Biology, Medicine, & Natural Product Chemistry最新文献_第6页

Preliminary Investigative Study on the Blood Pressure-Lowering Potential of Aqueous Leaf Extract of Simarouba glauca (AESG) on Normotensive Adult Wistar Rats 青叶水提物(AESG)对正常血压成年Wistar大鼠降血压电位的初步研究

Biology, Medicine, & Natural Product Chemistry Pub Date : 2022-09-13 DOI: 10.14421/biomedich.2023.121.1-4

S. E. Osagie-Eweka, N. Orhue, F. Amaechina, E. Omogbai, E. G. Moke

{"title":"Preliminary Investigative Study on the Blood Pressure-Lowering Potential of Aqueous Leaf Extract of Simarouba glauca (AESG) on Normotensive Adult Wistar Rats","authors":"S. E. Osagie-Eweka, N. Orhue, F. Amaechina, E. Omogbai, E. G. Moke","doi":"10.14421/biomedich.2023.121.1-4","DOIUrl":"https://doi.org/10.14421/biomedich.2023.121.1-4","url":null,"abstract":"Studies have shown that plants possess medicinal properties and compounds are beneficial in managing and treating diseases, including high blood pressure and related cardiovascular conditions. Simarouba glauca (SG) has been widely reported to possess antibacterial activity, anti-oxidant, anti-proliferative and hemolytic activity; amongst others. However, there is paucity of data on its effect on blood pressure. Hence, the study research aimed at assessing the hypotensive prospect inherent in the aqueous leaf extract of Simarouba glauca (AESG) on normotensive male Wistar rats. The study was conducted using adult male Wistar rats (n = 3), a urethane/thiopental (1205/20 mg/kg) anesthesia and a chart paper attached to Ugo Basile Uni-recorder Model 400700 data capsule. Under full anesthesia, the ratâ€™s trachea and the carotid artery were cannulated for assisted respiration and blood pressure measurement. At stable variables; following the administration of 0.2 mL normal saline, the AESG was administered intravenously via the caudal vein at 2.5 and 5.0 mg/kg body weight dose respectively. The data was recorded on a chart; indicated the characteristic dose-dependent hypotensive effect of AESG on normotensive rats; at doses of 2.5 mg/kg and 5.0 mg/kg, with marked decreases in the systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MAP) from basal levels of 127.83 Â± 1.01 mmHg, 91.00 Â± 1.00 mm Hg and 103.27 Â± 0.99 mm Hg respectively. The outcome of the preliminary investigation indicates that the AESG demonstrated a hypotensive effect on the BP of normotensive male Wistar rats dependent on varying doses administered; indicative of further evaluation.","PeriodicalId":188261,"journal":{"name":"Biology, Medicine, & Natural Product Chemistry","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114905855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Inhibitory Effect of Mammea africana on Alpha-Amylase and Alpha-Glucosidase Enzymes of Rats 非洲哺乳动物对大鼠α -淀粉酶和α -葡萄糖苷酶的抑制作用

Biology, Medicine, & Natural Product Chemistry Pub Date : 2022-09-12 DOI: 10.14421/biomedich.2022.112.175-180

Nwakaego Omonigho Ebong, J. Okokon, Jesse Idakwoji

引用次数: 0

The Weight Performance Stability of Mice on Modeling Obesity-Associated Hyperglycemia Induced by Dextrose Monohydrate 一水葡萄糖致肥胖相关高血糖模型小鼠体重表现稳定性研究

Biology, Medicine, & Natural Product Chemistry Pub Date : 2022-09-06 DOI: 10.14421/biomedich.2022.112.169-173

Deksa Yudha Syach Putra, Setiyo Budi Santoso, H. Lutfiyati

{"title":"The Weight Performance Stability of Mice on Modeling Obesity-Associated Hyperglycemia Induced by Dextrose Monohydrate","authors":"Deksa Yudha Syach Putra, Setiyo Budi Santoso, H. Lutfiyati","doi":"10.14421/biomedich.2022.112.169-173","DOIUrl":"https://doi.org/10.14421/biomedich.2022.112.169-173","url":null,"abstract":"Previously, streptozotocin and alloxan were employed to imitate hyperglycemia in mice. High doses of sucrose were also induced as an alternative. Due to body mass index has been associated with hyperglycemia, the evidence of weight body index in various induction alternate kinds, however, have not been fully reported. Here-in, we report on the weight performance stability of mice body weight induced by dextrose, streptozotocin, and alloxan. To begin, all mice were divided into six groups of five, with one reserve in each. Following seven days of acclimatization, the mice were induced for nine days of hyperglycemia modeling; alloxan (Groups A and D), streptozotocin (Group B and E), dextrose monohydrate (Groups C and F). On preclinical research animals modelling related to obesity-associated hyperglycemia in mice, dextrose monohydrate induction was most successful than streptozocotin and alloxan induction, which performed best during the induction period (31% weight growth) and after metformin intervention (36% weight growth). Overall, dextrose monohydrate is most suitable to be used for modeling type 2 diabetes mellitus test animals rather than alloxan and streptozocotin.","PeriodicalId":188261,"journal":{"name":"Biology, Medicine, & Natural Product Chemistry","volume":"357-360 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127898321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Anti-oxidant, Anti-inflammatory and Anti-Atherosclerotic Activity of Bioactive Peptide HPAEDR Isolated from Catla catal Muscle on LPS Induced Inflammation on 246.7RAW Macrophage Cells and HCF Induced Hyperlipidemic Zebrafish Larvae Catla catal肌生物活性肽HPAEDR对LPS诱导的246.7RAW巨噬细胞和HCF诱导的高脂血症斑马鱼幼鱼的抗氧化、抗炎和抗动脉粥样硬化活性

Biology, Medicine, & Natural Product Chemistry Pub Date : 2022-08-23 DOI: 10.14421/biomedich.2022.112.151-160

Sabarinathan Sethuramalingam, Revathy Leena Ravi, Janet Rani Rajiah

{"title":"Anti-oxidant, Anti-inflammatory and Anti-Atherosclerotic Activity of Bioactive Peptide HPAEDR Isolated from Catla catal Muscle on LPS Induced Inflammation on 246.7RAW Macrophage Cells and HCF Induced Hyperlipidemic Zebrafish Larvae","authors":"Sabarinathan Sethuramalingam, Revathy Leena Ravi, Janet Rani Rajiah","doi":"10.14421/biomedich.2022.112.151-160","DOIUrl":"https://doi.org/10.14421/biomedich.2022.112.151-160","url":null,"abstract":"A muscle wasdissected from the Catla catlafish and enzyme hydrolysis was done using various digestive enzymes such as pepsisn, protease, papine, trypsin and alcalase at verity of time intervals (0th, 3rd, 6th, 9th and 12th) hour respectively. Followed by, the amino acid composition was identified and the confirmative assays such as, the anti-oxidant assays (DPPH and Hydroxy radical scavenging activity) and anti-inflammatory assays (HRBC and AD) were done for various peptide hydrolysate. The active hr was identified as 9th hr alcalase hydrolysate which was purified through Ultrafiltration (>30 kDa, 30-10 kDa, 10-3 kDa and <3 kDa). These fractions were again studied for its anti-oxidant and anti-inflammatory activity. Based on the results obtained, the active fraction was identified as 10-3kDa which was further purified and identified using Gel filtration chromatography and LC-MS/MS as HPAEDR (723.76 Da). Further, for in vitro and in vivo studies the peptide derived from CCM was synthetically designed with 98% purity (PhtdPeptides Co., Ltd. Zhemgzhou, China). Additionally, the physiochemical properties (Solubility, emulsifying properties and foaming properties) of these fraction was studied. Finally, the purified fraction was tested for in vitro activity through cell viability, COX-2 production, NO production and TNF-α production. Moreover, the in vivo protective effect is tested on Zebrafish larvae. The results suggest that the active purified peptide fraction isolated from Catla catla muscle has a strong natural anti-oxidant, anti-inflammatory and cholesterol reduction activity which can be used in functional foods and pharmaceuticals.","PeriodicalId":188261,"journal":{"name":"Biology, Medicine, & Natural Product Chemistry","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129569399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Co-Existent Hypertension with Diabetes Mellitus Exacerbates Renal Dysfunctions 高血压合并糖尿病加重肾功能障碍

Biology, Medicine, & Natural Product Chemistry Pub Date : 2022-08-15 DOI: 10.14421/biomedich.2022.112.145-150

Eruore Amalaka Obore, J. N. Asiwe, V. Iyawe, A. Edo

引用次数: 0

Ethnobotanical Survey of Plants Used in The Management of Peptic Ulcer Diseases in Wukari Metropolis 乌卡里市消化性溃疡治疗植物的民族植物学调查

Biology, Medicine, & Natural Product Chemistry Pub Date : 2022-08-03 DOI: 10.14421/biomedich.2022.112.137-143

A. Agbatutu, E. Ogie-odia, Mary Oromioshemime Ifedele, Funmilola Modinat Abdulrasaq, Daniel Eseigbe, F. Imade

{"title":"Ethnobotanical Survey of Plants Used in The Management of Peptic Ulcer Diseases in Wukari Metropolis","authors":"A. Agbatutu, E. Ogie-odia, Mary Oromioshemime Ifedele, Funmilola Modinat Abdulrasaq, Daniel Eseigbe, F. Imade","doi":"10.14421/biomedich.2022.112.137-143","DOIUrl":"https://doi.org/10.14421/biomedich.2022.112.137-143","url":null,"abstract":"Peptic ulcer diseases (PUD) are sores formed in soft tissues present in the lining of the digestive tract as a result of excessive stomach acid or inability of the alimentary tract or stomach to protect itself. The increasing surge for plant based drugs in the management of PUD has increased scientific investigation of herbs and recipes from traditional medicinal practitioners (TMP) to ascertain their efficacy through pharmacological studies. Ethnobotanical survey of plants and recipes from TMP used in the management of PUD in Wukari metropolis, Taraba State, Northeastern Nigeria were documented. A total of twenty (20) TMP located in ten (10) different area of the town were interviewed using a semi structured questioner. Twenty-four (24) plant species from twenty (20) different families and sixteen (16) recipes were documented from the survey. It was observed that plant leaves were mostly used while C. longa (Zingberaceae), M. paradisiaca (Musaceae) had the highest frequency of occurrence in recipes formulation. Therefore, due to the proven efficacy of these herbal recipes as reported from correspondents, there is need for proper documentation, conservation, cultivation and use of these medicinal plants in the management of PUD to avoid them being endangered or going into extinction.","PeriodicalId":188261,"journal":{"name":"Biology, Medicine, & Natural Product Chemistry","volume":"257 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121176789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Triterpenes of Kageneckia oblonga Kageneckia oblonga的Triterpenes

Biology, Medicine, & Natural Product Chemistry Pub Date : 2022-08-01 DOI: 10.14421/biomedich.2022.112.133-136

Jorge Tapia-Merino, Lily Arrué, José San Martín, O. Muñoz

引用次数: 0

Phytochemical Compositions and Antioxidant Properties of Combined Funtumia africana and Abutilon mauritianum Extract (CFAE) 非洲真菌与毛里求斯Abutilon联合提取物(CFAE)的植物化学成分及抗氧化性能

Biology, Medicine, & Natural Product Chemistry Pub Date : 2022-07-31 DOI: 10.14421/biomedich.2022.112.111-118

Robert Ikechukwu Uroko, C. N. Chukwu, Chinomso Friday Aaron, Umezurike Benedict Chidozie, D. Akachukwu, Ndukwe Onyeani Atuh

{"title":"Phytochemical Compositions and Antioxidant Properties of Combined Funtumia africana and Abutilon mauritianum Extract (CFAE)","authors":"Robert Ikechukwu Uroko, C. N. Chukwu, Chinomso Friday Aaron, Umezurike Benedict Chidozie, D. Akachukwu, Ndukwe Onyeani Atuh","doi":"10.14421/biomedich.2022.112.111-118","DOIUrl":"https://doi.org/10.14421/biomedich.2022.112.111-118","url":null,"abstract":"Medically active compounds in plants confer biological effects including antioxidant properties. This study evaluated the phytochemical content and in vitro antioxidant properties of combined Funtumia africana leaves and Abutilon mauritianum extract (CFAE). The 1,1-diphenyl-2-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP), thiobarbituric acid reactive substances (TBARS), total antioxidant capacity (TAC), and nitric oxide radical (NO.) scavenging capabilities were used as antioxidant assay models. The results of the phytochemical analysis showed that CFAE is rich in alkaloids, flavonoids, tannins, saponins, phenols and cardiac glycosides. The extract contains antioxidant vitamins A, C and E, vitamin E being the most abundant. The CFAE showed a dose-dependent TAC based on the observed FRAP, TBARS, and DPPH scavenging activity which could be attributed to the presence of phenolic compounds and vitamins E. These strongly suggest that CFAE is a potential source of phytochemicals and antioxidants which could be exploited in the food and pharmaceutical industries in production of potent nutraceuticals or therapeutically-important products.","PeriodicalId":188261,"journal":{"name":"Biology, Medicine, & Natural Product Chemistry","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115303168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection of the Atherosclerotic PCSK9 gene Inhibitors Through in silico Method to Improve Targeted Therapy 通过计算机方法检测动脉粥样硬化PCSK9基因抑制剂以改进靶向治疗

Biology, Medicine, & Natural Product Chemistry Pub Date : 2022-07-31 DOI: 10.14421/biomedich.2022.112.119-131

Sabarinathan Sethuramalingam, Revathy Leena Ravi, Janet Rani Rajiah

{"title":"Detection of the Atherosclerotic PCSK9 gene Inhibitors Through in silico Method to Improve Targeted Therapy","authors":"Sabarinathan Sethuramalingam, Revathy Leena Ravi, Janet Rani Rajiah","doi":"10.14421/biomedich.2022.112.119-131","DOIUrl":"https://doi.org/10.14421/biomedich.2022.112.119-131","url":null,"abstract":"The PCSK9 is one of the most important marks for the evolution of therapeutic agents for atherosclerosis because its interaction with low-density lipoprotein receptors causes atherosclerosis. Protein-ligand interactions help us to understand the true mechanism of pharmacological action. This study seeks to identify the most powerful suppression options for PCSK9. Initially, the reported ACE inhibitors were included in pharmacophore modeling using PharmaGist. Next, ZINCPHARMER was used to screen the selected model against a ZINC database to identify putative drug candidates docked to the target protein to understand the interactions. The 10 best pharmacological candidates for PCSK9 with a binding energy of 9.8-8.2 kcal mol-1 were identified by molecular docking and their pharmacokinetic properties and oral bioavailability were evaluated. The (S) severalplant obtained chemicals have been discovered, including anti-hypersensitive drugs such as “Canadine, Hesperetin, and Labetalol”. According to Biochemistry, these compounds formed a stable “protein-ligand” complex. The (S) canadine PCSK9 complex had the lowest RMSD and was the most stable. Future in vitro studies could identify (S) canadin as a promising atherosclerosis inhibitor for the evolution of novel PCSK9 inhibitors.","PeriodicalId":188261,"journal":{"name":"Biology, Medicine, & Natural Product Chemistry","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116359399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Antiviral Potential of Iranian Herbal Pharmacopoeia (IHP) on Herpes Simplex Viruses (HSV): A Review Article 伊朗草药药典(IHP)对单纯疱疹病毒(HSV)的抗病毒潜力综述

Biology, Medicine, & Natural Product Chemistry Pub Date : 2022-07-30 DOI: 10.14421/biomedich.2022.112.89-109

S. Gavanji

{"title":"The Antiviral Potential of Iranian Herbal Pharmacopoeia (IHP) on Herpes Simplex Viruses (HSV): A Review Article","authors":"S. Gavanji","doi":"10.14421/biomedich.2022.112.89-109","DOIUrl":"https://doi.org/10.14421/biomedich.2022.112.89-109","url":null,"abstract":"Herpes Simplex Viruses (HSV) viruses are highly contagious that commonly cause dermatitis, encephalitis, meningitis and genitourinary infections and also can lead to cervical cancer. For treatment of HSV infections, several physical methods and antiviral drugs are introduced, antiviral medications can also prevent or reduce outbreaks. The use of herbal medicine with antiviral effects attracted worldwide attentions. The aim of this review article is to introduce the Iranian Herbal Pharmacopoeia (IHP) with antiviral potential against two HSV serotypes and help to evaluate and develop the new drugs from natural sources. To provide this review, relevant articles in some authentic databases including PubMed, Web of Science, Science Direct, Scopus, Google Scholar and SID (scientific information database), from 1967 to April 2022 were collected, and selected botanicals from (IHP) with their scientific names and classifications and their outcome (CC50 and IC50) were introduced. In this review, scientific data regarding anti-herpetic activities of Iranian Herbal Pharmacopoeia (IHP) showed that 34 herbs from 17 families have antiviral potential to inhibit two HSV serotypes. According to families, Lamiaceae family has the highest percentage (29.41 %) of plants with antiviral activity against two HSV serotypes, also review of recent data showed that Salvia officinalis, Melissa officinalis, Securigera Securidaca, Hyssopus officinalis, Quercus brantii, Artemisia aucheri and Curcuma longa have remarkable antiviral activity against two HSV serotypes. Results of this review suggest that further research to identify and purify the bioactive compounds to determine the molecular mechanisms of action is needed.","PeriodicalId":188261,"journal":{"name":"Biology, Medicine, & Natural Product Chemistry","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133101887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Biology, Medicine, &amp; Natural Product Chemistry最新文献

Biology, Medicine, & Natural Product Chemistry最新文献