Nature chemistry最新文献

Preparing and publishing a paper

IF 19.2 1区化学

Nature chemistry Pub Date : 2025-03-06 DOI: 10.1038/s41557-025-01759-2

Shira Joudan

引用次数: 0

The phosphate of life

IF 19.2 1区化学

Nature chemistry Pub Date : 2025-03-06 DOI: 10.1038/s41557-025-01758-3

Elena De Vita, Rebecca Page

引用次数: 0

Supramolecular coordination cages as crystalline sponges through a symmetry mismatch strategy.

IF 19.2 1区化学

Nature chemistry Pub Date : 2025-03-05 DOI: 10.1038/s41557-025-01750-x

Wei He, Yikuan Yu, Kenta Iizuka, Hiroki Takezawa, Makoto Fujita

{"title":"Supramolecular coordination cages as crystalline sponges through a symmetry mismatch strategy.","authors":"Wei He, Yikuan Yu, Kenta Iizuka, Hiroki Takezawa, Makoto Fujita","doi":"10.1038/s41557-025-01750-x","DOIUrl":"https://doi.org/10.1038/s41557-025-01750-x","url":null,"abstract":"The crystalline sponge method enables single-crystal X-ray diffraction analysis of guests absorbed within single-crystalline porous materials. However, its application with large or highly polar guests remains challenging. In this study, we addressed some of these limitations using palladium-based octahedron-shaped M6L4 (Td) coordination cages as crystalline sponges. The key to facilitate the crystallization of the cage is the addition of large aromatic polysulfonates ('sticker' anions); the symmetry mismatch between the cage and the sticker (D2h) results in a low-symmetry space group (P <math> <mover><mrow><mn>1</mn></mrow> <mo>¯</mo></mover> </math> ), preventing guest disorder and leading to the formation of guest-accessible channels in the crystal. Guests can be encapsulated either before or after cage crystallization. The size and host-guest properties of the cavity enable analysis of a broad range of compounds, including water-soluble molecules, large amphiphilic molecules (molecular weight of ~1,200) and molecular aggregates. We have demonstrated the versatility of the cage-sticker strategy through its application to a triaugmented triangular-prism-shaped M9L6 cage, extending the guest scope to medium-sized pharmaceutical molecules.","PeriodicalId":18909,"journal":{"name":"Nature chemistry","volume":" ","pages":""},"PeriodicalIF":19.2,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation, separation and storage of N-monofluoromethyl amides and carbamates

IF 21.8 1区化学

Nature chemistry Pub Date : 2025-03-04 DOI: 10.1038/s41557-025-01767-2

Min Tao, Jiasheng Qian, Linbei Deng, David M. Wilson, Xiangsong Zhang, Jianbo Liu

引用次数: 0

Direct stereoselective C(sp3)–H alkylation of saturated heterocycles using olefins 使用烯烃对饱和杂环进行直接立体选择性 C(sp3)-H 烷基化反应。

IF 19.2 1区化学

Nature chemistry Pub Date : 2025-02-28 DOI: 10.1038/s41557-025-01747-6

Zhijun Zhou, Yang Ke, Rui Miao, Fen Hu, Xiaoqin Wang, Yuanyuan Ping, Sheng Xu, Wangqing Kong

{"title":"Direct stereoselective C(sp3)–H alkylation of saturated heterocycles using olefins","authors":"Zhijun Zhou, Yang Ke, Rui Miao, Fen Hu, Xiaoqin Wang, Yuanyuan Ping, Sheng Xu, Wangqing Kong","doi":"10.1038/s41557-025-01747-6","DOIUrl":"10.1038/s41557-025-01747-6","url":null,"abstract":"Despite cross-coupling strategies that enable the functionalization of aromatic heterocycles, the enantioselective C(sp3)–H alkylation of readily available saturated hydrocarbons to construct C(sp3)–C(sp3) bonds remains a formidable challenge. Here we describe a nickel-catalysed enantioselective C(sp3)–H alkylation of saturated heterocycles using olefins, providing an efficient strategy for the stereoselective construction of C(sp3)–C(sp3) bonds. Using readily available and stable olefins and simple saturated nitrogen and oxygen heterocycles as prochiral nucleophiles, the coupling reactions proceed under mild conditions and exhibit broad scope and high functional group tolerance. Furthermore, the enantio- and diastereoselective C(sp3)–H alkylation of saturated hydrocarbons with alkenyl boronates has been achieved, enabling the synthesis of versatile alkyl boronates containing 1,2-adjacent C(sp3) stereocentres. Application of this approach to the late-stage modification of natural products and drugs, as well as to the enantioselective synthesis of a range of chiral building blocks and natural products, is demonstrated. The enantioselective C(sp3)–H alkylation of saturated hydrocarbons to construct C(sp3)–C(sp3) bonds is challenging. Now a nickel-catalysed enantioselective C(sp3)–H alkylation of saturated heterocycles using olefins has been developed. The enantio- and diastereoselective C(sp3)–H alkylation of saturated hydrocarbons with alkenyl boronates has also been achieved to give alkyl boronates containing 1,2-adjacent C(sp3) stereocentres.","PeriodicalId":18909,"journal":{"name":"Nature chemistry","volume":"17 3","pages":"344-355"},"PeriodicalIF":19.2,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stereoselective alkylation of saturated heterocycles

IF 19.2 1区化学

Nature chemistry Pub Date : 2025-02-28 DOI: 10.1038/s41557-025-01754-7

Yan Li, Xi Lu

引用次数: 0

Flexible interaction patches lead to building blocks with fluctuating valency

IF 19.2 1区化学

Nature chemistry Pub Date : 2025-02-27 DOI: 10.1038/s41557-025-01756-5

Tine C. M. Stevens, Pepijn G. Moerman

引用次数: 0

Flue gas desulfurization and SO₂ recovery within a flexible hydrogen-bonded organic framework.

IF 19.2 1区化学

Nature chemistry Pub Date : 2025-02-26 DOI: 10.1038/s41557-025-01744-9

Lin Li, Xuan Zhang, Xin Lian, Laiyu Zhang, Zhiyuan Zhang, Xiongli Liu, Tengfei He, Baiyan Li, Banglin Chen, Xian-He Bu

{"title":"Flue gas desulfurization and SO2 recovery within a flexible hydrogen-bonded organic framework.","authors":"Lin Li, Xuan Zhang, Xin Lian, Laiyu Zhang, Zhiyuan Zhang, Xiongli Liu, Tengfei He, Baiyan Li, Banglin Chen, Xian-He Bu","doi":"10.1038/s41557-025-01744-9","DOIUrl":"https://doi.org/10.1038/s41557-025-01744-9","url":null,"abstract":"The removal of SO2 from flue gas remains a challenge. Adsorption-based separation of SO2 using porous materials has been proposed as a more energy-efficient and cost-effective alternative to more traditional methods such as cryogenic distillations. Here we report a flexible hydrogen-bonded organic framework (HOF-NKU-1) that enables the sieving of SO2 through the guest-adaptive response and shape-memory effect of the material. HOF-NKU-1 exhibits a high selectivity of 7,331 for the separation of SO2/CO2 and a high SO2 storage density of 3.27 g cm-3 within the pore space at ambient conditions. The hydrophobic nature of HOF-NKU-1 enables high dynamic SO2 uptake and SO2 recovery, even in conditions of 95% humidity. The SO2/CO2 separation mechanism is studied through combinatorial gas sorption isotherms, breakthrough experiments and single-crystal diffraction studies, paving the way for the development of multifunctional shape-memory porous materials in the future.","PeriodicalId":18909,"journal":{"name":"Nature chemistry","volume":" ","pages":""},"PeriodicalIF":19.2,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A glycan foldamer that uses carbohydrate-aromatic interactions to perform catalysis.

IF 19.2 1区化学

Nature chemistry Pub Date : 2025-02-26 DOI: 10.1038/s41557-025-01763-6

Kaimeng Liu, Martina Delbianco

{"title":"A glycan foldamer that uses carbohydrate-aromatic interactions to perform catalysis.","authors":"Kaimeng Liu, Martina Delbianco","doi":"10.1038/s41557-025-01763-6","DOIUrl":"https://doi.org/10.1038/s41557-025-01763-6","url":null,"abstract":"In nature, the ability to catalyse reactions is primarily associated with proteins and ribozymes. Inspired by these systems, peptide-based catalysts have been designed to accelerate chemical reactions and/or ensure regio- and stereoselective transformations. We wondered whether other biomolecules (such as glycans) could be designed to perform catalytic functions, expanding the portfolio of synthetic functional oligomers. Here we report a glycan foldamer inspired by the natural Sialyl Lewis X antigen that acts as catalyst in a chemical reaction. This glycan-based catalyst benefits from structural rigidity and modular adaptability, incorporating a substrate-recognition motif alongside a catalytic active site. Leveraging the inherent ability of carbohydrates to engage in CH-π interactions with aromatic substrates, we demonstrate the recruitment and functionalization of a tryptophan via a Pictet-Spengler transformation. Our modular glycan catalyst accelerates the reaction kinetics, enabling the modification of tryptophan-containing peptides in aqueous environments. Our findings pave the way for the development of glycan-based catalysts and suggest the possibility of catalytic capabilities of glycans in biological contexts.","PeriodicalId":18909,"journal":{"name":"Nature chemistry","volume":" ","pages":""},"PeriodicalIF":19.2,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enantioselective photocatalytic synthesis of bicyclo[2.1.1]hexanes as ortho-disubstituted benzene bioisosteres with improved biological activity

IF 21.8 1区化学

Nature chemistry Pub Date : 2025-02-25 DOI: 10.1038/s41557-025-01746-7

Pablo Garrido-García, Irene Quirós, Paula Milán-Rois, Silvia Ortega-Gutiérrez, Mar Martín-Fontecha, Luis A. Campos, Álvaro Somoza, Israel Fernández, Thomas Rigotti, Mariola Tortosa

{"title":"Enantioselective photocatalytic synthesis of bicyclo[2.1.1]hexanes as ortho-disubstituted benzene bioisosteres with improved biological activity","authors":"Pablo Garrido-García, Irene Quirós, Paula Milán-Rois, Silvia Ortega-Gutiérrez, Mar Martín-Fontecha, Luis A. Campos, Álvaro Somoza, Israel Fernández, Thomas Rigotti, Mariola Tortosa","doi":"10.1038/s41557-025-01746-7","DOIUrl":"https://doi.org/10.1038/s41557-025-01746-7","url":null,"abstract":"1,5-Disubstituted bicyclo[2.1.1]hexanes are bridged scaffolds with well-defined exit vectors that are becoming increasingly popular building blocks in medicinal chemistry because they are saturated bioisosteres of ortho-substituted phenyl rings. Here we have developed a Lewis-acid-catalysed [2 + 2] photocycloaddition to obtain these motifs as enantioenriched scaffolds, providing an efficient approach for their incorporation in a variety of drug analogues. Retention of the biological activity of the bicyclo[2.1.1]hexane-containing analogues in the specific proteins targeted by the original drugs has confirmed the suitability of this moiety to serve as a bioisostere of ortho-substituted phenyl rings. Moreover, we have studied the potential of the different enantiomers of the drug analogues to selectively induce cytotoxicity in a panel of tumour cell lines, observing markedly differential effects for the two enantiomers and a substantial improvement over the corresponding sp2-based drugs. This showcases that the control of the absolute configuration and tridimensionality of the drug analogue has a large impact on its biological properties.<figure></figure>","PeriodicalId":18909,"journal":{"name":"Nature chemistry","volume":"18 1","pages":""},"PeriodicalIF":21.8,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143485626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0