The American Journal of Gastroenterology最新文献_第6页

S118 Impact of the Distance Approach on the Management of Patients With Inflammatory Bowel Disease (IBD) in the Outpatient and Infusion Centers of a Tertiary Hospital in Northeast Brazil S118 巴西东北部一家三甲医院门诊和输液中心采用的远程方法对炎症性肠病（IBD）患者管理的影响

The American Journal of Gastroenterology Pub Date : 2023-12-01 DOI: 10.14309/01.ajg.0000996216.94041.6c

Caio Cesar Furtado Freire, Milena Santana Girão, Arthur Alencar Arrais de Souza, Ricardo Alves Martins, Eliseu Sousa do Amaral Júnior, Carla Mendes Abreu, Yanna Thais Ramalho Dieb Venuto, Maria Regina Damasceno Dias, Luciana de Brito Falcão Moreno

引用次数: 0

S58 A Mixed Methods Exploration of Diversity, Equity, and Inclusion (DEI) Care Processes Within a Pediatric IBD Learning Health Network S58 儿科 IBD 学习健康网络中的多元化、公平与包容（DEI）护理流程的混合方法探索

The American Journal of Gastroenterology Pub Date : 2023-12-01 DOI: 10.14309/01.ajg.0000995976.46669.b3

Mahalakshmi Parakala, Sandra Kim, Jennie David, Lisa Pitch

{"title":"S58 A Mixed Methods Exploration of Diversity, Equity, and Inclusion (DEI) Care Processes Within a Pediatric IBD Learning Health Network","authors":"Mahalakshmi Parakala, Sandra Kim, Jennie David, Lisa Pitch","doi":"10.14309/01.ajg.0000995976.46669.b3","DOIUrl":"https://doi.org/10.14309/01.ajg.0000995976.46669.b3","url":null,"abstract":"Background: In response to the rising prevalence of in ﬂ ammatory bowel disease (IBD) in Brazil, which now exceeds 100 cases per 100,000 inhabitants, the Brazilian Crohn ’ s Disease and Colitis Organization (GEDIIB) established a National Registry of Patients with IBD to gather information about these conditions. This study presents a comprehensive analysis, encompassing all ﬁ ve geographic regions of the country (North, Northeast, Center-West, Southeast, and South), based on data collected over a span of three years. Methods: A cohort study was conducted from August 2020 to August 2023. The data were sourced from medical records and patient consultationsusing theREDCap platform, withapprovals obtained from the ethics boards of participating institutions. Results: The study comprised 2,831 patients, with 47% diagnosed with ulcerative colitis (UC) and 51.1% with Crohn ’ s disease (CD). Sixty-two percent were followed in public centers, and 38% in the private system. The average age at diagnosis was 38 6 15.5 years for UC and 33.7 6 14.9 years for CD. Females predominated, constituting 64.5% of UC cases and 53.4% of CD cases. The majority of patientswereofCaucasiandescent(58.4%forUC,63.7%forCD),followedbymixed-raceindividuals (32.3%forUC,29.1%forCD)andBlackindividuals(8.8%forUC,6.6%","PeriodicalId":188050,"journal":{"name":"The American Journal of Gastroenterology","volume":"37 5","pages":"S16 - S16"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139017641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

S138 Infliximab and Adalimumab Therapeutic Drug Monitoring (TDM): Analysis of >125,000 Patient Samples for Drug Levels and Designation of Anti-Drug Antibodies into Low, Intermediate and High Titers S138 英夫利西单抗和阿达木单抗治疗药物监测 (TDM)：分析 >125,000 份患者样本的药物水平并将抗药抗体分为低、中和高滴度

The American Journal of Gastroenterology Pub Date : 2023-12-01 DOI: 10.14309/01.ajg.0000996296.47951.54

Kelly Y. Chun, Monique Bastidas, Andrew Lehrhoff, M. Zikry, Jane M. Yang

{"title":"S138 Infliximab and Adalimumab Therapeutic Drug Monitoring (TDM): Analysis of >125,000 Patient Samples for Drug Levels and Designation of Anti-Drug Antibodies into Low, Intermediate and High Titers","authors":"Kelly Y. Chun, Monique Bastidas, Andrew Lehrhoff, M. Zikry, Jane M. Yang","doi":"10.14309/01.ajg.0000996296.47951.54","DOIUrl":"https://doi.org/10.14309/01.ajg.0000996296.47951.54","url":null,"abstract":"Background: Serum assays to measure biologic drugs, especially TNF inhibitors, and their anti-drug antibodies (ADAb) are utilized to manage suboptimal response including that caused by reversible immunogenicity and to proactively titrate doses and dosing intervals. Here, 72,819 in ﬂ iximab (IFX) and 53,131 adalimumab (ADL) recent patient results were analyzed. Methods: Drug and ADAb levels are measured by drug-speci ﬁ c lab-developed chemiluminescent immunoassays. Lower limits of quantitation are 0.4 and 0.6 ug/mL for IFX and ADL, and 22 and 25 ng/mL for respective ADAb assays. Drug assays measure free (ADAb-unbound) biologic drug (validated for originator as well as biosimilars) while ADAb assays detect total antibodies (including IgM & IgG subtypes) and are drug-tolerant to the presence of up to . 50 m g/mL drug. All ADAb positive samples undergo a con ﬁ rmatory step to con ﬁ rm the drug speci ﬁ city of antibodies. Results: Of a total of 72,819 IFX and 53,131","PeriodicalId":188050,"journal":{"name":"The American Journal of Gastroenterology","volume":"200 ","pages":"S37 - S37"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138992789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

S35 Granulomatous Opportunistic Infections in a Tertiary IBD Center Located in a Tuberculosis Hyperendemic Region in Brazil S35 位于巴西结核病高发区的一家三级肠道疾病中心的肉芽肿机会性感染

The American Journal of Gastroenterology Pub Date : 2023-12-01 DOI: 10.14309/01.ajg.0000995876.48058.78

J. Chebli, L. Chebli, Vinicius Andrade Chebli, Genesio Ferreira Lima, Tarsila Rocha Ribeirobr, Livia Almeida Rocha Ribeirobr, José Eugênio Ricci, Erika Ruback Bertges, Daniela Girardi Linhares Rodrigues

引用次数: 0

S18 Ustekinumab and Vedolizumab Drug and Anti-Drug Antibody Monitoring: Analysis of 45,429 Patient Results Using Lab Developed Chemiluminescent Immunoassays S18 Ustekinumab 和 Vedolizumab 药物和抗药抗体监测：使用实验室开发的化学发光免疫测定分析 45,429 例患者的结果

The American Journal of Gastroenterology Pub Date : 2023-12-01 DOI: 10.14309/01.ajg.0000995808.22591.ca

Jane M. Yang, Kelly Y. Chun

{"title":"S18 Ustekinumab and Vedolizumab Drug and Anti-Drug Antibody Monitoring: Analysis of 45,429 Patient Results Using Lab Developed Chemiluminescent Immunoassays","authors":"Jane M. Yang, Kelly Y. Chun","doi":"10.14309/01.ajg.0000995808.22591.ca","DOIUrl":"https://doi.org/10.14309/01.ajg.0000995808.22591.ca","url":null,"abstract":"Background: There are limited studies assessing the impact of pediatric-onset in ﬂ ammatory bowel disease (IBD) on infant and pregnancy outcomes. Low birth weight and preterm birth are known pregnancy complications in IBD patients with active disease. Therefore, this study sought to evaluate pregnancy outcomes in patients with pediatric-onset versus adult-onset Crohn ’ s disease (CD), particularly with regard to intrauterine growth and prematurity delivery. Methods: In this single center, retrospective comparative cohort study, patients with pediatric-onset (diagnosed , 18 years old) and adult-onset CD (diagnosed $ 18 years old) who had documented prenatal care between 2012-2023 were identi ﬁ ed. Patients were excluded for following at outside institutions for primary IBD care. We compared co-primary outcomes (gestational age and size), and secondary outcomes (assisted reproduction usage, mode of delivery, and neonatal intensive care unit (NICU) stay), between the two groups. Data was obtained from an electronic medical record via natural language processing and con ﬁ rmed with manual veri ﬁ cation. Categorical variables were analyzed using chi-squared test or Fisher exact test when appropriate; continuous variables were assessed with t-test if normally distributed. Statistical signi ﬁ cance was determined by p value , 0.05. Results: A total of 208 infants were delivered, 119 to pediatric-onset CD and eighty-nine to adult-onset CD mothers. There was no signi ﬁ cant di ﬀ erence with regard to race between the groups. The mother ’ s age at delivery was signi ﬁ cantly lower in pediatric-onset CD patients (median [IQR]: 30.2 [26.3, 34.5] vs 32.5 [29.8, 35.3] years, p 5 0.0006). There was a numerically","PeriodicalId":188050,"journal":{"name":"The American Journal of Gastroenterology","volume":"705 ","pages":"S6 - S6"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139012781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

S40 Impact of Enterography on the Outcomes of Endoscopic Balloon Dilation for Ileocolonic Anastomotic Strictures in Crohn‘s Disease S40 肠造影对克罗恩病回肠结肠吻合口狭窄内镜下球囊扩张术疗效的影响

The American Journal of Gastroenterology Pub Date : 2023-12-01 DOI: 10.14309/01.ajg.0000995896.73294.83

Joao Carlos Goncalves, T. Capela, T. Gonçalves, J. Magalhães, B. Rosa, J. Cotter

{"title":"S40 Impact of Enterography on the Outcomes of Endoscopic Balloon Dilation for Ileocolonic Anastomotic Strictures in Crohn‘s Disease","authors":"Joao Carlos Goncalves, T. Capela, T. Gonçalves, J. Magalhães, B. Rosa, J. Cotter","doi":"10.14309/01.ajg.0000995896.73294.83","DOIUrl":"https://doi.org/10.14309/01.ajg.0000995896.73294.83","url":null,"abstract":"and adalimumab (0.003), and ustekinumab/vedolizumab (0.002). We also looked at outcomes of the patients who had HF as an adverse event due to biologics, including hospitalizations and it showed it was highest with adalimumab,followed by In ﬂ iximab and vedolizumab. The other outcome we looked at was mortality for patients who had HF with biologics, it was highest in patients who had used adalimumab, followed by In ﬂ iximab and ustekinumab. Conclusions: Our study adds further to the literature regarding biologics adverse events, speci ﬁ cally heart failure. Tofacitinib had the highest ratio of heart failure among all adverse e ﬀ ects, followed by the already-established In ﬂ iximab. All other newer biologics had a relatively lower ratio. Despite tofacitinibhavingthehighestratioforheartfailure,wecannotattributesigni ﬁ cancetothisduetothis drug having only one reported case compared to other drugs. Furthermore, we can conclude that newer biologics have a relatively very small ratio for the risk of heart failure compared to In ﬂ iximab. Further data is needed for the newer biologics.","PeriodicalId":188050,"journal":{"name":"The American Journal of Gastroenterology","volume":"618 ","pages":"S11 - S11"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139013388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

S49 Medication Use Among Patients With Pouchitis After Total Proctocolectomy With Ileal-Pouch Anal Anastomosis for Ulcerative Colitis: A Retrospective Cohort Study S49 因溃疡性结肠炎行全直肠切除术并行回肠-肠袋肛门吻合术后的肠袋炎患者用药情况：回顾性队列研究

The American Journal of Gastroenterology Pub Date : 2023-12-01 DOI: 10.14309/01.ajg.0000995940.32036.ae

Nicole L. Miller, Chukwudumebi L. Uche, Kristen Tessiatore, Jennifer Seminerio, Ambuj Kumar

引用次数: 0

S20 Race is Associated With a Higher Uptake of COVID-19 Vaccine in Inflammatory Bowel Disease Patients S20 种族与炎症性肠病患者较高的 COVID-19 疫苗接种率有关

The American Journal of Gastroenterology Pub Date : 2023-12-01 DOI: 10.14309/01.ajg.0000995816.27986.e4

Mary C. Camacho, Daniel Berger, Kevin Do, Aaron Issac, Sobia Mujtaba, Heba N. Iskandar

{"title":"S20 Race is Associated With a Higher Uptake of COVID-19 Vaccine in Inflammatory Bowel Disease Patients","authors":"Mary C. Camacho, Daniel Berger, Kevin Do, Aaron Issac, Sobia Mujtaba, Heba N. Iskandar","doi":"10.14309/01.ajg.0000995816.27986.e4","DOIUrl":"https://doi.org/10.14309/01.ajg.0000995816.27986.e4","url":null,"abstract":"Background: There are limited studies assessing the impact of pediatric-onset in ﬂ ammatory bowel disease (IBD) on infant and pregnancy outcomes. Low birth weight and preterm birth are known pregnancy complications in IBD patients with active disease. Therefore, this study sought to evaluate pregnancy outcomes in patients with pediatric-onset versus adult-onset Crohn ’ s disease (CD), particularly with regard to intrauterine growth and prematurity delivery. Methods: In this single center, retrospective comparative cohort study, patients with pediatric-onset (diagnosed , 18 years old) and adult-onset CD (diagnosed $ 18 years old) who had documented prenatal care between 2012-2023 were identi ﬁ ed. Patients were excluded for following at outside institutions for primary IBD care. We compared co-primary outcomes (gestational age and size), and secondary outcomes (assisted reproduction usage, mode of delivery, and neonatal intensive care unit (NICU) stay), between the two groups. Data was obtained from an electronic medical record via natural language processing and con ﬁ rmed with manual veri ﬁ cation. Categorical variables were analyzed using chi-squared test or Fisher exact test when appropriate; continuous variables were assessed with t-test if normally distributed. Statistical signi ﬁ cance was determined by p value , 0.05. Results: A total of 208 infants were delivered, 119 to pediatric-onset CD and eighty-nine to adult-onset CD mothers. There was no signi ﬁ cant di ﬀ erence with regard to race between the groups. The mother ’ s age at delivery was signi ﬁ cantly lower in pediatric-onset CD patients (median [IQR]: 30.2 [26.3, 34.5] vs 32.5 [29.8, 35.3] years, p 5 0.0006). There was a numerically","PeriodicalId":188050,"journal":{"name":"The American Journal of Gastroenterology","volume":"67 ","pages":"S6 - S6"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139017603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

S96 Overcoming Patent Barriers in IBD Therapeutics: A Path to Affordable Access S96 克服 IBD 治疗药物的专利障碍：通往可负担得起的治疗之路

The American Journal of Gastroenterology Pub Date : 2023-12-01 DOI: 10.14309/01.ajg.0000996128.46896.09

Sneha P. Dave, Karen Mancera, Leah Clark, Erin Ard, Jeremy Adler, Ryleigh Adkins, Nikhil Jayswal

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S15 Recombinant Zoster Vaccine (RZV) is Effective in Reducing Herpes Zoster Infection in Patients With Inflammatory Bowel Disease: A US Propensity Matched Cohort Study S15 重组带状疱疹疫苗 (RZV) 可有效减少炎症性肠病患者的带状疱疹感染：美国倾向匹配队列研究

The American Journal of Gastroenterology Pub Date : 2023-12-01 DOI: 10.14309/01.ajg.0000995796.62296.2b

Aakash Desai, Jana G Hashash, G. Kochhar, F. Caldera, F A Farraye

引用次数: 0