Netherlands Heart Journal最新文献

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Prevalence of transthyretin amyloid cardiomyopathy in an unselected cohort with heart failure with preserved ejection fraction. 在未选择的有保留射血分数的心力衰竭患者中,转甲状腺素淀粉样蛋白心肌病的患病率。
IF 1.7 4区 医学
Netherlands Heart Journal Pub Date : 2025-06-01 Epub Date: 2025-04-28 DOI: 10.1007/s12471-025-01954-3
Anouk Achten, Vanessa P M van Empel, Jerremy Weerts, Sanne Mourmans, Hans-Peter Brunner-La Rocca, Sandra Sanders-van Wijk, Christian Knackstedt
{"title":"Prevalence of transthyretin amyloid cardiomyopathy in an unselected cohort with heart failure with preserved ejection fraction.","authors":"Anouk Achten, Vanessa P M van Empel, Jerremy Weerts, Sanne Mourmans, Hans-Peter Brunner-La Rocca, Sandra Sanders-van Wijk, Christian Knackstedt","doi":"10.1007/s12471-025-01954-3","DOIUrl":"10.1007/s12471-025-01954-3","url":null,"abstract":"<p><strong>Introduction: </strong>Heart failure with preserved ejection fraction (HFpEF) represents a heterogeneous syndrome characterised by various underlying aetiologies, such as transthyretin amyloid cardiomyopathy (ATTR-CM). The aim of this study was to determine the true prevalence of ATTR-CM in a Dutch all-comers cohort of HFpEF patients.</p><p><strong>Methods: </strong>From 2018 to 2023, all patients diagnosed with HFpEF underwent prospective screening for ATTR-CM. Diagnosis of ATTR-CM was made in accordance with guideline recommendations.</p><p><strong>Results: </strong>Of the 202 HFpEF patients included (mean ± standard deviation age: 76 ± 7 years; 64% female), 9 (5%) showed cardiac uptake on scintigraphy, of whom 6 (3%) were subsequently diagnosed with wild-type ATTR-CM. Left ventricular wall thickness (LVWT) was significantly higher in ATTR-CM patients than non-amyloid HFpEF patients (median interventricular septum diameter: 15 mm; interquartile range (IQR): 11-17 vs 10 mm; IQR: 9-11; p < 0.001). Interestingly, 2 ATTR-CM patients (33%) did not have increased LVWT at the time of diagnosis. These 2 patients were in a less advanced prognostic stage.</p><p><strong>Conclusion: </strong>This study revealed a low prevalence of ATTR-CM (3%) in an unselected HFpEF cohort. We identified ATTR-CM patients without increased LVWT (33%), who presented at an earlier disease stage. Hence, relying exclusively on LVWT for the diagnosis of ATTR-CM may result in delayed and/or missed diagnoses.</p>","PeriodicalId":18952,"journal":{"name":"Netherlands Heart Journal","volume":" ","pages":"193-198"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12098227/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The PLN Foundation is striving for a cure, but who owns the disease? PLN基金会正在努力寻找治疗方法,但谁拥有这种疾病?
IF 1.7 4区 医学
Netherlands Heart Journal Pub Date : 2025-06-01 Epub Date: 2025-05-08 DOI: 10.1007/s12471-025-01961-4
Luuk Kerckhaert, Pieter Glijnis, Annet N Linders, Cor Oosterwijk, Pieter A Doevendans
{"title":"The PLN Foundation is striving for a cure, but who owns the disease?","authors":"Luuk Kerckhaert, Pieter Glijnis, Annet N Linders, Cor Oosterwijk, Pieter A Doevendans","doi":"10.1007/s12471-025-01961-4","DOIUrl":"10.1007/s12471-025-01961-4","url":null,"abstract":"<p><p>The PLN Foundation, established in 2012, supports about 1700 individuals with a phospholamban (PLN) gene mutation causing severe cardiomyopathy. It aims to cure this rare disease by collaborating with universities, research institutions, and biotechnology companies. However, the foundation often faces challenges in being recognised as an equal research partner, with legal departments and technology transfer offices (TTOs) prioritising institutional interests over the public good, leading to delays and inefficiencies. The scientific culture's 'publish or perish' mentality, patent ownership issues, and bureaucratic ethics review processes further complicate progress. To overcome these barriers, the foundation advocates IP co-ownership, patient leadership, streamlined agreements, provisional ethical approvals, improved research logistics, revised evaluation metrics for scientists, and a shift in TTO strategies towards co-creation. These measures aim to enhance collaboration, accelerate therapeutic development, and ensure the accessibility and affordability of new treatments for rare diseases.</p>","PeriodicalId":18952,"journal":{"name":"Netherlands Heart Journal","volume":" ","pages":"206-210"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12098232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Remote monitoring in implantable cardiac devices: A care solution or alert pollution? 植入式心脏装置的远程监测:护理解决方案还是警戒污染?
IF 1.7 4区 医学
Netherlands Heart Journal Pub Date : 2025-06-01 Epub Date: 2025-05-05 DOI: 10.1007/s12471-025-01957-0
Cheyenne S L Chiu, Mathias Meine
{"title":"Remote monitoring in implantable cardiac devices: A care solution or alert pollution?","authors":"Cheyenne S L Chiu, Mathias Meine","doi":"10.1007/s12471-025-01957-0","DOIUrl":"10.1007/s12471-025-01957-0","url":null,"abstract":"","PeriodicalId":18952,"journal":{"name":"Netherlands Heart Journal","volume":" ","pages":"184-185"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12098226/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Studies on ICD guidelines, cardiac amyloidosis in HFpEF, and remote monitoring outcomes. ICD指南、HFpEF患者的心脏淀粉样变性和远程监测结果的研究。
IF 1.7 4区 医学
Netherlands Heart Journal Pub Date : 2025-06-01 Epub Date: 2025-05-22 DOI: 10.1007/s12471-025-01965-0
Pim van der Harst
{"title":"Studies on ICD guidelines, cardiac amyloidosis in HFpEF, and remote monitoring outcomes.","authors":"Pim van der Harst","doi":"10.1007/s12471-025-01965-0","DOIUrl":"10.1007/s12471-025-01965-0","url":null,"abstract":"","PeriodicalId":18952,"journal":{"name":"Netherlands Heart Journal","volume":"33 6","pages":"183"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12098239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144120345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Midnight punctual tachycardia. 午夜准时性心动过速。
IF 1.7 4区 医学
Netherlands Heart Journal Pub Date : 2025-06-01 Epub Date: 2025-05-08 DOI: 10.1007/s12471-025-01958-z
Robin Kuijpers, Kim Smulders, Pepijn van der Voort, René Tio, Luuk Otterspoor
{"title":"Midnight punctual tachycardia.","authors":"Robin Kuijpers, Kim Smulders, Pepijn van der Voort, René Tio, Luuk Otterspoor","doi":"10.1007/s12471-025-01958-z","DOIUrl":"10.1007/s12471-025-01958-z","url":null,"abstract":"","PeriodicalId":18952,"journal":{"name":"Netherlands Heart Journal","volume":" ","pages":"211-212"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12098216/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Midnight punctual tachycardia. 午夜准时性心动过速。
IF 1.7 4区 医学
Netherlands Heart Journal Pub Date : 2025-06-01 Epub Date: 2025-05-07 DOI: 10.1007/s12471-025-01959-y
Robin Kuijpers, Kim Smulders, Pepijn van der Voort, René Tio, Luuk Otterspoor
{"title":"Midnight punctual tachycardia.","authors":"Robin Kuijpers, Kim Smulders, Pepijn van der Voort, René Tio, Luuk Otterspoor","doi":"10.1007/s12471-025-01959-y","DOIUrl":"10.1007/s12471-025-01959-y","url":null,"abstract":"","PeriodicalId":18952,"journal":{"name":"Netherlands Heart Journal","volume":" ","pages":"213-214"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12098247/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Heart rhythm management optimisation of pacemaker recipients using remote monitoring: the HERO registry. 使用远程监测心脏起搏器接受者的心律管理优化:HERO注册表。
IF 1.7 4区 医学
Netherlands Heart Journal Pub Date : 2025-06-01 Epub Date: 2025-05-09 DOI: 10.1007/s12471-025-01953-4
Fleur W Adriaansen, Jaap Seelig, Tim A C de Vries, Leonard Voorhout, Frank P Brouwers, Balazs Manfai, Richard Derksen, Christiaan Aagenborg, Carine J M Doggen, Ron Pisters, Martin E W Hemels
{"title":"Heart rhythm management optimisation of pacemaker recipients using remote monitoring: the HERO registry.","authors":"Fleur W Adriaansen, Jaap Seelig, Tim A C de Vries, Leonard Voorhout, Frank P Brouwers, Balazs Manfai, Richard Derksen, Christiaan Aagenborg, Carine J M Doggen, Ron Pisters, Martin E W Hemels","doi":"10.1007/s12471-025-01953-4","DOIUrl":"10.1007/s12471-025-01953-4","url":null,"abstract":"<p><strong>Introduction: </strong>Current expert consensus recommends remote monitoring (RM) for cardiac implantable electronic devices (CIEDs). As this recommendation is primarily based on studies involving implantable cardioverter defibrillators (ICDs), the HERO (HEart Rhythm management Optimisation of pacemaker recipients using remote monitoring) study aimed to reinforce this recommendation for pacemaker recipients.</p><p><strong>Methods: </strong>The exploratory, retrospective, single-centre HERO study included 203 patients with an increased stroke risk (CHA<sub>2</sub>DS<sub>2</sub>-VASc score ≥ 2) but without a history of atrial fibrillation or flutter, who received a pacemaker between January 2016 and April 2018. Occurrence and detection time of atrial and ventricular arrhythmias were analysed in patients with RM (RM+; n = 60) and those without RM (RM-; n = 143), together with CIED adverse events, cardiology visits and anticoagulation adjustments.</p><p><strong>Results: </strong>The median age of the patients was 80 (73-85) years, with 55.2% being men. During a median follow-up of 5.0 years, 53.7% were diagnosed with at least one arrhythmic event (RM+ 60.0% vs RM- 51.0%, p = 0.28). The median time from pacemaker implantation to detection of first arrhythmic event was 2.5 (0.5-8.2) years in the RM+ group versus 2.8 (1.2-8.0) years in the RM- group (hazard ratio 0.89; 95% confidence interval 0.59-1.35; p = 0.58). There were no differences in the number of adverse events or anticoagulation adjustments during follow-up. More CIED telephone consultations were conducted in the RM+ group.</p><p><strong>Conclusion: </strong>A substantial proportion of pacemaker patients experienced one or more arrhythmic events during follow-up. The HERO study did not demonstrate a difference in time to detection of the first event when using remote monitoring.</p>","PeriodicalId":18952,"journal":{"name":"Netherlands Heart Journal","volume":" ","pages":"199-205"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12098215/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Primary prevention ICD in non-ischaemic cardiomyopathy: an ongoing search for improvement of current indications : A retrospective study analysing the impact of the new Dutch guideline on the use of ICDs. 非缺血性心肌病一级预防ICD:对当前适应症改进的持续探索:一项回顾性研究分析了新的荷兰指南对ICD使用的影响。
IF 1.7 4区 医学
Netherlands Heart Journal Pub Date : 2025-06-01 Epub Date: 2025-05-12 DOI: 10.1007/s12471-025-01960-5
Reinder Evertz, Rypko Beukema, Sjoerd Westra, Robin Nijveldt, Kevin Vernooy
{"title":"Primary prevention ICD in non-ischaemic cardiomyopathy: an ongoing search for improvement of current indications : A retrospective study analysing the impact of the new Dutch guideline on the use of ICDs.","authors":"Reinder Evertz, Rypko Beukema, Sjoerd Westra, Robin Nijveldt, Kevin Vernooy","doi":"10.1007/s12471-025-01960-5","DOIUrl":"10.1007/s12471-025-01960-5","url":null,"abstract":"<p><strong>Introduction: </strong>Patients with non-ischaemic cardiomyopathy (NICMP) have a class IIa primary prevention indication for an implantable cardioverter-defibrillator (ICD). Recent studies have shown that the evidence for a survival benefit following ICD implantation in this patient group is not particularly robust. In 2023, the Dutch Society of Cardiology published an update of the ESC guideline to better select patients with NICMP for ICD implantation. The objective of this study was to analyse the impact of this guideline on the number of indications in a retrospective cohort of patients who had received an ICD and whether the patients without an indication were also without appropriate ICD therapy.</p><p><strong>Methods: </strong>A single-centre, retrospective observational study was performed in 134 patients with NICMP who underwent ICD implantation for primary prevention between 2015 and 2020.</p><p><strong>Results: </strong>After applying the new Dutch guideline, 74 out of 134 patients with NICMP without a high-risk phenotype (35 patients) had no ICD indication (group 2). The remaining 25 patients were considered to have an ICD indication (group 1). During a median follow-up of 66 months (interquartile range 52-81) the incidence of appropriate ICD therapy (antitachycardia pacing and shock) was comparable in both groups: 4 patients in group 1 (16%) and 9 in group 2 (12%), p = 0.623.</p><p><strong>Conclusion: </strong>The new 2023 guideline for ICD implantation in NICMP patients does indeed rule out a significant group of patients from ICD implantation. Nevertheless, our data show that patients without an indication still had comparable rates of appropriate ICD therapy.</p>","PeriodicalId":18952,"journal":{"name":"Netherlands Heart Journal","volume":" ","pages":"186-192"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12098225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing heart failure detection and patient engagement with the Maastricht Decompensation Questionnaire. 加强心衰检测和患者参与马斯特里赫特失代偿问卷。
IF 1.7 4区 医学
Netherlands Heart Journal Pub Date : 2025-05-01 Epub Date: 2025-02-27 DOI: 10.1007/s12471-025-01945-4
Arno J Gingele, Hans-Peter Brunner-La Rocca
{"title":"Enhancing heart failure detection and patient engagement with the Maastricht Decompensation Questionnaire.","authors":"Arno J Gingele, Hans-Peter Brunner-La Rocca","doi":"10.1007/s12471-025-01945-4","DOIUrl":"10.1007/s12471-025-01945-4","url":null,"abstract":"","PeriodicalId":18952,"journal":{"name":"Netherlands Heart Journal","volume":" ","pages":"181"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12014867/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiomyopathy care and real-world practice in the Netherlands. 心肌病护理和现实世界的实践在荷兰。
IF 1.7 4区 医学
Netherlands Heart Journal Pub Date : 2025-05-01 Epub Date: 2025-04-22 DOI: 10.1007/s12471-025-01956-1
Pim van der Harst
{"title":"Cardiomyopathy care and real-world practice in the Netherlands.","authors":"Pim van der Harst","doi":"10.1007/s12471-025-01956-1","DOIUrl":"https://doi.org/10.1007/s12471-025-01956-1","url":null,"abstract":"","PeriodicalId":18952,"journal":{"name":"Netherlands Heart Journal","volume":"33 5","pages":"147"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12014881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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