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[Rise in incidence of early-onset colorectal cancer in the Netherlands: cause for concern?] 荷兰早发性结直肠癌发病率上升：值得关注吗？］
Nederlands tijdschrift voor geneeskunde Pub Date : 2025-04-24
Marloes A G Elferink, Laskarina J K Galanos, Femke P C Sijtsma, Maarten J Bijlsma, Tineke E Buffart, Ignace H J T de Hingh, Monique E van Leerdam, Felice N van Erning
{"title":"[Rise in incidence of early-onset colorectal cancer in the Netherlands: cause for concern?]","authors":"Marloes A G Elferink, Laskarina J K Galanos, Femke P C Sijtsma, Maarten J Bijlsma, Tineke E Buffart, Ignace H J T de Hingh, Monique E van Leerdam, Felice N van Erning","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>To describe trends in incidence of early-onset colorectal cancer in the Netherlands.</p><p><strong>Design: </strong>Observational research.</p><p><strong>Method: </strong>We selected colorectal cancer patients aged 15 to 49 years, diagnosed between 1989-2023, from the Netherlands Cancer Registry (NCR). We calculated incidence rates and determined changes in trends using Joinpoint regression analyses. Furthermore, we made a prediction of the number of early-onset colorectal cancer patients in 2035.</p><p><strong>Results: </strong>The number of new early-onset colorectal cancer patients has increased; from 6.3 per 100,000 in 1998 to 9.3 per 100,000 in 2023 (Annual Percentage Change 1.41% (95% confidence interval 1.18-1.71)). This incidence is expected to increase further in the future, reaching between 629 and 871 cases by 2035.</p><p><strong>Conclusion: </strong>There is an increase in the incidence of early-onset colorectal cancer in the Netherlands which appears to persist over the next 10 years. Further research is needed to identify the causes of this increase.</p>","PeriodicalId":18903,"journal":{"name":"Nederlands tijdschrift voor geneeskunde","volume":"169 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[White flakes in a wound: mucormycosis]. [伤口上的白色薄片；毛霉病]。
Nederlands tijdschrift voor geneeskunde Pub Date : 2025-04-23
Corieke van der Bas-Wolvers, Nicolas F Schroten, Alieke G Vonk
{"title":"[White flakes in a wound: mucormycosis].","authors":"Corieke van der Bas-Wolvers, Nicolas F Schroten, Alieke G Vonk","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A 71-year old woman was admitted on the Intensive Care Unit after repair of an ruptured abdominal aortic aneurysm. Afterwards she developed a compartment syndrome of the lower left leg with cotton wool-like patches on the fasciotomy wound. We suspected a fungal infection. A fungal culture revealed mucormycosis.</p>","PeriodicalId":18903,"journal":{"name":"Nederlands tijdschrift voor geneeskunde","volume":"169 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Falls in older persons]. [老年人跌倒]。
Nederlands tijdschrift voor geneeskunde Pub Date : 2025-04-22
Bouwien B E Smid, Nathalie van der Velde, Sofie Jansen, Irene E van de Vorst, Mathijs Kreeft, Floor J A van Deudekom
{"title":"[Falls in older persons].","authors":"Bouwien B E Smid, Nathalie van der Velde, Sofie Jansen, Irene E van de Vorst, Mathijs Kreeft, Floor J A van Deudekom","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Falling is a common issue among older persons, with significant consequences in terms of personal suffering and social care costs. There is often a wide range of underlying and treatable problems present. For instance, a fall may serve as a red flag for an underlying disease with an atypical presentation. Guidelines recommend a multifactorial fall risk assessment for every older patient presenting with a fall. In this article, we provide tools for use in the emergency department and primary care settings to assess fall risk, explore potential treatment options, and establish referral criteria for secondary care.</p>","PeriodicalId":18903,"journal":{"name":"Nederlands tijdschrift voor geneeskunde","volume":"169 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Sucking bruises in infants]. [吮吸婴儿身上的瘀伤]。
Nederlands tijdschrift voor geneeskunde Pub Date : 2025-04-21
Megan F C L Go, Adriënne J van der Neut, Caroline M Hartdorff, Judith M Bosman-Vermeeren
{"title":"[Sucking bruises in infants].","authors":"Megan F C L Go, Adriënne J van der Neut, Caroline M Hartdorff, Judith M Bosman-Vermeeren","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Bruises in premobile infants are alarming signals indicating possible child maltreatment and justify an additional workup. We describe two young infants who were presented with initially unexplained hematoma on the forearm. Additional medical examination was performed. Finally it turned out that the hematoma resulted from the vigorous sucking by the infant on the forearm with a so-called sucking bruise as a result. A thoroughly taken history is necessary and a fully head-to-toe exam is mandatory. When infants in the neonatal period present with bruises, the diagnosis of sucking bruise can be considered in some cases. The diagnosis can only be confirmed by observing the neonate sucking the affected area.</p>","PeriodicalId":18903,"journal":{"name":"Nederlands tijdschrift voor geneeskunde","volume":"169 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Liberal blood transfusion in acute brain injury?] 急性脑损伤的自由输血？］
Nederlands tijdschrift voor geneeskunde Pub Date : 2025-04-17
Korné Jellema, Teun P Saltzherr, Bram Jacobs
{"title":"[Liberal blood transfusion in acute brain injury?]","authors":"Korné Jellema, Teun P Saltzherr, Bram Jacobs","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Whether a liberal or restrictive blood transfusion strategy is the best treatment option in patients with an acute, severe neurological disease, such as traumatic brain injury, an intracranial hemorrhage or a subarachnoid hemorrhage, is unknown. In this article we discuss the TRAIN trial and the current literature regarding a liberal versus a restrictive blood transfusion strategy in this patient category. The TRAIN trial showed a positive effect of a liberal strategy compared to a restrictive blood transfusion strategy in patients with an acute neurological disease. Another study as well as a meta-analysis were also unable to show a positive effect of a liberal blood transfusion strategy in patients with traumatic brain injury. We therefore conclude that at this moment it is too early to adopt a new, liberal blood transfusion strategy in patients with acute, severe neurological disease.</p>","PeriodicalId":18903,"journal":{"name":"Nederlands tijdschrift voor geneeskunde","volume":"169 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Make medical research more sustainable]. [使医学研究更具可持续性]。
Nederlands tijdschrift voor geneeskunde Pub Date : 2025-04-15
Eileen Albers, Ewoud Schuit, Anneke Kwee
{"title":"[Make medical research more sustainable].","authors":"Eileen Albers, Ewoud Schuit, Anneke Kwee","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Healthcare is responsible for a significant part of the global CO2 footprint. Awareness of this contribution is now growing, and various actions are being taken to reduce the climate and environmental impact of the healthcare sector. However, little attention is paid to the impact of scientific medical research as part of healthcare.In this article, we advocate to include climate impact in all aspects of prioritizing, developing and conducting research. To address this the following questions are important: 1. Can the research be justified based on the usefulness for clinical practice and the use of climate impact-related resources? 2. Is the research carried out as sustainable as possible? 3. Is climate impact an outcome measure of the research? We discuss what is already known and can be used today. Furthermore, we provide suggestions on what is needed for further developments on this topic.</p>","PeriodicalId":18903,"journal":{"name":"Nederlands tijdschrift voor geneeskunde","volume":"169 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144018732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Nature prescriptions: is it time to bring more nature into healthcare?] 自然处方：是时候将更多的自然引入医疗保健了吗？］
Nederlands tijdschrift voor geneeskunde Pub Date : 2025-04-10
Pim Van den Dungen, Jolanda Maas
{"title":"[Nature prescriptions: is it time to bring more nature into healthcare?]","authors":"Pim Van den Dungen, Jolanda Maas","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Observational research indicates that living in a greener environment is associated with lower mortality from cardiovascular diseases and a reduced prevalence of type II diabetes and depression. Experimental studies suggest a partially causal relationship, supported by proven mechanisms such as promoting a healthy lifestyle and reducing stress through nature. Engaging in nature-based activities, such as gardening, walking, or other outdoor pursuits, appears to alleviate symptoms in individuals with mental health issues. Furthermore, there is evidence that offering psychotherapy in nature may have advantages over indoor treatment. On the physical health front, nature prescriptions show promising effects on cardiovascular risk predictors like blood pressure, though not yet on clinical endpoints. Given the growing burden on healthcare, driven by lifestyle-related and mental health issues, the potential benefits of integrating nature into care - through green interventions, nature prescriptions, and outdoor treatments - deserve greater recognition and exploration.</p>","PeriodicalId":18903,"journal":{"name":"Nederlands tijdschrift voor geneeskunde","volume":"169 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144010735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Trauma in the novels of Han Kang]. [韩康小说中的创伤]。
Nederlands tijdschrift voor geneeskunde Pub Date : 2025-04-10
Arko Oderwald, Henriëtte E van der Horst
{"title":"[Trauma in the novels of Han Kang].","authors":"Arko Oderwald, Henriëtte E van der Horst","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Psychological trauma can stem from a traumatic upbringing or after a life-threatening situation. These two different types of trauma are the subject of four novels by Han Kang, winner of the Nobel Prize for Literature 2024. In this article, we will discuss these novels and how Han Kang shapes them by mixing a poetic and fantastic style blending with realistic description. Unlike a medical book about trauma, such as Bessel van der Kolk's book, Han Kang brings you close to the experience of trauma, which brings insight into trauma experience and evokes compassion with the trauma victim.</p>","PeriodicalId":18903,"journal":{"name":"Nederlands tijdschrift voor geneeskunde","volume":"169 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A boy with red ears]. [一个红耳朵的男孩]。
Nederlands tijdschrift voor geneeskunde Pub Date : 2025-04-09
Joyce Anholts, Mariette Wagenaar, Laura Keukens
{"title":"[A boy with red ears].","authors":"Joyce Anholts, Mariette Wagenaar, Laura Keukens","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A previously healthy boy presented himself on a sunny day in May with swelling, pain and itchiness of both his ears. At physical examination we saw a healthy boy with indeed a lot of swelling of both his ears, redness of the skin and some little blisters. Under suspicion of juvenile spring eruption we started local corticosteroid crème as well as oral anti-histamine tablets to bring the swelling down. Juvenile spring eruption is a local reaction to sunlight, the precise mechanism of origin is unknown. It is usually seen in boys age 4 to 12 with uncovered ears. Most often it is seen on sunny days in spring. It is self-limiting, sometimes steroid crème is prescribed to reduce itchiness of the skin. It can be recurring, in which the advice is to wear sunscreen and a hat.</p>","PeriodicalId":18903,"journal":{"name":"Nederlands tijdschrift voor geneeskunde","volume":"169 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144044913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Age-specific reference intervals for thyroid-stimulating hormone and free thyroxine to optimize diagnosis of thyroid disease]. [促甲状腺激素和游离甲状腺素的年龄特异性参考区间优化甲状腺疾病的诊断]。
Nederlands tijdschrift voor geneeskunde Pub Date : 2025-04-09
Wendy P J den Elzen, Heleen I Jansen, Niek F Dirks, Jacquelien J Hillebrand, A S Paul van Trotsenburg, Martin den Heijer, Eveline Bruinstroop, Anita Boelen, Annemieke C Heijboer
{"title":"[Age-specific reference intervals for thyroid-stimulating hormone and free thyroxine to optimize diagnosis of thyroid disease].","authors":"Wendy P J den Elzen, Heleen I Jansen, Niek F Dirks, Jacquelien J Hillebrand, A S Paul van Trotsenburg, Martin den Heijer, Eveline Bruinstroop, Anita Boelen, Annemieke C Heijboer","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Most laboratories do not differentiate reference intervals for thyroid hormones for adults based on age. In a national study we established age-specific reference intervals for TSH and FT4. For children aged 2-12 years, TSH reference intervals were higher than for adults. In adults (female and male), the upper limits of the TSH reference intervals increased from the age of 50-60 years, while the lower limits remained stable until the age of 80. The FT4 reference intervals showed a moderate trend with age. These new age-specific reference intervals led to a decrease in subclinical hypothyroidism diagnoses. For women aged 50-60 from 13.1% to 8.6%; for women aged 90-100, from 22.7% to 8.1%. In men aged 60-70, it decreased from 10.9% to 7.7%, and aged 90-100, from 27.4% to 9.6%. This study confirms the importance of implementing age-specific reference intervals for TSH and FT4 to reduce the number of (unnecessary) diagnoses of subclinical hypothyroidism.</p>","PeriodicalId":18903,"journal":{"name":"Nederlands tijdschrift voor geneeskunde","volume":"9 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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