong>Conclusions: </strong>The proposed Transformer-based model demonstrates high accuracy and generalization capability in predicting ovarian cancer, and may thus offer a assistance in clinical diagnosis of ovarian tumors.</p>","PeriodicalId":18962,"journal":{"name":"南方医科大学学报杂志","volume":"46 4","pages":"939-945"},"PeriodicalIF":0.0,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13120988/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147776403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Erianin inhibits proliferation and migration of breast cancer cells <i>in vitro</i> by inhibiting Wnt/β-catenin signaling].","authors":"Dongwei Fan, Xuanhe Li, Tingjing Yao, Congwen Jin, Xingliang Wang, Cheng Huang","doi":"10.12122/j.issn.1673-4254.2026.04.12","DOIUrl":"https://doi.org/10.12122/j.issn.1673-4254.2026.04.12","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the effect of erianin on proliferation, migration, invasion, and apoptosis of breast cancer cells and the underlying mechanisms.</p><p><strong>Methods: </strong>Breast cancer cell lines T-47D and MCF-7 treated with 0, 12.5, 25, 50, and 100 nmol/L erianin for 12, 24, 36, 48, and 72 h were examined for cell viability using CCK-8 assay. The effects of erianin on cell proliferation, migration, invasion, senescence and apoptosis were evaluated using clone formation, wound healing, Transwell invasion, and senescence assays and flow cytometry. mRNA microarray analysis and the Enrichr database were used to explore the biological functions of erianin. Western blotting was used to detect the changes in protein expressions related to apoptosis, epithelial-mesenchymal transition (EMT), and the Wnt/β-catenin pathway.</p><p><strong>Results: </strong>Erianin concentration-dependently inhibited cell viability, proliferation, migration, and invasion, and promoted senescence in T-47D and MCF-7 cells. Microarray analysis identified 1064 differentially expressed genes (DEGs), including 948 upregulated and 116 downregulated genes, which were involved primarily in EMT regulation, collagen-containing extracellular matrix, calcium ion binding, the PI3K-Akt signaling pathway, the Wnt/β-catenin signaling pathway, and apoptosis. Flow cytometry confirmed that erianin concentration-dependently induced apoptosis in the breast cancer cells, upregulated the expressions of Bax and caspase-3, decreased Bcl-2 expression, and lowered the expressions of EMT-related proteins (Snail, N-cadherin, and β‑catenin) and Wnt/β‑catenin signaling proteins (TCF4, Cyclin D1, and c-Myc). In the breast cancer cells treated with 100 nmol/L erianin, the application of a Wnt/β‑catenin agonist significantly increased the proteins expressions of TCF4, Cyclin D1, and c-Myc.</p><p><strong>Conclusions: </strong>Erianin inhibits proliferation, migration, and invasion and induces senescence and apoptosis in breast cancer cells possibly by suppressing the Wnt/β-catenin signaling pathway to induce cell apoptosis and reverse EMT of the cells.</p>","PeriodicalId":18962,"journal":{"name":"南方医科大学学报杂志","volume":"46 4","pages":"838-847"},"PeriodicalIF":0.0,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13120925/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147776668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Swin-ResViT network for real-time generation of high-quality localization MR images from low-quality cine-MR].","authors":"Boyong Chen, Xinyi Wang, Xinxin Zhao, Ting Song, Yongbao Li","doi":"10.12122/j.issn.1673-4254.2026.04.21","DOIUrl":"https://doi.org/10.12122/j.issn.1673-4254.2026.04.21","url":null,"abstract":"<p><strong>Objectives: </strong>To obtain high-quality pre-treatment localization MR (sMR) images from dynamic cine-MR using the Swin-ResViT network for target tracking in MRgRT.</p><p><strong>Methods: </strong>We propose a ResViT model fused with a Swin Transformer module (Swin-ResViT) with an optimized bottleneck layer structure for enhancing feature extraction efficiency. Seventeen liver cancer patients were retrospectively enrolled from Sun Yat-sen University Cancer Center from February to July 2024, and 12 of them were assigned to the training set (using intra-treatment cine-MR and pre-treatment planning MR), with the remaining 5 patients as the test set. Image generation quality and model performance were comprehensively evaluated by quantifying the normalized root mean square error (NRMSE), peak signal-to-noise ratio (PSNR), structural similarity index (SSIM), motion marker point error, and model inference speed between sMR and reference localization MR.</p><p><strong>Results: </strong>Regarding image quality, Swin-ResViT reduced NRMSE and LPIPS by 90% and 82% compared to cine-MR (<i>P</i><0.001), and improved PSNR, SSIM, and CNR by 157%, 79%, and 181% (<i>P</i><0.001), respectively. Regarding structural accuracy, the mean localization error of motion markers at the right hepatophrenic junction in the generated dynamic sMR sequences was 0.7695±0.7294 mm (<i>P</i><0.05). Regarding model inference speed, for a single 224×224-pixel frame, the average processing time on an NVIDIA GeForce RTX 2080 Ti GPU was 15.5 ms for Swin-ResViT as compared with 41.4 ms for the ResViT network, demonstrating a 62% reduction.</p><p><strong>Conclusions: </strong>The Swin-ResViT model can synthesize high-quality sMR from cine-MR images. This method combines computational efficiency with significant image enhancement advantages, and thus has important clinical significance for real-time MRgRT.</p>","PeriodicalId":18962,"journal":{"name":"南方医科大学学报杂志","volume":"46 4","pages":"929-938"},"PeriodicalIF":0.0,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13120924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147776697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Modified <i>Gandou</i> Decoction improves cognitive function of TX mice with Wilson's disease by inhibiting the PKR/eIF2α pathway].","authors":"Chenchen Xu, Yongsheng Han, Nan Cheng, Jianjian Dong","doi":"10.12122/j.issn.1673-4254.2026.04.16","DOIUrl":"https://doi.org/10.12122/j.issn.1673-4254.2026.04.16","url":null,"abstract":"<p><strong>Objectives: </strong>To assess the effect of the Modified <i>Gandou</i> Decoction (MGDD, developed based on the <i>TongFuYangSui</i> strategy in traditional Chinese medicine) for improving cognitive function in a PKR-silenced Wilson's disease (WD) TX mouse model and explore the underlying mechanism.</p><p><strong>Methods: </strong>Thirty-six TX mice were randomized into TX group, TX+MGDD group, C16 group, and C16+MGDD group. In C16 and C16+MGDD group, the mice received daily intraperitoneal injections of 300 μg/kg C16 (a PKR inhibitor) for 30 days, and saline injections were given in the other two groups; after WD modeling, the mice in TX+MGDD and C16+MGDD groups received MGDD gavage for 4 weeks, while the other two groups were given saline gavage. After the treatments, the mice were examined using behavioral tests, followed by immunofluorescence staining, TUNEL staining, TEM, RT-qPCR and Western blotting analysis of the brain tissue.</p><p><strong>Results: </strong>In behavioral tests, the mice in C16+MGDD group showed significantly shorter time spent in the perimeter than those in C16 group without significant differences in other parameters. Immunofluorescence staining revealed obviously lowered hippocampal oxidative stress level in C16, TX+MGDD, and C16+MGDD groups compared with TX group. Both MGDD and C16 treatment alone increased the number of hippocampal synapses and vesicles and improved ultrastructural synaptic damages, but their combination exhibited no synergistic effect. The C16+MGDD group showed significantly higher expressions of PSD93, PSD95, synapsin1 and synaptophysin than C16 group, but had comparable PSD93 expression with TX+MGDD group. While the mRNA expressions in the PKR/eIF2α pathway were similar between C16+MGDD and C16 groups, the protein levels of P-eIF2α and CHOP were significantly lower and P-CREB protein level was higher in C16+MGDD group.</p><p><strong>Conclusions: </strong>MGDD improves cognitive dysfunction in WD TX mice possibly by inhibiting the PKR/eIF2α pathway, promoting expressions of synaptic proteins, and improving synaptic structure and function.</p>","PeriodicalId":18962,"journal":{"name":"南方医科大学学报杂志","volume":"46 4","pages":"880-889"},"PeriodicalIF":0.0,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13120979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147776703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}