Nanotoxicology最新文献

{"title":"Needlelike, short and thin multi-walled carbon nanotubes: comparison of effects on wild type and p53^+/- rat lungs.","authors":"Hélène Barthel,&nbsp;Sylvie Sébillaud,&nbsp;Mylène Lorcin,&nbsp;Henrik Wolff,&nbsp;Stéphane Viton,&nbsp;Frédéric Cosnier,&nbsp;Laurent Gaté,&nbsp;Carole Seidel","doi":"10.1080/17435390.2023.2204933","DOIUrl":"https://doi.org/10.1080/17435390.2023.2204933","url":null,"abstract":"<p><p>Carbon nanotubes (CNTs) are nanomaterials presenting an occupational inhalation risk during production or handling. The International Agency for Research on Cancer classified one CNT, Mitsui-7 (MWNT-7), as 'possibly carcinogenic to humans'. In recognition of their similarities, a proposal has been submitted to the risk assessment committee of ECHA to classify all fibers with 'Fibre Paradigm' (FP)-compatible dimensions as carcinogenic. However, there is a lack of clarity surrounding the toxicity of fibers that do not fit the FP criteria. In this study, we compared the effects of the FP-compatible Mitsui-7, to those of NM-403, a CNT that is too short and thin to fit the paradigm. Female Sprague Dawley rats deficient for p53 (GMO) and wild type (WT) rats were exposed to the two CNTs (0.25 mg/rat/week) by intratracheal instillation. Animals (GMO and WT) were exposed weekly for four consecutive weeks and were sacrificed 3 days or 8 months after the last instillation. Exposure to both CNTs induced acute lung inflammation. However, persistent inflammation at 8 months was only observed in the lungs of rats exposed to NM-403. In addition to the persistent inflammation, NM-403 stimulated hyperplasic changes in rat lungs, and no adenomas or carcinomas were detected. The degree and extent of hyperplasia was significantly more pronounced in GMO rats. These results suggest that CNT not meeting the FP criteria can cause persistent inflammation and hyperplasia. Consequently, their health effects should be carefully assessed.</p>","PeriodicalId":18899,"journal":{"name":"Nanotoxicology","volume":"17 3","pages":"270-288"},"PeriodicalIF":5.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9863831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing regulated cell death modalities as an efficient tool for <i>in vitro</i> nanotoxicity screening: a review.","authors":"Anton Tkachenko,&nbsp;Anatolii Onishchenko,&nbsp;Valeriy Myasoedov,&nbsp;Svetlana Yefimova,&nbsp;Ondrej Havranek","doi":"10.1080/17435390.2023.2203239","DOIUrl":"https://doi.org/10.1080/17435390.2023.2203239","url":null,"abstract":"<p><p>Nanomedicine is a fast-growing field of nanotechnology. One of the major obstacles for a wider use of nanomaterials for medical application is the lack of standardized toxicity screening protocols for assessing the safety of newly synthesized nanomaterials. In this review, we focus on less frequently studied nanomaterials-induced regulated cell death (RCD) modalities, including eryptosis, necroptosis, pyroptosis, and ferroptosis, as a tool for <i>in vitro</i> nanomaterials safety evaluation. We summarize the latest insights into the mechanisms that mediate these RCDs in response to nanomaterials exposure. Comprehensive data from reviewed studies suggest that ROS (reactive oxygen species) overproduction and ROS-mediated pathways play a central role in nanomaterials-induced RCDs activation. On the other hand, studies also suggest that individual properties of nanomaterials, including size, shape, or surface charge, could determine specific toxicity pathways with consequent RCD induction as well. We anticipate that the evaluation of RCDs can become one of the mechanism-based screening methods in nanotoxicology. In addition to the toxicity assessment, evaluation of necroptosis-, pyroptosis-, and ferroptosis-promoting capacity of nanomaterials could simultaneously provide useful information for specific medical applications as could be their anti-tumor potential. Moreover, a detailed understanding of molecular mechanisms driving nanomaterials-mediated induction of immunogenic RCDs will substantially aid novel anti-tumor nanodrugs development.</p>","PeriodicalId":18899,"journal":{"name":"Nanotoxicology","volume":"17 3","pages":"218-248"},"PeriodicalIF":5.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9458679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Algal extracellular polymeric substances (algal-EPS) for mitigating the combined toxic effects of polystyrene nanoplastics and nano-TiO₂ in <i>Chlorella</i> sp.","authors":"Lokeshwari Natarajan,&nbsp;M Annie Jenifer,&nbsp;Willie J G M Peijnenburg,&nbsp;Amitava Mukherjee","doi":"10.1080/17435390.2023.2179438","DOIUrl":"https://doi.org/10.1080/17435390.2023.2179438","url":null,"abstract":"<p><p>The continuous release of nanoparticles and nanoplastics into the marine environment necessitates the examination of their combined effects in marine organisms. Natural Organic Matter (NOM) can significantly influence the behavior of nanomaterials in the marine environment. The present study explores the effects of algal Extracellular Polymeric Substances (EPS) in reducing the combined toxic effects of three different polystyrene nanoplastics (PSNPs)- aminated (NH₂-PSNPs), carboxylated (COOH-PSNPs), and plain PSNPs - and P25 titanium dioxide nanoparticles (Nano-TiO₂) towards the marine alga, <i>Chlorella</i> sp. Two doses (0.25 and 2.5 mg/L) of nano-TiO₂ mixed with the PSNPs (1 mg/L) were employed. The COOH-PSNPs with 2.5 mg/L nano-TiO₂ exhibited higher growth inhibition toward algal cells. Addition of algal EPS to the mixture of NMs decreased the negative effect significantly. The mean hydrodynamic diameter increased significantly from 666 to 797 nm and 1248 to 3589 nm at concentrations 0.25 and 2.5 mg/L, respectively when the mixtures of nano-TiO₂ and COOH-PSNPs were incubated with the algal EPS. In comparison to the pristine NMs, the EPS-NMs were found to significantly reduce the superoxide and hydroxyl radical production. The results were further validated with the estimation of lipid peroxidation (LPO), esterase activity, photosynthetic efficiency, and membrane permeability in the cells. The major outcomes from this study highlight the role of algal EPS in significantly reducing the toxic impact of binary mixture of NMs in marine organisms.</p>","PeriodicalId":18899,"journal":{"name":"Nanotoxicology","volume":"17 2","pages":"143-156"},"PeriodicalIF":5.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9460717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ferritinophagy was involved in long-term SiNPs exposure induced ferroptosis and liver fibrosis.","authors":"Qingqing Liang,&nbsp;Yuexiao Ma,&nbsp;Fenghong Wang,&nbsp;Mengqi Sun,&nbsp;Lisen Lin,&nbsp;Tianyu Li,&nbsp;Junchao Duan,&nbsp;Zhiwei Sun","doi":"10.1080/17435390.2023.2197055","DOIUrl":"https://doi.org/10.1080/17435390.2023.2197055","url":null,"abstract":"<p><p>SiNPs could induce liver fibrosis<i>invivo</i>, but the mechanism was not completely clear. This study focused on exploring whether long-term SiNPs exposure at human-related exposure dosage could lead to ferritinophagy-mediated ferroptosis and liver fibrosis. <i>In vivo</i>, long-term SiNPs exposure induced liver fibrosis inrats accompanied by ferritinophagy and ferroptosis in hepatocytes. Interestingly, the progression of liver fibrosis was alleviated after exposure cessation and recovery, meanwhile ferritinophagy and ferroptosis were not further activated. <i>In vitro</i>, after long-term SiNPs exposure, the mitochondrial membrane ruptured, lipid peroxidation intensified, the level of redox active iron increased and the repair protein of lipid peroxidation were consumed in L-02 cells, demonstrating ferroptosis occurrence. Notably, <i>NCOA4</i> knockdown inhibited ferritin degradation, alleviated the increase of intracellular ferrous iron level, reduced lipid peroxidation and the depletion of glutathione peroxidase 4 (GPX4). In conclusion, ferritinophagy mediated by NCOA4 was responsible for long-term SiNPs exposure induced hepatocytes ferroptosis and liver fibrosis, which provided a scientific basis for toxicological assessment of SiNPs and would be benefited for the safety design of SiNPs-based products.</p>","PeriodicalId":18899,"journal":{"name":"Nanotoxicology","volume":"17 2","pages":"157-175"},"PeriodicalIF":5.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9827086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TiO₂ nanostructures - a double edged sword: current progress on their role in stem cells' differentiation, cancer therapy, and their toxicity issues.","authors":"Saravanan Ramesh,&nbsp;Kavitha Govarthanan,&nbsp;Arunkumar Palaniappan","doi":"10.1080/17435390.2023.2199858","DOIUrl":"https://doi.org/10.1080/17435390.2023.2199858","url":null,"abstract":"<p><p>Titanium dioxide (TiO₂)-based nanostructures have wide applications in cosmetics, toothpastes, pharmaceuticals, coatings, papers, inks, plastics, food products, textiles, and many others. Recently, they have also been found to have huge potential as stem cells' differentiation agents as well as stimuli-responsive drug delivery systems in cancer therapy. In this review, we present some of the recent progress in the role of TiO₂-based nanostructures toward the above-mentioned applications. We also present recent studies on the toxicity issues of these nanomaterials and the mechanisms behind the toxicity issues. We have reviewed the recent progress of TiO₂-based nanostructures on their stem cells' differentiation potentials, their photo- and sono-dynamic capabilities, as stimuli-responsive drug delivery systems, and finally their toxicity issues with mechanistic understanding on the same. We believe that this review will help researchers be aware of the latest progress in the applications as well as few toxicity issues associated with TiO₂-based nanostructures, which will help them design better nanomedicine for future applications.</p>","PeriodicalId":18899,"journal":{"name":"Nanotoxicology","volume":"17 2","pages":"176-201"},"PeriodicalIF":5.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9462079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of genotoxicity induced by subchronic exposure to graphene in HaCaT human skin cell line.","authors":"Javier Frontiñan-Rubio,&nbsp;Sonia García-Carpintero,&nbsp;Viviana Jehová González,&nbsp;Ester Vázquez,&nbsp;Mario Durán-Prado","doi":"10.1080/17435390.2023.2183653","DOIUrl":"https://doi.org/10.1080/17435390.2023.2183653","url":null,"abstract":"<p><p>The applications of graphene-based materials (GBMs) and their processing involve prolonged contact with cellular barriers such as human skin. Even though the potential cytotoxicity of graphene has been studied in recent years, the impact of long-term graphene exposure has rarely been explored. We tested in the HaCaT epithelial cells, <i>in vitro</i>, the effect of subchronic treatments with sublethal doses of four different, well-characterized GBMs, two commercial graphene oxides (GO) and two few-layer graphenes (FLG). Cells were exposed weekly to low doses of the GBMs for 14 days, 30 days, 3 months, and 6 months. GBMs-cells uptake was assessed by confocal microscopy. Cell death and cell cycle were determined by fluorescence microscopy and cytometry. DNA damage was measured by comet assay and γ-H2AX staining, followed by the determination of p-p53 and p-ATR by immunolabeling. Subchronic exposure to different GBMs at noncytotoxic doses has potential genotoxic effects on HaCaT epithelial cells that can be recovered depending on the GBM and exposure time. Specifically, GO-induced genotoxicity can be detected after 14 and 30 days from treatment. At this time, FLG appears less genotoxic than GO, and cells can recover more quickly when genotoxic pressure disappears after some days of removal of the GBM. Long-term exposure, 3 and 6 months, to different GBMs induces permanent, nonreversible, genotoxic damage comparable to the exerted by arsenite. This should be considered for the production and future applications of GBMs in scenarios where low concentrations of the material interact chronically with epithelial barriers.</p>","PeriodicalId":18899,"journal":{"name":"Nanotoxicology","volume":"17 1","pages":"42-61"},"PeriodicalIF":5.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9377899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polyethyleneimine/polyethylene glycol-conjugated gold nanoparticles as nanoscale positive/negative controls in nanotoxicology: testing in frog embryo teratogenesis assay-<i>Xenopus</i> and mammalian tissue culture system.","authors":"Yoo-Seok Hwang, Daeho So, Moonsup Lee, Jaeho Yoon, Vytas Reipa, Alessandro Tona, Feng Yi, Bryant C Nelson, David A LaVan, Vincent A Hackley, Ira O Daar, Tae Joon Cho","doi":"10.1080/17435390.2023.2187322","DOIUrl":"10.1080/17435390.2023.2187322","url":null,"abstract":"<p><p>Despite the great potential of using positively charged gold nanoparticles (AuNPs) in nanomedicine, no systematic studies have been reported on their synthesis optimization or colloidal stability under physiological conditions until a group at the National Institute of Standards and Technology recently succeeded in producing remarkably stable polyethyleneimine (PEI)-coated AuNPs (Au-PEI). This improved version of Au-PEI (Au-PEI25kB) has increased the demand for toxicity and teratogenicity information for applications in nanomedicine and nanotoxicology. In vitro assays for Au-PEI25kB in various cell lines showed substantial active cytotoxicity. For advanced toxicity research, the frog embryo teratogenesis assay-<i>Xenopus</i> (FETAX) method was employed in this study. We observed that positively-charged Au-PEI25kB exhibited significant toxicity and teratogenicity, whereas polyethylene glycol conjugated AuNPs (Au-PEG) used as comparable negative controls did not. There is a characteristic avidity of Au-PEI25kB for the jelly coat, the chorionic envelope (also known as vitelline membrane) and the cytoplasmic membrane, as well as a barrier effect of the chorionic envelope observed with Au-PEG. To circumvent these characteristics, an injection-mediated FETAX approach was utilized. Like treatment with the FETAX method, the injection of Au-PEI25kB severely impaired embryo development. Notably, the survival/concentration curve that was steep when the standard FETAX approach was employed became gradual in the injection-mediated FETAX. These results suggest that Au-PEI25kB may be a good candidate as a nanoscale positive control material for nanoparticle analysis in toxicology and teratology.</p>","PeriodicalId":18899,"journal":{"name":"Nanotoxicology","volume":"17 1","pages":"94-115"},"PeriodicalIF":5.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10471858/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10495639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting the toxicity of nanoparticles using artificial intelligence tools: a systematic review.","authors":"Alireza Banaye Yazdipour,&nbsp;Hoorie Masoorian,&nbsp;Mahnaz Ahmadi,&nbsp;Niloofar Mohammadzadeh,&nbsp;Seyed Mohammad Ayyoubzadeh","doi":"10.1080/17435390.2023.2186279","DOIUrl":"https://doi.org/10.1080/17435390.2023.2186279","url":null,"abstract":"<p><p>Nanoparticles have been used extensively in different scientific fields. Due to the possible destructive effects of nanoparticles on the environment or the biological systems, their toxicity evaluation is a crucial phase for studying nanomaterial safety. In the meantime, experimental approaches for toxicity assessment of various nanoparticles are expensive and time-consuming. Thus, an alternative technique, such as artificial intelligence (AI), could be valuable for predicting nanoparticle toxicity. Therefore, in this review, the AI tools were investigated for the toxicity assessment of nanomaterials. To this end, a systematic search was performed on PubMed, Web of Science, and Scopus databases. Articles were included or excluded based on pre-defined inclusion and exclusion criteria, and duplicate studies were excluded. Finally, twenty-six studies were included. The majority of the studies were conducted on metal oxide and metallic nanoparticles. In addition, Random Forest (RF) and Support Vector Machine (SVM) had the most frequency in the included studies. Most of the models demonstrated acceptable performance. Overall, AI could provide a robust, fast, and low-cost tool for the evaluation of nanoparticle toxicity.</p>","PeriodicalId":18899,"journal":{"name":"Nanotoxicology","volume":"17 1","pages":"62-77"},"PeriodicalIF":5.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9320659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A harmonized protocol for an international multicenter prospective study of nanotechnology workers: the NanoExplore cohort.","authors":"Irina Guseva Canu,&nbsp;Ekaterina Plys,&nbsp;Camille Velarde Crézé,&nbsp;Carlos Fito,&nbsp;Nancy B Hopf,&nbsp;Athena Progiou,&nbsp;Chiara Riganti,&nbsp;Jean-Jacques Sauvain,&nbsp;Giulia Squillacioti,&nbsp;Guillaume Suarez,&nbsp;Pascal Wild,&nbsp;Enrico Bergamaschi","doi":"10.1080/17435390.2023.2180220","DOIUrl":"https://doi.org/10.1080/17435390.2023.2180220","url":null,"abstract":"<p><p>Nanotechnology applications are fast-growing in many industrial fields. Consequently, health effects of engineered nanomaterials (ENMs) should be investigated. Within the EU-Life project NanoExplore, we developed a harmonized protocol of an international multicenter prospective cohort study of workers in ENM-producing companies. This article describes the development of the protocol, sample size calculation, data collection and management procedures and discusses its relevance with respect to research needs. Within this protocol, workers' ENM exposure will be assessed over four consecutive working days during the initial recruitment campaign and the subsequent follow-up campaigns. Biomonitoring using noninvasive sampling of exhaled breath condensate (EBC), exhaled air, and urine will be collected before and after 4-day exposure monitoring. Both exposure and effect biomarkers, will be quantified along with pulmonary function tests and diagnosed diseases reported using a standardized epidemiological questionnaire available in four languages. Until now, this protocol was implemented at seven companies in Switzerland, Spain and Italy. The protocol is well standardized, though sufficiently flexible to include company-specific conditions and occupational hygiene measures. The recruitment, to date, of 140 participants and collection of all data and samples, enabled us launching the first international cohort of nanotechnology workers. All companies dealing with ENMs could join the NanoExplore Consortium, apply this harmonized protocol and enter in the cohort, concieved as an open cohort. Its protocol meets all requirements of a hypotheses-driven prospective study, which will assess and reassess effects of ENM exposure on workers' health by updating the follow-up of the cohort. New hypothesis could be also considered.</p>","PeriodicalId":18899,"journal":{"name":"Nanotoxicology","volume":"17 1","pages":"1-19"},"PeriodicalIF":5.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9322281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficient predictions of cytotoxicity of TiO₂-based multi-component nanoparticles using a machine learning-based q-RASAR approach.","authors":"Arkaprava Banerjee,&nbsp;Supratik Kar,&nbsp;Souvik Pore,&nbsp;Kunal Roy","doi":"10.1080/17435390.2023.2186280","DOIUrl":"https://doi.org/10.1080/17435390.2023.2186280","url":null,"abstract":"<p><p>The availability of experimental nanotoxicity data is in general limited which warrants both the use of <i>in silico</i> methods for data gap filling and exploring novel methods for effective modeling. Read-Across Structure-Activity Relationship (RASAR) is an emerging cheminformatic approach that combines the usefulness of a QSAR model and similarity-based Read-Across predictions. In this work, we have generated simple, interpretable, and transferable quantitative-RASAR (q-RASAR) models which can efficiently predict the cytotoxicity of TiO₂-based multi-component nanoparticles. A data set of 29 TiO₂-based nanoparticles with specific amounts of noble metal precursors was rationally divided into training and test sets, and the Read-Across-based predictions for the test set were generated. The optimized hyperparameters and the similarity approach, which yield the best predictions, were used to calculate the similarity and error-based RASAR descriptors. A data fusion of the RASAR descriptors with the chemical descriptors was done followed by the best subset feature selection. The final set of selected descriptors was used to develop the q-RASAR models, which were validated using the stringent OECD criteria. Finally, a random forest model was also developed with the selected descriptors, which could efficiently predict the cytotoxicity of TiO₂-based multi-component nanoparticles superseding previously reported models in the prediction quality thus showing the merits of the q-RASAR approach. To further evaluate the usefulness of the approach, we have applied the q-RASAR approach also to a second cytotoxicity data set of 34 heterogeneous TiO₂-based nanoparticles which further confirmed the enhancement of external prediction quality of QSAR models after incorporation of RASAR descriptors.</p>","PeriodicalId":18899,"journal":{"name":"Nanotoxicology","volume":"17 1","pages":"78-93"},"PeriodicalIF":5.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9377366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}