Valérie C E Drost, Maaike Wösten, Luuk C Otterspoor, Kadir Caliskan, Linda W Van Laake
{"title":"Reply to 'Beyond socioeconomic status: structural determinants and strategic approaches to regional variation in left ventricular assist device utilization'.","authors":"Valérie C E Drost, Maaike Wösten, Luuk C Otterspoor, Kadir Caliskan, Linda W Van Laake","doi":"10.1007/s12471-026-02046-6","DOIUrl":"https://doi.org/10.1007/s12471-026-02046-6","url":null,"abstract":"","PeriodicalId":18952,"journal":{"name":"Netherlands Heart Journal","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147840154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Matthijs W Kanon, Elke S Hoendermis, Erik A Badings, Jan van Wijngaarden
{"title":"Stroke and transient ischemic attack recurrence after PFO closure in patients with cryptogenic embolism.","authors":"Matthijs W Kanon, Elke S Hoendermis, Erik A Badings, Jan van Wijngaarden","doi":"10.1007/s12471-026-02042-w","DOIUrl":"10.1007/s12471-026-02042-w","url":null,"abstract":"<p><strong>Background: </strong>Patent foramen ovale (PFO) closure is recommended in selected patients with a cryptogenic stroke and a PFO, as multiple randomized controlled trials (RCTs) have shown superiority of PFO closure over medical therapy in reducing recurrent stroke risk. However, follow-up data outside clinical trials remains scarce. The aim of this study is to evaluate the stroke/transient ischemic attack (TIA) recurrence after PFO closure.</p><p><strong>Methods: </strong>Data from 242 patients who underwent PFO closure at the University Medical Centre Groningen (UMCG) between February 2016 and June 2023, because of a cryptogenic stroke, TIA, or peripheral embolism, were collected.</p><p><strong>Results: </strong>During a median follow-up of 3.1 years (IQR: 1.9-4.3), a total of 5 recurrent strokes (0.70 per 100 person-years) and 11 recurrent TIAs (1.54 per 100 person-years) were documented. In patients with a recurrent neurological event, hypertension was more prevalent (30.8% vs. 9.6%, p = 0.040). Atrial fibrillation (AF) or atrial flutter was seen in 5.7% of the patients. Other adverse events were rare.</p><p><strong>Conclusion: </strong>In this study, the rate of recurrent stroke/TIA after PFO closure was low, but higher than reported in previous studies. These elevated values are primarily due to the higher risk of recurrent TIA, as the recurrent stroke risk in our cohort is comparable to that reported in RCTs. Hypertension was significantly associated with the recurrence of a stroke/TIA.</p>","PeriodicalId":18952,"journal":{"name":"Netherlands Heart Journal","volume":" ","pages":"170-178"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13090459/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147633388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Technology and evidence in daily cardiovascular practice.","authors":"Pim van der Harst","doi":"10.1007/s12471-026-02044-8","DOIUrl":"10.1007/s12471-026-02044-8","url":null,"abstract":"","PeriodicalId":18952,"journal":{"name":"Netherlands Heart Journal","volume":" ","pages":"163"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13090462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147639349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sophie H Kroesen, Thijs Vonk, Malou A H Nuijten, Erwin S Zegers, Maria T E Hopman, Esmée A Bakker, Thijs M H Eijsvogels
{"title":"A cardiac-rehab home-based mHealth program to improve physical activity in patients with coronary artery disease: a randomized controlled trial.","authors":"Sophie H Kroesen, Thijs Vonk, Malou A H Nuijten, Erwin S Zegers, Maria T E Hopman, Esmée A Bakker, Thijs M H Eijsvogels","doi":"10.1007/s12471-026-02039-5","DOIUrl":"10.1007/s12471-026-02039-5","url":null,"abstract":"<p><strong>Purpose: </strong>Contemporary cardiac rehabilitation (CR) has a moderate effect on physical activity (PA), whereas novel technologies offer promise for enhancing PA levels. Therefore, we assessed the effect of a home-based smartphone training program in addition to center-based CR on PA levels in patients with coronary artery disease (CAD).</p><p><strong>Methods: </strong>CAD patients participating in CR were included in this randomized controlled trial (1:1, stratified for index diagnosis). The control group received usual care CR, whereas the intervention group additionally received a 6-week remote smartphone program. The primary outcome was the change in accelerometer-derived moderate-to-vigorous PA (MVPA) from baseline to post-CR. Secondary outcomes included changes in light intensity PA, step count, sedentary time, functional parameters, quality of life, and cardiac anxiety. A baseline-adjusted linear mixed model was used.</p><p><strong>Results: </strong>Participants (16% female, intervention n = 44, control n = 49) were 63 [56-69] years old and had a baseline MVPA of 1.0 (95% Confidence interval (CI): 0.9; 1.1) h/day. Changes in MVPA did not differ between the intervention (0.1 (95% CI: -0.0; 0.2) h/day) and control group post-CR (0.1 (95% CI: -0.0; 0.2) h/day, p<sub>-interaction</sub> = 0.75). Also, no differences between the groups were observed for light intensity PA (0.5 (95% CI: 0.2; 0.8) versus 0.4 (95% CI: 0.1; 0.8) h/day, p<sub>-interaction</sub> = 0.79). Similarly, changes in other secondary outcomes did not differ among groups.</p><p><strong>Conclusions: </strong>A smartphone training program on top of the usual CR did not yield additional benefits. A more elaborate mHealth intervention seems needed to change PA during CR in active patients with CAD.</p>","PeriodicalId":18952,"journal":{"name":"Netherlands Heart Journal","volume":" ","pages":"189-196"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13090453/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147639371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jaouad Azzahhafi, Dean R P P Chan Pin Yin, Mirjam Epping, Hajar Bofarid, Thijs Verhagen, Rene Boomars, Anja Radstok, Jaco Houtgraaf, Gerardus P J van Hout, Angela Bikker, Jurriën M Ten Berg
{"title":"Performance of the HEART Score in pre-hospital settings for suspected non-ST-elevation acute coronary syndrome: The POPular HEART Study.","authors":"Jaouad Azzahhafi, Dean R P P Chan Pin Yin, Mirjam Epping, Hajar Bofarid, Thijs Verhagen, Rene Boomars, Anja Radstok, Jaco Houtgraaf, Gerardus P J van Hout, Angela Bikker, Jurriën M Ten Berg","doi":"10.1007/s12471-026-02041-x","DOIUrl":"10.1007/s12471-026-02041-x","url":null,"abstract":"<p><strong>Background: </strong>The HEART (history, ECG, age, risk factors, and troponin) score is used to stratify patients with chest pain into low- or higher-risk for major adverse cardiac events (MACE). We assessed the diagnostic performance and interobserver agreement of the pre-hospital HEART score for ruling out myocardial infarction (MI) and MACE.</p><p><strong>Methods: </strong>This prospective, multicentre study included 383 patients with suspected non-ST-elevation acute coronary syndrome. Patients with both a pre-hospital and in-hospital HEART scores were analysed (n = 331). Prehospital HEART scores (based on point-of-care troponin) were assessed by ambulance personnel, and in-hospital HEART scores (based on the European Society of Cardiology 0/1-hour high-sensitivity troponin algorithm) were assessed by emergency physicians blinded to the pre-hospital scores. Endpoints were interobserver agreement (intraclass correlation coefficient, ICC) and diagnostic performance for ruling out MI and MACE at 30 days.</p><p><strong>Results: </strong>Among the 331 patients (mean age: 65 years, 48% women), 26% were classified as low risk (pre-hospital HEART ≤ 3) of whom 4.7% had an index-admission NSTEMI. Of the patients with HEART score > 3, 12.1% experienced MACE. Interobserver agreement between the pre- and in-hospital HEART scores was moderate (ICC, 0.653), with the lowest concordance for history and ECG. The pre-hospital HEART score yielded a negative predictive value of 95.33% and a sensitivity of 91.7% for MACE at 30 days.</p><p><strong>Conclusion: </strong>Pre- and in-hospital HEART scores showed moderate agreement. The 30-day MACE rate (4.7%) in the pre-hospital low-risk group indicates that improved training in history and ECG assessment, and use of high-sensitivity assays are required.</p>","PeriodicalId":18952,"journal":{"name":"Netherlands Heart Journal","volume":" ","pages":"179-188"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13090458/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147675193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jos Perdeck, Gilmer A Sussenbach, Elliot N Bradshaw, Ingeborg K Go, Reinoud E Knops, Tom F Brouwer
{"title":"Automated monitoring of urine output in hospitalized patients with indwelling urinary catheters: a clinical evaluation on the cardiology ward.","authors":"Jos Perdeck, Gilmer A Sussenbach, Elliot N Bradshaw, Ingeborg K Go, Reinoud E Knops, Tom F Brouwer","doi":"10.1007/s12471-026-02038-6","DOIUrl":"10.1007/s12471-026-02038-6","url":null,"abstract":"<p><strong>Background: </strong>Urine output (UO) is a key clinical parameter for assessing hemodynamic status, yet manual UO measurements are labour-intensive, and documentation is often incomplete and error-prone. The Gravity of Flow study evaluated an in-house developed urine production gauge (UPG), designed as a reusable-cost system compatible with standard urine bags for automatic, continuous UO measurement and Electronic Health Record (EHR) integration.</p><p><strong>Methods: </strong>This single-centre observational study enrolled 25 cardiology patients (519 h) with indwelling urine catheters. To assess completeness and volume accuracy, UPG performance was compared against standard manual urine charting and a 24-hour container (gold standard).</p><p><strong>Results: </strong>The UPG achieved superior median completeness compared to manual charting (100% vs. 40%, p < 0.001). The device demonstrated high accuracy (median absolute percentage error 2.3%) and minimal bias (median -3 mL), meeting ±5% equivalence criteria (78.3% within bounds). In contrast, manual charting failed to meet equivalence. Performance of the UPG remained consistent across various UO flow rates.</p><p><strong>Conclusion: </strong>By providing superior, automated UO data (accuracy, completeness, reliability), the UPG has the potential to optimise fluid management, enable earlier intervention, and reduce nursing workload. Future research should validate these benefits across various clinical settings and over longer periods.</p>","PeriodicalId":18952,"journal":{"name":"Netherlands Heart Journal","volume":" ","pages":"164-169"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13090461/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147633345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}