Isabell Wiethoff, Birgit Goversen, Michelle Michels, Jolanda van der Velden, Mickaël Hiligsmann, Tom Kugener, Silvia Evers
{"title":"Reply to 'Cost-effectiveness of long term left ventricular assist devices'.","authors":"Isabell Wiethoff, Birgit Goversen, Michelle Michels, Jolanda van der Velden, Mickaël Hiligsmann, Tom Kugener, Silvia Evers","doi":"10.1007/s12471-024-01910-7","DOIUrl":"10.1007/s12471-024-01910-7","url":null,"abstract":"","PeriodicalId":18952,"journal":{"name":"Netherlands Heart Journal","volume":" ","pages":"463"},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11584807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luc Cozijnsen, Bouke P Adriaans, Tjard R Schermer, Maarten Groenink, Simon Schalla, Sebastiaan C A M Bekkers
{"title":"Growth rates in non-syndromic aneurysms of the ascending aorta: a systematic review.","authors":"Luc Cozijnsen, Bouke P Adriaans, Tjard R Schermer, Maarten Groenink, Simon Schalla, Sebastiaan C A M Bekkers","doi":"10.1007/s12471-024-01911-6","DOIUrl":"10.1007/s12471-024-01911-6","url":null,"abstract":"<p><p>The maximum aortic diameter is the main risk predictor for type A acute aortic syndromes and understanding the growth rate of ascending thoracic aortic aneurysms (aTAAs) is pivotal for risk assessment and stratification for pre-emptive aortic surgery. Prevailing guidelines recommend serial imaging of aTAA patients until the thresholds for prophylactic surgery are met. Based on early landmark studies, it was thought that the growth rate of aTAAs is substantially higher than that of the normal-sized aorta. However, more recent studies have reported that aTAA growth is generally slow, questioning the need for frequent imaging during follow-up. The current systematic review provides an overview of studies reporting annual diameter growth rates of non-syndromic aTAAs and explains differences in findings between early and recent studies.</p>","PeriodicalId":18952,"journal":{"name":"Netherlands Heart Journal","volume":" ","pages":"433-441"},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11584832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pim van der Harst, Peter Damman, Joris R de Groot, Maryam Kavousi, Clara E E van Ofwegen-Hanekamp, Martin E W Hemels
{"title":"Advancing cardiovascular care-key insights from the Netherlands Heart Journal 2024.","authors":"Pim van der Harst, Peter Damman, Joris R de Groot, Maryam Kavousi, Clara E E van Ofwegen-Hanekamp, Martin E W Hemels","doi":"10.1007/s12471-024-01912-5","DOIUrl":"10.1007/s12471-024-01912-5","url":null,"abstract":"","PeriodicalId":18952,"journal":{"name":"Netherlands Heart Journal","volume":"32 12","pages":"429-432"},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11584816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142687484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Victor A Verpalen, Casper F Coerkamp, Mark J Hinderks, Joan G Meeder, Michiel M Winter, E Karin Arkenbout, Jeroen C Vis, Jesse Habets, Martijn W Smulders, Casper Mihl, Clara E E van Ofwegen-Hanekamp, Tycho I G van der Spoel, Wilco Tanis, Rogier E van Gelder, Marloes L J van der Wielen, G Aernout Somsen, Wouter J Kikkert, Luc F Carati, Abdelilah El Barzouhi, Paul F M M van Bergen, Admir Dedic, Mathias Prokop, Hein P Stallmann, Xavier D Y Beele, Henriëtte M E Quarles van Ufford, Robin Nijveldt, Marcel G W Dijkgraaf, Peter Damman, R Nils Planken, José P S Henriques
{"title":"Combined strategy of upfront CTCA and optimal treatment for stable chest pain: rationale and design of the CLEAR-CAD trial.","authors":"Victor A Verpalen, Casper F Coerkamp, Mark J Hinderks, Joan G Meeder, Michiel M Winter, E Karin Arkenbout, Jeroen C Vis, Jesse Habets, Martijn W Smulders, Casper Mihl, Clara E E van Ofwegen-Hanekamp, Tycho I G van der Spoel, Wilco Tanis, Rogier E van Gelder, Marloes L J van der Wielen, G Aernout Somsen, Wouter J Kikkert, Luc F Carati, Abdelilah El Barzouhi, Paul F M M van Bergen, Admir Dedic, Mathias Prokop, Hein P Stallmann, Xavier D Y Beele, Henriëtte M E Quarles van Ufford, Robin Nijveldt, Marcel G W Dijkgraaf, Peter Damman, R Nils Planken, José P S Henriques","doi":"10.1007/s12471-024-01906-3","DOIUrl":"10.1007/s12471-024-01906-3","url":null,"abstract":"<p><strong>Background: </strong>Patients with stable chest pain suspected of coronary artery disease (CAD) usually undergo multiple diagnostic tests to confirm or rule out obstructive CAD. Some tests may not effectively assess the presence of CAD, precluding optimal treatment. A diagnostic strategy of upfront computed tomography coronary angiography (CTCA) combined with optimal medical therapy (OMT) tailored to the extent of CAD may be superior to standard care in preventing major adverse cardiac events.</p><p><strong>Study design: </strong>The CLEAR-CAD trial is a prospective, open-label, multicentre, randomised, superiority trial of an upfront CTCA-guided strategy in 6444 patients presenting in an outpatient setting with suspected CAD compared with standard care, in approximately 30 participating centres in the Netherlands. The upfront CTCA-guided strategy consists of an initial CTCA which is assessed using the Coronary Artery Disease-Reporting and Data System (CAD-RADS 2.0). In patients without CAD (CAD-RADS 0) no specific cardiac medication is mandated. Patients with non-obstructive CAD (CAD-RADS 1-2) are treated with preventive OMT. Patients with obstructive CAD (CAD-RADS ≥ 3) are treated with preventive and anti-anginal OMT; in the presence of pharmacologically refractory symptoms patients undergo selective revascularisation after non-invasive functional imaging for myocardial ischaemia (≥ 10%). Patients with significant left main or proximal left anterior descending coronary artery stenosis on CTCA undergo direct invasive coronary angiography and subsequent revascularisation. The primary endpoint is the composite of all-cause death and myocardial infarction.</p><p><strong>Conclusion: </strong>The CLEAR-CAD trial is the first randomised study to investigate the efficacy of a combined upfront CTCA-guided medical and selective revascularisation strategy in an outpatient setting with suspected CAD compared with standard care.</p>","PeriodicalId":18952,"journal":{"name":"Netherlands Heart Journal","volume":" ","pages":"387-396"},"PeriodicalIF":1.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11502636/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142470359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Leonie M Becker, Joyce Peper, Sophie H van Nes, Hendrik W van Es, Krischan D Sjauw, Tim P van de Hoef, Tim Leiner, Martin J Swaans
{"title":"Non-invasive physiological assessment of coronary artery obstruction on coronary computed tomography angiography.","authors":"Leonie M Becker, Joyce Peper, Sophie H van Nes, Hendrik W van Es, Krischan D Sjauw, Tim P van de Hoef, Tim Leiner, Martin J Swaans","doi":"10.1007/s12471-024-01902-7","DOIUrl":"10.1007/s12471-024-01902-7","url":null,"abstract":"<p><p>Computed tomography-derived fractional flow reserve (CT-FFR) enhances the specificity of coronary computed tomography angiography (CCTA) to that of the most specific non-invasive imaging techniques, while maintaining high sensitivity in stable coronary artery disease (CAD). As gatekeeper for invasive coronary angiography (ICA), use of CT-FFR results in a significant reduction of negative ICA procedures and associated costs and complications, without increasing cardiovascular events. It is expected that CT-FFR algorithms will continue to improve, regarding accuracy and generalisability, and that introduction of new features will allow further treatment guidance and reduced invasive diagnostic testing. Advancements in CCTA quality and artificial intelligence (AI) are starting to unfold the incremental diagnostic and prognostic capabilities of CCTA's attenuation-based images in CAD, with future perspectives promising additional CCTA parameters which will enable non-invasive assessment of myocardial ischaemia as well as CAD activity and future cardiovascular risk. This review discusses practical application, interpretation and impact of CT-FFR on patient care, and how this ties into the CCTA 'one stop shop' for coronary assessment and patient prognosis. In this light, selective adoption of the most promising, objective and reproducible techniques and algorithms will yield maximal diagnostic value of CCTA without overcomplicating patient management and guideline recommendations.</p>","PeriodicalId":18952,"journal":{"name":"Netherlands Heart Journal","volume":" ","pages":"397-404"},"PeriodicalIF":1.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11502690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sara-Joan Pinto-Sietsma, Birgitta K Velthuis, Nick S Nurmohamed, Rozemarijn Vliegenthart, Fabrice M A C Martens
{"title":"Computed tomography and coronary artery calcium score for screening of coronary artery disease and cardiovascular risk management in asymptomatic individuals.","authors":"Sara-Joan Pinto-Sietsma, Birgitta K Velthuis, Nick S Nurmohamed, Rozemarijn Vliegenthart, Fabrice M A C Martens","doi":"10.1007/s12471-024-01897-1","DOIUrl":"10.1007/s12471-024-01897-1","url":null,"abstract":"<p><p>Several risk prediction models exist to predict atherosclerotic cardiovascular disease in asymptomatic individuals, but systematic reviews have generally found these models to be of limited utility. The coronary artery calcium score (CACS) offers an improvement in risk prediction, yet its role remains contentious. Notably, its negative predictive value has a high ability to rule out clinically relevant atherosclerotic cardiovascular disease. Nonetheless, CACS 0 does not permanently reclassify to a lower cardiovascular risk and periodic reassessment every 5 to 10 years remains necessary. Conversely, elevated CACS (> 100 or > 75th percentile adjusted for age, sex and ethnicity) can reclassify intermediate-risk individuals to a high risk, benefiting from preventive medication. The forthcoming update to the Dutch cardiovascular risk management guideline intends to re-position CACS for cardiovascular risk assessment as such in asymptomatic individuals. Beyond CACS as a single number, several guidelines recommend coronary CT angiography (CCTA), which provides additional information about luminal stenosis and (high-risk) plaque composition, as the first choice of test in symptomatic patients and high-risk patients. Ongoing randomised studies will have to determine the value of atherosclerosis evaluation with CCTA for primary prevention in asymptomatic individuals.</p>","PeriodicalId":18952,"journal":{"name":"Netherlands Heart Journal","volume":" ","pages":"371-377"},"PeriodicalIF":1.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11502644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142361809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Simran P Sharma, Marie-Julie D K Lemmens, Martijn W Smulders, Ricardo P J Budde, Alexander Hirsch, Casper Mihl
{"title":"Photon-counting detector computed tomography in cardiac imaging.","authors":"Simran P Sharma, Marie-Julie D K Lemmens, Martijn W Smulders, Ricardo P J Budde, Alexander Hirsch, Casper Mihl","doi":"10.1007/s12471-024-01904-5","DOIUrl":"10.1007/s12471-024-01904-5","url":null,"abstract":"<p><p>Photon-counting detector computed tomography (PCD-CT) has emerged as a revolutionary technology in CT imaging. PCD-CT offers significant advancements over conventional energy-integrating detector CT, including increased spatial resolution, artefact reduction and inherent spectral imaging capabilities. In cardiac imaging, PCD-CT can offer a more accurate assessment of coronary artery disease, plaque characterisation and the in-stent lumen. Additionally, it might improve the visualisation of myocardial fibrosis through qualitative late enhancement imaging and quantitative extracellular volume measurements. The use of PCD-CT in cardiac imaging holds significant potential, positioning itself as a valuable modality that could serve as a one-stop-shop by integrating both angiography and tissue characterisation into a single examination. Despite its potential, large-scale clinical trials, standardisation of protocols and cost-effectiveness considerations are required for its broader integration into clinical practice. This narrative review provides an overview of the current literature on PCD-CT regarding the possibilities and limitations of cardiac imaging.</p>","PeriodicalId":18952,"journal":{"name":"Netherlands Heart Journal","volume":" ","pages":"405-416"},"PeriodicalIF":1.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11502613/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142361810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Moving towards a uniform diagnosis of coronary artery disease on coronary CTA : Coronary Artery Disease-Reporting and Data System 2.0.","authors":"Csilla Celeng, Richard A P Takx","doi":"10.1007/s12471-024-01903-6","DOIUrl":"10.1007/s12471-024-01903-6","url":null,"abstract":"<p><p>The Coronary Artery Disease-Reporting and Data System (CAD-RADS) is a standardised reporting method which was created in order to improve communication with referring physicians as well as for management considerations. The CAD-RADS score denotes the absence or presence of stenosis, while plaque burden and potential modifiers provide insight into plaque extent and characteristics. The modifier ischaemia enables the incorporation of fractional flow reserve CT and CT perfusion, while the modifier exception is used to denote potential coronary abnormalities. Higher CAD-RADS categories demonstrate incremental prognostic value, with further improvement when taking plaque burden into account. CAD-RADS improves communication with the referring clinician as well as guiding therapeutic management and as such is relevant to uniform patient care in the Netherlands.</p>","PeriodicalId":18952,"journal":{"name":"Netherlands Heart Journal","volume":" ","pages":"378-385"},"PeriodicalIF":1.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11502610/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142400791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"CT is the new standard for the diagnosis of coronary artery disease in daily practice.","authors":"José P S Henriques, R Nils Planken","doi":"10.1007/s12471-024-01907-2","DOIUrl":"10.1007/s12471-024-01907-2","url":null,"abstract":"","PeriodicalId":18952,"journal":{"name":"Netherlands Heart Journal","volume":" ","pages":"369-370"},"PeriodicalIF":1.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11502707/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rudolf L M van Herten, Ioannis Lagogiannis, Tim Leiner, Ivana Išgum
{"title":"The role of artificial intelligence in coronary CT angiography.","authors":"Rudolf L M van Herten, Ioannis Lagogiannis, Tim Leiner, Ivana Išgum","doi":"10.1007/s12471-024-01901-8","DOIUrl":"10.1007/s12471-024-01901-8","url":null,"abstract":"<p><p>Coronary CT angiography (CCTA) offers an efficient and reliable tool for the non-invasive assessment of suspected coronary artery disease through the analysis of coronary artery plaque and stenosis. However, the detailed manual analysis of CCTA is a burdensome task requiring highly skilled experts. Recent advances in artificial intelligence (AI) have made significant progress toward a more comprehensive automated analysis of CCTA images, offering potential improvements in terms of speed, performance and scalability. This work offers an overview of the recent developments of AI in CCTA. We cover methodological advances for coronary artery tree and whole heart analysis, and provide an overview of AI techniques that have shown to be valuable for the analysis of cardiac anatomy and pathology in CCTA. Finally, we provide a general discussion regarding current challenges and limitations, and discuss prospects for future research.</p>","PeriodicalId":18952,"journal":{"name":"Netherlands Heart Journal","volume":" ","pages":"417-425"},"PeriodicalIF":1.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11502768/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142470360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}