Netherlands Heart Journal最新文献

{"title":"The feasibility of the introduction of the Ross program in adults: early safety and quality outcomes in a single center.","authors":"Nabil Saouti, Anthonie L Duijnhouwer, Tim J Ten Cate, Arie P J van Dijk, Robin H Heijmen","doi":"10.1007/s12471-026-02062-6","DOIUrl":"10.1007/s12471-026-02062-6","url":null,"abstract":"<p><strong>Background: </strong>The optimal valve substitute for young and middle-aged patients with severe symptomatic aortic valve disease remains a subject of debate. In this patient group, prosthetic valves are associated with reduced survival, impaired hemodynamics, and lifelong risk of valve-related complications. The Ross procedure has re-emerged as the most optimal valve substitute following surgical refinements and improved perioperative care. The current study describes the feasibility in terms of safety and early outcomes of a newly initiated Ross program using the patient-tailored total root technique.</p><p><strong>Methods: </strong>All patients who underwent the Ross procedure at the Radboud University Medical Center between April 2024 and December 2025 were included. Baseline characteristics, operative details, and postoperative outcomes were extracted from the electronic medical record.</p><p><strong>Results: </strong>A total of 32 patients were included, with a median age of 39 years; 65% were male, and 94% had a bicuspid aortic valve. The predominant pathology was pure stenosis in 63%. All procedures were elective except one. There was no operative or 30-day mortality. Complications included one conversion to a Bentall procedure for leaflet retraction and one urgent percutaneous coronary intervention, probably due to right coronary button kinking. No patient had more than mild aortic regurgitation at discharge.</p><p><strong>Conclusions: </strong>The Ross procedure in young and middle-aged adults was associated with favorable short-term outcomes in this initial cohort. These results support the feasibility and safety of the Ross procedure when performed in a dedicated expert center. Ongoing follow-up will be essential to assess medium- and long-term durability.</p>","PeriodicalId":18952,"journal":{"name":"Netherlands Heart Journal","volume":" ","pages":"306-311"},"PeriodicalIF":2.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13504054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148620822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study designs and outcomes.","authors":"Pim van der Harst","doi":"10.1007/s12471-026-02072-4","DOIUrl":"10.1007/s12471-026-02072-4","url":null,"abstract":"","PeriodicalId":18952,"journal":{"name":"Netherlands Heart Journal","volume":" ","pages":"287"},"PeriodicalIF":2.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13504035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148701804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Dutch cardiomyopathy registry (DCR); rationale and registry design.","authors":"Peter-Paul Zwetsloot, Michiel T H M Henkens, Erik P A van Iperen, Michiel Minten, Evelien van der Schaaf-de Wolf, Linda W van Laake, Anneline S J M Te Riele, Pim van der Harst, Jessica van Setten, Vanessa P M van Empel, Hans-Peter Brunner-La Rocca, D Job A J Verdonschot, Moniek G P J Cox, Imke Christiaans, Nina Ajmone Marsan, Karin van Spaendonck-Zwarts, Daniela Qcm Barge-Schaapveld, Etienne Cramer, Yvonne M Hoedemakers, Michelle Michels, Judith M A Verhagen, Henk S Schipper, Malou van den Boogaard, Folkert W Asselbergs, Dennis van Veghel, Katja Zeppenfeld, Robin Nijveldt, Peter van Tintelen, Peter van der Meer, J Wouter Jukema, Jolanda van der Velden, Connie R Bezzina, Rudolf A de Boer, Stephane R B Heymans","doi":"10.1007/s12471-026-02063-5","DOIUrl":"10.1007/s12471-026-02063-5","url":null,"abstract":"<p><strong>Background: </strong>Cardiomyopathies are important causes of arrhythmias, sudden cardiac death, and heart failure. With accumulating knowledge in clinical, genetic, and molecular phenotyping, the number of distinct disease entities is growing. There is a need for broad, inclusive, high-quality prospective multi-center registries to better analyze these phenotypes, provide accurate risk stratification, and tailor therapies. The Dutch Cardiomyopathy Registry (DCR) will serve as a longitudinal registry for all cardiomyopathy patients, exploiting previously built local databases, allowing adequately powered research studies.</p><p><strong>Methods: </strong>The DCR is a multi-center observational registry that unites all Dutch University Medical centers. The registry will have local and central shared databases, which will be hosted and coordinated by the Netherlands Heart Institute. Patients with an established cardiomyopathy diagnosis and carriers of pathogenic or likely-pathogenic cardiomyopathy gene variants will be included. Furthermore, selected family members and individuals who are referred for screening for potential cardiomyopathy are eligible for inclusion. The subjects will receive, per best clinical practice, guideline-recommended diagnostics and treatment. Clinical data will be collected from clinical care at baseline and follow-up, including clinical visits, imaging studies, laboratory assessments, ECG, and additional functional tests. Outcome data consists of clinical performance status, cardiovascular complications and major adverse events, recorded through regular electronic health record files.</p><p><strong>Conclusion: </strong>The DCR will function as a national database, providing relevant information on epidemiology, demographics, natural history, diagnosis, and treatment. This will aid risk prediction and monitoring of new therapies. The DCR can identify patients who are eligible for future studies, including registry-based research.</p>","PeriodicalId":18952,"journal":{"name":"Netherlands Heart Journal","volume":" ","pages":"288-298"},"PeriodicalIF":2.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13504138/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148701721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Invasive and echocardiographic gradients of self- and balloon-expandable valves in failing aortic bioprostheses.","authors":"Sraman Chatterjee, Mark van den Dorpel, Rik Adrichem, Claire Ben Ren, Isabella Kardys, Rutger-Jan Nuis, Joost Daemen, Alexander Hirsch, Marcel L Geleijnse, Nicolas M Van Mieghem","doi":"10.1007/s12471-026-02061-7","DOIUrl":"10.1007/s12471-026-02061-7","url":null,"abstract":"<p><strong>Background: </strong>Transcatheter aortic valve implantation (TAVI) is an established treatment for a failing aortic bioprosthesis. The hemodynamics of TAVI in degenerated transcatheter or surgical aortic valves (TAV-in-TAV or TAV-in-SAV) are unknown. We aimed to investigate hemodynamic differences between self- and balloon-expandable TAV-in-TAV and TAV-in-SAV groups, and transthoracic echocardiography-derived (TTE) versus invasive transaortic pressure gradients.</p><p><strong>Methods: </strong>Patients ≥ 18 years with a self-expanding EVOLUT (SEV) or balloon-expandable SAPIEN3 (BEV) valve for TAV-in-TAV or TAV-in-SAV were included. Transaortic gradients were determined invasively and by TTE within 48 h post-intervention.</p><p><strong>Results: </strong>We identified 56 patients with SEV (n = 36) or BEV (n = 20) TAV in a failing aortic bioprosthesis. Fourteen cases involved failing transcatheter valves and 42 surgical bioprostheses. Invasive mean gradients were similar after BEV and SEV (median (25th-75th percentile): 6.0 (1.5-6.5) vs 7.0 (2.0-10.0) mm Hg, p = 0.109). Mean gradients by TTE were higher for BEV than SEV at discharge (16.0 (10.8-19.8) versus 10.0 (7.0-12.0) mm Hg, p = 0.003) and 12-month follow-up (13.0 (11.0-15.5) versus 9.0 (7.0-12.3) mm Hg, p = 0.025). The discrepancy between TTE and invasive mean gradients was significantly larger for BEV than SEV (13.0 (6.3-14.0) vs 3.0 (1.5-8.3) mm Hg, p = 0.001) and most pronounced in TAV-in-SAV (BEV 13.0 (6.3-17.0) vs SEV 3.0 (1.0-8.5) mm Hg, p = 0.004).</p><p><strong>Conclusion: </strong>Mean gradient after TAV in a failing bioprosthesis is similar for BEV and SEV, when measured invasively, but higher with BEV than SEV by TTE. The discordance between invasive and TTE-derived mean gradients is the largest in BEV.</p>","PeriodicalId":18952,"journal":{"name":"Netherlands Heart Journal","volume":" ","pages":"312-322"},"PeriodicalIF":2.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13504006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148795926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An old drug, a classic signature.","authors":"Francisco Rodrigues Dos Santos, Mariana Duarte Almeida, Davide Moreira, João Miguel Santos, Inês Fiúza Pires","doi":"10.1007/s12471-026-02064-4","DOIUrl":"10.1007/s12471-026-02064-4","url":null,"abstract":"","PeriodicalId":18952,"journal":{"name":"Netherlands Heart Journal","volume":" ","pages":"323-324"},"PeriodicalIF":2.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13504146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148585009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An old drug, a classic signature.","authors":"Francisco Rodrigues Dos Santos, Mariana Duarte Almeida, Davide Moreira, João Miguel Santos, Inês Fiúza Pires","doi":"10.1007/s12471-026-02065-3","DOIUrl":"10.1007/s12471-026-02065-3","url":null,"abstract":"","PeriodicalId":18952,"journal":{"name":"Netherlands Heart Journal","volume":" ","pages":"325-326"},"PeriodicalIF":2.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13504005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148584996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optical coherence tomography-guided orbital atherectomy for calcified coronary lesions: rationale and design of the CROWN study.","authors":"Eleni Ntantou, Alexandros A Siskos, Nicolas M van Mieghem, Joost Daemen, Isabella Kardys, Koen Teeuwen, Gioel G Secco, Jan-Malte Sinning, Daniele Forlani, Wijnand K den Dekker","doi":"10.1007/s12471-026-02055-5","DOIUrl":"10.1007/s12471-026-02055-5","url":null,"abstract":"<p><strong>Background: </strong>The Orbital Atherectomy System (OAS) has demonstrated high procedural success, with excellent stent deliverability and low complication rates. The effects of orbital atherectomy (OA) and its impact on calcified coronary plaques are not yet fully understood, highlighting the need for a larger and more comprehensive study.</p><p><strong>Objective: </strong>Calcium Reduction by Orbital Atherectomy in Western Europe (CROWN) is an ongoing study that aims to evaluate the effects of OA in treating de novo, severely calcified coronary lesions before stent placement using optical coherence tomography (OCT), and to assess stent expansion by measuring the OCT-derived minimum stent area (MSA).</p><p><strong>Methods: </strong>The CROWN study is a prospective, multicenter, international, single-arm observational study. We will enroll 100 patients with severely calcified coronary lesions undergoing OCT-guided orbital atherectomy and stent placement. All patients will undergo peri-procedural OCT imaging, with assessments conducted before and after OA, as well as following stent placement. Patients will be enrolled at a maximum of 6 sites in the Netherlands, Germany, and Italy. The primary endpoint is to assess the proportion of patients achieving stent expansion, defined as an OCT-derived MSA ≥ 5.5 mm².</p><p><strong>Conclusion: </strong>The CROWN study will evaluate the impact of OA on calcified plaques, potentially refine operator practices, and provide additional insights on device selection for treating severely calcified lesions (clinicaltrials.gov NCT06035783).</p>","PeriodicalId":18952,"journal":{"name":"Netherlands Heart Journal","volume":" ","pages":"299-305"},"PeriodicalIF":2.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13504061/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148670263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When atrial \"smoke\" signals bioprosthetic mitral valve thrombosis.","authors":"Marta Catarina Almeida, Francisco Sampaio, Gustavo Pires-Morais, Bruno Melica, Ricardo Fontes-Carvalho","doi":"10.1007/s12471-026-02070-6","DOIUrl":"https://doi.org/10.1007/s12471-026-02070-6","url":null,"abstract":"","PeriodicalId":18952,"journal":{"name":"Netherlands Heart Journal","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148818817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiology in numbers: coronary artery disease in the Netherlands.","authors":"Maaike M Roefs, Giovanni Amoroso, Cyril Camaro, Edgar J Daeter, Maik J Grundeken, Arnoud W J van 't Hof, Robert A F de Lind van Wijngaarden, Erik Lipsic, Martijn Meuwissen, Pim van der Harst, Dennis van Veghel","doi":"10.1007/s12471-026-02058-2","DOIUrl":"10.1007/s12471-026-02058-2","url":null,"abstract":"","PeriodicalId":18952,"journal":{"name":"Netherlands Heart Journal","volume":" ","pages":"283-284"},"PeriodicalIF":2.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13376289/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148412509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative pericardial effusion on routine echocardiography: A review of incidence, progression, and management : To dissolve or to be resolved.","authors":"Stefan van Dinter, Laurens Wollersheim, Wilson Li, Rogier Donders, Niels van Royen, Hendrik-Jan Dieker, Ad Verhagen","doi":"10.1007/s12471-026-02054-6","DOIUrl":"10.1007/s12471-026-02054-6","url":null,"abstract":"<p><p>Postoperative pericardial effusion (PPE) is a common finding after cardiac surgery, with reported incidences ranging widely from 2% to 85%. While most effusions resolve spontaneously, a subset progresses to cardiac tamponade requiring urgent intervention. This systematic review evaluated the true incidence of PPE and PPE-related reinterventions based on routine echocardiographic screening, and explored temporal evolution, symptomatology, and perioperative risk factors. A comprehensive search of Embase, PubMed, and Web of Science through May 2025 identified 26 eligible studies including 8,495 patients. Data extraction followed PRISMA guidelines and quality assessment with the JBI checklist. Random-effects meta-analysis demonstrated a pooled PPE incidence of 36% (95% confidence interval (CI) 25-49%), whereas only 3% (95% CI 2-4%) required reintervention, ranging from 2% after CABG to 6% after aortic surgery. Large effusions (> 2 cm) were associated with a substantially higher likelihood of intervention (54% [14-90%]), although spontaneous resolution remained common. Preventive strategies such as posterior pericardiotomy and posterior chest tube placement significantly reduced both PPE incidence and reintervention rates. Despite these findings, interpretation is limited by substantial heterogeneity in study design, definitions, and follow-up protocols. Standardized definitions, structured echocardiographic follow-up, and prospective studies are needed to improve risk stratification and guide clinical decision-making.</p>","PeriodicalId":18952,"journal":{"name":"Netherlands Heart Journal","volume":" ","pages":"254-264"},"PeriodicalIF":2.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13375986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148163656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}