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Netherlands Journal of Medicine最新文献

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Septicaemia and liver abscesses after a skin ulcer in the tropics. 热带地区皮肤溃疡后的败血症和肝脓肿。
4区 医学
Netherlands Journal of Medicine Pub Date : 2020-09-01
D A R Castelijn, S G Vreden, C R C Doorenbos, J Kropff
{"title":"Septicaemia and liver abscesses after a skin ulcer in the tropics.","authors":"D A R Castelijn, S G Vreden, C R C Doorenbos, J Kropff","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":18918,"journal":{"name":"Netherlands Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38616035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Symptomatic rebound methaemoglobinaemia after treatment with dapsone. 氨苯砜治疗后出现反跳性甲基血红蛋白血症。
4区 医学
Netherlands Journal of Medicine Pub Date : 2020-09-01
B R P Jonkers, G Cobanoglu, E J Blok, J J Köbben, M W van der Helm, I J A M van Hoof, A N Tintu, C Bethlehem, J Versmissen
{"title":"Symptomatic rebound methaemoglobinaemia after treatment with dapsone.","authors":"B R P Jonkers,&nbsp;G Cobanoglu,&nbsp;E J Blok,&nbsp;J J Köbben,&nbsp;M W van der Helm,&nbsp;I J A M van Hoof,&nbsp;A N Tintu,&nbsp;C Bethlehem,&nbsp;J Versmissen","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A 28-year-old female patient was admitted to our hospital with severe dyspnoea and hypoxemia due to methaemoglobinaemia caused by dapsone. The patient recovered completely after repeated infusions of methylene blue and cessation of dapsone. However, 12 days after cessation of dapsone, the patient was readmitted due to recurrence of symptoms based on a relapse of methaemoglobinaemia. Toxicological analysis revealed a toxic dapsone level at readmission and no other explanation for methaemoglobinaemia. Several possible mechanisms as explanation for the recurrence of methaemoglobinaemia are listed and additional tests were performed. In addition to supportive care, treatment consisted of methylene blue; furthermore, cimetidine and ascorbic acid were added. An overview of the pathophysiology, diagnostics, treatment, and possible explanations for this relapse of methaemoglobinaemia caused by dapsone are given. This case shows the importance of considering the possibility of a late rebound methaemoglobinaemia after discontinuation of dapsone.</p>","PeriodicalId":18918,"journal":{"name":"Netherlands Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38519206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Invasive fungal infections in patients treated with Bruton's tyrosine kinase inhibitors. 布鲁顿酪氨酸激酶抑制剂治疗患者的侵袭性真菌感染。
4区 医学
Netherlands Journal of Medicine Pub Date : 2020-09-01
A Dunbar, M E Joosse, F de Boer, M Eefting, B J A Rijnders
{"title":"Invasive fungal infections in patients treated with Bruton's tyrosine kinase inhibitors.","authors":"A Dunbar,&nbsp;M E Joosse,&nbsp;F de Boer,&nbsp;M Eefting,&nbsp;B J A Rijnders","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Bruton's tyrosine kinase (BTK) inhibitors are increasingly used in untreated and previously treated chronic lymphocytic leukaemia (CLL) patients. Invasive fungal infections (IFI) were rarely observed in patients treated for CLL in the pre-BTK era. In this article, we describe two patients with CLL who developed an IFI during treatment with the BTK inhibitor ibrutinib. The atypical presentation and the serious course of this complication are described.</p>","PeriodicalId":18918,"journal":{"name":"Netherlands Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38616032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HIV-associated and idiopathic-acquired haemophilia A: A single-centre case series from Cape Town, South Africa. 艾滋病毒相关和特发性获得性血友病A:来自南非开普敦的单中心病例系列。
4区 医学
Netherlands Journal of Medicine Pub Date : 2020-07-01
R Shein, J du Toit, M Goeijenbier, C du Toit, Estelle Verburgh
{"title":"HIV-associated and idiopathic-acquired haemophilia A: A single-centre case series from Cape Town, South Africa.","authors":"R Shein,&nbsp;J du Toit,&nbsp;M Goeijenbier,&nbsp;C du Toit,&nbsp;Estelle Verburgh","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Acquired haemophilia A is a rare coagulation disorder, which can lead to life-threatening haemorrhages if not identified and treated promptly. It is characterised by the presence of autoantibodies (inhibitors) to factor VIII. Acquired haemophilia A associated with HIV is a rare but well described phenomenon with limited directions to its management. We comparatively describe four patients - two with HIV and two without - that presented with unusual bleeding episodes with a prolonged activated partial thromboplastin time secondary to factor VIII inhibitors. An empiric observation is that the patients with acquired haemophilia A associated with HIV had higher antibody titres at presentation, that required more prolonged immunosuppressive therapy to induce remission.</p>","PeriodicalId":18918,"journal":{"name":"Netherlands Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38132592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Answer to Photoquiz Red streaks arising from the periumbilical area in a mirror-like pattern. 从脐周区域出现的象镜子一样的红色条纹。
4区 医学
Netherlands Journal of Medicine Pub Date : 2020-07-01
M Puerta-Peña, J Fulgencio-Barbarin, D Falkenhain, P L Ortiz-Romero, V Monsálvez-Honrubia
{"title":"Answer to Photoquiz Red streaks arising from the periumbilical area in a mirror-like pattern.","authors":"M Puerta-Peña,&nbsp;J Fulgencio-Barbarin,&nbsp;D Falkenhain,&nbsp;P L Ortiz-Romero,&nbsp;V Monsálvez-Honrubia","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":18918,"journal":{"name":"Netherlands Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38132608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Blood pressure variability within a single visit and all-cause mortality. 单次就诊的血压变异性和全因死亡率。
4区 医学
Netherlands Journal of Medicine Pub Date : 2020-07-01
T G Papaioannou, G Georgiopoulos, K S Stamatelopoulos, A D Protogerou, K I Alexandraki, A Argyris, D A Vrachatis, D Soulis, A Papanikolaou, D Manolesou, S S Daskalopoulou, D Tousoulis
{"title":"Blood pressure variability within a single visit and all-cause mortality.","authors":"T G Papaioannou,&nbsp;G Georgiopoulos,&nbsp;K S Stamatelopoulos,&nbsp;A D Protogerou,&nbsp;K I Alexandraki,&nbsp;A Argyris,&nbsp;D A Vrachatis,&nbsp;D Soulis,&nbsp;A Papanikolaou,&nbsp;D Manolesou,&nbsp;S S Daskalopoulou,&nbsp;D Tousoulis","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Within-visit variability of repeated sequential readings of blood pressure (BP) is an important phenomenon that may affect precision of BP measurement and thus decision making concerning BP-related risk and hypertension management. However, limited data exist concerning predictive ability of within-visit BP variability for clinical outcomes. Therefore, we aimed to investigate the association between the variability of three repeated office BP measurements and the risk of all-cause mortality, independent of BP levels.</p><p><strong>Methods: </strong>Data collected through the National Health and Nutrition Examination Survey (NHANES) were analysed. NHANES is a program of studies designed to assess health and nutritional status of adults and children in the United States. A complete set of three sequential BP measurements, together with survival status, were available for 24969 individuals (age 46.8±;19.3 years, 49% males). Multivariable logistic regression models were used to determine the prognostic ability of the examined demographic, clinical, and haemodynamic indices.</p><p><strong>Results: </strong>Among various examined indices of variability of systolic (SBP) and diastolic (DBP) blood pressure measurements, the standard deviation of DBP (DBPSD) was the stronger independent predictor of mortality (odds ratio 1.064, 95% Confidence Interval: 1.011-1.12) after adjustment for age, sex, body mass index, smoking, SBP, heart rate, history of hypertension, diabetes mellitus, hypercholesterolaemia, and cardiovascular events.</p><p><strong>Conclusion: </strong>Within-visit variability of three sequential office DBP readings may allow for the identification of high-risk patients better than mean SBP and DBP levels. The predictive value of within-visit BP variability and methods to improve its clinical application are worthy of further research.</p>","PeriodicalId":18918,"journal":{"name":"Netherlands Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38132723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Monoclonal gammopathy with significance: case series and literature review. 具有重要意义的单克隆γ病:病例系列和文献复习。
4区 医学
Netherlands Journal of Medicine Pub Date : 2020-07-01
T S Schoot, M van Apeldoorn, H A M Sinnige, J J Beutler
{"title":"Monoclonal gammopathy with significance: case series and literature review.","authors":"T S Schoot,&nbsp;M van Apeldoorn,&nbsp;H A M Sinnige,&nbsp;J J Beutler","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Monoclonal gammopathy of undetermined significance (MGUS) is considered an asymptomatic precursor of malignant lymphoid disorders. This case series and literature review shows that these monoclonal gammopathies can cause significant morbidity. We describe a patient with angioedema due to acquired C1-esterase inhibitor deficiency, a patient with cryoglobulinemia type II causing skin vasculitis and glomerulonephritis, and a patient with glomerulonephritis and nephrotic syndrome - all caused by a monoclonal gammopathy that can be classified as MGUS. Clinicians should be familiar with these consequences of monoclonal gammopathies. The term MGUS should only be used in patients without organ damage caused by monoclonal gammopathies.</p>","PeriodicalId":18918,"journal":{"name":"Netherlands Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38132600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Attitudes of Dutch intensive care unit clinicians towards oxygen therapy. 荷兰重症监护病房临床医生对氧疗的态度。
4区 医学
Netherlands Journal of Medicine Pub Date : 2020-07-01
C C A Grim, A D Cornet, A Kroner, A J Meiners, A J B W Brouwers, A C Reidinga, D J van Westerloo, D C J J Bergmans, D Gommers, D Versluis, D Weller, E Christiaan Boerma, E van Driel, E de Jonge, F J Schoonderbeek, H J F Helmerhorst, H G Jongsma-van Netten, J Weenink, K J Woittiez, K S Simons, L van Ewelie, M Petjak, M J Sigtermans, M van der Woude, O L Cremer, P Bijlstra, P van der Heiden, R K L So, R Vink, T Jansen, W de Ruijter
{"title":"Attitudes of Dutch intensive care unit clinicians towards oxygen therapy.","authors":"C C A Grim,&nbsp;A D Cornet,&nbsp;A Kroner,&nbsp;A J Meiners,&nbsp;A J B W Brouwers,&nbsp;A C Reidinga,&nbsp;D J van Westerloo,&nbsp;D C J J Bergmans,&nbsp;D Gommers,&nbsp;D Versluis,&nbsp;D Weller,&nbsp;E Christiaan Boerma,&nbsp;E van Driel,&nbsp;E de Jonge,&nbsp;F J Schoonderbeek,&nbsp;H J F Helmerhorst,&nbsp;H G Jongsma-van Netten,&nbsp;J Weenink,&nbsp;K J Woittiez,&nbsp;K S Simons,&nbsp;L van Ewelie,&nbsp;M Petjak,&nbsp;M J Sigtermans,&nbsp;M van der Woude,&nbsp;O L Cremer,&nbsp;P Bijlstra,&nbsp;P van der Heiden,&nbsp;R K L So,&nbsp;R Vink,&nbsp;T Jansen,&nbsp;W de Ruijter","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Over the last decade, there has been an increasing awareness for the potential harm of the administration of too much oxygen. We aimed to describe self-reported attitudes towards oxygen therapy by clinicians from a large representative sample of intensive care units (ICUs) in the Netherlands.</p><p><strong>Methods: </strong>In April 2019, 36 ICUs in the Netherlands were approached and asked to send out a questionnaire (59 questions) to their nursing and medical staff (ICU clinicians) eliciting self-reported behaviour and attitudes towards oxygen therapy in general and in specific ICU case scenarios.</p><p><strong>Results: </strong>In total, 1361 ICU clinicians (71% nurses, 24% physicians) from 28 ICUs returned the questionnaire. Of responding ICU clinicians, 64% considered oxygen-induced lung injury to be a major concern. The majority of respondents considered a partial pressure of oxygen (PaO2) of 6-10 kPa (45-75 mmHg) and an arterial saturation (SaO2) of 85-90% as acceptable for 15 minutes, and a PaO2 7-10 kPa (53-75 mmHg) and SaO2 90-95% as acceptable for 24-48 hours in an acute respiratory distress syndrome (ARDS) patient. In most case scenarios, respondents reported not to change the fraction of inspired oxygen (FiO2) if SaO2 was 90-95% or PaO2 was 12 kPa (90 mmHg).</p><p><strong>Conclusion: </strong>A representative sample of ICU clinicians from the Netherlands were concerned about oxygen-induced lung injury, and reported that they preferred PaO2 and SaO2 targets in the lower physiological range and would adjust ventilation settings accordingly.</p>","PeriodicalId":18918,"journal":{"name":"Netherlands Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38132724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Answer to Photoquiz Sharp abdominal and scrotal pain. 剧烈的腹部和阴囊疼痛。
4区 医学
Netherlands Journal of Medicine Pub Date : 2020-07-01
W van 't Hart, I J S M L Vanhooymissen, S M Pasha
{"title":"Answer to Photoquiz Sharp abdominal and scrotal pain.","authors":"W van 't Hart,&nbsp;I J S M L Vanhooymissen,&nbsp;S M Pasha","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":18918,"journal":{"name":"Netherlands Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38132595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Answer to Photoquiz Does it bite? 它咬人吗?
4区 医学
Netherlands Journal of Medicine Pub Date : 2020-07-01
G J A M Boon, K van der Putten, J M van Hattem, J Heidt
{"title":"Answer to Photoquiz Does it bite?","authors":"G J A M Boon,&nbsp;K van der Putten,&nbsp;J M van Hattem,&nbsp;J Heidt","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":18918,"journal":{"name":"Netherlands Journal of Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38132521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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