Netherlands Heart Journal最新文献

{"title":"Effects on atrial fibrillation symptom burden of an obesity-focused cardiac rehabilitation program: Insights from the OPTICARE XL trial.","authors":"Nicole Tenbült-van Limpt, Richard A J Post, Nienke Ter Hoeve, Iris den Uijl, Madoka Sunamura, Yuan Lu, Eric Boersma, Rita van den Berg-Emons, Hareld Kemps, Rutger Brouwers","doi":"10.1007/s12471-026-02079-x","DOIUrl":"10.1007/s12471-026-02079-x","url":null,"abstract":"","PeriodicalId":18952,"journal":{"name":"Netherlands Heart Journal","volume":" ","pages":"384-386"},"PeriodicalIF":2.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13615248/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148920372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of epicardial and pericardial adipose tissue in patients with chronic heart failure.","authors":"Yoran Crum, Dirk J van Veldhuisen, Michelle Lobeek, Adriaan A Voors, Michiel Rienstra, Thomas M Gorter","doi":"10.1007/s12471-026-02077-z","DOIUrl":"10.1007/s12471-026-02077-z","url":null,"abstract":"<p><strong>Background: </strong>Central obesity, rather than overall obesity, may influence heart failure (HF) outcomes. Alternative anthropometric measures remain limited in assessing the actual amount and distribution of visceral adiposity. We hypothesize that epicardial and pericardial adipose tissue (EAT and PAT) are easily obtainable on standard echocardiography and provide prognostic value in patients with HF.</p><p><strong>Methods: </strong>In total, 572 patients with HF with reduced, mildly reduced and preserved ejection fraction (HFrEF, HFmrEF, and HFpEF, respectively) were included. EAT (the adipose tissue between the myocardium and the visceral layer of the pericardium) and PAT (the adipose tissue outside the parietal layer of the pericardium) thickness were measured on echocardiography and expressed in mm. Patients were followed for the combined outcome of all-cause mortality and HF hospitalization.</p><p><strong>Results: </strong>Mean age was 67 ± 14 years, 38% were women, 346 had HFrEF, 100 had HFmrEF and 126 had HFpEF. Mean body mass index (BMI) was 27 ± 6 kg/m², mean EAT thickness 4.8 ± 2.1 mm, and mean PAT thickness 5.7 ± 2.8 mm. During a median follow-up of 3.2 ± 1.9 years, both EAT and PAT thickness were associated with an increased risk for the combined outcome [HR 1.15 (95% CI 1.03-1.30), p = 0.006 and HR 1.25 (95% CI 1.10-1.41), p < 0.001, respectively], whereas BMI was not. In a multivariable model, only PAT thickness remained associated with poor outcome [HR 1.49 per SD (95% CI 1.10-2.03), p = 0.011].</p><p><strong>Conclusion: </strong>Increased PAT thickness, more than EAT, assessed on routine echocardiography, may serve as a valuable prognostic marker in chronic HF.</p>","PeriodicalId":18952,"journal":{"name":"Netherlands Heart Journal","volume":" ","pages":"369-379"},"PeriodicalIF":2.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13615238/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148983020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DUTCH weight control in atrial fibrillation study (DUTCH-WAIST) : Design and rationale of a randomised controlled trial.","authors":"Leonard Voorhout, Ron Pisters, Menno Huisman, Erik Klok, Frans Rutten, Geert-Jan Geersing, Robert Tieleman, Jan Hein Cornel, Astrid Schut, Jan Tijssen, Arianne van Bon, Martin Hemels","doi":"10.1007/s12471-026-02074-2","DOIUrl":"10.1007/s12471-026-02074-2","url":null,"abstract":"<p><strong>Background: </strong>Obesity is a well-established and highly prevalent risk factor for atrial fibrillation (AF) and its progression by promoting structural and electrical atrial remodelling, leading to AF recurrence and persistence. Weight loss is expected to reverse atrial remodelling and improve rhythm control. Optimal strategies for weight management are, however, under-explored.</p><p><strong>Objective: </strong>To quantify the effect of clinically meaningful weight loss on rhythm control in overweight patients with first detected persistent AF.</p><p><strong>Design: </strong>A multicentre, double-blind, randomised, placebo-controlled trial evaluating semaglutide 2.4 mg once weekly versus placebo, in addition to combined lifestyle intervention (CLI), during a one-year period.</p><p><strong>Participants: </strong>Adults with a BMI > 30 kg/m², or BMI > 27 kg/m² with a weight-related comorbidity, and first detected (< 6 months) persistent AF scheduled for electrical cardioversion.</p><p><strong>Intervention: </strong>Weekly subcutaneous injections of semaglutide 2.4 mg or placebo, alongside CLI and standard AF care in both groups.</p><p><strong>Outcomes: </strong>The co-primary outcome is (i) a hierarchical assessment of rhythm status at one year, ranking patients by severity from arrhythmic death to sinus rhythm without any additional rhythm control support. (ii) the composite of either persistent atrial fibrillation on ECG, catheter ablation for AF, arrhythmic death, or any serious adverse event due to anti-arrhythmic drugs occurring within 1 year.</p><p><strong>Conclusion: </strong>This study investigates whether treatment of overweight with semaglutide, as an adjunct to lifestyle intervention, enhances rhythm control in AF patients with first detected persistent AF and overweight, offering a potential new approach to reducing AF burden and cardiovascular risk in this population.</p>","PeriodicalId":18952,"journal":{"name":"Netherlands Heart Journal","volume":" ","pages":"363-368"},"PeriodicalIF":2.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13615193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148970218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity and cardiovascular disease: Time for a paradigm shift.","authors":"Martin E W Hemels","doi":"10.1007/s12471-026-02080-4","DOIUrl":"10.1007/s12471-026-02080-4","url":null,"abstract":"","PeriodicalId":18952,"journal":{"name":"Netherlands Heart Journal","volume":" ","pages":"329"},"PeriodicalIF":2.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13615229/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148977312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of GLP-1 receptor agonists on body weight and cardiovascular outcomes: a review.","authors":"Susan J F van Maren, Eveline P M van Doorn, Mark M Smits, Cees J J Tack, Elisabeth F C van Rossum, Saloua El Messaoudi","doi":"10.1007/s12471-026-02073-3","DOIUrl":"10.1007/s12471-026-02073-3","url":null,"abstract":"<p><p>Obesity is a rapidly increasing global health challenge that is strongly linked to the cardiorenometabolic syndrome, cardiovascular morbidity, and mortality. Lifestyle interventions remain the cornerstone of treatment, but average long-term weight loss is modest and durable weight maintenance is often limited. Bariatric surgery is not suitable for all patients, and substantial weight regain occurs in a considerable proportion over time. Glucagon-like peptide‑1 receptor agonists (GLP-1RAs), originally developed for type 2 diabetes (T2D), have emerged as potent agents for weight reduction and cardiometabolic risk improvement. By enhancing glucose-dependent insulin secretion, suppressing appetite, improving lipid metabolism, and exerting anti-inflammatory, endothelial, and haemodynamic effects, GLP-1RAs influence multiple pathways relevant to cardiovascular disease.Across large cardiovascular-outcome trials, GLP-1RAs consistently reduce major adverse cardiovascular events (MACE), all-cause mortality, and heart-failure hospitalizations in individuals with T2D. In populations with overweight or obesity without diabetes, semaglutide, as shown in the SELECT trial, has demonstrated significant cardiovascular risk reduction, partly independent of weight loss. Overall, GLP-1RAs represent a therapeutic option for cardiovascular prevention across a broad spectrum of patients at high-risk for or with established CVD. This review provides a comprehensive overview of the pleiotropic cardiovascular effects associated with GLP-1RAs and discusses their potential integration into cardiovascular care.</p>","PeriodicalId":18952,"journal":{"name":"Netherlands Heart Journal","volume":" ","pages":"352-362"},"PeriodicalIF":2.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13615203/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148963606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The value of repeating genetic analysis over time illustrated by familial childhood onset HCM caused by a homozygous LZTR1 variant.","authors":"A E van den Hazel, Q Waisfisz, P G Postema, A C Houweling","doi":"10.1007/s12471-026-02069-z","DOIUrl":"https://doi.org/10.1007/s12471-026-02069-z","url":null,"abstract":"","PeriodicalId":18952,"journal":{"name":"Netherlands Heart Journal","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149075458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The feasibility of the introduction of the Ross program in adults: early safety and quality outcomes in a single center.","authors":"Nabil Saouti, Anthonie L Duijnhouwer, Tim J Ten Cate, Arie P J van Dijk, Robin H Heijmen","doi":"10.1007/s12471-026-02062-6","DOIUrl":"10.1007/s12471-026-02062-6","url":null,"abstract":"<p><strong>Background: </strong>The optimal valve substitute for young and middle-aged patients with severe symptomatic aortic valve disease remains a subject of debate. In this patient group, prosthetic valves are associated with reduced survival, impaired hemodynamics, and lifelong risk of valve-related complications. The Ross procedure has re-emerged as the most optimal valve substitute following surgical refinements and improved perioperative care. The current study describes the feasibility in terms of safety and early outcomes of a newly initiated Ross program using the patient-tailored total root technique.</p><p><strong>Methods: </strong>All patients who underwent the Ross procedure at the Radboud University Medical Center between April 2024 and December 2025 were included. Baseline characteristics, operative details, and postoperative outcomes were extracted from the electronic medical record.</p><p><strong>Results: </strong>A total of 32 patients were included, with a median age of 39 years; 65% were male, and 94% had a bicuspid aortic valve. The predominant pathology was pure stenosis in 63%. All procedures were elective except one. There was no operative or 30-day mortality. Complications included one conversion to a Bentall procedure for leaflet retraction and one urgent percutaneous coronary intervention, probably due to right coronary button kinking. No patient had more than mild aortic regurgitation at discharge.</p><p><strong>Conclusions: </strong>The Ross procedure in young and middle-aged adults was associated with favorable short-term outcomes in this initial cohort. These results support the feasibility and safety of the Ross procedure when performed in a dedicated expert center. Ongoing follow-up will be essential to assess medium- and long-term durability.</p>","PeriodicalId":18952,"journal":{"name":"Netherlands Heart Journal","volume":" ","pages":"306-311"},"PeriodicalIF":2.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13504054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148620822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study designs and outcomes.","authors":"Pim van der Harst","doi":"10.1007/s12471-026-02072-4","DOIUrl":"10.1007/s12471-026-02072-4","url":null,"abstract":"","PeriodicalId":18952,"journal":{"name":"Netherlands Heart Journal","volume":" ","pages":"287"},"PeriodicalIF":2.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13504035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148701804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Dutch cardiomyopathy registry (DCR); rationale and registry design.","authors":"Peter-Paul Zwetsloot, Michiel T H M Henkens, Erik P A van Iperen, Michiel Minten, Evelien van der Schaaf-de Wolf, Linda W van Laake, Anneline S J M Te Riele, Pim van der Harst, Jessica van Setten, Vanessa P M van Empel, Hans-Peter Brunner-La Rocca, D Job A J Verdonschot, Moniek G P J Cox, Imke Christiaans, Nina Ajmone Marsan, Karin van Spaendonck-Zwarts, Daniela Qcm Barge-Schaapveld, Etienne Cramer, Yvonne M Hoedemakers, Michelle Michels, Judith M A Verhagen, Henk S Schipper, Malou van den Boogaard, Folkert W Asselbergs, Dennis van Veghel, Katja Zeppenfeld, Robin Nijveldt, Peter van Tintelen, Peter van der Meer, J Wouter Jukema, Jolanda van der Velden, Connie R Bezzina, Rudolf A de Boer, Stephane R B Heymans","doi":"10.1007/s12471-026-02063-5","DOIUrl":"10.1007/s12471-026-02063-5","url":null,"abstract":"<p><strong>Background: </strong>Cardiomyopathies are important causes of arrhythmias, sudden cardiac death, and heart failure. With accumulating knowledge in clinical, genetic, and molecular phenotyping, the number of distinct disease entities is growing. There is a need for broad, inclusive, high-quality prospective multi-center registries to better analyze these phenotypes, provide accurate risk stratification, and tailor therapies. The Dutch Cardiomyopathy Registry (DCR) will serve as a longitudinal registry for all cardiomyopathy patients, exploiting previously built local databases, allowing adequately powered research studies.</p><p><strong>Methods: </strong>The DCR is a multi-center observational registry that unites all Dutch University Medical centers. The registry will have local and central shared databases, which will be hosted and coordinated by the Netherlands Heart Institute. Patients with an established cardiomyopathy diagnosis and carriers of pathogenic or likely-pathogenic cardiomyopathy gene variants will be included. Furthermore, selected family members and individuals who are referred for screening for potential cardiomyopathy are eligible for inclusion. The subjects will receive, per best clinical practice, guideline-recommended diagnostics and treatment. Clinical data will be collected from clinical care at baseline and follow-up, including clinical visits, imaging studies, laboratory assessments, ECG, and additional functional tests. Outcome data consists of clinical performance status, cardiovascular complications and major adverse events, recorded through regular electronic health record files.</p><p><strong>Conclusion: </strong>The DCR will function as a national database, providing relevant information on epidemiology, demographics, natural history, diagnosis, and treatment. This will aid risk prediction and monitoring of new therapies. The DCR can identify patients who are eligible for future studies, including registry-based research.</p>","PeriodicalId":18952,"journal":{"name":"Netherlands Heart Journal","volume":" ","pages":"288-298"},"PeriodicalIF":2.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13504138/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148701721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Invasive and echocardiographic gradients of self- and balloon-expandable valves in failing aortic bioprostheses.","authors":"Sraman Chatterjee, Mark van den Dorpel, Rik Adrichem, Claire Ben Ren, Isabella Kardys, Rutger-Jan Nuis, Joost Daemen, Alexander Hirsch, Marcel L Geleijnse, Nicolas M Van Mieghem","doi":"10.1007/s12471-026-02061-7","DOIUrl":"10.1007/s12471-026-02061-7","url":null,"abstract":"<p><strong>Background: </strong>Transcatheter aortic valve implantation (TAVI) is an established treatment for a failing aortic bioprosthesis. The hemodynamics of TAVI in degenerated transcatheter or surgical aortic valves (TAV-in-TAV or TAV-in-SAV) are unknown. We aimed to investigate hemodynamic differences between self- and balloon-expandable TAV-in-TAV and TAV-in-SAV groups, and transthoracic echocardiography-derived (TTE) versus invasive transaortic pressure gradients.</p><p><strong>Methods: </strong>Patients ≥ 18 years with a self-expanding EVOLUT (SEV) or balloon-expandable SAPIEN3 (BEV) valve for TAV-in-TAV or TAV-in-SAV were included. Transaortic gradients were determined invasively and by TTE within 48 h post-intervention.</p><p><strong>Results: </strong>We identified 56 patients with SEV (n = 36) or BEV (n = 20) TAV in a failing aortic bioprosthesis. Fourteen cases involved failing transcatheter valves and 42 surgical bioprostheses. Invasive mean gradients were similar after BEV and SEV (median (25th-75th percentile): 6.0 (1.5-6.5) vs 7.0 (2.0-10.0) mm Hg, p = 0.109). Mean gradients by TTE were higher for BEV than SEV at discharge (16.0 (10.8-19.8) versus 10.0 (7.0-12.0) mm Hg, p = 0.003) and 12-month follow-up (13.0 (11.0-15.5) versus 9.0 (7.0-12.3) mm Hg, p = 0.025). The discrepancy between TTE and invasive mean gradients was significantly larger for BEV than SEV (13.0 (6.3-14.0) vs 3.0 (1.5-8.3) mm Hg, p = 0.001) and most pronounced in TAV-in-SAV (BEV 13.0 (6.3-17.0) vs SEV 3.0 (1.0-8.5) mm Hg, p = 0.004).</p><p><strong>Conclusion: </strong>Mean gradient after TAV in a failing bioprosthesis is similar for BEV and SEV, when measured invasively, but higher with BEV than SEV by TTE. The discordance between invasive and TTE-derived mean gradients is the largest in BEV.</p>","PeriodicalId":18952,"journal":{"name":"Netherlands Heart Journal","volume":" ","pages":"312-322"},"PeriodicalIF":2.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13504006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148795926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}